Publications

Main Content

2020 Publications

  • Wang S,  Lv W,  Zhang H, Liu Y, Li L, Jefferson JR, Guo Y, Li M , Gao W, Fang X, Paul IA, Rajkowska G, Shaffery JP, Mosley TH , Hu X, Liu R, Wang Y, Yu H, Roman RJ, Fan F. Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats.  Geroscience. 2020 Oct; 42(5):1387-1410. doi: 10.1007/s11357-020-00233-w. Epub 2020 Jul 21.
  • Szczepanski J, Spencer SK, Griffin A, Bowles T, Williams JM, Kyle PB, Dumas JP, Araji S, Wallace K. Acute kidney injury during pregnancy leads to increased sFlt-1 and sEng and decreased renal T regulatory cells in pregnant rats with HELLP syndrome. Biol Sex Differ. 2020 Sep 24;11(1):54. doi: 10.1186/s13293-020-00331-6.
  • Hinds Jr TD, Creeden JF, Gordon DM, Spegele AC, Britton SL, Koch LG, Stec DE. Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1. Antioxidants (Basel). 2020 Sep 19;9(9):E889. doi: 10.3390/antiox9090889.
  • Sachdeva  R, Jia  M, Wang S, Yung A, Zheng MMZ, Lee AHX, Monga A, Leong  S, Kozlowski P, Fan F, Roman RJ, Phillips AA, Krassioukov AV. Vascular-Cognitive Impairment following High-Thoracic Spinal Cord Injury Is Associated with Structural and Functional Maladaptations in Cerebrovasculature. J Neurotrauma. 2020 Sep 15;37(18):1963-1970. doi: 10.1089/neu.2019.6913. Epub 2020 Jul 1.
  • Mouton AJ, Hall JE. Novel roles of immunometabolism and non-myocyte metabolism in cardiac remodeling and injury. Am J Physiol Regul Integr Comp Physiol.  2020 Sep 2. doi: 10.1152/ajpregu.00188.2020. Online ahead of print.
  • Fan L, Gao W, Nguyen BV, Jefferson JR, Liu Y, Fan F, Roman RJ. Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury. Am J Physiol Renal Physiol. 2020 Aug 24.doi: 10.1152/ajprenal.00239.2020. Online ahead of print.
  • Speed JS, Pruett WA, Lirette ST, Cook JJ, Phillips CL, Grayson BE. Cardiovascular Risk Factors Following Vertical Sleeve Gastrectomy in Black Americans Compared with White Americans. Obes Surg. 2020 Aug 22. doi: 10.1007/s11695-020-04938-x. Online ahead of print.
  • Dent EL, Broome HJ, Sasser JM, Ryan MJ.  Blood pressure and albuminuria in a female mouse model of systemic lupus erythematosus: Impact of long-term high salt consumption. Am J Physiol Regul Integr Comp Physiol. 2020 Aug 19. doi: 10.1152/ajpregu.00070.2020. Online ahead of print.
  • Raffaele M, Licari M, Amin S, Alex R, Shen H, Singh SP, Vanella L, Rezzani R, Bonomini F, Peterson SJ, Stec DE, Abraham NG.Cold Press Pomegranate Seed Oil Attenuates Dietary-Obesity Induced Hepatic Steatosis and Fibrosis through Antioxidant and Mitochondrial Pathways in Obese Mice. Int J Mol Sci. 2020 Jul 31;21(15):5469. doi: 10.3390/ijms21155469.
  • Lomax TM, Ashraf S, Yilmaz G, Harmancey R.  Loss of Uncoupling Protein 3 Attenuates Western Diet-Induced Obesity, Systemic Inflammation, and Insulin Resistance in Rats. Obesity (Silver Spring).  2020 Sep;28(9):1687-1697. doi: 10.1002/oby.22879. Epub 2020 Jul 27.
  • Cunningham MW, Jayaram A, Deer E, Amaral LM, Vaka RV, Ibrahim T, Cornelius DC, La Marca B. Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia. Hypertens Pregnancy. 2020 Jul 10;1-6. 10.1080/10641955.2020.1793999.
  • Jenkins HN, Rivera-Gonzalez O, Gibert Y, Speed JS. Endothelin-1 in the pathophysiology of obesity and insulin resistance. Obes Rev. 2020 Jul 6. doi: 10.1111/obr.13086. Online ahead of print.
  • Sachdeva R, Jia M, Wang S, Yung A, Zheng MMZ, Lee AHX, Monga A, Leong S,  Kozlowski P, Fan F, Roman RJ, Phillips AA, Krassioukov AV. Vascular-Cognitive Impairment following High-Thoracic Spinal Cord Injury Is Associated with Structural and Functional Maladaptations in Cerebrovasculature. J Neurotrauma. 2020 Jul 1. doi: 10.1089/neu.2019.6913. Online ahead of print.
  • Spann RA, Grayson BE. Curbing Obesity from One Generation to Another: the Effects of Bariatric Surgery on the In Utero Environment and Beyond. Reprod Sci.2020 Jun 23.doi: 10.1007/s43032-020-00221-7.
  • Poudel B, Shields CA, Brown AK, Ekperikpe US, Johnson TD, Cornelius DC, Williams JM.  Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats. Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1489-1499.
  • Daseke MJ, Tenkorang-Impram MAA, Ma Y, Chalise U, Konfrst SR, Garrett MR, Deleon-Pennell K, Lindsey ML. Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction. J Mol Cell Cardiol.2020 Jun 20;145:112-121.doi:10.1016/j.yjmcc.2020.06.006.
  • da Silva AA, do Carmo JM, Li X, Wang Z, Mouton AJ, Hall JE. Role of Hyperinsulinemia and Insulin Resistance in Hypertension: Metabolic Syndrome Revisited. Can J Cardiol. 2020 May; 36 (5) :671-682.
  • Nemeth Z, Hildebrandt E, Ryan MJ, Granger JP, Drummond HA. Pressure-induced constriction of the middle cerebral artery is abolished in TrpC6 knockout mice. Am J Physiol Heart Circ Physiol. 2020 May 15. doi:10.1152/ajpheart.00126.2020.
  • Surh JY, Chung, TH, Na HK, Dulak, J and Stec DE. Progress in heme oxygenase research. Arch Biochem Biophys. 2020 May 30; 685: 108321.
  • McCauley M, German DP, Lujan NK, Jackson CR. Gut microbiomes of sympatric Amazonian wood-eating catfishes (Loricariidae) reflect host identity and little role in wood digestion. Ecol Evol.2020 May 25;10(14):7117-7128. doi: 10.1002/ece3.6413. eCollection 2020 Jul.
  • Ren D, Quan N, Fedorova J, Zhang J, He Z, Li, J. Sestrin2 modulates cardiac inflammatory response through maintaining redox homeostasis during ischemia and reperfusion. Redox Biol. 2020 May 5;34:101556.
  • Fan F, Geurts AM, Pabbidi MR, Ge Y, Zhang C, Wang Sh, Liu Y, Ga W, Guo Y, Li L, He X, Lv W, Muroya Y, Hirata T, Prokop J, Booz GW, Jacob HJ, Roman RJ. A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. J Am Soc Nephrol.
    2020 Apr;31(4):687-700.doi: 10.1681/ASN.2019080784.
  • Travis OK, White D, Baik CH, Giachelli C, Thompson W, Stubbs C, Greer M, Lemon JP, Williams JM, Cornelius DC. Interleukin-17 Signaling Mediates Cytolytic Natural Killer Cell Activation in Response to Placental Ischemia. Am J Physiol Regul Integr Comp Physiol. 2020 Apr 22.doi: 10.1152/ajpregu.00285.2019.
  • Duncan JW, Younes ST, Hildebrandt E, Ryan MJ, Granger JP, Drummond  HA.  Tumor necrosis factor-α impairs cerebral blood flow in pregnant rats: role of vascular β-epithelial Na+ channel. Am J Physiol Heart Circ Physiol. 2020 Apr 1;318 (4) :H1018-H1027.
  • Wang S, Zhang H, Liu Y, Li L, Guo Y, Jiao F, Fang X, Jefferson JR, Li M, Gao W, Gonzalez-Fernandez E, Maranon RO, Pabbidi MR, Liu R, Alexander BT, Roman RJ, Fan F. Sex differences in the structure and function of rat middle cerebral arteries. Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1219-H1232. doi: 10.1152/ajpheart.00722.2019. Epub 2020 Mar 27.PMID: 32216612
  • Johnson, AC, Wu, W, Attipoe, EM, Sasser, JM, Taylor, EB, Showmaker, KC, Kyle, PB, Lindsey, ML Garrett, MR. Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury. Hypertension. 2020 Apr;75(4):1012-1024. doi: 10.1161/HYPERTENSIONAHA.119.14338. Epub 2020 Mar 9.
  • Mouton AJ, Li X, Hall ME Hall JE. Obesity, Hypertension, and Cardiac Dysfunction: Novel Roles of Immunometabolism in Macrophage Activation and Inflammation. Circ Res. 2020 Mar 13; 126 (6) :789-806
  • Chen, MB, Yang, AC, Yousef, H, Lee, D, Chen, W, Schaum, N, Lehallier, B, Quake, SR, Wyss-Coray, T. Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues. Cell Rep.  2020 Mar 31;30(13):4418-4432.e4. doi: 10.1016/j.celrep.2020.03.012.
  • Dent EL, Taylor EB, Sasser JM, Ryan MJ. Temporal hemodynamic changes in a female mouse model of systemic lupus erythematosus. Am J Physiol Renal Physiol. 2020 Mar 9. doi: 10.1152/ajprenal.00598.2019.
  • Spradley FT, Ge Y, Granger JP, Chade AR. Utero-placental vascular remodeling during late gestation in Sprague-Dawley rats. Pregnancy Hypertens. 2020 Mar 3;20:36-43. doi: 10.1016/j.preghy.2020.02.007.
  • Juraschek SP, Miller ER 3rd, Chang AR, Anderson CAM, Hall JE, Appel LJ. Effects of Sodium Reduction on Energy, Metabolism, Weight, Thirst, and Urine Volume: Results From the DASH (Dietary Approaches to Stop Hypertension)-Sodium Trial. Hypertension. 2020 Mar;75(3):723-729. doi: 10.1161/HYPERTENSIONAHA.119.13932.
  • Kaminski AR, Moore ET, Daseke MJ 2nd, Valerio FM, Flynn ER, Lindsey ML. The compendium of matrix metalloproteinase expression in the left ventricle of mice following myocardial infarction. Am J Physiol Heart Circ Physiol.2020 Mar 1;318(3):H706-H714. doi: 10.1152/ajpheart.00679.
  • Stec DE, Gordon DM, Nestor-Kalinoski AL, Donald MC, Mitchell ZL, Creeden JF, Hinds TD Jr. Biliverdin reductase A (BVRA) knockout in adipocytes induces hypertrophy and reduces mitochondria in white fate of obese mice. Biomolecules. 2020 Mar 2;10(3). pii: E387. doi: 10.3390/biom10030387.
  • Zhang D, Jin C, Obi IE, Rhoads MK, Soliman RH, Sedaka RS, Allan JM, Tao B, Speed JS, Pollock JS, Pollock DM. Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice. Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F710-F719. doi: 10.1152/ajprenal.00364.2019.
  • Eddy AC, Chapman H, Brown DT, George EM. Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells. Biosci Rep. 2020 Feb 28;40(2). pii: BSR20193252. doi: 10.1042/BSR20193252.
  • Wilson JG, et al. National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Population Genetics Working Group, O'Connor TD. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2560-2569. doi: 10.1073/pnas.1902766117.
  • Rivera-Gonzalez OJ, Kasztan M, Johnston JG, Hyndman KA, Speed JS. Loss of endothelin type B receptor function improves insulin sensitivity in rats. Can J Physiol Pharmacol. 2020 Feb 21. doi: 10.1139/cjpp-2019-0666.
  • Sigmund CD, Carey RM, Appel LJ, Arnett DK, Bosworth HB, Cushman WC, Galis ZS, Green Parker M, Hall JE, Harrison DG, McDonough AA, Nicastro HL, Oparil S, Osborn JW, Raizada MK, Wright JD, Oh YS. Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: barriers to translation. Hypertension. 2020 Feb 17:HYPERTENSIONAHA11913887. doi: 10.1161/HYPERTENSIONAHA.119.13887.
  • Van Tassell JC, Shimbo D, Hess R, Kittles R, Wilson JG, Jorde LB, Li M, Lange EM, Muntner P, Bress AP. Association of West African ancestry and blood pressure control among African Americans taking antihypertensive medication of the Jackson Heart Study. J Clin Hypertens (Greenwich).2020 Feb;22(2):157-166. doi: 10.1111/jch.13824.
  • Lu Q, Liu J, Li X, Sun X, Zhang J, Ren D, Tong N, Li J. Empagliflozin attenuates ischemia and reperfusion injury through LKB1/AMPK signaling pathway. Mol Cell Endocrinol. 2020 Feb 5;501:110642. doi: 10.1016/j.mce.2019.110642.
  • Wang Z, do Carmo JM, da Silva AA, Fu Y, Hall JE. Mechanisms of synergistic interactions of diabetes and hypertension in chronic kidney disease: role of mitochondrial dysfunction and ER stress. Curr Hypertens Rep. 2020 Feb 3;22(2):15. doi: 10.1007/s11906-020-1016-x.
  • Guo H, Xu D, Kuroki M, Lu Z, Xu X, Geurts A, Osborn JW, Chen Y. Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. Free Radic Biol Med. 2020 Jan 21. pii: S0891-5849(19)31433-9. doi: 10.1016/j.freeradbiomed.2020.01.023.
  • Eddy AC, Howell JA, Chapman H, Taylor E, Mahdi F, George EM, Bidwell GL 3rd. Biopolymer-delivered, maternall sequestered NF-kB (Nuclear Factor-kB) inhibitory peptide for treatment of preeclampsia. Hypertension. 2020 Jan;75(1):193-201. doi: 10.1161/HYPERTENSIONAHA.119.13368.
  • Ashraf S, Yilmaz G, Chen X, Harmancey R. Dietary fat and sugar differentially affect β-adrenergic stimulation of cardiac ERK and AKT pathways in C57BL/6 male mice subjected to high-calorie feeding. J Nutr. 2020 Jan 17. pii: nxz342. doi: 10.1093/jn/nxz342.
  • Williams E, Chade AR. A Boolean model of microvascular rarefaction to predict treatment outcomes in renal disease. Sci Rep. 2020 Jan 16;10(1):440. doi: 10.1038/s41598-019-57386-8.
  • Clark 3rd D, Hall ME, Jones DW. Dilemma of Blood Pressure Management in Older and Younger Adults. Hypertension (Dallas, Tex. : 1979). 2020 Jan; 75 (1) :35-37
  • Younes ST, Maeda KJ, Sasser J, Ryan MJ. The glucagon-like peptide 1 receptor agonist liraglutide attenuates placental ischemia-induced hypertension. Am J Physiol Heart Circ Physiol. 2020 Jan 1;318(1):H72-H77. doi: 10.1152/ajpheart.00486.
  • Zhang H, Zhang C, Liu Y, Gao W, Wang S, Fang X, Guo Y, Li M, Liu R, Roman RJ, Sun P, Fan F. Influence of dual-specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles. Physiol Rep. 2020 January;8(2):e14345. PubMed PMID: 31960618; PubMed Central PMCID: PMC6971329; DOI: 10.14814/phy2.14345.
  • Williams E, Chade AR. A Boolean Model of Microvascular Rarefaction to Predict Treatment Outcomes in Renal Disease. Sci Rep. 2020 January 16;10(1):440. PubMed PMID: 31949240; PubMed Central PMCID: PMC6965143; DOI: 10.1038/s41598-019-57386-8.
  • Deer EM, Welch B, Hernandez LL, Seeley RJ, Grayson BE. Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery. J Dev Orig Health Dis. 2020 February;11(1):71-77. PubMed PMID: 31397254; PubMed Central PMCID: PMC6934892; DOI:10.1017/S2040174419000424.
  • Wang Z, do Carmo JM, da Silva AA, Fu Y, Hall JE. Mechanisms of Synergistic Interactions of Diabetes and Hypertension in Chronic Kidney Disease: Role of Mitochondrial Dysfunction and ER Stress. Curr Hypertens Rep. reports. 2020 February 3;22(2):15. PubMed PMID: 32016622; DOI: 10.1007/s11906-020-1016-x.
  • Showmaker KC, Cobb MB, Johnson AC, Yang W, Garrett MR. Whole genome sequencing and novel candidate genes for CAKUT and altered nephrogenesis in the HSRA rat. Physiol Genomics. 2020 Jan 1; 52 (1) :56-70.