Student Publications

2020

• Casey G, Askew C, Brimble MA, Samulski RJ, Davidoff AM, Li C, Walters BJ. Self-complementarity in adeno-associated virus enhances transduction and gene expression in mouse cochlear tissues. PLoS One. 2020 Nov 23;15(11):e0242599. 
• Cushnie AK, El-Nahal HG, Bohlen MO, May PJ, Basso MA, Grimaldi P, Wang MZ, de Velasco EMF, Sommer MA, Heilbronner SR. Using rAAV2-retro in rhesus macaques: Promise and caveats for circuit manipulation. J Neurosci Methods. 2020 Jul 12:108859.
• Eddy AC, Howell JA, Chapman H, Taylor E, Mahdi F, George EM, Bidwell GL 3rd. (2020) Biopolymer-Delivered, Maternally Sequestered NF-κB (Nuclear Factor-κB) Inhibitory Peptide for Treatment of Preeclampsia. Hypertension. Jan;75(1):193-201. 
• Howell JA, Bidwell GL 3rd. (2020) Targeting the NF-κB pathway for therapy of ischemic
  stroke. Ther Deliv. Feb;11(2):113-123.
• Kuiper LB, Lucas KA, Mai V, Coolen LM. Enhancement of Drug Seeking Following Drug Taking in a Sexual Context Requires Anterior Cingulate Cortex Activity in Male Rats. Front Behav Neurosci. 2020 Jun 25;14:87.
• Maynard ME, Redell JB, Zhao J, Hood KN, Vita SM, Kobori N, Dash PK. (2020) Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury. Exp Neurol. May;327:113207.
• Pantazopoulos H, Gisabella B, Rexrode L, Benefield D, Yildiz E, Seltzer P, Valeri J, Chelini G, Reich A, Ardelt M, Berretta S. Circadian Rhythms of Perineuronal Net Composition. eNeuro. 2020; ENEURO.0034-19.2020. 
• Person JM, Welch BA, Spann RA, Harris KK, Pride Y, Tucci MA, Taylor EB, Grayson BE. (2020) Immuno-hematologic parameters following rodent spinal cord contusion are negatively influenced by high-fat diet consumption. J Neuroimmun. Jun 15;343:577226.
• Redell JB, Maynard ME, Underwood EL, Vita SM, Dash PK, Kobori N. (2020) Traumatic brain injury and hippocampal neurogenesis: Functional implications. Exp Neurol. Jun 3:113372. 
• Spann RA, Grayson BE. Curbing Obesity from One Generation to Another: the Effects of Bariatric Surgery on the In Utero Environment and Beyond. Reprod Sci. 2020 Jun 23. doi: 10.1007/s43032-020-00221-7. 
• Spann RA, Welch BA, Grayson BE. (2020) Ghrelin signalling is dysregulated in male but not female offspring in a rat model of maternal vertical sleeve gastrectomy. J Neuroendocrinol. Oct 16:e12913.
• Szczepanski J, Griffin A, Novotny S, Wallace K. (2020) Acute Kidney Injury in Pregnancies Complicated With Preeclampsia or HELLP Syndrome. Front Med (Lausanne). Feb 7;7:22. 
• Szczepanski J, Spencer SK, Griffin A, Bowles T, Williams JM, Kyle PB, Dumas JP, Araji S, Wallace K. Acute kidney injury during pregnancy leads to increased sFlt-1 and sEng and decreased renal T regulatory cells in pregnant rats with HELLP syndrome. Biol Sex Differ. 2020 Sep 24;11(1):54.
• Vita S, Grayson BE, Grill RJ (2020) Acute damage to the blood-brain barrier and perineuronal net integrity in a clinically-relevant model of traumatic brain injury. Neuroreport 31(16):1167-74. 
• Yu Y, Huang J, Tang X, Allison J, Sandlin D, Ding D, Pang Y, Zhang C, Chen T, Yin N, Chen L, Mustain W, Zhou W, Zhu H. (2020) Exposure to blast shock waves via the ear canal induces deficits in vestibular afferent function in rats. J Otol. Sep;15(3):77-85. 
• Zamarripa CA, Naylor JE, Huskinson SL, Townsend EA, Prisinzano TE, Freeman KB. (2020) Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys. Psychopharmacology (Berl). May;237(5):1471-1480. 
• Zamarripa CA, Patel TR, Williams BC, Pareek T, Schrock HM, Prisinzano TE, Freeman KB. (2020) The kappa-opioid receptor agonist, nalfurafine, blocks acquisition of oxycodone self-administration and oxycodone's conditioned rewarding effects in male rats. Behav Pharmacol. 
• Zhang X, Hutchins SD, Blough BE, Vallender EJ. (2020) In Vitro Effects of Ligand Bias on Primate Mu Opioid Receptor Downstream Signaling. Int J Mol Sci. Jun 3;21(11). pii: E3999. doi: 10.3390/ijms21113999. 

2019

• Adeosun SO, Hou X, Shi L, Stockmeier CA, Zheng B, Raffai RL, Weisgraber KH, Mosley TH, Wang JM. (2019) Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture. Neurobiol Learn Mem 161:106-114
• Bohlen MO, Bui K, Stahl JS, May PJ, Warren S. (2019) Mouse Extraocular Muscles and the Musculotopic Organization of Their Innervation. Anat Rec (Hoboken). Oct;302(10):1865-1885.
• Chandler CM, Reeves-Darby J, Jones SA, McDonald JA, Li G, Rahman MT, Cook JM, Platt DM. (2019) α5GABAA subunit-containing receptors and sweetened alcohol cue-induced reinstatement and active sweetened alcohol self-administration in male rats. Psychopharmacology (Berl). 236(6):1797-1806.
• Gilmore RA, Hutchins SD, Zhang X, Vallender EJ. (2019) MicrobiomeR: An R Package for Simplified and Standardized Microbiome Analysis Workflows. J. Open Source Software. 4(35):1299
• Himel AR, Taylor EB, Phillips CL, Welch BA, Spann RA, Bandyopadhyay S, Grayson BE. (2019) Splenectomy fails to attenuate immuno-hematologic changes after rodent vertical sleeve gastrectomy. Exp Biol Med. Jun 244(13):1125-1135.
• Hou X, Adeosun SO, Zhao X, Hill R, Zheng B, Reddy R, Su X, Meyer J, Mosley T, Wang JM. (2019) ERβ agonist alters RNA splicing factor expression and has a longer window of antidepressant effectiveness than estradiol after long-term ovariectomy. J Psychiatry Neurosci 44(1):19-31.
• Kuiper LB, Beloate LN, Dupuy BM, Coolen LM. (2019) Drug-taking in a socio-sexual context enhances vulnerability for addiction in male rats. Neuropsychopharmacology. 44(3):503-513.
• Jones-Muhammad M, Warrington JP. (2019) Cerebral Blood Flow Regulation in Pregnancy, Hypertension, and Hypertensive Disorders of Pregnancy. Brain Sci. 9(9):224.
• Porter DT, Moore AM, Cobern JA, Padmanabhan V, Goodman RL, Coolen LM, Lehman MN. Prenatal Testosterone Exposure Alters GABAergic Synaptic Inputs to GnRH and KNDy Neurons in a Sheep Model of Polycystic Ovarian Syndrome. Endocrinology. 160(11):2529-2542.
• Spann RA, Taylor EB, Welch BA, Grayson BE. (2019) Altered immune system in offspring of rat maternal vertical sleeve gastrectomy. Am J Physiol Regul Integr Comp Physiol. Dec 1;317(6):R852-R863.
• Wiggins JW, Kozyrev N, Sledd JE, Wilson GG, and Coolen LM. (2019) Chronic Spinal Cord Injury Reduces Gastrin-Releasing Peptide in the Spinal Ejaculation Generator in Male Rats. J Neurotrauma. Dec 15;36(24):3378-3393.
• Yu Y, Huang J, Zhang CM, Chen TW, Sandlin DS, Wang SX, Arteaga AA, Allison J, Ou Y, Warren S, May P, Zhu H, Zhou W. (2019) Passive eye movements induced by electromagnetic force (EMF) in rats. Zool Res. 40(3):211-218.
• Zhang X, Yasuda K, Gilmore RA, Westmoreland SV, Platt DM, Miller GM, Vallender EJ. (2019) Alcohol-induced changes in the gut microbiome and metabolome of rhesus macaques. Psychopharmacology (Berl). 236(5):1531-1544.

2018

• Beloate LN, Coolen LM. (2018) Effects of Sexual Experience on Psychostimulant- and Opiate-Induced Behavior and Neural Plasticity in the Mesocorticolimbic Pathway. Int Rev Neurobiol. 140:249-270.
• Chandler CM, Overton JS, Rüedi-Bettschen D, Platt DM (2018) GABAA Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence. Handb Exp Pharmacol. 248:3-27.
• Kuiper LB, Coolen LM (2018) Compulsive sexual behavior in humans and preclinical models. Curr Sex Health Rep. 10:124-131.
• Lazenka ML, Moerke MJ, Townsend EA, Freeman KB, Carroll FI, Negus SS (2018) Dissociable effects of the kappa opioid receptor agonist nalfurafine on pain/itch-stimulated and pain/itch-depressed behaviors in male rats. Psychopharmacology (Berl) 235(1):203-213.
• Moore AM, Coolen LM, Porter DT, Goodman RL, Lehman MN. (2018) KNDy cells revisited. Endocrinology. 1559:3219-3234.
• Sandlin DS, Yu Y, Huang J, Zhang C, Arteaga AA, Lippincott JK, Peeden EOH, Guyton RR, Chen L, Allison JC, Zhu H, Zhou W (2018) Autonomic responses to blast overpressure can be elicited by exclusively exposing the ear in rats. J Otology. 13(2):44-53.
• Schmidt MF, Storrs JM, Freeman KB, Jack CR Jr, Turner ST, Griswold ME, Mosley TH (2018) A comparison of manual tracing and FreeSurfer for estimating hippocampal volume over the adult lifespan. Hum Brain Mapp. 39(6):2500-2513
• Smith A, Varney E, Zand K, Lewis T, Sirous R, York J, Florez E, Abou Elkassem A, Howard-Claudio CM, Roda M, Parker E, Scortegagna E, Joyner D, Sandlin D, Newsome A, Brewster P, Lirette ST, Griswold M (2018) Precision analysis of a quantitative CT liver surface nodularity score. Abdom Radiol (NY). 43(12):3307-3316
• Spann RA, Lawson WJ, Bidwell GL 3rd, Zamarripa CA, Maranon RO, Bandyopadhyay S, Taylor ER, Reckelhoff JF, Garrett MR, Grayson BE. (2018) Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development. Clin Sci (Lond) 132(2):295-312
• Weems PW, Coolen LM, Hileman SM, Hardy S, McCosh RB, Goodman RL, Lehman MN. Evidence that Dynorphin Acts upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe (2018) Endocrinology. 159(9):3187-3199.
• Weems PW, Lehman MN, Coolen LM, Goodman RL (2018) The Roles of Neurokinins and Endogenous Opioid Peptides in Control of Pulsatile LH Secretion. Vitam Horm 2018;107:89-135.
• Zamarripa CA, Edwards SR, Qureshi HN, Yi JN, Blough BE, Freeman KB. (2018) The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats. Drug Alcohol Depend. 192:158-162.

2017

• Adeosun SO, Hou X, Zheng B, Melrose HL, Mosley T, Wang JM Human (2017) LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice. Neurobiol Learn Mem 142(Pt B):182-189
• Beloate LN, Coolen LM. (2017) Influences of social reward experience on behavioral responses to drugs of abuse: Review of shared and divergent neural plasticity mechanisms for sexual reward and drugs of abuse. Neurosci Biobehav Rev 83:356-372
• Bohlen MO, Warren S, May PJ (2017) A central mesencephalic reticular formation projection to medial rectus motoneurons supplying singly and multiply innervated extraocular muscle fibers. J Comp Neurol 525: 2000-2018
• Bohlen MO, Warren S, Mustari MJ, May PJ (2017) Examination of feline extraocular motoneuron pools as a function of muscle fiber innervation type and muscle layer. J Comp Neurol 525: 919-935
• Chandler CM, Follett ME, Porter NJ, Liang KY, Vallender EJ, Miller GM, Rowlett JK, Platt DM (2017) Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques. Alcohol 63:19-26
• Gomez-Sanchez CE, Qi X, Gomez-Sanchez EP, Sasano H, Bohlen MO, Wisgerhof M (2017) Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3. Mol Cell Endocrinol 439:74-80
• Huskinson SL, Naylor JE, Townsend EA, Rowlett JK, Blough BE, Freeman KB (2017) Self-administration and behavioral economics of second-generation synthetic cathinones in male rats. Psychopharmacology 234: 589-598
• Kuiper LB, Frohmader KS, Coolen LM (2017) Maladaptive sex behavior following concurrent methamphetamine and sexual experience in male rats is associated with altered neural activity in frontal cortex. Neuropsychopharmacology 42: 2011-2020
• Kuppusamy M, Gomez-Sanchez EP, Beloate LN, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez CE (2017) Interaction of the mineralocorticoid receptor with RACK1 and its role in aldosterone signaling. Endocrinology 158(7):2367-2375
• Lawson WJ, Shirey K, Spann RA, Zamarripa CA, Hosler JP, Grayson BE. (2017) Vertical sleeve gastrectomy improves indices of metabolic disease in rodent model of surgical menopause. Menopause 24(4):426-436
• Spann R, Lawson W, Grill R, Garrett M, Grayson B (2017) Chronic spinal cord changes in a high-fat diet fed male rat model of thoracic spinal contusion. Physiol Genomics 49(9):519-529
• Townsend EA, Naylor JE, Negus SS, Edwards SR, Qureshi HN, McLendon HW, McCurdy CR, Kapanda CN, do Carmo JM, da Silva FS, Hall JE, Sufka KJ, Freeman KB (2017) Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: Modeling an abuse-deterrent opioid analgesic in rats. Psychopharmacology (Berl) 234(17):2597-2605
• Townsend EA, Platt DM, Rowlett JK, Roma PG, Freeman KB (2017) Reinforcing effectiveness of midazolam, ethanol, and sucrose: Behavioral economic comparison of a mixture relative to its component solutions. Behav Pharmacol 28: 386-393
• Townsend EA, Freeman KB (2017) Comparison of cocaine reinforcement in lean and obese Zucker rats: Relative potency and reinstatement of extinguished operant responding. Physiol Behav 170: 88-92
• Weems P, Smith J, Clarke IJ, Coolen LM, Goodman RL, Lehman ML (2017) Effects of season and estradiol on KNDy neuron peptides, colocalization with  D2 dopamine receptors, and dopaminergic inputs, in the ewe. Endocrinology 158: 831-841

2016

• Beloate LN, Omrani A, Adan RA, Webb IC, Coolen LM (2016) Ventral tegmental area dopamine cell activation during male rat sexual behavior regulates neuroplasticity and d-amphetamine cross-sensitization following sex abstinence. J Neurosci 36: 9949-9961
• Beloate LN, Weems PW, Casey GR, Webb IC, Coolen LM (2016) Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats. Neuropharmacology 101: 154-164
• Bohlen MO, Chen LL (2016) A noninvasive electromagnetic perturbation approach to probe extraocular proprioception. J AAPOS 20: 12-18
• Bohlen MO, Warren S, May PJ (2016) A central mesencephalic reticular formation projection to the supraoculomotor area in macaque monkeys. Bran Struct Funct 221: 2209-2229
• Cobb JA, O’Neill K, Milner J, Mahajan GJ, Lawrence TJ, May WL, Miguel-Hidalgo J, Rajkowska G, Stockmeier CA (2016) Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder. Neuroscience 316: 209-220
• Duncan JW, Johnson S, Zhang X, Zheng B, Luo J, Ou XM, Stockmeier CA, Wang JM (2016) Up-regulation of PKR signaling pathway by ethanol displays an age of onset-dependent relationship. Alcohol Clin Exp Ther 40: 2320-2328
• Duncan JW, Zhang X, Wang N, Johnson S, Harris S, Udemgba C, Ou XM, Youdim MB, Stockmeier CA, Wang JM (2016) Binge ethanol exposure increases the Kruppel-like factor 11-monoamine oxidase (MAO) pathway in rats: Examining the use of MAO inhibitors to prevent ethanol-induced brain injury. Neuropharmacology 105: 329-340
• Gunter BW, Jones SA, Paul IA, Platt DM, Rowlett JK (2016) Benzodiazepine and neuroactive steroid combinations in rats: Anxiolytic-like and discriminative stimulus effects. Psychopharmacology 233: 3237-3247
• Logue OC, McGowan JW, George EM, Bidwell GL 3rd (2016) Therapeutic angiogenesis by vascular endothelial growth factor supplementation for treatment of renal disease. Curr Opin Nephrol Hypertens 25: 404-409
• Lopez JA, Bedenbaugh MN, McCosh RB, Weems PW, Meadows LJ, Wisman B, Coolen LM, Goodman RL, Hileman SM (2016) Does dynorphin play a role in the onset of puberty in female sheep? J Neuroendocrinol 28: doi: 10.1111/jne.12445
• May PJ, Warren S, Bohlen MO, Barnerssoi M, Horn AK (2016) A central mesencephalic reticular formation projection to the Edinger-Westphal nuclei. Brain Struct Funct 221(8):4073-4089
• McGowan JW, Shao Q, Vig PJ, Bidwell GL 3rd (2016) Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system. Drug Des Devel Ther 10: 2803-2813
• McGowan JW, Bidwell GL 3rd (2016) The use of ex vivo whole-organ imaging and quantitative tissue histology to determine the bio-distribution of fluorescently labeled molecules. J Vis Exp 118
• Schmidt MF, Freeman KB, Windham BG, Griswold ME, Kullo IJ, Turner ST, Mosley TH Jr (2016) Associations between serum inflammatory markers and hippocampal volume in a community sample. J Am Geriatr Soc 64: 1823-1829
• Stewart C, Yu Y, Huang J, Maklad A, Tang X, Allison J, Mustain W, Zhou W, Zhu H (2016) Effects of high intensity noise on the vestibular system in rats. Hear Res 335: 118-127
• Weems PW, Witty CF, Amstalden M, Coolen LM, Goodman RL, Lehman MN (2016) κ-opioid receptor Is colocalized in GnRH and KNDy cells in the female ovine and rat brain. Endocrinology 157: 2367-237

2015

• Duncan J, Wang N, Zhang X, Johnson S, Harris S, Zheng B, Zhang Q, Rajkowska G, Miguel-Hidalgo JJ, Sittman D, Ou XM, Stockmeier CA, Wang JM (2015) Chronic social stress and ethanol increase expression of KLF11, a cell death mediator, in rat brain. Neurotox Res 28: 18-31
• Gunter BW, Platt DM, Rowlett JK (2015) Differential interactions engendered by benzodiazepine and neuroactive steroid combinations on schedule-controlled responding in rats. Pharmacol Biochem Behav 137: 53-59
• Harris S, Johnson S, Duncan JW, Udemgba C, Meyer JH, Albert PR, Lomberk G, Urrutia R, Ou XM, Stockmeier CA, Wang JM (2015) Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders. Neuropsychopharmacology 40: 1373-1382
• Hou X, Adeosun SO, Zhang Q, Barlow B, Brents M, Zheng B, Wang J (2015) Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Ab deposition and learning and memory in mouse models of Alzheimer’s disease. Front Aging Neurosci Oct 31;7:207. doi: 10.3389/fnagi.2015.00207
• Johnson S, Duncan J, Hussain SA, Chen G, Luo J, Mclaurin C, May W, Rajkowska G, Ou XM, Stockmeier CA, Wang JM (2015) The IFNg-PKR pathway in the prefrontal cortex reactions to chronic excessive alcohol use. Alcohol Clin Exp Res 39: 476-484
• McGowan JW, Bidwell GL 3rd, Vig PJ (2015) Challenges and new strategies for therapeutic peptide delivery to the CNS. Ther Deliv 6: 841-853
• Naylor JE, Freeman KB, Blough BE, Woolverton WL, Huskinson SL (2015) Discriminative-stimulus effects of second generation synthetic cathinones in methamphetamine-trained rats. Drug Alcohol Depend 149: 280-284
• Riaz MS, Bohlen MO, Gunter BW, Henry Q, Stockmeier CA, Paul IA (2015) Attenuation of social-interaction-associated ultrasonic vocalizations and spatial working memory performance in rats exposed to chronic unpredictable stress. Physiol Behav 152: 128-134
• Townsend EA, Beloate LN, Huskinson SL, Roma PG, Freeman KB (2015) Corn oil, but not cocaine, is a more effective reinforcer in obese than in lean Zucker rats. Physiol Behav 143: 136-141
• Weems PW, Goodman RL, Lehman MN (2015) Neural mechanisms controlling seasonal reproduction: principles derived from the sheep model and its comparison with hamsters. Front Neuroendocrinol 37: 43-51

2014

• Adeosun SO, Hou X, Zheng B, Stockmeier C, Ou X, Paul I, Mosley T, Weisgraber K, Wang JM (2014) Cognitive deficits and disruption of neurogenesis in a mouse model of apolipoprotein E4 domain interaction. J Biol Chem 289: 2946-2959
• Freeman KB, Naylor JE, Prisinzano TE, Woolverton WL (2014) Assessment of the kappa opioid agonist, salvinorin A, as a punisher of drug self-administration in monkeys. Psychopharmacology 231: 2751-2758
• Huskinson SL, Naylor JE, Rowlett JK, Freeman KB (2014) Predicting abuse potential of stimulants and other dopaminergic drugs: Overview and recommendations. Neuropharmacology 87: 66-80
• Ou XM, Udemgba C, Wang N, Dai X, Lomberk G, Seo S, Urrutia R, Wang J, Duncan J, Harris S, Fairbanks CA, Zhang X (2014) Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake. Alcohol Clin Exp Res 38: 401-408
• Pitchers KK, Coppens CM, Beloate LN, Fuller J, Van S, Frohmader KS, Laviolette SR, Lehman MN, Coolen LM (2014) Endogenous opioid-induced neuroplasticity of dopaminergic neurons in the ventral tegmental area influences natural and opiate reward. J Neurosci 34: 8825-8836