Faculty

Fan Fan, MD, MS

Assistant Professor
Office: G328
(601) 984-1600
Fax: (601) 984-1637

Research interests

  • The genetic basis of the impaired myogenic response and autoregulation of renal and cerebral blood flow
  • End organ damage in hypertension and mechanisms underlying hypertension and diabetic nephropathy

Current research

Currently I am working on the following projects:

  • Identification of genes on chromosome 1 that cause the impaired myogenic response in renal and cerebral arterioles that contributes to the development of glomerular disease and vascular dementia in Fawn Hooded Hypertensive rats;
  • Studying the roles of cytochrome P450 metabolites (4A) of arachidonic acid in the control of tubular sodium transport and the development of hypertension and the roles of this pathway in the regulation of myogenic response and autoregulation of renal and cerebral blood flow using a newly developed CYP4A1 transposon transgenic, CYP4A2, and CYP4A3 ZFN KO rats in various genetic backgrounds;
  • Studying the mechanisms by which hypertension and diabetes increase the renal formation of transforming growth factor beta in the kidney, which plays a major role in the development of proteinuria and renal fibrosis;
  • Research spotlight: Fan et al. article entitled "Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat" was chosen by American Physiological Society Select as one of the best APS research articles for April 2015.

Selected publications

  • Pabbidi MR, Mazur O, Fan F, Farley JM, Gebremedhin D, Harder DR and Roman RJ. Enhanced large conductance K+ channel (BK) activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats. Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H989-H1000.PMID:24464756, PMCID:PMC 3962634
  • Ge Y, Murphy SR, Fan F, Williams JM, Falck J, Liu R, Roman RJ. Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl Salt-sensitive rats. Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F509-15. PMID: 25007877, PMCID:PMC 4154113
  • Warrington JP, Fan F, Murphy SR, Roman RJ, Drummond HA, Granger JP, Ryan MJ. Placental ischemia in pregnant rats impairs cerebral blood flow autoregulation and increases blood-brain barrier permeability. Physiol Rep. 2014 Aug 28;2(8). PMID: 25168877, PMCID:PMC 4246592
  • Fan F, Guerts A, Pabbidi MR, Harder DR, Jacob H, Roman RJ. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances myogenic response in autoregulation of cerebral blood flow in FHH.1BN rats. PLoS One. 2014 Nov 14;9(11):e112878. PMID: 25397684, PMCID: PMC4232417
  • Fan F, Geurts AR, Murphy SR, Pabbidi MR, Jacob H and Roman RJ. Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. Am J Physiol Regul Integr Comp Physiol. 2014 Dec 24. PMID: 25540098, [Epub ahead of print] PMCID: PMC: in progress
  • Fan F, Muroya Y, and Roman RJ. Cytochrome p450 eicosanoids in hypertension and renal disease. Curr Opin Nephrol Hypertens. 2015 Jan;24(1):37-46. PMID: 25427230, PMCID: PMC4260681
  • Muroya Y, FanF, Regner KR, Marthaler B, Falck JR, Garrett MR, Juncos L Protective role of endogenous 20-HETE in renal ischemia-reperfusion injury. JASN 00:000-000, 2014. [Epub ahead of print] PMCID: PMC: in progress