Seema Singh, PhD, MBA
Professor
Department:
SOM-Cell and Molecular Biology
Email:
ssingh3@umc.edu
Work Phone:
(601) 815-5232
Biography
Dr. Seema Singh is a tenured Professor of Cell and Molecular Biology and an Associate Director of Education and Training at the Cancer Center and Research Institute. Her lab focuses on inflammation and immunobiology, especially studying these aspects in racially diverse patient populations. She has recently been interested in studying how adverse social exposures impact human physiology, creating a hormonal imbalance and inflammation to provide a fertile ground for cancer development. In breast cancer, she is exploring the epigenomic consequences of these systemic alterations promoting early onset and aggressive progression of certain breast cancer molecular subtypes. In addition, her lab is interested in whether the immune landscape of tumors is also impacted and if that can be utilized to predict responses to immune checkpoint therapy. Dr. Singh has been a prolific researcher with numerous publications and multiple US patents. She also co-founded a biotech start-up, Tatva Biosciences, to commercialize laboratory findings and find innovative solutions for effective cancer management. Her scientific and scholarly achievements have been recognized with various honors and awards. She has secured funding from the National Institutes of Health (NIH) and private foundations. She is actively engaged in the scientific community, serving as reviewer/chair on national and international grant study sections and as an editorial board member for several high-impact scientific journals.
Education
| Aligarh M University, PhD, Life Sciences | 2001 |
| Aligarh M University, MS, Botany (Pathology) | 1994 |
| Aligarh M University, BS, Botany (honours) | 1992 |
Current Positions
| Professor, School of Medicine | 07/2024 - Present |
| Associate Director of Education and Training, School of Medicine | 07/2024 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Professor, Mitchell Cancer Institute, University of South Alabama, School of Medicine | 08/2020 - 07/2024 |
| Associate Professor, Mitchell Cancer Institute, University of South Alabama, School of Medicine | 08/2016 - 08/2020 |
| Assistant Professor, Mitchell Cancer Institute, University of South Alabama | 08/2012 - 08/2016 |
| Instructor, Mitchell Cancer Institue, University of South Alabama | 06/2009 - 08/2012 |
Publications
Journal Article | |
| Sharma A, Vikramdeo KS, Sudan SK, Anand S, Deshmukh SK, Singh AP, Singh S, Cortisol affects macrophage polarization by inducing miR-143/145 cluster to reprogram glucose metabolism and by promoting TCA cycle anaplerosis. The Journal of biological chemistry, 2024 Oct;300(10):107753 | 2024 |
| Sudan SK, Sharma A, Vikramdeo KS, Davis W, Deshmukh SK, Poosarla T, Holliday NP, Prodduturvar P, Nelson C, Singh KP, Singh AP, Singh S, Obesity and Early-Onset Breast Cancer and Specific Molecular Subtype Diagnosis in Black and White Women: NIMHD Social Epigenomics Program. JAMA network open, 2024 Jul 1;7(7):e2421846 | 2024 |
| Anand S, Vikramdeo KS, Sudan SK, Sharma A, Acharya S, Khan MA, Singh S, Singh AP, From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies. Cancer metastasis reviews, 2024 Mar;43(1):409-421 | 2024 |
| Haastrup MO, Vikramdeo KS, Anand S, Khan MA, Carter JE, Singh S, Singh AP, Dasgupta S, Mitochondrial Translocase TOMM22 Is Overexpressed in Pancreatic Cancer and Promotes Aggressive Growth by Modulating Mitochondrial Protein Import and Function. Molecular cancer research : MCR, 2024 Feb 1;22(2):197-208 | 2024 |
| Khan MA, Acharya S, Anand S, Sameeta F, Pramanik P, Keel C, Singh S, Carter JE, Dasgupta S, Singh AP, MYB exhibits racially disparate expression, clinicopathologic association, and predictive potential for biochemical recurrence in prostate cancer. iScience, 2023 Dec 15;26(12):108487 | 2023 |
| Vikramdeo KS, Anand S, Sudan SK, Pramanik P, Singh S, Godwin AK, Singh AP, Dasgupta S, Profiling mitochondrial DNA mutations in tumors and circulating extracellular vesicles of triple-negative breast cancer patients for potential biomarker development. FASEB bioAdvances, 2023 Oct;5(10):412-426 | 2023 |
| Hertweck KL, Vikramdeo KS, Galeas JN, Marbut SM, Pramanik P, Yunus F, Singh S, Singh AP, Dasgupta S, Clinicopathological significance of unraveling mitochondrial pathway alterations in non-small-cell lung cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023 Jul;37(7):e23018 | 2023 |
| Kakkat S, Pramanik P, Singh S, Singh AP, Sarkar C, Chakroborty D, Cardiovascular Complications in Patients with Prostate Cancer: Potential Molecular Connections. International journal of molecular sciences, 2023 Apr 10;24(8) | 2023 |
| Anand S, Khan MA, Zubair H, Sudan SK, Vikramdeo KS, Deshmukh SK, Azim S, Srivastava SK, Singh S, Singh AP, MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming. EMBO reports, 2023 Mar 6;24(3):e55643 | 2023 |
| Vikramdeo KS, Sharma A, Anand S, Sudan SK, Singh S, Singh AP, Dasgupta S, Mitochondrial Alterations in Prostate Cancer: Roles in Pathobiology and Racial Disparities. International journal of molecular sciences, 2023 Feb 24;24(5) | 2023 |
| Haastrup MO, Vikramdeo KS, Singh S, Singh AP, Dasgupta S, The Journey of Mitochondrial Protein Import and the Roadmap to Follow. International journal of molecular sciences, 2023 Jan 27;24(3) | 2023 |
| Acharya S, Anand S, Khan MA, Zubair H, Srivastava SK, Singh S, Singh AP, Biphasic transcriptional and posttranscriptional regulation of MYB by androgen signaling mediates its growth control in prostate cancer. The Journal of biological chemistry, 2023 Jan;299(1):102725 | 2023 |
| Vikramdeo KS, Anand S, Pierce JY, Singh AP, Singh S, Dasgupta S, Distribution of microbiota in cervical preneoplasia of racially disparate populations. BMC cancer, 2022 Oct 18;22(1):1074 | 2022 |
| Zubair H, Khan MA, Anand S, Srivastava SK, Singh S, Singh AP, Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy. Seminars in cancer biology, 2022 May;80:237-255 | 2022 |
| Srivastava SK, Khan MA, Anand S, Zubair H, Deshmukh SK, Patel GK, Singh S, Andrews J, Wang B, Carter JE, Singh AP, MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer. British journal of cancer, 2022 May;126(8):1205-1214 | 2022 |
| Saranyutanon S, Acharya S, Deshmukh SK, Khan MA, Singh S, Singh AP, Nicotine causes alternative polarization of macrophages via Src-mediated STAT3 activation: Potential pathobiological implications. Journal of cellular physiology, 2022 Feb;237(2):1486-1497 | 2022 |
| Vikramdeo KS, Anand S, Khan MA, Khushman M, Heslin MJ, Singh S, Singh AP, Dasgupta S, Detection of mitochondrial DNA mutations in circulating mitochondria-originated extracellular vesicles for potential diagnostic applications in pancreatic adenocarcinoma. Scientific reports, 2022 Nov 2;12(1):18455 | 2022 |
| Vikramdeo KS, Sudan SK, Singh AP, Singh S, Dasgupta S, Mitochondrial respiratory complexes: Significance in human mitochondrial disorders and cancers. Journal of cellular physiology, 2022 Nov;237(11):4049-4078 | 2022 |
| Khan MA, Vikramdeo KS, Sudan SK, Singh S, Wilhite A, Dasgupta S, Rocconi RP, Singh AP, Platinum-resistant ovarian cancer: From drug resistance mechanisms to liquid biopsy-based biomarkers for disease management. Seminars in cancer biology, 2021 Dec;77:99-109 | 2021 |
| Deshmukh SK, Srivastava SK, Zubair H, Khan MA, Singh AP, Singh S, Resistin Induces LIN28A-Mediated Let-7a Repression in Breast Cancer Cells Leading to IL-6 and STAT3 Upregulation. Cancers, 2021 Sep 7;13(18) | 2021 |
| Miree O, Srivastava SK, Khan MA, Sameeta F, Acharya S, Ndetan H, Singh KP, Hertweck KL, Dasgupta S, da Silva LM, Rocconi RP, Carter JE, Singh S, Singh AP, Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer. Scientific reports, 2021 Jun 18;11(1):12901 | 2021 |
| Adebayo M, Singh S, Singh AP, Dasgupta S, Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021 Jun;35(6):e21620 | 2021 |
| Deshmukh SK, Khan MA, Singh S, Singh AP, Extracellular Nanovesicles: From Intercellular Messengers to Efficient Drug Delivery Systems. ACS omega, 2021 Jan 26;6(3):1773-1779 | 2021 |
| Sudan SK, Deshmukh SK, Poosarla T, Holliday NP, Dyess DL, Singh AP, Singh S, Resistin: An inflammatory cytokine with multi-faceted roles in cancer. Biochimica et biophysica acta. Reviews on cancer, 2020 Dec;1874(2):188419 | 2020 |
| Saranyutanon S, Deshmukh SK, Dasgupta S, Pai S, Singh S, Singh AP, Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers, 2020 Sep 17;12(9) | 2020 |
| Kanchanapally R, Khan MA, Deshmukh SK, Srivastava SK, Khushman M, Singh S, Singh AP, Exosomal Formulation Escalates Cellular Uptake of Honokiol Leading to the Enhancement of Its Antitumor Efficacy. ACS omega, 2020 Sep 15;5(36):23299-23307 | 2020 |
| Anand S, Khan MA, Khushman M, Dasgupta S, Singh S, Singh AP, Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer. International journal of molecular sciences, 2020 Aug 4;21(15) | 2020 |
| Khan MA, Srivastava SK, Zubair H, Patel GK, Arora S, Khushman M, Carter JE, Gorman GS, Singh S, Singh AP, Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer. The Journal of biological chemistry, 2020 Jun 19;295(25):8413-8424 | 2020 |
| Khan MA, Zubair H, Anand S, Srivastava SK, Singh S, Singh AP, Dysregulation of metabolic enzymes in tumor and stromal cells: Role in oncogenesis and therapeutic opportunities. Cancer letters, 2020 Mar 31;473:176-185 | 2020 |
| Zubair H, Patel GK, Khan MA, Azim S, Zubair A, Singh S, Srivastava SK, Singh AP, Proteomic Analysis of MYB-Regulated Secretome Identifies Functional Pathways and Biomarkers: Potential Pathobiological and Clinical Implications. Journal of proteome research, 2020 Feb 7;19(2):794-804 | 2020 |
| Patton MC, Zubair H, Khan MA, Singh S, Singh AP, Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival. Journal of cellular biochemistry, 2020 Jan;121(1):828-839 | 2020 |
| Saranyutanon S, Srivastava SK, Pai S, Singh S, Singh AP, Therapies Targeted to Androgen Receptor Signaling Axis in Prostate Cancer: Progress, Challenges, and Hope. Cancers, 2019 Dec 23;12(1) | 2019 |
| Deshmukh SK, Srivastava SK, Poosarla T, Dyess DL, Holliday NP, Singh AP, Singh S, Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy. Annals of translational medicine, 2019 Oct;7(20):593 | 2019 |
| Khushman M, Patel GK, Laurini JA, Bhardwaj A, Roveda K, Donnell R, Sherling K, Case B, Frankel AE, Pai S, Taylor W, Tan MCB, Mizrahi M, Nelson C, Wyatt M, Patton M, McClellan S, Singh S, Wang B, Singh AP, Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma. Journal of gastrointestinal oncology, 2019 Aug;10(4):695-702 | 2019 |
| Patel GK, Khan MA, Zubair H, Srivastava SK, Khushman M, Singh S, Singh AP, Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications. Scientific reports, 2019 Mar 29;9(1):5335 | 2019 |
| Chavva SR, Deshmukh SK, Kanchanapally R, Tyagi N, Coym JW, Singh AP, Singh S, Epigallocatechin Gallate-Gold Nanoparticles Exhibit Superior Antitumor Activity Compared to Conventional Gold Nanoparticles: Potential Synergistic Interactions. Nanomaterials (Basel, Switzerland), 2019 Mar 8;9(3) | 2019 |
| Deshmukh SK, Singh AP, Singh S, ETV4: an emerging target in pancreatic cancer. Oncoscience, 2018 Sep;5(9-10):260-261 | 2018 |
| Deshmukh SK, Tyagi N, Khan MA, Srivastava SK, Al-Ghadhban A, Dugger K, Carter JE, Singh S, Singh AP, Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophages. Scientific reports, 2018 Aug 10;8(1):12000 | 2018 |
| Tyagi N, Deshmukh SK, Srivastava SK, Azim S, Ahmad A, Al-Ghadhban A, Singh AP, Carter JE, Wang B, Singh S, ETV4 Facilitates Cell-Cycle Progression in Pancreatic Cells through Transcriptional Regulation of Cyclin D1. Molecular cancer research : MCR, 2018 Feb;16(2):187-196 | 2018 |
| Srivastava SK, Ahmad A, Zubair H, Miree O, Singh S, Rocconi RP, Scalici J, Singh AP, MicroRNAs in gynecological cancers: Small molecules with big implications. Cancer letters, 2017 Oct 28;407:123-138 | 2017 |
| Srivastava SK, Ahmad A, Miree O, Patel GK, Singh S, Rocconi RP, Singh AP, Racial health disparities in ovarian cancer: not just black and white. Journal of ovarian research, 2017 Sep 21;10(1):58 | 2017 |
| Deshmukh SK, Srivastava SK, Tyagi N, Ahmad A, Singh AP, Ghadhban AAL, Dyess DL, Carter JE, Dugger K, Singh S, Emerging evidence for the role of differential tumor microenvironment in breast cancer racial disparity: a closer look at the surroundings. Carcinogenesis, 2017 Aug 1;38(8):757-765 | 2017 |
| Ahmad A, Azim S, Zubair H, Khan MA, Singh S, Carter JE, Rocconi RP, Singh AP, Epigenetic basis of cancer health disparities: Looking beyond genetic differences. Biochimica et biophysica acta. Reviews on cancer, 2017 Aug;1868(1):16-28 | 2017 |
| Deshmukh SK, Srivastava SK, Zubair H, Bhardwaj A, Tyagi N, Al-Ghadhban A, Singh AP, Dyess DL, Carter JE, Singh S, Resistin potentiates chemoresistance and stemness of breast cancer cells: Implications for racially disparate therapeutic outcomes. Cancer letters, 2017 Jun 28;396:21-29 | 2017 |
| Khan MA, Azim S, Zubair H, Bhardwaj A, Patel GK, Khushman M, Singh S, Singh AP, Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward. International journal of molecular sciences, 2017 Apr 6;18(4) | 2017 |
| Zubair H, Azim S, Ahmad A, Khan MA, Patel GK, Singh S, Singh AP, Cancer Chemoprevention by Phytochemicals: Nature's Healing Touch. Molecules (Basel, Switzerland), 2017 Mar 3;22(3) | 2017 |
| Patel GK, Khan MA, Bhardwaj A, Srivastava SK, Zubair H, Patton MC, Singh S, Khushman M, Singh AP, Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK. British journal of cancer, 2017 Feb 28;116(5):609-619 | 2017 |
| Bhardwaj A, Srivastava SK, Khan MA, Prajapati VK, Singh S, Carter JE, Singh AP, Racial disparities in prostate cancer: a molecular perspective. Frontiers in bioscience (Landmark edition), 2017 Jan 1;22(5):772-782 | 2017 |
| Zubair H, Azim S, Srivastava SK, Ahmad A, Bhardwaj A, Khan MA, Patel GK, Arora S, Carter JE, Singh S, Singh AP, Glucose Metabolism Reprogrammed by Overexpression of IKKε Promotes Pancreatic Tumor Growth. Cancer research, 2016 Dec 15;76(24):7254-7264 | 2016 |
| Tyagi N, Srivastava SK, Arora S, Omar Y, Ijaz ZM, Al-Ghadhban A, Deshmukh SK, Carter JE, Singh AP, Singh S, Comparative analysis of the relative potential of silver, Zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis. Cancer letters, 2016 Dec 1;383(1):53-61 | 2016 |
| Averett C, Bhardwaj A, Arora S, Srivastava SK, Khan MA, Ahmad A, Singh S, Carter JE, Khushman M, Singh AP, Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk. Carcinogenesis, 2016 Nov 1;37(11):1052-1061 | 2016 |
| Bhardwaj A, Srivastava SK, Singh S, Tyagi N, Arora S, Carter JE, Khushman M, Singh AP, MYB Promotes Desmoplasia in Pancreatic Cancer through Direct Transcriptional Up-regulation and Cooperative Action of Sonic Hedgehog and Adrenomedullin. The Journal of biological chemistry, 2016 Jul 29;291(31):16263-70 | 2016 |
| Azim S, Zubair H, Srivastava SK, Bhardwaj A, Zubair A, Ahmad A, Singh S, Khushman M, Singh AP, Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer. Scientific reports, 2016 Jun 29;6:28446 | 2016 |
| Tyagi N, Marimuthu S, Bhardwaj A, Deshmukh SK, Srivastava SK, Singh AP, McClellan S, Carter JE, Singh S, p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling. Cancer letters, 2016 Jan 28;370(2):260-7 | 2016 |
| Tyagi N, Arora S, Deshmukh SK, Singh S, Marimuthu S, Singh AP, Exploiting Nanotechnology for the Development of MicroRNA-Based Cancer Therapeutics. Journal of biomedical nanotechnology, 2016 Jan;12(1):28-42 | 2016 |
| Srivastava SK, Bhardwaj A, Arora S, Singh S, Azim S, Tyagi N, Carter JE, Wang B, Singh AP, MYB is a novel regulator of pancreatic tumour growth and metastasis. British journal of cancer, 2015 Dec 22;113(12):1694-703 | 2015 |
| Khan MA, Srivastava SK, Bhardwaj A, Singh S, Arora S, Zubair H, Carter JE, Singh AP, Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications. Oncotarget, 2015 Nov 17;6(36):39140-50 | 2015 |
| Palanki R, Arora S, Tyagi N, Rusu L, Singh AP, Palanki S, Carter JE, Singh S, Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes. BMC cancer, 2015 Sep 15;15:636 | 2015 |
| Tyagi N, Bhardwaj A, Srivastava SK, Arora S, Marimuthu S, Deshmukh SK, Singh AP, Carter JE, Singh S, Development and Characterization of a Novel in vitro Progression Model for UVB-Induced Skin Carcinogenesis. Scientific reports, 2015 Sep 9;5:13894 | 2015 |
| Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh S, Andrews J, McClellan S, Wang B, Singh AP, MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways. British journal of cancer, 2015 Aug 11;113(4):660-8 | 2015 |
| Arora S, Tyagi N, Bhardwaj A, Rusu L, Palanki R, Vig K, Singh SR, Singh AP, Palanki S, Miller ME, Carter JE, Singh S, Silver nanoparticles protect human keratinocytes against UVB radiation-induced DNA damage and apoptosis: potential for prevention of skin carcinogenesis. Nanomedicine : nanotechnology, biology, and medicine, 2015 Jul;11(5):1265-75 | 2015 |
| Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh AP, Carter JE, Scammell JG, Fodstad Ø, Singh S, Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis. British journal of cancer, 2015 May 26;112(11):1772-81 | 2015 |
| Deshmukh SK, Srivastava SK, Bhardwaj A, Singh AP, Tyagi N, Marimuthu S, Dyess DL, Dal Zotto V, Carter JE, Singh S, Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation. Oncotarget, 2015 May 10;6(13):11231-41 | 2015 |
| Bhardwaj A, Srivastava SK, Singh S, Arora S, Tyagi N, Andrews J, McClellan S, Carter JE, Singh AP, CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-activated kinase 4-dependent activation of LIM domain kinase 1. Oncotarget, 2014 Nov 30;5(22):11490-500 | 2014 |
| Tyagi N, Bhardwaj A, Singh AP, McClellan S, Carter JE, Singh S, p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway. Oncotarget, 2014 Sep 30;5(18):8778-89 | 2014 |
| Bhardwaj A, Arora S, Prajapati VK, Singh S, Singh AP, Cancer "stemness"- regulating microRNAs: role, mechanisms and therapeutic potential. Current drug targets, 2013 Sep;14(10):1175-84 | 2013 |
| Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Nirodi CS, Piazza GA, Grizzle WE, Owen LB, Singh AP, An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor κB- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4. The Journal of biological chemistry, 2013 Jul 19;288(29):21197-21207 | 2013 |
| Arora S, Singh S, Piazza GA, Contreras CM, Panyam J, Singh AP, Honokiol: a novel natural agent for cancer prevention and therapy. Current molecular medicine, 2012 Dec;12(10):1244-52 | 2012 |
| Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE, Owen LB, Singh S, CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: implications for bidirectional tumor-stromal interactions. The Journal of biological chemistry, 2012 Nov 9;287(46):39115-24 | 2012 |
| Srivastava SK, Bhardwaj A, Singh S, Arora S, McClellan S, Grizzle WE, Reed E, Singh AP, Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance. Carcinogenesis, 2012 Jun;33(6):1149-57 | 2012 |
| Sadanandam A, Sidhu SS, Wullschleger S, Singh S, Varney ML, Yang CS, Ashour AE, Batra SK, Singh RK, Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation. British journal of cancer, 2012 Jul 24;107(3):501-7 | 2012 |
| Harris LG, Pannell LK, Singh S, Samant RS, Shevde LA, Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61. Oncogene, 2012 Jul 12;31(28):3370-80 | 2012 |
| Srivastava SK, Bhardwaj A, Singh S, Arora S, Wang B, Grizzle WE, Singh AP, MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis, 2011 Dec;32(12):1832-9 | 2011 |
| Bhardwaj A, Singh S, Srivastava SK, Honkanen RE, Reed E, Singh AP, Modulation of protein phosphatase 2A activity alters androgen-independent growth of prostate cancer cells: therapeutic implications. Molecular cancer therapeutics, 2011 May;10(5):720-31 | 2011 |
| Singh S, Wu S, Varney M, Singh AP, Singh RK, CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation. Microvascular research, 2011 Nov;82(3):318-25 | 2011 |
| Varney ML, Singh S, Li A, Mayer-Ezell R, Bond R, Singh RK, Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases. Cancer letters, 2011 Jan 28;300(2):180-8 | 2011 |
| Singh S, Srivastava SK, Bhardwaj A, Owen LB, Singh AP, CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy. British journal of cancer, 2010 Nov 23;103(11):1671-9 | 2010 |
| Singh S, Singh AP, Sharma B, Owen LB, Singh RK, CXCL8 and its cognate receptors in melanoma progression and metastasis. Future oncology (London, England), 2010 Jan;6(1):111-6 | 2010 |
| Sadanandam A, Varney ML, Singh S, Ashour AE, Moniaux N, Deb S, Lele SM, Batra SK, Singh RK, High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis. International journal of cancer, 2010 Sep 1;127(6):1373-83 | 2010 |
| Sharma B, Singh S, Varney ML, Singh RK, Targeting CXCR1/CXCR2 receptor antagonism in malignant melanoma. Expert opinion on therapeutic targets, 2010 Apr;14(4):435-42 | 2010 |
| Singh S, Sadanandam A, Varney ML, Nannuru KC, Singh RK, Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion. International journal of cancer, 2010 Jan 15;126(2):328-36 | 2010 |
| Sadanandam A, Rosenbaugh EG, Singh S, Varney M, Singh RK, Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvascular research, 2010 Jan;79(1):1-9 | 2010 |
| Singh S, Zahid M, Saeed M, Gaikwad NW, Meza JL, Cavalieri EL, Rogan EG, Chakravarti D, NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. The Journal of steroid biochemistry and molecular biology, 2009 Oct;117(1-3):56-66 | 2009 |
| Varney ML, Singh S, Backora M, Chen Z, Singh RK, Lymphangiogenesis and anti-tumor immune responses. Current molecular medicine, 2009 Aug;9(6):694-701 | 2009 |
| Singh S, Nannuru KC, Sadanandam A, Varney ML, Singh RK, CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion. British journal of cancer, 2009 May 19;100(10):1638-46 | 2009 |
| Singh S, Sadanandam A, Nannuru KC, Varney ML, Mayer-Ezell R, Bond R, Singh RK, Small-molecule antagonists for CXCR2 and CXCR1 inhibit human melanoma growth by decreasing tumor cell proliferation, survival, and angiogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009 Apr 1;15(7):2380-6 | 2009 |
| Singh S, Varney M, Singh RK, Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis. Cancer research, 2009 Jan 15;69(2):411-5 | 2009 |
| Singh S, Sadanandam A, Singh RK, Chemokines in tumor angiogenesis and metastasis. Cancer metastasis reviews, 2007 Dec;26(3-4):453-67 | 2007 |
| Singh S, Chakravarti D, Edney JA, Hollins RR, Johnson PJ, West WW, Higginbotham SM, Cavalieri EL, Rogan EG, Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma. Oncology reports, 2005 Oct;14(4):1091-6 | 2005 |
| Kakkat S, Suman P, Turbat-Herrera EA, Singh S, Chakroborty D, Sarkar C, Exploring the multifaceted role of obesity in breast cancer progression. Frontiers in cell and developmental biology, 2024;12:1408844 | |
| Khan MA, Anand S, Deshmukh SK, Singh S, Singh AP, Determining the Size Distribution and Integrity of Extracellular Vesicles by Dynamic Light Scattering. Methods in molecular biology (Clifton, N.J.), 2022;2413:165-175 | |
| Patel GK, Taylor W, Singh S, Khushman M, Singh AP, Revisiting the Clinical Importance of DPYD*9A (c.85T>C) Variant of Dihydropyrimidine Dehydrogenase (DPYD) Gene in Patients Treated with Fluoropyrimidine-Based Chemotherapy. Journal of molecular biomarkers & diagnosis, 2018;9(3) | |
| Bhardwaj A, Singh S, Singh AP, MicroRNA-based Cancer Therapeutics: Big Hope from Small RNAs. Molecular and cellular pharmacology, 2010;2(5):213-219 | |
| Deshmukh SK, Azim S, Ahmad A, Zubair H, Tyagi N, Srivastava SK, Bhardwaj A, Singh S, Rocconi RP, Singh AP, Biological basis of cancer health disparities: resources and challenges for research. American journal of cancer research, 2017;7(1):1-12 | |
| Khan MA, Zubair H, Srivastava SK, Singh S, Singh AP, Insights into the Role of microRNAs in Pancreatic Cancer Pathogenesis: Potential for Diagnosis, Prognosis, and Therapy. Advances in experimental medicine and biology, 2015;889:71-87 | |
| Kanchanapally R, Deshmukh SK, Chavva SR, Tyagi N, Srivastava SK, Patel GK, Singh AP, Singh S, Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis. International journal of nanomedicine, 2019;14:531-541 | |
| Khan MA, Patel GK, Srivastava SK, Carter JE, Pierce JY, Rocconi RP, Singh S, Singh AP, Looking at cancer health disparities without the colored lenses. Cancer health disparities, 2019;3:e1-e9 | |
| Averett C, Arora S, Zubair H, Singh S, Bhardwaj A, Singh AP, Molecular Targets of Honokiol: A Promising Phytochemical for Effective Cancer Management. The Enzymes, 2014;36:175-93 | |
| Srivastava SK, Arora S, Averett C, Singh S, Singh AP, Modulation of microRNAs by phytochemicals in cancer: underlying mechanisms and translational significance. BioMed research international, 2015;2015:848710 | |
| Arora S, Bhardwaj A, Srivastava SK, Singh S, McClellan S, Wang B, Singh AP, Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. PloS one, 2011;6(6):e21573 | |
| Arora S, Swaminathan SK, Kirtane A, Srivastava SK, Bhardwaj A, Singh S, Panyam J, Singh AP, Synthesis, characterization, and evaluation of poly (D,L-lactide-co-glycolide)-based nanoformulation of miRNA-150: potential implications for pancreatic cancer therapy. International journal of nanomedicine, 2014;9:2933-42 | |
| Brady KC, Stephens CP, Sudan SK, Singh AP, Dasgupta S, Singh S, Breast and Cervical cancer disparities in Alabama: current scenario, ongoing efforts to reduce the disparity gaps, and what more we could be doing. Cancer health disparities, 2022;6:e1-e10 | |
| Miree O, Srivastava SK, Dasgupta S, Singh S, Rocconi R, Singh AP, Current and Futuristic Roadmap of Ovarian Cancer Management: An Overview. Advances in experimental medicine and biology, 2021;1330:1-19 | |
| Goswami S, Sarkar C, Singh S, Singh AP, Chakroborty D, Racial differences in prostate tumor microenvironment: implications for disparate clinical outcomes and potential opportunities. Cancer health disparities, 2022;6 | |
| Anand S, Vikramdeo KS, Singh S, Singh AP, Dasgupta S, Racial disparities in the genetic landscape of lung cancer. Cancer health disparities, 2022;6 | |
| Patel GK, Patton MC, Singh S, Khushman M, Singh AP, Pancreatic Cancer Exosomes: Shedding Off for a Meaningful Journey. Pancreatic disorders & therapy, 2016;6(2):e148 | |
Editorial | |
| Sharma A, Singh AP, Singh S, Shaping Up the Tumor Microenvironment: Extracellular Vesicles as Important Intermediaries in Building a Tumor-Supportive Cellular Network. Cancers, 2023 Jan 13;15(2) | 2023 |
| Singh S, Singh AP, Featuring the special issue guest editors. Cancer letters, 2022 Nov 1;548:215866 | 2022 |
| Singh S, Singh AP, Exosomes: Tools and targets for cancer diagnosis, prognosis, and therapy. Cancer letters, 2022 Oct 28;547:215865 | 2022 |
| El Bairi K, Singh S, Le Page C, Revisiting platinum-resistant ovarian cancer: Advances in therapy, molecular biomarkers, and clinical outcomes. Seminars in cancer biology, 2021 Dec;77:1-2 | 2021 |
Honors, Awards, and Recognition
| Junior Research Fellowship of CSIR, Central Institute of Medicinal and Aromatic Plants | |
| Senior Research Fellowship of CSIR, Central Institute of Medicinal and Aromatic Plants | |
| R03-Role of ETV4 in pancreatic cancer, National Institute of Health/NCI | |
| R03-Chemoprotective role of silver nanoparticles in UV radiation-induced skin carcinogenesis, National Institute of Health/NCI | |
| SBIR-Establishment of cancer cell lines for advancing ovarian cancer health disparity research, National Institute of Health/NCI | |
| R01-Molecular causes and mechanistic underpinning of breast cancer racial disparity, National Institute of Health/NCI | |
| Russell and Robin Lea National Alumni Excellence in Faculty Innovation Award, University of South Alabama | |
| SBIR-Establishment of 3D human tissue culture model system for advancing breast cancer health disparity research, National Institute of Health/NCI | |
| R01-Impact of social factors on breast cancer biology in African American Women, National Institute of Health/NCI | |
| Mayer Mitchell Annual Award for Excellence in Cancer Research, University of South Alabama Mitchell Cancer Institute | |
| Outstanding Cancer Scientist, Society of American Asian Scientists in Cancer Research (SAASCR) | |
| Healers Medal: A Night Honoring Healers by The Mapp Family Foundation, University of South Alabama |