| Institute/Center | Type | Director or Designee |
| Alyce G. Clarke Center for Medically Fragile Children | External Designation | Brandy Wilson, DNP, FNP, RN |
| Cancer Center & Research Institute | Institute | Rodney P. Rocconi, MD, FACOG, FASCO |
| Cardiorenal and Metabolic Diseases Research Center | External Designation | John E. Hall, PhD |
| Cardiovascular-Renal Research Center (CRRC) | Center | David E. Stec, PhD (Director) & Josh Speed, PhD (Associate Director) |
| Center for Advancement of Youth (CAY) | Clinical Center | Barbara Saunders, DO, FAAP (Medical Director) & Dustin Sarver, PhD (Executive Director) |
| Center for Bioethics and Medical Humanities | Center | Ralph Didlake, MD, FACS |
| Center for Children with Medical Complexity | Center | Keith E. Parker, MS (Administrative Director) & Christian Paine, MD (Medical Director) |
| Center for Clinical and Translational Science | Center | Meagan Brown, PharmD, BCACP |
| Center for Comparative Research | Center | Andrew W. Grady, DVM, Diplomate ACLAM |
| Center for HIV/AIDS Research, Education and Policy (within Myrlie Evers Williams Institute) | Center | Mauda L. Monger, PhD |
| Center for Immunology and Microbial Research | Center | Eva Bengten, PhD (Director) & Jorge Vidal, PhD (Associate Director) |
| Center for Informatics and Analytics | Center | Sandeep Rustagi, PhD (Director) & Keely Frederick (Co-Director) |
| Center for Innovation and Discovery in Addictions | Center | James Rowlett, PhD & Andrew Voluse, PhD |
| Center for Integrative Health | Clinical Center | Danny Burgess, PhD (Director) & Rachel Dear, PT (Associate Director) |
| Center for Maternal and Fetal Care | Clinical Center | Angelle Klar, MD; Sarah Novotny, MD & Alicon Johnson, MSN, RN, CPNP-AC |
| Center for Neuromuscular Disorders | Clinical Center | Amanda Witt, MD |
| Center for Telehealth and Emerging Technologies | External Designation | Saurabh Chandra, MD |
| Center for Tobacco Treatment, Education, and Research (ACT) | Center | Jonathan Hontzas, DNP |
| Children's Heart Center | Clinical Center | Phillip Burch, MD; Viswanath Gajula, MD; Scott Simpson, MD & Alicon Johnson, MSN, RN, CPNP-AC |
| Children's of Mississippi Center for Cancer and Blood Disorders | Clinical Center | Betty Herrington, MD, FAAP |
| Children's Safe Center | External Designation | Scott Benton, MD & Courtney Helfrich, MBA |
| Comprehensive Epilepsy Center | Clinical Center | John B. Ingram, MD (Interim) |
| Cystic Fibrosis Care Center (Adult/Pediatric) | External Designation | Andrew Wilhelm, MD (Adult); David Josey, MD & Joseph 'Marc' Majure, MD (Pediatric) |
| Esophageal Health and Reflux Center | Clinical Center | Jacob Moremen, MD |
| Face and Skin Center | Clinical Center | Jeremy Jackson, MD & Kim Ward, MD |
| Jabaley-Songcharoen Center for Hand, Upper Extremity and Nerve Surgery | Center | Marc E. Walker, MD, MBA, FACS |
| The Memory Impairment and Neurodegenerative Dementia Center (MIND) | Center | Thomas H. Mosley, Jr., PhD |
| Mississippi AIDS Education Training Center | External Designation | Sherry Stephens-Gibson, DrPH, MCHES®, MPH |
| Mississippi Burn Center | Clinical Center | Juvonda Hodge, MD |
| Mississippi Center for Clinical and Translational Research (MCCTR) | External Designation | Joey Granger, PhD |
| Mississippi Center for Emergency Services | Clinical Center | Jeremy Benson, MCES |
| Mississippi Center for Heart Research (MCHR) | Center | Michael Hall, MD & Yingjie Chen, PhD |
| Mississippi Center for Obesity Research (MCOR) | Center | John E. Hall, PhD |
| Mississippi Center for Violence Research | Center | Lei Zhang, PhD, MBA (Director) & Matthew Kutcher, MD (Deputy Director) |
| Mississippi Center of Excellence in Perinatal Research | External Designation | Jane F. Reckelhoff, PhD & Babbette LaMarca, PhD |
| Mississippi Centre for Evidence-Based Practice: A Joanna Briggs Institute Centre of Excellence | External Designation | Robin Christian, DNP, APRN, FNP-C & Michelle Palokas, DNP, RN-CPN |
| Mississippi Clinical Research and Trials Center | Center | Gailen Marshall, MD, PhD |
| Mississippi Poison Control Center | External Designation | Michael Marlin, MD (Medical Director) & Jenna Davis, MSN, FNP-C (Managing Director) |
| Mississippi Preeclampsia Collaborative Center | Center | Babbette LaMarca, PhD (Director) & J. Martin Tucker, MD (Associate Director) |
| Molecular Center of Health and Disease (MCHD) | External Designation | Michael R. Garrett, PhD |
| Myrlie Evers-Williams Institute for the Elimination of Health Disparities | Institute | Victoria Gholar, DNP, PMH-BC (Executive Director); Abigail Gamble, PhD, MS (Director, Research and Community Engagement) & Juanyce Taylor, PhD (Director, Interdisciplinary Learning Lab) |
| Southeast Center for Health Achievement and Growth in Equity (SEACHANGE) | External Designation | Caroline Compretta, PhD |
| Stephanie & Mitchell Morris Center for Cleft and Craniofacial Research and Innovation | Clinical Center | Ian Hoppe, MD |
| The Skin Cancer Center | Clinical Center | William Black, MD |
| UMMC Biobank | Center | Shelia Belk, MD (Regulatory Director) & Evangeline Deer, PhD (Scientific Director) |
| UMMC Neuro Institute | Institute | John B. Ingram, MD (Interim) |
| UMMC Stroke Center | External Designation | Shreyas Gangadhara, MD, MS, RPNI, FAAN, FANA, FAHA (Medical Director) & Allison Strickland, MD (Endovascular Director) |
| UMMC Voice and Swallowing Center | Clinical Center | John Schweinfurth, MD & Laura Vaughan-Robinson, PhD |
| University Heart Center | Clinical Center | Michael McMullan, MD |
| Women's Health Research Center | Center | Licy Yanes Cardozo, MD (Director) & Jane Reckelhoff, PhD (Co-Director) |
