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Noha M. Shawky Elsayed

CURRICULUM VITAE 

OFFICE ADDRESS: Office G222-1; 2500 North State street, Jackson, MS 39216 

CONTACT: 601-984-1877 - Office 
email: nelsayed@umc.edu 

 

EDUCATION and TRAINING: 

01/2020-02/2021 
American Heart Association Post-doctoral fellowship – Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center. 
 
01/2019-01/2020 
Post-doctoral fellowship – Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center. 
 
09/2012-07/2017  
Ph.D. (Pharmaceutical Sciences, Pharmacology), Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Egypt. 
Thesis title: “Potential Effect of Some Drugs on Insulin Resistance Induced Experimentally”.  
 
11/2013-12/2016 
Exchange graduate PhD student – (Part of Ph.D. - Research scholar), Atherosclerosis lab (Dr Lakshman Segar), Clinical and Experimental therapeutic, Faculty of Pharmacy, University of Georgia, USA 
Performing research entitled: “Regulation of vascular smooth muscle cell phenotype; implications toward suppression of injury-induced neointima formation by sulforaphane”. 
 
12/2008-05/2011 
Master of Science (Pharmaceutical Sciences, Pharmacology): 
Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (2011). 
 
09/2002-07/2007 
Bachelor degree of science (Pharmaceutical sciences): 
School of Pharmacy, Mansoura University, Mansoura, Egypt (2007), excellent degree with honor and graduation ranking 2nd achiever (~1000 students). 

 

WORK EXPERIENCE: 

02/2021-present: Assistant Professor – Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center. 

08/2020-02/2021: Instructor – Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center. 

01/2020-08/2020: American heart Association Post-doctoral research fellow – Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center. 

01/2019-12/2019: Post-doctoral research fellow – Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center. 

07/2017-12/2018: Lecturer - Pharmacology and Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. 

11/2015-12/2016: Research assistant – Atherosclerosis lab, Clinical and Experimental therapeutics, University of Georgia/ Veterans Affairs Medical Centre, Augusta, GA, USA. 

11/2013-11/2015: Research scholar/Exchange graduate student – Atherosclerosis lab, Clinical and Experimental therapeutics, University of Georgia/ Veterans Affairs Medical Centre, Augusta, GA, USA. 

06/2011-07/2017: Assistant lecturer - Pharmacology and Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. 

11/2007-06/2011: Demonstrator - Pharmacology and Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. 

 

HONORS AND SCHOLARSHIPS: 

  1. Finalist for Stephanie Watts Career Development Award from the American Heart Association (2022). 
  2. Trainee Advocacy Committee Poster Award from the American Heart Association (2022). 
  3. Invited chair session; “New Trends in Sex Differences in Developmental Programming” in the American Physiological Society’s seventh conference on New Trends in Sex and Gender Medicine meeting -  (October 2021 - virtually). 
  4. Young investigator award from the basic science forum for emerging kidney scientists from the American society of Nephrology (October 2020). 
  5. Council for Kidney in Cardiovascular Diseases (KCVD) New Investigator Travel Award from the American Heart Association (2020). 
  6. 2020 Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award from the American Physiological Society. 
  7. Top 10 % of Abstracts submitted to American Heart Association Council on Hypertension” (presented as an oral presentation at the annual meeting in New Orleans, September 2019).  
  8. Joint supervision scholarship (Part of the PhD) from the Egyptian Government 2013-2015. 

 

PROFESSIONAL MEMBERSHIPS: 

American Physiological Society (2019-present) 

American Heart Association (2019-present) 

 

MENTORING: 

Micaiah McDonald (SURE student – Summer 2022) 

Dominique Self, BS in Biology (Graduate Student -  MS of Biomedical Sciences at UMMC, 01/10/2022 – 05/06/2022) 

Ahmed Abdel Hameed, M.S. or Pharmacology and Toxicology (Graduate Student – PhD of Cell and Molecular Biology at UMMC, lab rotation 01/24/2022 – 03/04/2022). 

Skylarr Beerman, M.S. of Biomedical Sciences, UMMC (Research Volunteer, 06/2021 – 08/2021) 

Reneisha Sweet (INBRE program, summer 2019) 

Ahmed Khookh, B.Sc. in Pharmaceutical Sciences (M.Sc. candidate, Mansoura University, Egypt, 2017-2018) 

 

SERVICE: 

  1. 2021 The School of Graduate Studies in the Health Sciences (SGSHS) Research Day Poster Judge -  October 2021, UMMC
  2. Chair of session; “New Trends in Sex Differences in Developmental Programming” in the American Physiological Society’s seventh conference on New Trends in Sex and Gender Medicine meeting -  October 2021 (virtually).
  3. Serves as a Guest Associate Editor for Frontiers in Pharmacology (cardiovascular and Smooth Muscle Pharmacology).
  4. Serves as a reviewer for; Hypertension, Journal of Life Sciences, Journal of Toxicology Reports, Journal of Pharmaceutical Research International, International Journal of Biochemistry Research & Review, Diabetology & Metabolic Syndrome Journal and Journal of Physiology. 

 

GRANTS AND FUNDING: 

  1. American Heart Association Postdoctoral Fellowship 2020 – Completed 
  2. Active funding: 
    1. Project Number: P20GM121334  
      Title:Mississippi Center of Excellence in Perinatal Research COBRE, Phase 2 
      PI:  Reckelhoff 
      Source of Support:  NIH NIGMS  
      My Role in the project:  Principal Investigator, Project 1 
      Project 1 Title: Long term consequences of hyperandrogenemic pregnancy on offspring. 
      Person Months (Calendar/Academic/Summer) per budget period.  6 mos(50% effort) 
      Project/Proposal Start and End Date:08/2022 – 05/2027 
      Major Goals:  To determine the cardiovascular-renal consequences of hyperandrogenemic pregnancy in male and female offspring and potential mechanisms. 
      Annual Direct Costs: $155,357.00 
    2. Project Number: 938320  
      Title: Career Development Award 
      Source of Support: American heart Association 
      My Role: Principal Investigator 
      Project Title: Consequences of maternal hyperandrogenemia on adult male and female offspring. 
      Person Months (Calendar/Academic/Summer) per budget period.  1.2 mos(10% effort) 
      Project/Proposal Start and End Date:07/2022 – 06/2025 
      Major Goals: To study the sex differences in the intrarenal mitochondrial function, intrarenal inflammation and renal injury in offspring born to hyperandrogenemic dams. 
      Annual Direct Costs: $70,000.00 

PUBLICATIONS: 

  1. Reckelhoff J., Shawky NM., Romero D. and Cardozo LY. (2022): Polycystic ovary syndrome: Insights from pre-clinical research. Kidney360. 3(8): 1449-1457. 
  2. Shawky NM.#, Dalmasso C., Ojeda N., Zuchowski Y., Stachenfeld N., Alexander BT. and Reckelhoff J. (2022): Consequences of Hyperandrogenemia during Pregnancy on Female Offspring: Attenuated response to Angiotensin II. J Hypertension. 40 (4): 712-722. # Corresponding author. 
  3. Zuchowski Y., Dalmasso C., Shawky NM. and Reckelhoff J. (2021):Cardiometabolic Consequences of Maternal Hyperandrogenemia in Male Offspring. Physiological Reports. 9 (14): e14941. 
  4. Pichavaram P., Shawky NM.*, Hartney TJ., Jun JY. and Segar L. (2021): Imatinib improves insulin resistance and inhibits injury-induced neointimal hyperplasia in high fat diet-fed mice. European Journal of Pharmacology. 890: p.173666 * Co-first author. 
  5. Shawky NM., Patil C.*, Dalmasso C., Maranon R., Romero D., Drummond H., and Reckelhoff J. (2020): Pregnancy protects hyperandrogenemic female rats from postmenopausal hypertension. Hypertension. 76 (3): 943-952. * Co-first author 
  6. Amen Y., Sherif AE, Shawky NM., Abdelrahman RS., Wink M. and Sobeh M. (2020): Grape-Leaf Extract Attenuates Alcohol-Induced Liver Injury via Interference with NF-κB Signaling Pathway. Biomolecules.10(4), 558. 
  7. Srinivasan MP., Shawky NM.*, Kaphalia BS., Thangaraju M. and Segar L. (2019): Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice. Biochemical Pharmacology. 160: 46-61.*Co-first author 
  8. Shawky NM.,Shehatou GSG., Suddek GM. and Gameil NM. (2019): Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats. Environmental Toxicology and Pharmacology. 66: 43-54. 
  9. Shawky NM.and Segar L. (2018): Sulforaphane improves leptin responsiveness in western diet-fed mice. European Journal of Pharmacology. 835: 108-114. 
  10. Shawky NM.and Segar L. (2017):Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation. Pharmacological Research.119: 251-264. 
  11. Fairaq A., Shawky NM., Osman I., Pichavaram P. and Segar L. (2017): AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: implications toward suppression of neointimal hyperplasia. Pharmacological Research. 119:289-302. 
  12. Shawky NM., Pichavaram P., Shehatou GSG., Suddek GM., Gameil NM., Jun JY. and Segar L. (2016): Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice. Journal of Nutritional Biochemistry. 32: 73-84. 
  13. Shawky NM., Shehatou GSG., Abdel Rahim M., Suddek GM. and Gameil NM. (2014): Levocetirizine ameliorates high fructose diet-induced insulin resistance, vascular dysfunction and hepatic steatosis in rats. European Journal of Pharmacology. 740: 353-63. 
  14. Ammar EM., Gameil NM., Nader MA., Shawky NM. (2013): Chinese Propolis attenuates in-vivo and in-vitro asthmatic reactions. Journal of Allergy and Therapy. S11: 006. 
  15. Ammar EM., Gameil NM., Shawky NM., Nader MA. (2011): Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model. International Immunopharmacology. 11(12), 2232-2236. 
  16. Ammar EM., Gameil NM., Nader MA., Shawky NM. (2010): Comparative Effects of Ethanolic Extract of Propolis, Thymoquinone and Curcumin on Anaphylactic Reactions. Mansoura journal of pharmaceutical sciences. 26(2), 1-10. 

 

PUBLISHED ABSTRACTS 

  1. Quin RM, Davenport K and Shawky NM (2022). Western Diet Consumption Exacerbates Hypertension In Hyperandrogenemic Female Rat, A Model Of Polycystic Ovary Syndrome. Hypertension. 79 (S1): AP048 
  2. Alexander BT, Rawls AZ, Cockrell K, Davenport K, Crudup BF, Mcneal MJ, Rafiqu JF, Ojeda NB and Shawky NM (2022). 17b-estradiol Implants With An Antiandrogen Or Castration Attenuate Body Weight And Total Lean Mass But Differentially Modulate Total Cholesterol And The Pressor Response To Chronic Angiotensin II In The Male Rat. Hypertension. 79 (S1): A077 
  3. Edwards K., Hoang N., Reckelhoff J. and Shawky NM. (2022). Aging Female Offspring Exposed to Maternal Hyperandrogenemia have Increased Renal Mitochondrial Content and Decreased Mitochondrial Reactive Oxygen Species. The FASEB Journal. 36 (S1) 
  4. Alexander BT., Rawls AZ., Cockrell K., Davenport K., Ojeda NB., Reckelhoff J., Cardozo LY. and Shawky NM. (2022). Administration of Estradiol in Young Adulthood in the Male Sprague Dawley Rat to Mimic Female Physiological Levels is Associated with a Reduction in Body Weight, Lean Mass and Testicular Size. The FASEB Journal. 36 (S1) 
  5. Shawky NM., Cardozo LY. and Reckelhoff JF (2022). Post-Pubertal Testosterone Implants Induce Hypertension in Female-to-Male Trans-Sex Rat Model. The FASEB Journal. 36 (S1) 
  6. Shawky NM. and Reckelhoff JF (2021).Adult Male Offspring of Polycystic Ovary Syndrome (PCOS) Rat Model Have Exaggerated Pressor Response to Low Dose Angiotensin (Ang) II. The FASEB Journal. 35 (S1) 
  7. Shawky NM. and Reckelhoff JF (2021). Sex Differences in The Blood Pressure Response to Angiotensin (Ang) II in Aging Offspring of Polycystic Ovary Syndrome (PCOS) Rat Model. The FASEB Journal. 35 (S1) 
  8. Shawky NM. and Reckelhoff JF (2020). Androgen Receptor Antagonist, Bicalutamide, And Androgen Receptor Degradation Enhancer, Asc-j9, Decrease Blood Pressure Similarly In Male Spontaneously-hypertensive Rats. Hypertension. 76 (S1): AP 209 
  9. Shawky NM., Vinson RM, Zuchowski YP. and Reckelhoff JF (2020).Female Offspring of Hyperandrogenemic Female (HAF) Rat Model Exhibit Insulin Resistance and Increased Blood Pressure With Aging. The FASEB Journal. 34 (S1), p. 1-1. 
  10. Zuchowski YP., Dalmasso C. , Shawky NM., Vinson RM. and Reckelhoff JF (2020).Male Offspring of Hyperandrogenemic Female (HAF) Rats Develop Hypertension Beginning at 16 Weeks of Age. The FASEB Journal. 34 (S1), p. 1-1. 
  11. Shawky NM., Vinson RM. and Reckelhoff JF. (2019): Female Offspring of Polycystic Ovary Syndrome Rat Model Exhibit Insulin Resistance and Tendency Toward Increased Blood Pressure With Aging. Hypertension. 74, A018 
  12. Segar L., Pichavaram P.,Shawky NM.and Jun JY (2015): Imatinib attenuates exaggerated intimal hyperplasia after arterial injury and improves glycemic control and lipid profile in high fat diet-fed mice. Atherosclerosis. 241(1), e61. 

ORAL PRESENTATIONS/TALKS/WORKSHOPS: 

  1. Shawky NM: Blood Pressure Measurement in Freely-Moving Rats by Telemetry: The Gold Standard Method. [Workshop on Methods to Assess Blood Pressure Regulation in Humans and in Animal Models, Experimental Biology 2021]. 
  2. Shawky NM and Reckelhoff JF.: Adult Male Offspring of Polycystic Ovary Syndrome (PCOS) Rat Model Have Exaggerated Pressor Response to Low Dose Angiotensin (Ang) II. Abstract-based oral presentation,Experimental Biology 2021. 
  3. Shawky NM: Methods of Blood Pressure measurement in Experimental animals. Invited speaker,1st Virtual Pharmacology Scientific Conference, Mansoura University, 2020. 
  4. Shawky NM., Vinson RM. and Reckelhoff JF.: Female offspring of polycystic ovary syndrome (PCOS) rat model exhibit insulin resistance and tendency toward increased blood pressure with aging. Abstract-based oral presentation, Hypertension Council Meeting, New Orleans, 2019. 
  5. Shawky NM., Pichavaram P., Segar L.:Sulforaphane attenuates exaggerated intimal hyperplasia in western diet-fed obese mice. Abstract-based oral presentation, Southern Translational Education and Research (STAR) conference, 2014.  
  6. Shawky NM., Ammar EM., Gameil NM. and Nader MA.: Comparative pharmacological evaluation of the antiasthmatic effect of propolis, thymoquinone and curcumin. Abstract-based oral presentation, 1st international pharmaceutical sciences conference – Tanta, Egypt, 2009. 

POSTER PRESENTATIONS: 

  1. Alexander BT., Rawls AZ., Cockrell K., Davenport K., Reckelhoff J., Yanes-cardozo L. and Shawky NM. Administration of estradiol in the male Sprague Dawley rat to female physiological levels lowers weight gain in association with a reduction in lean mass and testicular size in young adulthood. Experimental Biology, 2022. 
  2. Edwards K, Hoang N., Reckelhoff J. and Shawky NM. Aging female offspring exposed to maternal hyperandrogenemia have decreased renal mitochondrial respiration. Experimental Biology, 2022. 
  3. Shawky NM, Yanes-Cardozo L and Reckelhoff J. Post-Pubertal Testosterone Implants Induce Hypertension in Female-to-Male Trans-Sex Rat Model. Experimental Biology, 2022. 
  4. Beerman S, Reckelhoff JF and Shawky NM. Sex differences in the expression of the renin angiotensin system (RAS) components in aging offspring of polycystic ovary syndrome (PCOS) rat model. The American Physiological Society (APS) 7th Conference on New Trends in Sex and Gender Medicine, 2021. 
  5. Sweet R.,Shawky NM., Vinson RM, Zuchowski Y., Torres Fernandez ED and Reckelhoff JF. Acetazolamide pretreatment restores the blood pressure-lowering effect of Tempol in female spontaneously-hypertensive rats. Mississippi Academy of Sciences 84th Annual Meeting, 2020. 
  6. Zuchowski Y., Shawky NM., Vinson RM and Reckelhoff JF. Male offspring of hyperandrogenemic female (HAF) rat model exhibit an increase in their blood pressure as adults. University of Mississippi Medical Center Research day, 2019. 
  7. Sweet R.,Shawky NM., Vinson RM, Zuchowski Y., Torres Fernandez ED and Reckelhoff JF. Acetazolamide pretreatment restores the blood pressure-lowering effect of Tempol in female spontaneously-hypertensive rats. Mississippi IDeA Conference, 2019. 
  8. Shawky NM.and Segar L. Sulforaphane inhibits PDGF-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6 kinase signaling independent of Nrf2 activation. Southern Translational Education and Research (STAR) conference, 2016. 
  9. Fairaq A., Osman I.,Shawky NM.and Segar L.AdipoRon, a small molecule adiponectin receptor agonist, promotes vasorelaxation in endothelium-denuded rat aorta through AMPK-independent mechanism. Southern Translational Education and Research (STAR) conference, 2016. 
  10. Shawky NM., Osman I., Fairaq A. and Segar L. Sulforaphane attenuates VSMC proliferation by inhibiting mTOR signaling independent of Nrf2 activation: Implications toward suppressing intimal hyperplasia. Augusta University- Graduate Research Day, 2016. 
  11. Shawky NM., Pichavaram P. and Segar L.: Sulforaphane attenuates PDGF-induced VSMC proliferation by inhibiting mTOR signaling: Implications toward suppression of neointima formation after arterial injury. Southern Translational Education and Research (STAR) conference, 2015. 
  12. Shawky NM., Pichavaram P., Segar L.Sulforaphane inhibition of PDGF-induced VSMC proliferation is associated with disruption of mTOR-raptor complex: Implications toward suppression of neointima formation. North American Vascular Biology Organization (NAVBO) Vasculata, Charlottesville, VA, USA, August 2015. 
  13. Shawky NM, Pichavaram P. and Segar L.Sulforaphane inhibition of injury-induced neointima formation in western diet-fed obese mice is associated with decreased plasma leptin, improved insulin sensitivity, and diminished leptin-induced VSMC proliferation. North American Vascular Biology Organization (NAVBO) Vasculata, Charlottesville, VA, USA, August 2015. 
  14. Shawky NM, Pichavaram P. and Segar L.Sulforaphane attenuates neointimal formation after arterial injury by preventing dysregulated insulin/leptin responsiveness and inhibiting leptin-induced VSMC proliferation in diet-induced obese mice. Charlie Norwood-VA Medical Centre Research week, 2015. 
  15. Shawky NM, Pichavaram P. and SegarL.Sulforaphane inhibition of neointimal growth after arterial injury is associated with improved insulin and leptin responsiveness in western diet-fed obese mice. Georgia Regents University - Graduate Research Day, 2015. 
  16. Pichavaram P.,Shawky NM and Segar L.Imatinib attenuates exaggerated intimal hyperplasia after arterial injury and improves glycemic control and lipid profile in high fat diet-fed mice. Georgia Regents University- Graduate Research Day, 2015. 
  17. Pichavaram P.,Shawky NMand Segar L.Imatinib inhibits exaggerated intimal hyperplasia in high fat-fed mice by preventing insulin resistance and dyslipidemia.Southern Translational Education and Research (STAR) conference, Augusta, GA, USA, 2014. 
  18. Shawky NMand Segar L.Western diet induces insulin and leptin resistance in C57BL/6 mice. Charlie Norwood-VA Medical Centre Research week, 2014. 
  19. Pichavaram P.,Shawky NMand Segar L.Imatinib, an inhibitor of PDGF receptor tyrosine kinase, attenuates high fat diet-induced insulin resistance and exaggerated intimal hyperplasia after arterial injury. Charlie Norwood-VA Medical Centre Research week, 2014.