General: Cardiovascular, renal and endocrine physiology
Specific: Mechanisms of hypertension and target organ injury; obesity and insulin resistance; the renin-angiotensin-aldosterone system; modeling and computer simulation of the cardiovascular-renal systems
Genetically engineered mouse models; chronic instrumentation for long-term cardiovascular and renal studies in dogs, rats, and mice; 24-hr/day studies of metabolic functions (oxygen consumption, activity, energy expenditure, food intake, etc.) in mice and rats; imaging methods (e.g. echocardiography) for studying cardiac function; histology, morphmetric analyses, immunohistochemistry, and molecular biology methods for studying target organ injury and cytokine expression; isotope methods for measuring renal function.