Faculty

Fan Fan, MD, MS

Assistant Professor
Office: G328
(601) 984-1600
Fax: (601) 984-1637

Research interests

I am interested in the genetic basis of the cerebral and renal microvascular dysfunction, and role of microvascular dysfunction contributes end organ damage including vascular cognitive impairment, Alzheimer's disease-related dementias, stroke and renal disease, especially with aging, hypertension, diabetes and obesity.

I use an array of techniques including molecular biology, gene therapy, cell culture, immunohistology, laser Doppler flowmetry, mass spectroscopy, patch clamp, intracellular imaging, measurement of myogenic response in isolated perfused cerebral and renal arteries in vitro, measurement of autoregulation of cerebral and renal blood flow in vivo and the generation and characterization of transgenic and Zinc-finger KO rat models.

Selected publications

 

  • Fan F and Roman RJ. GPR75 identified as the first 20-HETE receptor: a chemokine receptor adopted by another family. Circ Res. 120: 1696-1698, 2017. PMID: 28546348
  • Fan F, Pabbidi MR, Ge Y, Li L, Wang S, Mims PM and Roman RJ. Knockdown of Gamma-Adducin Impairs the Myogenic Response of Renal Afferent Arterioles and Middle Cerebral Arteries.  Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F971-F981. PMID: 27927653.
  • Wang S, Mims PN, Roman RJ and Fan F. Is Beta-Amyloid Accumulation a Cause of Alzheimer's Disease or a Consequence of Vascular Dysfunction? J Alzheimers Dis Parkinsonism.  2016; 1(2):007. PMCID: PMC5555607
  • Fan F, Geurts AR, Murphy SR, Pabbidi MR, Jacob H and Roman RJ. Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. Am J Physiol Regul Integr Comp Physiol. (APSselect), 2015 Mar 1;308(5): R379-90. PMID: 25540098.
  • Fan F, Guerts A, Pabbidi MR, Harder DR, Jacob H, Roman RJ. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances myogenic response in autoregulation of cerebral blood flow in FHH.1BN rats. PLoS One. 2014 Nov 14;9(11): e112878. PMID: 25397684