| Institute/Center | Type | Director |
| Basic and Advanced Resuscitation Training Center | Center | Michelle Schweinfurth, RN, MSN |
| Cancer Institute | Institute | Jack Ruckdeschel, MD |
| Cardiorenal and Metabolic Diseases Research Center | External Designation Center | John Hall, PhD |
| Cardiovascular-Renal Research Center (CRRC) | Center | Joey Granger, PhD |
| Center for Advancement of Youth (CAY) | Center | T. David Elkin, PhD |
| Center for Bioethics and Medical Humanities | Center | Ralph Didlake, MD |
| Center for Clinical and Translational Science | Center | Leigh Ann Ross, PhD |
| Center for Comparative Research | Center | Andrew W. Grady, DVM |
| Center for Computational Research | Center | Robert Hester, PhD |
| Center for Developmental Disorders Research (CDDR) | Center | Rob Annett, PhD |
| Center for Genetic Medicine | Center | Center not currently active |
| Center for HIV/AIDS Research, Education and Policy (within Myrlie Evers-Williams Institute) | Center | Leandro Mena MD, MPH |
| Center for Informatics and Analytics | Center | Alex Castillo |
| Center for Integrative Health | Center | Danny Burgess, PhD |
| Center for LGBTQ Health | Center | Leandro Mena, MD, MPH; Scott Rodgers, MD |
| Center for Maternal and Fetal Care | Clinical Center | Sarah Novotny, MD |
| Center for Neuromuscular Disorders | Clinical Center | Amanda Witt, MD |
| Center for Psychiatric Neuroscience | External Designation Center | Donna Platt, PhD |
| Center for Sialendoscopy and Salivary Gland Disorders | Clinical Center | J. Randall Jordan |
| Center for Telehealth | External Designation Center | Michael Adcock |
| Center for Tobacco Treatment, Education and Research (ACT) | Center | Thomas J. Payne, PhD |
| Center for Voice and Swallowing | Clinical Center | John Schweinfurth, MD |
| Children's Heart Center | Clinical Center | Brian Kogon |
| Children's of Mississippi Cancer Center | Center | Anderson Collier |
| Children's Safe Center | Center | Rebecca Mansell |
| Cleft and Craniofacial Center | Clinical Center | Ravi Chandran, Peter Arnold |
| Comprehensive Epilepsy Center | Clinical Center | Mecheri Sundaram, MD |
| Comprehensive Stroke Center | External Designation Center | Chad Washington, MD |
| Cystic Fibrosis Care Center (Adult) | External Designation Center | |
| Cystic Fibrosis Care Center (Pediatric) | External Designation Center | Joseph Majure |
| Face and Skin Center | Clinical Center | Jennifer B. Bryant |
| Health Innovation and Transformation (HIT) Center | Center | Terrence Hibbert |
| Judith Gore Gearhart Clinical Skills Center | Clinical Center | Kathleen Young, PhD, MPH |
| Memory Impairment and Neurodegenerative Dementia (MIND) Center | Center | Thomas Mosley, PhD |
| Mississippi AIDS Education Training Center | External Designation Center | Mauda Monger |
| Mississippi Center for Clinical and Translational Research | External Designation Center | James G. Wilson, MD |
| Mississippi Center for Emergency Services | Clinical Center | Jonathan Wilson, PhD, MSN, RN |
| Mississippi Center for Heart Research (MCHR) | Center | Merry Lindsey PhD |
| Mississippi Center for Obesity Research (MCOR) | Center | John E. Hall, PhD |
| Mississippi Center of Excellence in Perinatal Research | Center | Jane F. Reckelhoff, PhD |
| Mississippi Centre for Evidence-Based Practice: A Joanna Briggs Institute Centre of Excellence | External Designation Center | Drs. Robin Christian, Michelle Palokas |
| Mississippi Clinical Research and Trials Center | Center | Gailen Marshall, MD, PhD |
| Mississippi Poison Control Center | External Designation Center | Robert Cox, MD, PhD |
| Myrlie Evers-Williams Institute for the Elimination of Health Disparities | Institute | Bettina Beech, DrPH, MPH |
| Simulation and Interprofessional Education Center | Center | Anna Lerant, MD |
| UMMC Biobank | Center | Stephanie C. Tanner, MD |
| UMMC Neuro Institute | Institute | Michael Lehman, PhD |
| University Heart Center | Clinical Center | Michael McMullan |
| Women's Health Research Center | Center | Jane F. Recklehoff, PhD |