Publications

Publication archives

2022

• Ashraf S, Ashraf N, Yilmaz G, Harmancey R. Crosstalk between beta-adrenergic and insulin signaling mediates mechanistic target of rapamycin hyperactivation in liver of high-fat diet-fed male mice. Physiol Rep. 2021 Jul;9(13):e14958. doi: 10.14814/phy2.14958.PMC8261682
• Ashraf UM, Hall DL, Rawls AZ, Alexander BT. Epigenetic processes during preeclampsia and effects on fetal development and chronic health. Clin Sci (Lond). 2021 Oct 15;135(19):2307-2327.
• Badmus OO, Hillhouse SA, Anderson CD, Hinds TD, Stec DE. Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways. Clin Sci (Lond). 2022 Sep 30;136(18):1347-1366. doi: 10.1042/CS20220572. PMID: 36148775; PMCID: PMC9508552.
• Bakrania BA, Palei AC, Bhattarai U, Chen Y, Granger, JP, Shahul S. Sustained elevated circulating activin a impairs global longitudinal strain in pregnant rats: a potential mechanism for preeclampsia-related cardiac dysfunction. Cells. 2022 Feb 21;11(4):742. doi: 10.3390-cells11040742. PMID: 35203391
• Bakrania BA, George EM, Granger JP. Animal models of preeclampsia: investigating pathophysiology and therapeutic targets. Am J Obstet Gynecol. 2022 Feb;226(2S):S973-S987. doi: 10.1016/j.ajog.2020.10.025. PMID: 33722383
• Banek CT, Bradshaw JL, Coats LE, Alexander BT, Goulopoulou S. Getting it right: preventing drift in baseline cardiovascular phenotype when using Sprague-Dawley Rats. Am J Physiol. Heart Circ Physiol. 2021;321(3):H475-H478.
• Bentz AB, Empson TA, George EM, Rusch DB, Buechlein A, Rosvall KA. How experimental competition changes ovarian gene activity in free-living birds: Implications for steroidogenesis, maternal effects, and beyond. Horm Behav. 2022 Jun;142:105171. doi: 10.1016/j.yhbeh.2022.105171. Epub 2022 Apr 2. PMID: 35381449.
• Chade AR, Engel J, Hall ME, Eirin-Massat, A, Bidwell GL. Intra-renal Modulation of NF-kB Activity Attenuates Cardiac Injury in a Swine Model of CKD: A Renal-Cardio Axis. Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F411-F423. doi: 10.1152/ajprenal.00158.2021. Epub 2021 Aug 16.
• Chade AR and Bidwell GL. Novel Drug Delivery Technologies and Targets for Renal Disease. Hypertension. 2022 Jun 2;101161HYPERTENSIONAHA12217944.
• Chatre L, Ducat A, Spradley FT, Palei AC, Chéreau C, Couderc B, Thomas KC, Wilson AR, Amaral LM, Gaillard I, Méhats C, Lagoutte I, Jacques S, Miralles F, Batteux F, Granger JP, Ricchetti M, Vaiman D. Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences. Redox Biol. 2022 Jul 30;55:102406. doi: 10.1016/j.redox.2022.102406. Epub ahead of print. PMID: 35964341; PMCID: PMC9389306.
• Chen X, Ashraf S, Ashraf N, Harmancey R. UCP3 insufficiency exacerbates left ventricular diastolic dysfunction during angiotensin II-induced hypertension. J Am Heart Assoc. 2021 Sep 21;10(18):e022556. doi: 10.1161/JAHA.121.022556. Epub 2021 Sep 17.
• Clemmer, JS, Hillegass WB, Taylor EB. Antihypertensice effects of immunosuppressive therapy in autoimmune disease. J Hum Hypertens. 2022 Apr 8. doi: 10.1038/s41371-022-00682-0. PMID: 35396536
• Clemmer JS, Pruett WA, Hester RL. In silico trial of baroreflex activation therapy for the treatment of obesity-induced hypertension. PLoS One. 2021 Nov 18;16(11):e0259917.doi: 10.1371/journal.pone.0259917. eCollection 2021.
• da Silva AA, Hall JE, Dai X, Wang Z, Salgado MC, do Carmo JM. Evidence from parabiosis studies for a CNS-derived circulating antidiabetic circulating factor. Diabetes. 2021 Oct;70(10):2264-2274.doi: 10.2337/db21-0126. Epub 2021 Aug 3.
• da Silva AA, Moak SP, Dai X, Borges GC, Omoto ACM, Wang Z, Li X, Mouton AJ, Hall JE, do Carmo JM. Parental obesity alters offspring blood pressure regulation and cardiovascular responses to stress: role of P2X7R and sex differences. Am J Physiol Regul Integr Comp Physiol. 2022 May 1;322(5):R421-R433. doi: 10.1152/ajpregu.00300.2021. Epub 2022 Mar 23. PMID: 35318854
• do Carmo JM, Omoto AC, Dai X, Moak SP, Li X, Wang Z, Mouton A, Hall JE, da Silva AA. Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency and diastolic function early in life. Am J Physiol Heart and Circ Physiol 321(3):H485-H495, 2021
• Drummond HA. What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells. Physiology (Bethesda). 2021 Sep 1;36(5):292-306. doi: 10.1152/physiol.00008.2021.
• Echouffo-Tcheugui JB, Mwasongwe SE, Musani SK, Hall ME, Correa A, Hernandez AF, Golden SH, Menta RJ, Bertoni AG.  Dysglycemia and incident heart failure among blacks: the jackson heart study. Am Heart J. 2022 Mar;245:1-0. doi: 10.1016/j.ahj.2021.11.003. PMID: 34808103
• Farahani RA, Yu S, Ferguson CM, Zhu YX, Tang H, Jordan KL, Saadiq IM, Chade AR, Lerman A, Lerman LO, Eirin A. Renal Revascularization Attenuates Myocardial Mitochondrial Damage and Improves Diastolic Function in Pigs with Metabolic Syndrome and Renovascular Hypertension. J Cardiovasc Transl Res. 2022 Feb;15(1):15-26. doi: 10.1007/s12265-021-10155-3. Epub 2021 Jul 16. 
• Gava FN, da Silva AA, Dai X, Harmacey R, Ashraf S, Omoto ACM, Salgado M, Moak SP, Hall JE, Do Carmo JM. Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System. JAAC Basic Transl Sci, 6(1):55-70, eCollection 2021. 
• Gohar EY, De Miguel C, Obi IE, Daugherty EM, Hyndman KA, Becker BK, Jin C, Sedaka R, Johnston JG, Liu P, Speed JS, Mitchell T, Kriegel AJ, Pollock JS, Pollock DM. Acclimation to a High-Salt Diet Is Sex Dependent. J Am Heart Assoc. 2022 Mar; 11(5):e020450. doi: 10.1161/JAHA.120.020450. Epub 2022 Feb 22.
• Green PA, George EM, Rosvall KA, Johnsen S, Nowicki S. Testosterone, signal coloration, and signal color perception in male zebra finch contests. Ethology. 2022 Feb;128(2):131-142. doi: 10.1111/eth.13247. Epub 2021 Nov 2. PMID: 35185233
• Hall JE, Mouton AJ, da Silva AA, Omoto ACM, Wang Z, Li X, do Carmo JM. Obesity, kidney dysfunction, and inflammation: interactions in hypertension. Cardiovasc Res. 2021 Jul 7;117(8):1859-1876. doi: 10.1093/cvr/cvaa336
• Hall JE, Navar LG, Cowley AW Jr, Summers RL, Hester RL. Thomas George Coleman, PhD (1940-2021). Hypertension. 2021 Jun;77(6):1800-1803. doi: 10.1161/HYPERTENSIONAHA.121.17287. Epub 2021 May 3.PMID: 33934621 
• Hall ME, Hall JE. Sex differences in hypertension: related to genes, jean sizes, and salt sensitivity? Hypertension. 2022. PMID: 34878896
• Han Y, Taylor EB, Luthe D. Maize Endochitinase Expression in Response to Fall Armyworm Herbivory. J Chem Ecol. 2021 Jul;47(7):689-706.
• Hinds TD Jr., Kipp ZA, Xu Z, Yiannikouris FB, Morris AJ, Stec DF, Wahli W, Stec DE. Adipose-specific PPARα knockout mice have increased lipogenesis by PASK-SREBP1 signaling and a polarity shift to inflammatory macrophages in white adipose tissue (WAT). Cells, 11(1):4, 2021. PMCID:PMC8750478.
• Li X, Flynn ER, do Carmo JM, Wang Z, da Silva AA, Mouton AJ, Omoto ACM, Hall ME, Hall JE. Direct cardiac actions of sodium-glucose cotransporter 2 inhibition improve mitochondrial function and attenuate oxidative stress in pressure overload-induced heart failure. Front Cardiovasc Med. 2022 May 12;9:859253. doi: 10.3389/fcvm.2022.859253. PMID: 35647080
• Lipshutz JA, Hall JE, Penman-Aguilar A, Skillen E, Naoom S. Irune I. Leveraging social and structural determinants of health at the centers for disease control and prevention: a systems-level opportunity to improve public health. J Public Health Manag Pract. 2022 Mar-Apr 01;28(2):E380-E389. doi: 10.1097/PHH.0000000000001363. PMID: 33938483
• Lu Y, Stec DE, Liu R, Ryan M, Drummond HA. βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole. Am J Physiol Renal Physiol. 2022 May 1;322(5):F498-F511. doi: 10.1152/ajprenal.00003.2022. Epub 2022 Mar 14. PMID: 35285274
• McClung JA, Levy L, Garcia V, Stec DE, Peterson SJ, Abraham NG. Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: thereapeutic implications. Pharmacol Ther. 2022 Mar;231:107975. doi: 10.1016/j.pharmthera.2021.107975. Epub 2021 Sep 6. PMID: 35204062
• Moore KH, Clemmer JS. Questioning the renoprotective role of L-type calcium channel blockers in chronic kidney disease using physiological modeling. Am J Physiol Renal Physiolhttps://pubmed.ncbi.nlm.nih.gov/34486399/. 321(4):F548-F557, 2021. 
• Moore KH, Murphy HA, Chapman H, George EM. Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts. Am J Physiol Cell Physiol. 2021 Oct 1;321(4):C694-C703.
• Nemeth, Zoltan; Granger, Joey P; Ryan, Michael J; Drummond, Heather A. Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia? Physiol Rep. 2022 Jul;10(13):e15376.doi: 10.14814/phy2.15376.
• Omoto ACM, Lataro RM, Silva TM, Silva LEV, Salgado HCS, Fazan-Jr. R. Heart rate fragmentation, a novel approach in heart rate variability analysis, is altered in rats 4 and 12 weeks after myocardial infarction. Med Biol Eng Comput, v.59 (11-12):2373-2382, 2021.
• Oshunbade AA, Lirette ST, Windham BG, Shafi T, Hamid A, Gbadamosi SO, Tin A, Yimer WK, Tibuakuu M, Clark D 3rd, Kamimura D, Lutz EA, Mentz RJ, Fox ER, Butler J, Butler KR, Garovic VD, Turner ST, Mosley TH Jr, Hall ME. Hypertensice diseases in pregnancy and kidney function later in life: the genetic epidemiology network of arteriopathy (GENOA) study. Mayo Clin Proc. 2022 Jan;97(1):78-87. doi: 10.1016/j.mayocp.2021.07.018. PMID: 34565606
• Palei AC, Granger JP, Spradley FT. Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia. Int J Mol Sci. 2021 Oct 19;22(20):11261.doi: 10.3390/ijms222011261.
• Pan L, Bai P, Weng X, Liu J, Chen Y, Chen S, Ma X, Hu K, Sun A, Ge J. Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection, and Rupture. Circulation. 2022 Mar;145(9):659-674. PMID: 35100526.10.1161/CIRCULATIONAHA.121.056640.
• Parente JM, de Mello MMB, da Silva PHL, Omoto ACM, Pernomian L, de Oliveira IS, Mahmud Z, Fazan Jr R, Arantes EC, Schulz R, Castro MM. MMP inhibition attenuates hypertensive eccentric cardiac hypertrophy and dysfunction by preserving troponin I and dystrophin. Biochem Pharmacol. 2021 Nov;193:114744. doi: 10.1016/j.bcp.2021.114744. Epub 2021 Aug 25.
• Rajagopalan KS, Glasstetter LM, Zhy XY, Thaler R, Tang H, Jordan KL, Saadiq IM, Herrmann SM, Chade AR, Irazabal MV, Lerman LO. Renal ischemia induces epigenetic changes in apoptotic, proteolytic, and mitochondrial genes in swine scattered tubular-like cells. Cells. 2022 May 31;11(11):1803
• Rivera-Gonzalez O, Wilson NA, Coats LE, Taylor EB, Speed JS. Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice. Clin Sci (Lond). 2021 Jul 30;135(14):1773-1789.doi: 10.1042/CS20210549.
• Rhoads MK, Speed JS, Roth KJ, Zhang D, Jin C, Gamble KL, Pollock DM. Short-term daytime restricted feeding in rats with high salt impairs diurnal variation of Na+ excretion. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F335-F343
• Rodionov RN, Jarzebska N, Burdin D, Todorov V, Martens-Lobenhoffer J, Hofmann A, Kolouschek A, Cordasic N, Jacobi J, Rubets E, Morawietz H, O'Sullivan JF, Markov AG, Bornstein SR, Hilgers K, Maas R, Pfluecke C, Chen Y, Bode-Böger SM, Hugo CPM, Hohenstein B, Weiss N. Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. Sci Rep. 2022 Jun 7;12(1):9381. PMC9174227.10.1038/s41598-022-13169-2
• Shawky NM, Dalmasso C, Ojeda NB, Zuckowski Y, Stachenfeld N, Alexander BT, Reckelhoff JF. Consequences of hyperandrogenemia during pregnancy in femail offspring: attenuated response to angiotensin II. J Hyperten. 2022.
• Stapel JR, Speed JS, Clemmer JS. Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension. Can J Physiol Pharmacol. 2022 Aug 1;100(8):828-833. doi: 10.1139/cjpp-2022-0132. Epub 2022 Jun 3.
• Stec DE, Weigel B, Hinds TD Jr. Editorial: Oxidative stress, antioxidants, transcription factors, and assimilation of signal transduction pathways in obesity-related disorders. Frontiers in Pharmacology. 12:759468. doi: 10.3389/fphar.2021.759468, 2021. PMCID:PMC8452909.
• Stec DE, Tiribelli C, Badmus OO, Hinds TD Jr. Novel function for bilirubin as a metabolic signaling molecule: Implications for kidney diseases. Kidney360 Publish Ahead of Print, 10.34067/KID.0000062022
• Taylor EB, George EM, Ryan MJ, Garrett MR, Sasser JM. Immunological Comparison of Pregnant Dahl Salt-Sensitive and Sprague Dawley Rats Commonly Used to Model Characteristics of Preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2021 Aug 1;321(2): R125-R138.
• Thomas DT, DelCimmuto NR, Flack KD, Stec DE, Hinds TD Jr. Reactive oxygen species (ROS) and antioxidants as immunonomodulators in exercise: implications for heme oxygenase and bilirubin. Antioxidants (Basel). 2022 Jan 18;11(2):179. doi: 10.3390/antiox11020179 PMID: 35204062
• Waller JP, Howell JA, Peterson H, George EM, Bidwell GL 3rd. Elastin-Like Polypeptide: VEGF-B Fusion Protein for Treatment of Preeclampsia.  Hypertension. 2021 Dec;78(6):1888-1901.doi: 10.1161/HYPERTENSIONAHA.121.17713.
• Wang Y, Angom RS, Kulkarni TA, Hoeppner LH, Pal K, Wang E, Tam A, Valiunas RA, Dutta SK, Ji B, Jarzebska N, Chen Y, Rodionov RN, Mukhopadhyay D. Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1. iScience. 2021 Sep 30;24(10):103189. PMCID: PMC8521174. 10.1016/j.isci.2021.103189.
• Wang Z, Fu Y, Do Carmo JM, da Silva AA, Li X, Mouton A, Omoto ACM, Sears J, Hall JE. Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension. Am J Physiol Renal Physiol. 2022 Jan 1;322(1):F76-F88.
• Wang Z, do Carmo JM, da Silva AA, Fu Y, Jaynes LT, Sears J, Li X, Mouton AJ, Omoto ACM, Xu BP, Hall JE. Transient receptor potential cation channel 6 (TRPC6) deficiency leads to increased body weight and metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol. 2022 May 10. doi: 10.1152/ajpregu.00097.2021. Epub ahead of print. PMID: 35537100.
• J. Wei; J. Zhang; S. Jiang; L. Xu; L. Qu; B. Pang; K. Jiang; L. Wang; S. Intapad; J. Buggs; F. Cheng; S. Mohapatra; L. A. Juncos; J. L. Osborn; J. P. Granger; R. S. Liu. Macula Densa NOS1b Modulates Renal Hemodynamics and Blood Pressure during Pregnancy: Role in Gestational Hypertension. JASN October 2021, 32 (10) 2485-2500; DOI: https://doi.org/10.1681/ASN.2020070969
• Yang J, Hall JE, Jose PA, Chen K, Zeng C. Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics. Pharmacol Ther. 2022 Apr 26:108194. doi: 10.1016/j.pharmthera.2022.108194. PMID: 35487286