| Institute/Center | Type | Director or Designee |
| Alyce G. Clarke Center for Medically Fragile Children | External Designation | Ellen Hansen, MS, BSN, RN, CENP |
| Cancer Center & Research Institute | Institute | Rodney P. Rocconi, MD, FACOG, FASCO |
| Cardiorenal and Metabolic Diseases Research Center | External Designation | John Hall, PhD |
| Cardiovascular-Renal Research Center (CRRC) | Center | David E. Stec, PhD (Director) & Josh Speed, PhD (Associate Director) |
| Center for Advancement of Youth (CAY) | Clinical Center | Barbara Saunders, DO, FAAP (Medical Director) |
| Center for Bioethics and Medical Humanities | Center | Ralph Didlake, MD, FACS |
| Center for Children with Medical Complexity | Center | C. Christian Payne, MD, MHIIM (Clinical Director) & Chris Collado, DHA, NP-C, CPNP (Admin Director) |
| Center for Clinical and Translational Science | Center | Meagan Brown, PharmD |
| Center for Comparative Research | Center | Andrew W. Grady, DVM, Diplomate ACLAM |
| Center for HIV/AIDS Research, Education and Policy (within Myrlie Evers Williams Institute) | Center | Mauda L. Monger, PhD |
| Center for Immunology and Microbial Research | Center | Larry McDaniel, PhD, FIDSA, FAAM (Director) & Eva Bengten, PhD (Associate Director) |
| Center for Informatics and Analytics | Center | Ramona Sandlin, RHIA |
| Center for Innovation and Discovery in Addictions | Center | James Rowlett, PhD & Andrew Voluse, PhD |
| Center for Integrative Health | Clinical Center | Danny Burgess, PhD (Director) & Rachel Dear, PT (Associate Director) |
| Center for Maternal and Fetal Care | Clinical Center | Angelle Klar, MD; Sarah Novotny, MD & Chris Collado DHA, NP-C, CPNP-Dual |
| Center for Neuromuscular Disorders | Clinical Center | Amanda Witt, MD |
| Center for Telehealth and Emerging Technologies | External Designation | Saurabh Chandra, MD |
| Center for Tobacco Treatment, Education, and Research (ACT) | Center | Jonathan Hontzas, DNP |
| Children's Heart Center | Clinical Center | Phillip Burch, MD, Viswanath Gajula, MD, Scott Simpson, MD, & Alicon Johnson, MSN CPNP-AC |
| Children's of Mississippi Center for Cancer and Blood Disorders | Center | Betty Herrington, MD, FAAP |
| Children's Safe Center | External Designation | Scott Benton, MD |
| Comprehensive Epilepsy Center | Clinical Center | John Ingram, MD (Interim) |
| Cystic Fibrosis Care Center (Adult/Pediatric) | External Designation | Andrew Wilhelm, MD (adult); David Josey, MD & Joseph 'Marc' Majure, MD (pediatric) |
| Esophageal Health and Reflux Center | Clinical Center | Jacob Moremen, MD |
| Face and Skin Center | Clinical Center | Jeremy Jackson, MD & Kim Ward, MD |
| Jabaley-Songcharoen Center for Hand, Upper Extremity and Nerve Surgery | Center | Marc E. Walker, MD, MBA, FACS |
| The Memory Impairment and Neurodegenerative Dementia Center (MIND) | Center | Thomas Mosley, PhD |
| Mississippi AIDS Education Training Center | External Designation | Sherry Stephens-Gibson, DrPH, MCHES®, MPH |
| Mississippi Burn Center | Clinical Center | Juvonda Hodge, MD |
| Mississippi Center for Clinical and Translational Research (MCCTR) | External Designation | Joey Granger, PhD |
| Mississippi Center for Emergency Services | Clinical Center | Kendall McKenzie, MD |
| Mississippi Center for Heart Research (MCHR) | Center | Michael Hall, MD; Yingjie Chen, PhD & Ji Li, PhD |
| Mississippi Center for Obesity Research (MCOR) | Center | John E. Hall, PhD |
| Mississippi Center for Violence Research | Center | Lei Zhang, PhD, MBA |
| Mississippi Center of Excellence in Perinatal Research | External Designation | Jane F. Reckelhoff, PhD |
| Mississippi Centre for Evidence-Based Practice: A Joanna Briggs Institute Centre of Excellence | External Designation | Robin Christian, DNP, APRN, FNP-C & Michelle Palokas, DNP, RN-CPN |
| Mississippi Clinical Research and Trials Center | Center | Gailen Marshall, MD, PhD |
| Mississippi Poison Control Center | External Designation | Michael Marlin, MD (Medical Director) & Jenna Davis, NP (Managing Director) |
| Mississippi Preeclampsia Collaborative Center | Center | Babbette LaMarca, PhD (director) & J. Martin Tucker, MD (associate director) |
| Molecular Center of Health and Disease (MCHD) | External Designation | Michael R. Garrett, PhD |
| Myrlie Evers-Williams Institute for the Elimination of Health Disparities | Institute | Victoria Gholar, DNP, PMH-BC (Executive Director); Abigail Gamble, PhD, MS (Director, Research and Community Engagement) & Juanyce Taylor, PhD (Director, Interdisciplinary Learning Lab) |
| Southeast Center for Health Achievement and Growth in Equity (SEACHANGE) | External Designation | Caroline Compretta, PhD |
| Stephanie & Mitchell Morris Center for Cleft and Craniofacial Research and Innovation | Clinical Center | Ian Hoppe, MD |
| The Skin Cancer Center | Clinical Center | William Black, MD & Jeremy Jackson, MD |
| UMMC Biobank | Center | Shelia Belk, MD & Evangeline Deer, PhD |
| UMMC Neuro Institute | Institute | John Ingram, MD |
| UMMC Stroke Center | External Designation | Chad Washington, MS, MD, MPHS |
| UMMC Voice and Swallowing Center | Clinical Center | John Schweinfurth, MD |
| University Heart Center | Clinical Center | Michael McMullan, MD |
| Women's Health Research Center | Center | Licy Yanes Cardozo, MD (Director) & Jane Reckelhoff, PhD (Co-Director) |
