Manipulation or propagation of recombinant DNA must be done in accordance with the current National Institutes of Health (NIH) Guidelines for Research Involving Recombinant DNA Molecules.
Supervisors must consult the NIH guidelines to determine whether or not their activities are covered by the guidelines and, if so, what biosafety level is required for either in vitro manipulation of recombinant DNA or its in vivo propagation in living cells and organisms, including transgenic animals.
UMMC requires IBC registration of all exempt and covered activities involving recombinant DNA to confirm proper classification of the activity and assure compliance with prescribed laboratory safety practices and use of containment barriers. When applicable, the IBC will assist in acquiring approval from higher authorities such as the NIH Office of Recombinant DNA Activities.
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