Recent Publications

2017

• Bux AS, Lindsey ML, Vasquez HG, Taegtmeyer H, Harmancey R. Glucose Regulates the Intrinsic Inflammatory Response of the Heart to Surgically Induced Hypothermic Ischemic Arrest and Reperfusion. Physiological Genomics. 2017 January 1;49(1):37-52. PubMed PMID: 27940566; PubMed Central PMCID: PMC5283920.
• Chade AR. Small Vessels, Big Role: Renal Microcirculation and Progression of Renal Injury. Hypertension (Dallas, Tex. : 1979). 2017 April;69(4):551-563. PubMed PMID: 28193706; PubMed Central PMCID: PMC5344725.
• Davis GK, Newsome AD, Ojeda NB, Alexander BT. Effects of Intrauterine Growth Restriction and Female Sex on Future Blood Pressure and Cardiovascular Disease. Current Hypertension Reports. 2017 February; 19(2):13. PubMed PMID: 28233240.
• Faulkner JL, Amaral LM, Cornelius DC, Cunningham MW, Ibrahim T, Heep A, Campbell N, Usry N, Wallace K, Herse F, Dechend R, LaMarca B. Vitamin D Supplementation Reduces Some AT1-AA-Induced Downstream Targets Implicated in Preeclampsia Including Hypertension. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2017 January 1;312(1):R125-R131. PubMed PMID: 27903510; PubMed Central PMCID: PMC5283941.
• Hinds TD Jr, Hosick PA, Hankins MW, Nestor-Kalinoski A, Stec DE. Mice With Hyperbilirubinemia Due to Gilbert's Syndrome Polymorphism are Resistant to Hepatic Steatosis by Decreased Serine 73 Phosphorylation of PPARα. American Journal of Physiology. Endocrinology and Metabolism. 2017 January 17;::ajpendo.00396.2016. PubMed PMID: 28096081.
• Meschiari CA, Ero OK, Pan H, Finkel T, Lindsey ML. The Impact of Aging on Cardiac Extracellular Matrix. GeroScience. 2017 February;39(1):7-18. PubMed PMID: 28299638; PubMed Central PMCID: PMC5352584.
• Paauw ND, Joles JA, Spradley FT, Bakrania B, Zellenger ZK, Franx A, Verhaar MC, Granger JP, Lely AT. Exposure to Placental Ischemia Impairs Postpartum Maternal Renal and Cardiac Function in Rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2017 February 15;::ajpregu.00510.2016. PubMed PMID: 28202440.
• Palei AnaC, Spradley FT, Granger JoeyP. Role of Nitric Oxide Synthase on Blood Pressure Regulation and Vascular Function in Pregnant Rats on a High-Fat Diet. American Journal of Hypertension. 2017 January 27;30(3):240-248.
• Taylor EB, Ryan MJ. Immunosuppression with Mycophenolate Mofetil Attenuates Hypertension in an Experimental Model of Autoimmune Disease. Journal of the American Heart Association. 2017 February 27;6(3). PubMed PMID: 28242635.
• Toba H, Cannon PL, Yabluchanskiy A, Iyer RP, D'Armiento J, Lindsey ML. Transgenic Overexpression of Macrophage Matrix Metalloproteinase-9 Exacerbates Age-Related Cardiac Hypertrophy, Vessel Rarefaction, Inflammation, and Fibrosis. American Journal of Physiology. Heart and Circulatory Physiology. 2017 March 1;312(3):H375-H383. PubMed PMID: 28011588.

2016

• Altara R, Harmancey R, Didion SP, Booz GW, Zouein FA. Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension. Frontiers in Pharmacology. 2016 November 16;7:436. PubMed PMID: 27899891; PubMed Central PMCID: PMC5110511.
• Bakrania B, Granger JP, Harmancey R. Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart. Journal of Visualized Experiments : JoVE. 2016 September 28;(115). PubMed PMID: 27768055; PubMed Central PMCID: PMC5092065.
• Blenck CL, Harvey PA, Reckelhoff JF, Leinwand LA. The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease. Circulation Research. 2016 April 15;118(8):1294-312. PubMed PMID: 27081111; PubMed Central PMCID: PMC4834858.
• Chade AR, Hall JE. Role of the Renal Microcirculation in Progression of Chronic Kidney Injury in Obesity. American Journal of Nephrology. 2016;44(5):354-367. PubMed PMID: 27771702; PubMed Central PMCID: PMC5117364
• Chade AR, Tullos NA, Harvey TW, Mahdi F, Bidwell GL 3rd. Renal Therapeutic Angiogenesis Using a Bioengineered Polymer-Stabilized Vascular Endothelial Growth Factor Construct. Journal of the American Society of Nephrology: JASN. 2016 June;27(6):1741-52. PubMed PMID: 26541349; PubMed Central PMCID: PMC4884109.
• Chade AR. Vascular endothelial growth factor therapy for the kidney: Are we there yet? J Am Soc Nephrol. 2016; 27:1-3. PMCID: PMC4696589
• Clemmer JS, Xiang L, Lu S, Mittwede PN, Hester RL. Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular Permeability. Microcirculation. 2016 Jan 7;PubMed PMID: 26749564; NIHMSID: 749604.
• Clemmer JS, Pruett WA, Coleman TG, Hall JE, Hester RL. Mechanisms of Blood Pressure Salt Sensitivity: New Insights from Mathematical Modeling. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2016 December 14;::ajpregu.00353.2016. PubMed PMID: 27974315.
• Cunningham MW Jr, Williams JM, Amaral L, Usry N, Wallukat G, Dechend R, LaMarca B. Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor Enhance Angiotensin II-Induced Renal Vascular Sensitivity and Reduce Renal Function During Pregnancy. Hypertension (Dallas, Tex : 1979). 2016 November;68(5): 1308-1313. PubMed PMID: 27698062; PubMed Central PMCID: PMC5142826.
• Dalmasso C, Maranon R, Patil C, Moulana M, Romero DG, Reckelhoff JF. 20-HETE and CYP4A2 ω-hydroxylase Contribute to the Elevated Blood Pressure in Hyperandrogenemic Female Rats. American Journal of Physiology. Renal Physiology. 2016 July 1;311(1):F71-7. PubMed PMID: 27194719; PubMed Central PMCID: PMC4967161.
• Dalmasso C, Maranon R, Patil C, Bui E, Moulana M, Zhang H, Smith A, Yanes Cardozo LL, Reckelhoff JF. Cardiometabolic Effects of Chronic Hyperandrogenemia in a New Model of Postmenopausal Polycystic Ovary Syndrome. Endocrinology. 2016 July;157(7):2920-7. PubMed PMID: 27145003; PubMed Central PMCID: PMC4929551. 
• da Silva AA, Hall JE, Moak SP, Browning J, Houghton HJ, Micheloni GC, do Carmo JM. Role of Autonomic Nervous System in Chronic CNS-Mediated Anti-Diabetic Action of Leptin. American Journal of Physiology. Endocrinology and Metabolism. 2016 December 6;::ajpendo.00301.2016. PubMed PMID: 27923809.
• Dasinger JH, Alexander BT. Gender differences in developmental programming of cardiovascular diseases. Clin Sci (Lond). 2016 Mar 1;130(5):337-48. PubMed PMID: 26814204.
• Dasinger JH, Intapad S, Rudsenske BR, Davis GK, Newsome AD, Alexander BT. Chronic Blockade of the Androgen Receptor Abolishes Age-Dependent Increases in Blood Pressure in Female Growth-Restricted Rats. Hypertension (Dalls, Tx. : 1979). 2016 June:67(6):1281-90. PubMed PMID: 27113045; PubMed Central PMCID: PMC4865435.
• Dasinger JH, Davis GK, Newsome AD, Alexander BT. Developmental Programming of Hypertension: Physiological Mechanisms. Hypertension (Dallas, Tex : 1979). 2016 October;68(4):826-31. PubMed PMID: 27550912; PubMed Central PMCID: PMC5016247.
• Dasinger JH, Intapad S, Backstrom MA, Carter AJ, Alexander BT. Intrauterine Growth Restriction Programs an Accelerated Age-Related Increase in Cardiovascular Risk in Male Offspring. American Journal of Physiology. Renal Physiology. 2016 August 1;311(2):F312-9. PubMed PMID: 27147668; PubMed Central PMCID: PMC5005278.
• DeLeon-Pennell KY, Tian Y, Zhang B, Cates CA, Iyer RP, Cannon P, Shah P, AiyetaP, Halade GV, Ma Y, Flynn E, Zhang Z, Jin YF, Zhang H, Lindsey ML. CD36 Is a MatrixMetalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling. Circ Cardiovasc Genet. 2016 Feb;9(1):14-25. PubMed PMID: 26578544; PubMed Central PMCID: PMC4758866.
• DeLeon-Pennell KY. May the Fibrosis Be With You: Is Discoidin Domain Receptor 2 The Receptor We Have Been Looking For? Journal of Molecular and Cellular Cardiology. 2016 February;91:201-3. PubMed PMID: 26772530.
• do Carmo JM, da Silva AA, Wang Z, Fang T, Aberdein N, de Lara Rodriguez CE, Hall JE. Obesity-Induced Hypertension: Brain Signaling Pathways. Current Hypertension Reports. 2016 July;18(7):58. PubMed PMID: 27262997.
• do Carmo JM, da Silva AA, Wang Z, Freeman NJ, Alsheik AJ, Adi A, Hall JE. Regulation of Blood Pressure, Appetite, and Glucose by Leptin After Inactivation of Insulin Receptor Substrate 2 Signaling in the Entire Brain or in Proopiomelanocortin Neurons. Hypertension. 2016 Feb;67(2):378-86. PubMed PMID: 26628674; PubMed Central PMCID: PMC4763950.
• Evaristi MF, Caubere C, Harmancey R, Desmoulin F, Peacock WF, Berry M, Turkieh A, Barutaut M, Galinier M, Dambrin C, Polidori C, Miceli C, Chamontin B, Koukoui F, Roncalli J, Massabuau P, Smith F, Rouet P. Increased Mean Aliphatic Lipid Chain Length in Left Ventricle Hypertrophy Secondary to Arterial Hypertension: A Cross-Sectional Study. Medicine. 2016 November;95(46):e4965. PubMed PMID: 27861330; PubMed Central PMCID: PMC5120887.
• Flanagan TW, Files JK, Casano KR, George EM, Brown DT. Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H11 and H15. Biol Open. 2016 Feb 24;5(3):372-80. PubMed PMID: 26912777.
• Gillis EE, Mooney JN, Garrett MR, Granger JP, Sasser JM. Sildenafil Treatment Ameliorates the Maternal Syndrome of Preeclampsia and Rescues Fetal Growth in the Dahl Salt-Sensitive Rat. Hypertension. 2016 Mar;67(3):647-53. PubMed PMID 26729752; PubMed Central PMCID: PMC4752413.
• Harvey TW, Engel JE, Chade AR. Vascular Endothelial Growth Factor and Podocyte Protection in Chronic Hypoxia: Effects of Endothelin-A Receptor Antagonism. American Journal of Nephrology. 2016;43(2):74-84. PubMed PMID: 26930122; PubMed Central PMCID: PMC4828273.
• Hinds TD Jr, Burns KA, Hosick PA, McBeth L, Nestor-Kalinoski A, Drummond HA, AlAmodi AA, Hankins MW, Vanden Heuvel JP, Stec DE. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-Activated Receptor (PPAR) α. The Journal of Biological Chemistry. 2016 November 25;291(48):25179-25191. PubMed PMID: 27738106; PubMed Central PMCID: PMC5122784.
• Hosick PA, AlAmodi AA, Hankins MW, Stec DE. Chronic treatment with a carbon monoxide releasing molecule reverses dietary induced obesity in mice. Adipocyte. 2016;5:1-10.
• Intapad S, Dasinger JH, Brown AD, Fahling JM, Esters J, Alexander BT. Glucose intolerance develops prior to increased adiposity and accelerated cessation of estrous cyclicity in female growth-restricted rats. Pediatr Res. 2016 Feb 8;PubMed PMID: 26854801; NIHMSID: 736555.
• Iyer RP, de Castro Bras LE, Cannon PL, Ma Y, DeLeon-Pennell KY, Jung M, Flynn ER, Henry JB, Bratton DR, White JA, Fulton LK, Grady AW, Lindsey ML. Defining the Sham Environment for Post-Myocardial Infarction Studies in Mice. American Journal of Physiology. Heart and Circulatory Physiology. 2016 September 1;311(3):H822-36. PubMed PMID: 27521418; PubMed Central PMCID: PMC5024439.
• Iyer RP, de Castro Bras LE, Patterson NL, Bhowmick M, Flynn ER, Asher M, Cannon PL, Deleon-Pennell KY, Fields GB, Lindsey ML. Early Matrix Metalloproteinase-9 Inhibition Post-Myocardial Infarction Worsens Cardiac Dysfunction by Delaying Inflammation Resolution. Journal of Molecular and Cellular Cardiology. 2016 November; 100: 109-117. PubMed PMID: 27746126; PubMed Central PMCID: PMC5319826.\
• Iyer RP, Jung M, Lindsey ML. MMP-9 Signaling in the Left Ventricle Following Myocardial Infarction. American Journal of Physiology. Heart and Circulatory Physiology. 2016 July 1;311(1):H190-8. PubMed PMID: 27208160; PubMed Central PMCID: PMC4967202.
• Karumanchi SA, Granger JP. Preeclampsia and Pregnancy-Related Hypertensive Disorders. Hypertension. 2016 Feb;67(2):238-42. PubMed PMID: 26693822; PubMed Central PMCID: PMC4755281.
• Lindsey ML, Hall ME, Harmancey R, Ma Y, Adapting Extracellular Matrix Proteomics for Clinical Studies on Cardiac Remodeling Post-Myocardial Infarction. Clinical Proteomics. 2016 September 15; 13:19. PubMed PMID: 27651752; PubMed Central PMCID: PMC5024439.
• Lindsey ML, Saucerman JJ, DeLeon-Pennell KY. Knowledge Gaps to Understanding Cardiac Macrophage Polarization Following Myocardial Infarction. Biochima et Biophysica Acta. 2016 December; 1862(12):2288-2292. PubMed PMID: 27240543; PubMed Central: PMCID: PMC5124538.
• Lindsey ML, Iyer RP, Jung M, DeLeon-Pennell KY, Ma Y. Matrix metalloproteinases ainput and output signals for post-myocardial infarction remodeling. J Mol Cell Cardiol.2016 Feb;91:134-40. PubMed PMID: 26721597; PubMed Central PMCID:PMC4764435.
• Lohmeier TE, Iliescu R, Tudorancea I, Cazan R, Cates AW, Georgakopoulos D, Irwin ED, Chronic Interactions Between Carotid Baroreceptors and Chemoreceptors in Obesity Hypertension. Hypertension (Dallas, Tx. : 1979). 2016 July;68(1):227-35. PubMed PMID: 27160198; PubMed Central PMCID: PMC4900898.
• Ma Y. LRP5: A Novel Anti-Inflammatory Macrophage Marker That Positively Regulates Migration and Phagocytosis. Journal of Molecular and Cellular Cardiology. 2016 February;91:61-2. PubMed PMID: 26739212.
• Ma Y, Yabluchanskiy A, Iyer RP, Cannon PL, Flynn ER, Jung M, Henry J, Cates CA, Deleon-Pennell KY, Lindsey ML. Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res. 2016 May 1;110(1):51-61. PubMed PMID: 26825554; PubMed Central PMCID: PMC4798046.
• Maranon RO, Reckelhoff JF. Mechanisms responsible for postmenopausal hypertension in a rat model: Roles of the renal sympathetic nervous system and the renin-angiotensin system. Physiol Rep. 2016 Feb;4(2)PubMed PMID: 26811052; PubMed Central PMCID:
  PMC4760383.
• Marino JS, Stechschulte LA, Stec DE, Nestor-Kalinoski A, Coleman S, Hinds TD Jr. Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-Activated Receptor (PPAR) α. The Journal of Biological Chemistry. 2016 December 9;291(50):25776-25788. PubMed PMID: 27784782; PubMed Central PMCID: PMC5203696.
• Padmanabhan Iyer R, Chiao YA, Flynn ER, Hakala K, Cates CA, Weintraub ST, de Castro Bras LE. Matrix Metalloproteinase-9-Dependent Mechanisms of Reduced Contractility and Increased Stiffness in the Aging Heart. Proteomics. Clinical Applications. 2016 January;10(1):92-107. PubMed PMID: 26415707; PubMed Central PMCID: PMC4922304.
• Patil CN, Wallace K, LaMarca BD, Moulana M, Lopez-Ruiz A, Soljancic A, Juncos LA, Grande JP, Reckelhoff JF, Low-Dose Testosterone Protects Against Renal Ischemia-Reperfusion Injury by Increasing Renal IL-10-to-TNF-α Ratio and Attenuating T-Cell Infiltration. American Journal of Physiology. Renal Physiology. 2016 August 1;311(2):F395-403. PubMed PMID: 27252490; PubMed Central PMCID: PMC5008676.
• Ryan MJ, Coleman TT, Sasser JM, Pittman KM, Hankins MW, Stec DE. Vascular smooth muscle specific deletion of the leptin receptor attenuates leptin induced vascular relaxation. Am. J. Physiol. Regul. Integr. Comp. Physiol.310(10):R960-7, 2016.PMCID:PMC4896083.
• Thomas W. Flanagan, Jacob K. Files, Kelsey Rose Casano, Eric M. George and David T. Brown. Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H1.1 and H1.5. Biology Open. 2016;0:1-9.
• Spradley FT, Palei AC, Granger JP. Differential Body Weight, Blood Pressure and Placental Inflammatory Responses to Normal Versus High-Fat Diet in Melanocortin-4 Receptor-Deficient Pregnant Rats. Journal of Hypertension. 2016 October;34(10): 1998-2007. PubMed PMID: 27467764; PubMed Central PMCID: PMC5310251.
• Spradley FT, Tan AY, Joo WS, Daniels G, Kussie P, Karumanchi SA, Granger JP. Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension. Hypertension. 2016 Apr;67(4):740-7. PubMed PMID: 26831193; PubMed Central PMCID: PMC4786447.
• Stec DE, John K, Trabbic CJ, Luniwal A, Hankins MW, Baum J, Hinds TD Jr. Bilirubin binding to PPARa inhibits lipid accumulation. PloS ONE 11(4):e0153427. Doi:10.1371/journal.prone.0153427, 2016. PMCID:PMC4829185.
• Stec DE, Juncos LA, Granger JP. Renal Intramedullary Infusion of Tempol Normalizes the Blood Pressure Response to Intrarenal Blockade of Heme Oxygenase-1 in Angiotensin II-Dependent Hypertension.J. Am. Soc. Hypertens. 2016 Jan 30;PubMed PMID: 26922123; NIHMSID: 761563.
• Sun W, Quan N, Wang L, Yang H, Chu D, Liu Q, Zhao X, Leng J, Li J. Cardiac-Specific Deletion of the Pdha 1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress. Toxicological Sciences: An Official Journey of the Society of Toxicology. 2016 May;151(1):193-203. PubMed PMID: 26884059; PubMed PMCID: PMC4914805.
• Taylor EB, Ryan MJ. Understanding Mechanisms of Hypertension in Systemic Lupus Erythematosus. Therapeutic Advances in Cardiovascular Disease. 2016 March 15. PubMed PMID: 26985016; PubMed Central PMCID: PMC5065379.
• Tostes RC, Carneiro FS, Carvalho MH, Reckelhoff JF. Reactive oxygen species: players in the cardiovascular effects of testosterone. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R1-R14. PubMed PMID: 26538238; PubMed Central PMCID: PMC4796634.
• Yabluchanskiy A, Ma Y, DeLeon-Pennell KY, Altara R, Halade GV, Voorhees AP, Nguyen NT, Jin YF, Winniford MD, Hall ME, Han HC, Lindsey ML. Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization.  Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):475-83. PubMed PMID: 25878031.
• Yang H, Sun W, Quan N, Wang L, Chu D, Cates C, Liu Q, Zheng Y, Li J. Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway. Biochem Pharmacol. 2016 Mar 22;PubMed PMID: 27015742; NIHMSID: 771796.
• Zhang LW, Warrington JP. Magnesium Sulfate Prevents Placental Ischemia-Induced Increases in Brain Water Content and Cerebrospinal Fluid Cytokines in Pregnant Rats. Frontiers in Neuroscience. 2016 December 8; 10:561. PubMed PMID: 28008305; PubMed Central PMCID: PMC5143678.