| Institute/Center | Type | Director or Designee |
| Basic and Advanced Resuscitation Training Center | Center | Jereme King, Paramedic, RN, NRP, MSEFL |
| Cancer Center & Research Institute | Institute | Rodney P. Rocconi, MD |
| Cardiorenal and Metabolic Diseases Research Center | External Designation | John Hall, PhD |
| Cardiovascular-Renal Research Center (CRRC) | Center | David E. Stec, PhD |
| Center for Advancement of Youth (CAY) | Clinical Center | David Elkin, PhD, ABPP (Executive Director) & Barbara Saunders, DO, FAAP (Medical Director) |
| Center for Bioethics and Medical Humanities | Center | Ralph Didlake, MD, FACS |
| Center for Children with Medical Complexity | Center | C. Christian Payne, MD, MHIIM (Clinical Director) & Chris Collado, DHA, NP-C, CPNP (Admin Director) |
| Center for Clinical and Translational Science | Center | Meagan Brown, PharmD |
| Center for Comparative Research | Center | Andrew W. Grady, DVM, Diplomate ACLAM |
| Center for HIV/AIDS Research, Education and Policy (within Myrlie Evers Williams Institute) | Center | Thomas Dobbs, MD, MPH |
| Center for Immunology and Microbial Research | Center | Larry S. McDaniel, PhD, FIDSA, FAAM |
| Center for Informatics and Analytics | Center | Ramona Sandlin |
| Center for Innovation and Discovery in Addictions | Center | Jefferson Parker, PhD & James Rowlett, PhD |
| Center for Integrative Health | Clinical Center | Danny Burgess, PhD & Rachel Dear, PT (Associate Director) |
| Center for Maternal and Fetal Care | Clinical Center | Chris Collado, DHA, NP-C, CPNP-Dual |
| Center for Neuromuscular Disorders | Clinical Center | Amanda Witt, MD |
| Center for Sialendoscopy and Salivary Gland Disorders | Clinical Center | J. Randall Jordan, MD |
| Center for Tobacco Treatment, Education, and Research (ACT) | Center | Jonathan Hontzas, DNP |
| Children's Heart Center | Center | William B. Moskowitz, MD; Phillip T. Burch, MD; Viswanath Gajula, MD; Scott A. Simpson, MD & Alicon K. Johnson, ED |
| Children's of Mississippi Center for Cancer and Blood Disorders | Center | Betty Herrington, MD, FAAP |
| Children's Safe Center | External Designation | Scott Benton, MD & Courtney Helfrich, MBA |
| Comprehensive Epilepsy Center | Clinical Center | Olga Selioutski, DO |
| Comprehensive Stroke Center | External Designation | Chad Washington, MD |
| Cystic Fibrosis Care Center (Adult/Pediatric) | External Designation | Andrew Wilhelm, MD (Adult) & Joseph Majure, MD (Pediatric) |
| Esophageal Health and Reflux Center | Clinical Center | Jacob R. Moremen, MD |
| Face and Skin Center | Clinical Center | Jeremy Jackson, MD & Kim Ward, MD |
| Jabaley-Songcharoen Center for Hand, Upper Extremity and Nerve Surgery | Center | Marc E. Walker, MD, MBA, FACS |
| Judith Gore Gearhart Clinical Skills Center | Clinical Center | Norma Ojeda, MD |
| Memory Impairment and Neurodegenerative Dementia Center (MIND) | Center | Thomas Mosley, PhD |
| Mississippi AIDS Education Training Center | External Designation | Sherry Stephens-Gibson, DrPH, MPH, MCHES & James B. Brock, PhD |
| Mississippi Burn Center | Clinical Center | Juvonda Hodge, MD |
| Mississippi Center for Clinical and Translational Research (MCCTR) | External Designation | Joey Granger, PhD |
| Mississippi Center for Emergency Services | Clinical Center | Stephen Houck, MSHS, RN, FP-C, MS-CCP, CHEP |
| Mississippi Center for Heart Research (MCHR) | Center | Michael Hall, MD; Yingjie Chen, PhD & Ji Li, PhD |
| Mississippi Center for Obesity Research (MCOR) | Center | John E. Hall, PhD |
| Mississippi Center of Excellence in Perinatal Research | External Designation | Jane F. Reckelhoff, PhD & Denise Cornelius, PhD |
| Mississippi Centre for Evidence-Based Practice: A Joanna Briggs Institute Centre of Excellence | External Designation | Robin Christian, DNP, APRN, FNP-C & Michelle Palokas, DNP, RN-CPN |
| Mississippi Clinical Research and Trials Center | Center | Gailen Marshall, MD, PhD |
| Mississippi Poison Control Center | External Designation | Michael Marlin, MD |
| Molecular Center of Health and Disease (MCHD) | External Designation | Michael R. Garrett, PhD |
| Myrlie Evers-Williams Institute for the Elimination of Health Disparities | Institute | Victoria M. Gholar, DNP, RN, PMH-BC & Abigail Gamble, PhD, MS |
| Simulation and Interprofessional Education Center | Center | Norma Ojeda, MD; Joyce Shelby, MBA; Patrick Newman, MD; Patricia Amolenda, MD & Kimberley Harper, MD |
| Stephanie & Mitchell Morris Center for Cleft and Craniofacial Research and Innovation | Clinical Center | Ian Hoppe, MD |
| The Skin Cancer Center | Clinical Center | William Black, MD |
| UMMC Biobank | Center | BabbetteLaMarca, PhD; Shelia Belk, MD & Evangeline Deer, PhD |
| UMMC Neuro Institute | Institute | Mary A. Willis, MD |
| UMMC Telehealth Center of Excellence | External Designation | Saurabh Chandra, MD |
| UMMC Voice and Swallowing Center | Clinical Center | John Schweinfurth, MD & Josephine Alston, SLP |
| University Heart Center | Clinical Center | Michael McMullan, MD & Abbey Street, FACHE |
| Women's Health Research Center | Center | Licy Yanes Cardozo, MD; Co-Directors Damian G. Romero, PhD; Barbara T. Alexander, PhD & Josie Bidwell, DNP, RN, FNP-C |