Main Content

2016 Publications

  1. Altara R, Harmancey R, Didion SP, Booz GW, Zouein FA. Cardiac STAT3 deficiency impairs contractility and metabolic homeostasis in hypertension. Front Pharmacol. 2016; 16:7:436. PMCID: PMC5110511.
  2. Bakrania B, Granger JP, Harmancey R. Methods for the determination of rates of glucose and fatty acid oxidation in the isolated working rat heart. J Vis Exp. 2016; 115. PMCID: PMC5092065.
  3. Bean C, Spencer SK, Bowles T, Kyle PB, Williams JM, Gibbens J, Wallace K. Inhibition of T-cell activation attenuates hypertension. TNFα, IL-17, and blood-brain barrier permeability in pregnant rats with angiogenic imbalance. Am J Reprod Immunol. 2016; 76:272-279. PMCID: PMC5023479.
  4. Blenck CL, Harvey PA, Reckelhoff JF, Leinwand, LA. The importance of biological sex and estrogen in rodent models of cardiovascular health and disease. Circ Res. 2016; 118:1294-1312. PMCID: PMC4834858.
  5. Chade AR. Vascular endothelial growth factor therapy for the kidney: are we there yet? J Am Soc Nephrol. 2016; 27:1-3. PMCID: PMC4696589.
  6. Chade AR, Hall JE. Role of the renal microcirculation in progression of chronic kidney injury in obesity. Am J Nephrol. 2016; 44:354-367. PMCID: PMC5117364.
  7. Chade AR, Tullos NA, Harvey TW, Mahdi F, Bidwell GL 3rd. Renal therapeutic angiogenesis using a bioengineered polymer-stabilized vascular endothelial growth factor construct. J Am Soc Nephrol. 2016; 27:1741-1752. PMCID: PMC4884109.
  8. Chandrashekar K, Lopez-Ruiz A, Juncos LI and Juncos LA. The Promise of Mineralocorticoid Antagonism in Acute Kidney Injury. Nephron. 2016; 134:154-159. PMID: 27504633.
  9. Clemmer JS, Xiang L, Lu S, Mittwede PN, Hester RL. Hyperglycemia-mediated oxidative stress increases pulmonary vascular permeability. Microcirculation. 2016; 23:221-229. PMCID: PMC4818684.
  10. Cunningham MW Jr, Williams JM, Amaral L, Usry N, Wallukat G, Dechend R, LaMarca B. Agonistic autoantibodies to the angiotensin II type 1 receptor enhance angiotensin II-induced renal vascular sensitivity and reduce renal function during pregnancy. Hypertension. 2016; 68:1308-1313. PMCID: PMC5142826.
  11. Dalmasso C, Maranon R, Patil C, Moulana M, Romero DG, Reckelhoff JF. 20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats. Am J Physiol Renal Physiol. 2016; 311:F71-F77. PMCID: PMC4967161.
  12. Dalmasso C, Maranon R, Patil C, Bui E, Moulana M, Zhang H, Smith A, Yanes Cardozo, LL, Reckelhoff JF. Cardiometabolic effects of chronic hyperandrogenemia in a new model of postmenopausal polycystic ovary syndrome. Endocrinology. 2016; 157:2920-2727. PMCID: PMC4929551.
  13. Dasinger JH, Alexander BT. Gender differences in developmental programming of cardiovascular diseases. Clin Sci (Lond). 2016; 130:337-348. PMCID: PMC4912835.
  14. Dasinger JH, David GK, Newsome AD, Alexander BT. Developmental programming of hypertension: physiological mechanisms. Hypertension. 2016; 68:826-831. PMCID: PMC5016247.
  15. Dasinger JH, Intapad S, Backstrom MA, Carter AJ, Alexander BT. Intrauterine growth restriction programs an accelerated age-related increase in cardiovascular risk in male offspring. Am J Physiol Renal Physiol. 2016; 311:F312-F319. PMCID: PMC5005278.
  16. Dasinger JH, Intapad S, Rudsenske BR, Davis GK, Newsome AD, Alexander BT. Chronic blockade of the androgen receptor abolishes age-dependent increases in blood pressure in female growth-restricted rats. Hypertension. 2016; 67:1281-1290. PMCID: PMC4865435.
  17. DeLeon-Pennell KY. May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for? J Mol Cell Cardiol. 2016; 91:201-213. PMID: 26772530.
  18. DeLeon-Pennell KY, Tian Y, Zhang B, Cates CA, Iyer RP, Cannon P, Shah P, Aiyetan P, Halade GV, Ma Y, Flynn E, Zhang Z, Jin YF, Zhang H, Lindsey ML. CD36 is a matrix metalloproteinase-9 substrate that stimulates neutrophil apoptosis and removal during cardiac remodeling. Circ Cardiovasc Genet. 2016; 9:14-25. PMCID: PMC4758866.
  19. do Carmo JM, da Silva AA, Moak SP, Houghton HJ, Smith A, Hall JE. Regulation of blood pressure, appetite, and glucose by CNS melanocortin system in hyperandrogenemic female SHR. Am J Hypertens. 2016; 29:832-840. PMCID: PMC4901857.
  20. do Carmo JM, da Silva AA, Wang Z, Fang T, Aberdein N, de Lara Rodriquez CE, Hall JE. Obesity-induced hypertension: brain signaling pathways. Curr Hypertens Rep. 2016; 18:58. PMCID: PMC5448788.
  21. do Carmo JM, da Silva AA, Wang Z, Freeman NJ, Alsheik AJ, Adi A, Hall JE. Regulation of blood pressure, appetite, and glucose by leptin after inactivation of insulin receptor substrate 2 signaling in the entire brain or in proopiomelanocortin neurons. Hypertension. 2016; 67:378-386. PMCID: PMC4763950.
  22. Drummond CA, Hill MC, Shi H, Fan X, Xie JX, Haller ST, Kennedy DJ, Liu J, Garrett MR, Xie Z, Cooper CJ, Shapiro JI, Tian J. Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts. Physiol Genomics. 2016; 48:220-229. PMCID: PMC4773889.
  23. Enriori PJ, Chen W, Garcia-Rudaz MC, Grayson BE, Evans AE, Comstock SM, Gebhardt U, Reinehr T, Henry BA, Brown RD, Bruce CR, Simonds SE, Litwak SA, McGee SL, Luquet S, Martinez S, Jastroch M, Tschöp MH, Watt JM, Clarke IJ, Roth CL, Grove KL, Cowley MA. α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors. Mol Metab. 2016; 5:807-822. PMCID: PMC5034615.
  24. Evaristi MF, Caubere C, Harmancey R, Desmoulin F, Peacock WF, Berry M, Turkieh A, Barutaut M, Gailiner M, Dambrin C, Polidori C, Miceli C, Chamontin B, Koukoui F, Roncalli J, Massabuau P, Smih F, Rouet P. Increased mean aliphatic lipid chain length in left ventricular hypertrophy secondary to arterial hypertension: A cross-sectional study. Medicine (Baltimore). 2016; 95:E4965. PMCID: PMC5120887.
  25. Fan F, Ge Y, LvW, Elliott MR, Muroya Y, Hirata T, Booz GW, Roman RJ.  Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology. Frontiers in BioSci (Landmark Ed). 2016; 21:1427-1463. PMCID: PMC5064940.
  26. Flanagan TW, Files JK, Casano KR, George EM, Brown DT.  Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H1.1 and H1.5. Biol Open2016: 5:372-380. PMCID: PMC4810752.
  27. Gebremedhin D, Zhang DX, Carver KA, Rau N, Rarick KR, Roman RJ, Harder DR. Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes. Prostaglandins Other Lipid Mediat. 2016; 124:16-26. PMCID: PMC5287377.
  28. George EM, Mahdi F, Logue OC, Robinson GG, and Bidwell GL 3rd. Corneal Penetrating Elastin-like Polypeptide Carriers. J Ocul Pharmacol Ther. 2016: 32:163-171. PMCID: PMC4939452.
  29. Gillis EE, Mooney JN, Garrett MR, Granger JP, Sasser JM. Sildenafil treatment ameliorates the maternal syndrome of preeclampsia and rescues fetal growth in the Dahl salt-sensitive rat. Hypertension. 2016; 67:647-653. PMCID: PMC4752413.
  30. Gillis EE, Sasser JM, Sullivan JC. Endothelin, sex, and pregnancy: unique considerations for blood pressure control in females. Am J Physiol Regul Integr Comp Physiol. 2016; 310:R691-R696. PMCID: PMC4867412.
  31. Hall JE. Renal dysfunction, rather than nonrenal vascular dysfunction, mediates salt-induced hypertension. Circulation. 2016; 133:894-906. PMCID: PMC5009905.
  32. Hall ME, Brinkley TE, Chughtai H, Morgan TM, Hamilton CA, Jordan JH, Stacey RB, Soots S, Hundley WG. Adiposity is associated with gender-specific reductions in left ventricular myocardial perfusion during dobutamine stress. PLoS One. 2016; 11:e0146519. PMCID: PMC4709095.
  33. Hall ME, Rocco MV, Morgan TM, Hamilton CA, Jordan JH, Edwards MS, Hall JE. Hundley WG. Beta-blocker use is associated with higher renal tissue oxygenation in hypertensive patients suspected of renal artery stenosis. Cardiorenal Med. 2016; 6:261-268. PMCID: PMC5020395.
  34. Hall ME, Wang W, Okhomina V, Agarwal M, Hall JE, Dresibach AW, Juncos LA, Winniford MD, Payne TJ, Robertson RM, Bhatnagar A, Young BA. Cigarette smoking and chronic kidney disease in African Americans in the Jackson Heart Study. J Am Heart Assoc. 2016; 25:5. PMCID: PMC4937270.
  35. Harvey TW, Engel JE, Chade AR. Vascular endothelial growth factor and podocyte protection in chronic hypoxia: effects of endothelin-A receptor antagonism. Am J Nephrol. 2016; 43:74-84. PMCID: PMC4828273. 
  36. Hinds TD Jr, Adeosun SO, Alamodi AA, Stec DE. Does bilirubin prevent hepatic steatosis through activation of the PPARα nuclear receptor? Med Hypotheses. 2016; 95:54-57. PMCID: PMC5433619.
  37. Hinds TD Jr, Burns KA, Hosick PA, McBeth L, Nestor-Kalinoski A, Drummond HA, AlAmodi AA, Hankins MW, Vanden Heuvel JP, Stec DE. Biliverdin reductase A attenuates hepatic steatosis by inhibition of glycogen synthase kinase (GSK) 3β phosphorylation of serine 73 of peroxisome proliferator-activated receptor (PPAR) α. J Biol Chem. 2016; 291:25179-25191. PMCID: PMC5122784.
  38. Intapad S. Reprogramming essential hypertension: the role of resveratrol. Hypertension. 2016; 67:829-830. PMCID: PMC4833559.
  39. Intapad S, Dasinger JH, Brown AD, Fahling JM, Esters J, Alexander BT. Glucose intolerance develops prior to increased adiposity and accelerated cessation of estrous cyclicity in female growth-restricted rats. Pediatr Res. 2016; 79:962-970. PMCID: PMC4899212.
  40. Iyer RP, de Castro Brás LE, Cannon PL, Ma Y, DeLeon-Pennell KY, Jung M, Flynn ER, Henry JB, Bratton DR, Fulton LK, Grady AW, Lindsey ML. Defining the sham environment for post-myocardial infarction studies in mice. Am J Physiol Heart Circ Physiol. 2016; 311:H822-H836. PMCID: PMC5142180.
  41. Iyer RP, de Castro Brás LE, Patterson NL, Bhowmick M, Flynn ER, Asher M, Cannon PL, Deleon-Pennell KY, Fields GB, Lindsey ML. Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution. J Mol Cell Cardiol. 2016; 100:109-117. PMCID: PMC5319826.
  42. Iyer RP, Jung M, Lindsey ML. MMP-9 signaling in the left ventricle following myocardial infarction. Am J Physiol Heart Circ Physiol. 2016; 311:H190-H198. PMCID: PMC4967202.
  43. Iwano H, Kamimura D, Fox ER, Hall ME, Vlachos P, Little WC.  Presence and implication of temporal non-uniformity of early diastolic left ventricular wall expansion in patients with heart failure. J Card Fail.  2016; 22:945-953. PMID: 27095528.
  44. Juncos LA, Juncos LI. Mineralocorticoid receptor antagonism in AKI: a new hope? J Am Soc Nephrol. 2016; 27:335-337. PMCID: PMC4731135.
  45. Kamimura D, Hans S, Suzuki T, Fox E, Hall ME, McMullan MR, Little WC.  Delayed time to peak velocity is useful for detecting severe aortic stenosis.  J Am Heart Assoc.  2016; 5:e003907.  PMCID: PMC5121493.
  46. Kamimura D, Uchino K, Ishigami T, Hall ME, Umemura S.  Activation of Peroxisome Proliferator-Activated Receptor γ Prevents Development of Heart Failure with Preserved Ejection Fraction; Inhibition of Wnt-β-catenin Signaling as a Possible Mechanism. J Cardiovasc Pharmacol. 2016; 68:155-161.
  47. Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer H. Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci USA. 2016; 113:10436-10441. PMCID: PMC5027422.
  48. Karumanchi SA, Granger JP. Preeclampsia and pregnancy-related hypertensive disorders. Hypertension. 2016; 67:238-242. PMCID: PMC4755281.
  49. Lam T, Harmancey R, Vasquez H, Gilbert B, Patel N, Hairharan V, Lee A, Covey M, Taegtmeyer H. Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway. Cell Death Discov. 2016; 2:16061. PMCID: PMC4993124.
  50. Lindsey ML, Hall ME, Harmancey R, Ma Y. Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction. Clin Proteomics. 2016; 13:19. PMCID: PMC5024439.
  51. Lindsey ML, Iyer RP, Jung M, DeLeon-Pennell KY, Ma Y. Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling. J Mol Cell Cardiol. 2016; 91:134-140. PMCID: PMC4764435.
  52. Lindsey ML, Saucerman JJ, DeLeone-Pennell KY. Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction. Biochim Biophys Acta. 2016; 1862:2288-2292. PMCID: PMC5124538.
  53. Logue OC, George EM, Bidwell GL 3rd.  Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia. Clin Sci (Lond). 2016; 130:1417-1434. PMCID: PMC4958371.
  54. Logue OC, McGowan JW, George EM, Bidwell GL 3rd.  Therapeutic angiogenesis by vascular endothelial growth factor supplementation for treatment of renal disease. Curr Opin Nephrol Hypertens. 2016; 25:404-409. PMCID: PMC4974125.
  55. Lohmeier TE, Iliescu R, Tudorancea I, Cazan R, Cates AW, Georgakopoulos D, Irwin ED. Chronic interactions between carotid baroreceptors and chemoreceptors in obesity hypertension. Hypertension. 2016; 68:227-235. PMCID: PMC4900898.
  56. Lu Y, Wei J, Stec DE, Roman RJ, Ge Y, Cheng L, Liu EY, Zhang J, Hansen PB, Fan F, Juncos LA, Wang L, Pollock J, Huang PL, Fu Y, Wang S, Liu R. Macula densa nitric oxide synthase 1β protects against salt-sensitive hypertension. J Am Soc Nephrol. 2016; 27:2346-2356. PMCID: PMC4978040.
  57. Ma Y. LRP5: A novel anti-inflammatory macrophage marker that positively regulates migration and phagocytosis. J Mol Cell Cardiol. 2016; 91:61-62. PMID: 26739212.
  58. Ma Y, Yabluchanskiy A, Iyer RP, Cannon PL, Flynn ER, Jung M, Henry J, Cates CA, Deleon-Pennell KY, Lindsey ML. Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res. 2016; 110:51-61. PMCID: PMC4798046.
  59. Maranon RO, Reckelhoff JF. Mechanisms responsible for postmenopausal hypertension in a rat model: Roles of the renal sympathetic nervous system and the renin-angiotensin system. Physiol Rep. 2016; 4. PMCID: PMC4760383.
  60. Marino JS, Stechschulte LA, Stec DE, Nestor-Kalinoski A, Coleman S, Hinds TD Jr. Gucocorticoid receptor β induces hepatic steatosis by augmenting inflammation and inhibition of the peroxisome proliferator-activated receptor (PPAR) α. J Biol Chem. 2016; 291:25776-25778. PMCID: PMC5203696.
  61. McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM. Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. Am J Physiol Renal Physiol. 2016; 311:F793-F804. PMCID: PMC5142236.
  62. Mittwede PN, Clemmer JS, Bergin PF, Xiang L. Obesity and critical illness: insights from animal models. Shock. 2016; 45:349-358. PMCID: PMC4792709.
  63. Morris R, Spencer SK, Kyle PB, Williams JM, Harris A, Owens MY, Wallace K. Hypertension in an animal model of HELLP syndrome is associated with activation of endothelin 1. Reprod Sci. 2016; 23:42-50. PMID: 26130680.
  64. Padmanabhan IR, Chiao YA, Flynn ER, Hakala K, Cates CA, Weintraub ST, de Castro Brás LE. Matrix metalloproteinase-9-dependent mechanisms of reduced contractility and increased stiffness in the aging heart. Proteomics Clin Appl. 2016; 10:92-107. PMCID: PMC4922304.
  65. Patil CN, Wallace K, LaMarca BD, Moulana M, Lopez-Ruiz A, Soljancic A, Juncos LA, Grande JP, Reckelhoff JF. Low-dose testosterone protects against renal ischemia-reperfusion injury by increasing renal IL-10-to-TNF-α ratio and attenuating T-cell infiltration. Am J Physiol Renal Physiol. 2016; 311:F395-F403. PMCID: PMC5008676.
  66. Roman RJ, Fan F, Zhuo JL. Intrarenal renin-angiotensin system: locally synthesized or taken up via endocytosis? Hypertension. 2016; 67:831-833. PMCID: PMC4833086.
  67. Ryan MJ, Coleman TT, Sasser JM, Pittman KM, Hankins MW, Stec DE. Vascular smooth muscle-specific deletion of the leptin receptor attenuates leptin-induced alterations in vascular relaxation. Am J Physiol Regul Integr Comp Physiol. 2016; 310:R960-R967. PMCID: PMC4896083.
  68. Spinale FG, Frangogiannis NG, Hinz B, Holmes JW, Kassiri Z, Lindsey MS. Crossing into the next frontier of cardiac extracellular matrix research. Circ Res. 2016; 119:1040-1045. PMCID: PMC5123693.
  69. Spradley FT. Optimizing inhibition of the renin-angiotensin system in hypertension. J Hypertens. 2016; 34:838-841. PMID: 27027379.
  70. Spradley FT, Ho DH, Pollock JS. Dahl SS rats demonstrate enhanced aortic perivascular adipose tissue-mediated buffering of vasoconstriction through activation of NOS in the endothelium. Am J Physiol Regul Integr Comp Physiol. 2016; 310:R286-R296. PMCID: PMC4796750.
  71. Spradley FT, Palei AC, Granger JP. Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats. J Hypertens. 2016; 34:1998-2007. PMCID: PMC5310251.
  72. Spradley FT, Sasser JM, Musall JB, Sullivan JC, Granger JP. Nitric oxide synthase-mediated blood pressure regulation in obese melanocortin-4 receptor-deficient pregnant rats. Am J Physiol Integr Comp Physiol. 2016; 311:R851-R857. PMCID: PMC5130576.
  73. Spradley FT, Tan AY, Joo WS, Daniels G, Kussie P, Karumanchi SA, Granger JP. Placental growth factor administration abolishes placental ischemia-induced hypertension. Hypertension. 2016; 67:740-747. PMCID: PMC4786447.
  74. Stec DE, John K, Trabbic CJ, Luniwal A, Hankins MW, Baum J, Hinds TD Jr. Bilirubin binding to PPARα inhibits lipid accumulation. PLoS One. 2016; 11:e0153427. PMCID: PMC4829185.
  75. Stec DE, Juncos LA, Granger JP. Renal intramedullary infusion of tempol normalizes the blood pressure response to intrarenal blockade of heme oxygenase-1 in angiotensin II-dependent hypertension. J Am Soc Hypertens. 2016; 10:346-351. PMCID: PMC4829442.
  76. Sun W, Quan N, Wang L, Yang H, Chu D, Liu Q, Zhao X, Leng J, Li J. Cardiac-specific deletion of the Pdha1 gene sensitizes heart to toxicological actions of ischemic stress. Toxicol Sci. 2016; 151:193-203. PMCID: PMC4914805.
  77. Taylor EB, Ryan MJ. Understanding mechanisms of hypertension in systemic lupus erythematosus. Ther Adv Cardiovasc Dis. 2016. PMCID: PMC5065379.
  78. Tostes RC, Carneiro FS, Carvalho MH, Reckelhoff JF. Reactive oxygen species: players in the cardiovascular effects of testosterone. Am J Physiol Regul Integr Comp Physiol. 2016; 310:R1-R14. PMCID: PMC4796634.
  79. Wang S, Mims PN, Roman RJ, Fan F. Is Beta-amyloid accumulation a cause of alzheimer's disease or a consequence of vascular dysfunction? J Alzheimers Parkinsonism Dement. 2016; 1:2. PMCID: PMC5555607.
  80. Wang X, Chandrashekar K, Wang L, Lai EY, Wei J, Zhang G, Wang S, Zhang J, Juncos LA, Liu R. Inhibition of Nitric Oxide Synthase 1 Induces Salt-Sensitive Hypertension in Nitric Oxide Synthase 1α Knockout and Wild Type Mice. Hypertension. 2016; 67:792-799. PMCID: PMC4802158.
  81. Wang X, Johnson AC, Sasser JM, Williams JM, Solberg Woods LC, Garrett MR. Spontaneous one-kidney rats are more susceptible to develop hypertension by DOCA-NaCl and subsequent kidney injury compared with uninephrectomized rats. Am J Physiol Renal Physiol. 2016; 310:F1054-F1064. PMCID: PMC5002061.
  82. West CA, Sasser JM, Baylis C. The enigma of continual plasma volume expansion in pregnancy: critical role of the renin-angiotensin-aldosterone system. Am J Physiol Renal Physiol. 2016; 311:F1125-F1134. PMID:27707703.
  83. Yabluchanskiy A, Ma Y, DeLeon-Pennell KY, Halade GV, Voorhees AP, Nguyen NT, Jin YF, Winniford MD, Hall ME, Han HC, Lindsey ML. Myocardial infarction superimposed on aging: MMP-9 deletion promotes M2 macrophage polarization. J Gerontol A Biol Sci Med Sci. 2016; 71:475-483. PMCID: PMC5175450.
  84. Yang H, Sun W, Quan N, Wang L, Chu D, Cates C, Liu Q, Zheng Y, Li J. Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway. Biochem Pharmacol. 2016; 108:47-57. PMCID: PMC4959604.
  85. Zhang LW, Warrington JP. Magnesium sulfate prevents placental ischemia-induced increases in brain water content and cerebrospinal fluid cytokines in pregnant rats. Front Neurosci2016;10:561. PMCID: PMC5143678.