About the Division

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The Division of Endocrinology, Metabolism, and Diabetes at UMMC is committed to clinical and translational research in diabetes, osteoporosis, polycystic ovarian syndrome, and other diverse topics in general endocrinology. Examples of several of our ongoing projects follow:

  • Metabolic bone disease: Division faculty are conducting studies to determine the potential effect of diabetes medications on the trabecular bone score. Other studies include exploring novel opportunities for diagnosing osteoporosis utilizing imaging studies done for other indications and the impact of various chronic diseases on bone strength.
  • PCOS: Our research seeks to understand the role of androgens in mediating the negative cardiometabolic profile often seen in patients with PCOS. Additionally, the basic research in our lab is focused on androgen regulation of adipose tissue  using  integrative physiological methods with whole animal, cellular, molecular, and imaging studies.
  • Inpatient diabetes management and insulin safety, lipids, and metabolic syndrome: Faculty in the division have experience in multiple aspects of clinical and translational research in diabetes and metabolism. A small sampling of published literature is given below, (and a more detailed listing can be found by searching an individual faculty member’s name in PubMed).


  • Davis ED, Harwood K, Midgett L, Mabrey M, Lien LF. “Implementation of a new intravenous insulin method on intermediate-care units in hospitalized patients.” Diabetes Educator. 2005 Nov-Dec;31(6):818-21, 823.
  • Evans KJ, Thompson J, Spratt S, Lien LF, Vorderstrasse A. "The Implementation and Evaluation of an Evidence-Based Protocol to Treat Diabetic Ketoacidosis: A Quality Improvement Study." Advanced Emergency Nursing Journal. 2014 Apr-Jun;36(2):189-98. PMID: 24785671
  • Kreider KE, Lien LF.  “Transitioning safely from intravenous to subcutaneous insulin.” Curr Diab Rep. 2015 May;15(5):23. PMID: 25772640
  • Garla VV, Sonani H, Venkataraman P, Gomez-Sanchez C, Subauste J, Lien LF.  “Non islet cell hypoglycemia: Case series and review of the literature.” Front. Endocrinol. 2019 May 15; 10:316.  doi: 10.3389/fendo.2019.00316.  PMID: 31156561
  • Lien LF. “Answering the challenge: Prevention of Inpatient Hypoglycemia.”  Endocrine Practice. 2016 Dec;22(12): 1456-1458  Epub 2016 Oct 17.PMID: 27749133
  • Lien LF, Guyton JR. “Metabolic syndrome.” Dermatologic Therapy. 2008 Sep-Oct;21(5):362-75.
  • Olson RP, Bethel MA, Lien L. “Preoperative Hypoglycemia in a Patient Receiving Insulin Detemir” Anesth Analg 2009 June;108(6):1836-8.
  • Lien LF, Bethel MA, Feinglos MN. “In-hospital Management of Type 2 Diabetes Mellitus” Medical Clinics of North America. 2004 Jul;88(4):1085-105, xii.
  • Lien LF, Feinglos MN. “Protease Inhibitor-Induced Diabetic Complications: Incidence, Management, and Prevention” Drug Safety. 2005;28(3):209-26.
  • Lien LF, Spratt SE, Woods Z, Osborne KK, Feinglos MN. “Optimizing Hospital Use of Intravenous Insulin: Improved hyperglycemic management and error reduction with a new nomogram” Endocrine Practice. 2005 Jul-Aug;11(4):240-53.
  • Garla V, Kanduri S, Yanes-Cardozo L, Lien LF.  =“Management of Diabetes Mellitus in Chronic Kidney Disease: An overview.” Minerva Endocrinologica. 2019 May 15. doi: 10.23736/S0391-1977.19.03015-3. PMID: 31112029
  • Garla V, Yanes-Cardozo L, Lien LF. Current therapeutic approaches in the management of hyperglycemia in chronic renal disease. Rev Endocr Metab Disord. 2017;18(1):5-19.
  • Sohail S. Medaura J, Malhotra B, Garla V, Ahuja S, Lawson N, Pamarthy A, Sonani H, Kovvuru K, Palabindala V. Nephrology key information for residents. Journal of Community Hospital Internal Medicine Perspectives 2017;7(2):70-72
  • Bhanat E, Koch CA, Parmar R, Garla V, Vijayakumar V. Somatostatin receptor expression in non-classical locations - clinical relevance? Rev Endocr Metab Disord. 2018 Oct 15.
  • Sanpureddy P, Garla V, Pabbidi M. Primary hyperparathyroidism: Labs to order, Tx to consider. J Fam Pract.2018; 67(11) E16-21.
  • Garla V, Kovvuru K, Ahuja S, Palabindala V, Malhotra B, Salim S. Severe Hyperthyroidism complicated by agranulocytosis treated with therapeutic  plasma exchange: Case report and review of the literature. Case Rep Endocrinol.2018 Jan10; 2018: 4135940
  • Yanes LL, Romero DG, Iliescu R, Cucchiarelli VE, Fortepiani LA, Santacruz F, Bell W, Zhang H, Reckelhoff JF. Systemic arterial pressure response to 2-week Tempol therapy in SHR: Involvement of NO, RAS and oxidative stress. Am J Physiol Regul Integr Comp Physiol 288(4): R903-R908, 2005.
  • Yanes LL, Romero DG, Bell W, Gomez-Sanchez CE, Santacruz F, Reckelhoff JF. Role of endothelin in postmenopausal hypertensive rats. Am J Physiol Regul Integr Comp Physiol 288(1): R229-R233, 2005.
  • Yanes LL, Romero DG, Iles J, Iliescu R, Gomez-Sanchez CE, Reckelhoff JF. Sexual dimorphism in the renin angiotensin system in aging spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 291(2):R383-R390, 2006.
  • Yanes LL, Fortepiani L, Sartori J, Iliescu R and Reckelhoff JF. Postmenopausal hypertension: Insights from rat .Models. Current Hypertension Reviews 3(3): 177-181, 2007.
  • Yanes LL, Sartori-Valinotti JC, Reckelhoff JF. Sex steroids and renal disease: Lessons from animal studies. Hypertension 51(4):976-981, 2008.
  • Yanes LL, Romero DG. Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells. Mol Cell Endocrinol 303(1-2):50-56, 2009.
  • Yanes LL, Sartori-Valinotti JC, Iliescu R, Romero DG, Lorraine CR, Zhang H, Reckelhoff JF. Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats. Am J Physiol Renal Physiol 296(4):F771-F779, 2009.
  • Yanes LL, Reckelhoff JF. A new piece in the hypertension puzzle: central blood pressure regulation by sex steroids. Am J Physiol Heart Circ Physiol 297(5):H1583-4, 2009.
  • Yanes LL, Romero DG, Iliescu R, Zhang H, Davis D, Reckelhoff JF. Postmenopausal hypertension: role of the Renin-Angiotensin system. Hypertension. 56(3):359-63, 2010.
  • Yanes LL, Romero DG, Iliescu R, Reckelhoff JF. A single pill to treat postmenopausal hypertension? Not yet. Curr Top Med Chem. 11(13):1736-41, 2011.
  • Yanes Cardozo LL, Romero DG, Reckelhoff JF. Cardiometabolic features of Polycystic Ovary Syndrome: Role of Androgens. Physiology (Bethesda). 2017 Sep;32(5):357-366.
  • Reckelhoff JF, Romero DG, Yanes Cardozo LL. Sex, Oxidative Stress and Hypertension: Insights From Animal Models. Physiology May 2019.