Michael D. Hebert, PhD
Professor
Department:
SOM-Cell and Molecular Biology
Email:
mhebert@umc.edu
Work Phone:
(601) 984-1526
Biography
Research interests
Our work centers upon understanding the functional organization of the nucleus. In particular, we are interested in understanding how certain human diseases alter nuclear efficiency. The nucleus contains a myriad of dynamic, highly organized domains, territories and bodies. All of these structures somehow work together; seamlessly allowing important nuclear activities, such as RNA synthesis and processing, to occur in an efficient manner. In certain disease states, the organization of the nucleus is altered.
We hypothesize that diseases which disrupt the functional organization of the nucleus adversely affect ribonucleoprotein maturation. The ribonucleoproteins we investigate are small nuclear ribonucleoproteins (snRNPs), small Cajal body-specific ribonucleoproteins (scaRNPs) and telomerase. The biogenesis of these ribonucleoproteins is altered in the genetic diseases spinal muscular atrophy and dyskeratosis congenita. Furthermore, the transformation of a normal cell into a cancer cell results in the upregulation of these ribonucleoproteins and subsequent changes in the organization of the nucleus. The goal of our work is to clarify the mechanisms by which these and other diseases impact subnuclear organization and function.
The following organizations have supported our work: Muscular Dystrophy Association, National Ataxia Foundation, Friedreich's Ataxia Research Alliance, Luckyday Foundation and the National Institutes of Health.
Education
| Georgia State University, PhD, Biology/Molecular Genetics | 1997 |
| Kennesaw State University, BS, Biology/Cytogenetics | 1990 |
Current Positions
| Associate Member, School of Medicine, Department of Cancer Institute | 2012 - Present |
| Professor, School of Medicine, Department of Biochemistry | 07/2010 - Present |
| Assistant Professor, School of Medicine, Department of Neurology | 04/2003 - Present |
| Assistant Professor, School of Medicine, Department of Neurology | 2003 - Present |
| Member of Graduate Faculty, School of | 2002 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Associate Professor, University of Mississippi Medical Center, School of Medicine, Department of Biochemistry | 07/2007 - 06/2010 |
| Assistant Professor, University of Mississippi Medical Center, School of Medicine, Department of Biochemistry | 08/2002 - 07/2007 |
| Post-doctoral fellow, Case Western Reserve University, School of , Department of Genetics | 1998 - 2002 |
| Post-doctoral fellow, Emory University, School of , Department of Pathology | 1997 - 1998 |
| Cytogenetic Specialist (Nationally Certified), Emory University, School of , Department of Population and Molecular Cytogenetics Laboratory | 1990 - 1992 |
Sponsored Program Funding
| Intramural, Regulation of nuclear SMN activity by coilin, UMMC | 11/2013 - 10/2014 |
| Extramural, Administrative Supplement, National Institutes of Health | 08/2009 - 07/2011 |
| Extramural, Nuclear bodies and ribonucleoprotein biogenesis, National Institutes of Health | 04/2008 - 01/2013 |
| Extramural, Disrupted pre-mRNA splicing in Machado-Joseph disease, National Ataxia Foundation | 01/2008 - 12/2008 |
| Extramural, Nuclear inclusions and neuronal death, Carraway Foundation | 08/2007 - 08/2008 |
| Extramural, Rational selection of Friedreich’s ataxia therapeutics, Muscular Dystrophy Association | 01/2007 - 12/2008 |
| Extramural, PolyQ proteins and pre-mRNA splicing, National Ataxia Foundation | 01/2006 - 12/2006 |
| Extramural, An in vivo reporter system for measuring the transcription of sticky DNA found in Friedreich’s ataxia, Friedreich’s Ataxia Research Alliance | 04/2005 - 03/2006 |
| Intramural, Disrupted Nuclear Organization and Function in Machado-Joseph disease, University of Mississippi Medical Center | 11/2003 - 10/2004 |
| Extramural, Regulation of coilin and SMN interaction by coilin associated proteins, Muscular Dystrophy Association, Research Grant | 07/2003 - 06/2006 |
| Extramural, Regulation of coilin and SMN interaction by coilin associated proteins, Muscular Dystrophy Association, Research Development Grant | 01/2002 - 01/2003 |
Publications
News | |
| Matera AG, Hebert MD, The survival motor neurons protein uses its ZPR for nuclear localization. Nature cell biology, 2001 Apr;3(4):E93-5 | 2001 |
Journal Article | |
| Enwerem II, Wu G, Yu YT, Hebert MD. Cajal Body Proteins Differentially Affect the Processing of Box C/D scaRNPs. PLoS One. 2015 Apr 13;10(4):e0122348. doi: 10.1371/journal.pone.0122348. eCollection 2015. | 2015 |
| Yujing Li, Ka-wing Fong, Mengfan Tang, Xin Han, Zihua Gong, Wenbin Ma, Michael Hebert, Zhou Songyang, and Junjie Chen Fam118B, a novel component in Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability J Cell Sci jcs.143453; Advance Online Article February 25, 2014, doi:10.1242/jcs.143453 | 2014 |
| Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG, Husedzinovic A, Gruss OJ, Hebert MD Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines J Cell Sci. 2009 Jun 1;122:1872-81. Epub 2009 May 12. PMID: 19435804 | 2009 |
| Whittom AA, Xu H, Hebert MD. Coilin levels and modifications influence artificial reporter splicing.Coilin levels and modifications influence artificial reporter splicing. Cell Mol Life Sci. 2008 Apr;65(7-8):1256-71. | 2008 |
| Sun J, Xu H, Negi S, Subramony SH, Hebert MD. Differential effects of polyglutamine proteins on nuclear organization and artificial reporter splicing. J Neurosci Res. 2007 Aug 15;85(11):2306-17 | 2007 |
| Vig PJ, Wei J, Shao Q, Hebert MD, Subramony SH, Sutton LT. Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1. Neurosci Lett. 2007 Jun 8;420(1):53-7 | 2007 |
| D'Souza DR, Wei J, Shao Q, Hebert MD, Subramony SH, Vig PJ. Tissue transglutaminase crosslinks ataxin-1: possible role in SCA1 pathogenesis. Neurosci Lett. 2006 Nov 27;409(1):5-9. | 2006 |
| Grant L, Sun J, Xu H, Subramony SH, Chaires JB, Hebert MD. Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia. FEBS Lett. 2006 Oct 2;580(22):5399-405 | 2006 |
| Sun J, Xu H, Subramony SH, Hebert MD. Interactions between coilin and PIASy partially link Cajal bodies to PML bodies. J Cell Sci. 2005 Nov 1;118(Pt 21):4995-5003 | 2005 |
| Hongzhi Xu, Ramesh S. Pillai, Teldja N. Azzouz, Karl B. Shpargel, Christian Kambach, Michael D. Hebert, Daniel Schümperli, A. Gregory Matera The C-terminal domain of coilin interacts with Sm proteins and U snRNPs Chromosoma 2005 Aug; 114(3):155-66 | 2005 |
| Hongzhi Xu, Z. Brad Somers, Melvin L. Robinson II and Michael D. Hebert Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis BMC Cell Biol 2005 Jul 11; 6(1):29 | 2005 |
| Xu H, Hebert MD A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin BMC Cell Biol 2005 Apr 29;6(1):23 | 2005 |
| Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, Shpargel KB, Meier UT, Neugebauer KM, Matera AG, Misteli T In vivo kinetics of Cajal body components J. Cell Biol. 2004 Mar 15, 164:831-842. | 2004 |
| Karl B. Shpargel, Jason K. Ospina, Karen E. Tucker, A. Gregory Matera and Michael D. Hebert Control of Cajal body number is mediated by the coilin C-terminus J Cell Sci. 2003 Jan 15; 116(Pt2):303-312. | 2003 |
| Hebert M.D., Shpargel K.B., Ospina J.K., Tucker K.E. and Matera A.G Coilin methylation regulates nuclear body formation Developmental Cell. 2002 Sept 3: 329-337 | 2002 |
| Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta Hum Mol Genet. 2002 Jul 15;11(15):1785-95. | 2002 |
| Hebert MD, Szymczyk PW, Shpargel KB, Matera AG Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein Genes Dev. 2001 Oct 15;15(20):2720-9 | 2001 |
| Matera AG, Hebert MD The survival motor neurons protein uses its ZPR for nuclear localization Nat Cell Biol. 2001 Apr;3(4):E93-5 | 2001 |
| Hebert MD, Matera AG Self-association of coilin reveals a common theme in nuclear body localization Mol Biol Cell. 2000 Dec;11(12):4159-71 | 2000 |
| Liu J, Hebert MD, Ye Y, Templeton DJ, Kung H, Matera AG Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies J Cell Sci. 2000 May;113 ( Pt 9):1543-52 | 2000 |
| Tucker KE, Massello LK, Gao L, Barber TJ, Hebert MD, Chan EK, Matera AG Structure and characterization of the murine p80 coilin gene, Coil J Struct Biol. 2000 Apr;129(2-3):269-77 | 2000 |
| Curtis SK, Hebert MD, Saha BK Carriers of X-linked agammaglobulinemia (XLA) due to germline mutation in the Btk gene Am J Med Genet. 2000 Jan 31;90(3):229-32. | 2000 |
| Hebert MD, Houghton JE Regulation of ornithine utilization in Pseudomonas aeruginosa (PAO1) is mediated by a transcriptional regulator, OruR J Bacteriol. 1997 Dec;179(24):7834-42. | 1997 |
| McLaurin DM, Tucker SK, Siddique SJ, Challagundla L, Gibert Y, Hebert MD, A Novel Role for Coilin in Vertebrate Innate Immunity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025 Apr 30;39(8):e70580 | 2025 |
| Tucker SK, McLaurin DM, Hebert MD, Cajal body formation is regulated by coilin SUMOylation. Journal of cell science, 2024 Dec 1;137(23) | 2024 |
| McLaurin DM, Tucker SK, Hebert MD, Coilin mediates m6A RNA methylation through phosphorylation of METTL3. Biology open, 2023 Dec 15;12(12) | 2023 |
| Logan MK, Lett KE, McLaurin DM, Hebert MD, Coilin as a regulator of NF-kB mediated inflammation in preeclampsia. Biology open, 2022 Jul 15;11(7) | 2022 |
| Lett KE, Logan MK, McLaurin DM, Hebert MD, Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis. Molecular biology of the cell, 2021 Oct 1;32(20):br4 | 2021 |
| Logan MK, Lett KE, Hebert MD, The Cajal body protein coilin is a regulator of the miR-210 hypoxamiR and influences MIR210HG alternative splicing. Journal of cell science, 2021 Jun 15;134(12) | 2021 |
| Monroe JD, Moolani SA, Irihamye EN, Lett KE, Hebert MD, Gibert Y, Smith ME, Cisplatin and phenanthriplatin modulate long-noncoding RNA expression in A549 and IMR90 cells revealing regulation of microRNAs, Wnt/β-catenin and TGF-β signaling. Scientific reports, 2021 May 17;11(1):10408 | 2021 |
| Logan MK, McLaurin DM, Hebert MD, Synergistic interactions between Cajal bodies and the miRNA processing machinery. Molecular biology of the cell, 2020 Jul 15;31(15):1561-1569 | 2020 |
| McLaurin DM, Logan MK, Lett KE, Hebert MD, Molecular determinants that govern scaRNA processing by Drosha/DGCR8. Biology open, 2020 Oct 26;9(10) | 2020 |
| Burke MF, McLaurin DM, Logan MK, Hebert MD, Alteration of 28S rRNA 2'-O-methylation by etoposide correlates with decreased SMN phosphorylation and reduced Drosha levels. Biology open, 2019 Mar 27;8(3) | 2019 |
| Logan MK, Burke MF, Hebert MD, Altered dynamics of scaRNA2 and scaRNA9 in response to stress correlates with disrupted nuclear organization. Biology open, 2018 Sep 27;7(9) | 2018 |
| Burke MF, Logan MK, Hebert MD, Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation. Biology open, 2018 Aug 10;7(8) | 2018 |
| Hebert MD, Poole AR, Towards an understanding of regulating Cajal body activity by protein modification. RNA biology, 2017 Jun 3;14(6):761-778 | 2017 |
| Poole AR, Vicino I, Adachi H, Yu YT, Hebert MD, Regulatory RNPs: a novel class of ribonucleoproteins that potentially contribute to ribosome heterogeneity. Biology open, 2017 Sep 15;6(9):1342-1354 | 2017 |
| Poole AR, Enwerem II, Vicino IA, Coole JB, Smith SV, Hebert MD, Identification of processing elements and interactors implicate SMN, coilin and the pseudogene-encoded coilp1 in telomerase and box C/D scaRNP biogenesis. RNA biology, 2016 Oct 2;13(10):955-972 | 2016 |
| Poole AR, Hebert MD, SMN and coilin negatively regulate dyskerin association with telomerase RNA. Biology open, 2016 Jun 15;5(6):726-35 | 2016 |
| Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J, Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. Journal of cell science, 2014 May 1;127(Pt 9):2029-39 | 2014 |
| Enwerem II, Velma V, Broome HJ, Kuna M, Begum RA, Hebert MD, Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis. Biology open, 2014 Apr 15;3(4):240-9 | 2014 |
| Broome HJ, Hebert MD, Coilin displays differential affinity for specific RNAs in vivo and is linked to telomerase RNA biogenesis. Journal of molecular biology, 2013 Feb 22;425(4):713-24 | 2013 |
| Hebert MD, Signals controlling Cajal body assembly and function. The international journal of biochemistry & cell biology, 2013 Jul;45(7):1314-7 | 2013 |
| Broome HJ, Carrero ZI, Douglas HE, Hebert MD, Phosphorylation regulates coilin activity and RNA association. Biology open, 2013 Apr 15;2(4):407-15 | 2013 |
| Velma V, Broome HJ, Hebert MD, Regulated specific proteolysis of the Cajal body marker protein coilin. Chromosoma, 2012 Dec;121(6):629-42 | 2012 |
| Velma V, Carrero ZI, Allen CB, Hebert MD, Coilin levels modulate cell cycle progression and γH2AX levels in etoposide treated U2OS cells. FEBS letters, 2012 Sep 21;586(19):3404-9 | 2012 |
| Gilder AS, Do PM, Carrero ZI, Cosman AM, Broome HJ, Velma V, Martinez LA, Hebert MD, Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage. Molecular biology of the cell, 2011 Apr;22(7):1070-9 | 2011 |
| Velma V, Carrero ZI, Cosman AM, Hebert MD, Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining. FEBS letters, 2010 Dec 1;584(23):4735-9 | 2010 |
| Bidwell GL 3rd, Whittom AA, Thomas E, Lyons D, Hebert MD, Raucher D, A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation. Peptides, 2010 May;31(5):834-41 | 2010 |
| Hebert MD, Phosphorylation and the Cajal body: modification in search of function. Archives of biochemistry and biophysics, 2010 Apr 15;496(2):69-76 | 2010 |
| Toyota CG, Davis MD, Cosman AM, Hebert MD, Coilin phosphorylation mediates interaction with SMN and SmB'. Chromosoma, 2010 Apr;119(2):205-15 | 2010 |
| Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG, Husedzinovic A, Gruss OJ, Hebert MD, Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines. Journal of cell science, 2009 Jun 1;122(Pt 11):1872-81 | 2009 |
| Whittom AA, Xu H, Hebert MD, Coilin levels and modifications influence artificial reporter splicing. Cellular and molecular life sciences : CMLS, 2008 Apr;65(7-8):1256-71 | 2008 |
| Hebert MD, Targeting the gene in Friedreich ataxia. Biochimie, 2008 Aug;90(8):1131-9 | 2008 |
| Hebert MD, Whittom AA, Gene-based approaches toward Friedreich ataxia therapeutics. Cellular and molecular life sciences : CMLS, 2007 Dec;64(23):3034-43 | 2007 |
| Sun J, Xu H, Negi S, Subramony SH, Hebert MD, Differential effects of polyglutamine proteins on nuclear organization and artificial reporter splicing. Journal of neuroscience research, 2007 Aug 15;85(11):2306-17 | 2007 |
| Vig PJ, Wei J, Shao Q, Hebert MD, Subramony SH, Sutton LT, Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1. Neuroscience letters, 2007 Jun 8;420(1):53-7 | 2007 |
| D'Souza DR, Wei J, Shao Q, Hebert MD, Subramony SH, Vig PJ, Tissue transglutaminase crosslinks ataxin-1: possible role in SCA1 pathogenesis. Neuroscience letters, 2006 Nov 27;409(1):5-9 | 2006 |
| Grant L, Sun J, Xu H, Subramony SH, Chaires JB, Hebert MD, Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia. FEBS letters, 2006 Oct 2;580(22):5399-405 | 2006 |
| Sun J, Xu H, Subramony SH, Hebert MD, Interactions between coilin and PIASy partially link Cajal bodies to PML bodies. Journal of cell science, 2005 Nov 1;118(Pt 21):4995-5003 | 2005 |
| Xu H, Somers ZB, Robinson ML 2nd, Hebert MD, Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. BMC cell biology, 2005 Jul 11;6(1):29 | 2005 |
| Xu H, Pillai RS, Azzouz TN, Shpargel KB, Kambach C, Hebert MD, Schümperli D, Matera AG, The C-terminal domain of coilin interacts with Sm proteins and U snRNPs. Chromosoma, 2005 Aug;114(3):155-66 | 2005 |
| Xu H, Hebert MD, A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC cell biology, 2005 Apr 29;6(1):23 | 2005 |
| Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, Shpargel KB, Meier UT, Neugebauer KM, Matera AG, Misteli T, In vivo kinetics of Cajal body components. The Journal of cell biology, 2004 Mar 15;164(6):831-42 | 2004 |
| Shpargel KB, Ospina JK, Tucker KE, Matera AG, Hebert MD, Control of Cajal body number is mediated by the coilin C-terminus. Journal of cell science, 2003 Jan 15;116(Pt 2):303-12 | 2003 |
| Hebert MD, Shpargel KB, Ospina JK, Tucker KE, Matera AG, Coilin methylation regulates nuclear body formation. Developmental cell, 2002 Sep;3(3):329-37 | 2002 |
| Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG, SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. Human molecular genetics, 2002 Jul 15;11(15):1785-95 | 2002 |
| Hebert MD, Szymczyk PW, Shpargel KB, Matera AG, Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. Genes & development, 2001 Oct 15;15(20):2720-9 | 2001 |
| Hebert MD, Matera AG, Self-association of coilin reveals a common theme in nuclear body localization. Molecular biology of the cell, 2000 Dec;11(12):4159-71 | 2000 |
| Tucker KE, Massello LK, Gao L, Barber TJ, Hebert MD, Chan EK, Matera AG, Structure and characterization of the murine p80 coilin gene, Coil. Journal of structural biology, 2000 Apr;129(2-3):269-77 | 2000 |
| Liu J, Hebert MD, Ye Y, Templeton DJ, Kung H, Matera AG, Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies. Journal of cell science, 2000 May;113 ( Pt 9):1543-52 | 2000 |
| Curtis SK, Hebert MD, Saha BK, Twin carriers of X-linked agammaglobulinemia (XLA) due to germline mutation in the Btk gene. American journal of medical genetics, 2000 Jan 31;90(3):229-32 | 2000 |
| Hebert MD, Houghton JE, Regulation of ornithine utilization in Pseudomonas aeruginosa (PAO1) is mediated by a transcriptional regulator, OruR. Journal of bacteriology, 1997 Dec;179(24):7834-42 | 1997 |
| Förthmann B, van Bergeijk J, Lee YW, Lübben V, Schill Y, Brinkmann H, Ratzka A, Stachowiak MK, Hebert M, Grothe C, Claus P, Regulation of neuronal differentiation by proteins associated with nuclear bodies. PloS one, 2013;8(12):e82871 | |
| Enwerem II, Wu G, Yu YT, Hebert MD, Cajal body proteins differentially affect the processing of box C/D scaRNPs. PloS one, 2015;10(4):e0122348 | |
| Broome HJ, Hebert MD, In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing. PloS one, 2012;7(4):e36300 | |
| Carrero ZI, Velma V, Douglas HE, Hebert MD, Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product. PloS one, 2011;6(10):e25743 | |
| Lett KE, McLaurin DM, Tucker SK, Hebert MD, The Cajal body marker protein coilin is SUMOylated and possesses SUMO E3 ligase-like activity. Frontiers in RNA research, 2023;1 | |
Review Article | |
| Hebert MD Phosphorylation and the Cajal body: modification in search of function Arch Biochem Biophys. 2010 Apr 15;496(2):69-76. Epub 2010 Mar 1. Review. PMID: 20193656 | 2010 |
| Hebert MD. Targeting the gene in Friedreich ataxia. Biochimie. 2008 Aug;90(8):1131-9. | 2008 |
| Hebert MD, Whittom AA. Gene-based approaches toward Friedreich ataxia therapeutics. Cell Mol Life Sci. 2007 Dec;64(23):3034-43 | 2007 |
Abstracts | |
| Hanna J. Broome and Michael D. Hebert Coilin implicated in U snRNA 3’ end processing: nucleic acid interaction studies point to additional functions of the Cajal body marker protein | 2011 |
| Venkatramreddy Velma, Zunamys Carrero, Carmen Allen and Michael D. Hebert Coilin levels modulate cell cycle progression and gamma H2AX levels in etoposide treated U2OS cells | 2011 |
| Andrew Gilder, Zunamys Carrero, Michelle Cosman, Venkatramreddy Velma, Luis Martinez and Michael Hebert DNA damage induced apoptosis requires coilin. Presented at the Subnuclear Structures and Disease meeting | 2010 |
| Andrew Gilder, Cory Toyota, Misty Davis, Michelle Cosman and Michael Hebert Coilin phosphorylation modulates its interaction with SmB and SMN | 2009 |
| Angela A. Whittom, Sana Bhatti, Patricia A. Ragazzon, S.H. Subramony, David W. Boykin, Jonathan B. Chaires and Michael D. Hebert Aromatic amidines increase transcription through GAA repeats found in Friedreich ataxia | 2008 |
| LaKechia Grant, June Sun, HonghzhiXu, S.H. Subramony, Jonathan B. Chaires and Michael D. Hebert Rational selection of Friedreich’s ataxia therapeutics | 2006 |
| June Sun, H. Xu, S.H. Subramony and Michael Hebert Ataxin-3 Polyglutamine Mutant Reduces m-RNA Splicing Efficiency | 2005 |
| H. Xu, M. D. Hebert Knockout of Cajal Body Marker Protein Coilin Results in Decreased Transcription Efficiency | 2005 |
| June Sun, Hongzhi Xu, S.H. Subramony and Michael D. Hebert Disrupted Nuclear Organization in Machado-Joseph Disease | 2005 |
| Michael D. Hebert, Hongzhi Xu and A. Gregory Matera CAP36C, a Novel Coilin Associated Protein Involved in snRNP Biogenesis | 2003 |
| Kyla M. Lewis, Hongzhi Xu, Eric M. George, S. H. Subramony and Michael D. Hebert Disrupted Nuclear Organization and Function in Machado-Joseph disease | 2003 |
Book Chapter | |
| Michael D. Hebert and Andrew S. Gilder. The relationship of the Cajal body to the nucleolus "The Nucleolus”, Mark Olson, Ed. | 2011 |
| Michael D. Hebert and Andrew S. Gilder The relationship of the Cajal body to the nucleolus Chapter in the book “The Nucleolus”, Mark Olson, Ed. 2011 | 2011 |
Presentations
| State/Local Invited Seminars/Lectures, The Cajal body and microRNA biogenesis | 10/2020 |
| Invited Symposia, Ribosome specialization in health and disease, UMMC Cell and Mol Biol | 10/2018 |
| State/Local Invited Seminars/Lectures, Research in the Department of Cell and Molecular Biology at UMMC, Alcorn University | 09/2018 |
| State/Local Invited Seminars/Lectures, Coilin: Not just the Cajal body marker protein., Kennesaw State University | 02/2013 |
| State/Local Invited Seminars/Lectures, “Coilin: Not just the Cajal body marker protein.”, Department of Biochemistry, for the departmental annual retreat., UMMC | 09/2012 |
| Meeting Abstract, Coilin implicated in U snRNA 3’ end processing: nucleic acid interaction studies point to additional functions of the Cajal body marker protein. Hanna J. Broome and Michael D. Hebert, ASCB General meeting, Denver, Colorado | 12/2011 |
| Meetinig Abstract, Coilin levels modulate cell cycle progression and gamma H2AX levels in etoposide treated U2OS cells. Venkatramreddy Velma, Zunamys Carrero, Carmen Allen and Michael D. Hebert, ASCB General meeting, Denver, Colorado | 12/2011 |
| State/Local Invited Seminars/Lectures, The Cajal body: What have we learned in the last 108 years?, Department of Chemistry and Biochemistry, Millsaps College | 09/2011 |
| State/Local Invited Seminars/Lectures, The Cajal body: What have we learned in the last 108 years?, Department of Pharmacology and Toxicology, University of Mississippi Medical Center | 09/2011 |
| State/Local Invited Seminars/Lectures, The Science of Employee Management: Creating a More Productive Laboratory Environment, UMMC Basic Science Faculty, In partnership with the UMMC Office of Research and Human Resources., University of Mississippi Medical Center | 09/2011 |
| State/Local Invited Seminars/Lectures, “The Cajal body: What have we learned in the last 108 years?”, Department of Chemistry and Biochemistry, Millsaps College | 09/2011 |
| State/Local Invited Seminars/Lectures, “The Cajal body: What have we learned in the last 108 years?”, Department of Pharmacology and Toxicology, UMMC | 09/2011 |
| State/Local Invited Seminars/Lectures, “The Science of Employee Management: Creating a More Productive Laboratory Environment”, UMMC Basic Science Faculty, In partnership with the UMMC Office of Research and Human Resources., UMMC | 09/2011 |
| State/Local Invited Seminars/Lectures, The Cajal body: What have we learned in the last 108 years?, Department of Biochemistry, University of Mississippi Medical Center | 04/2011 |
| National and International Invited Seminars/Lectures, DNA damage induced apoptosis requires coilin, Presented at the Subnuclear Structures and Disease meeting, The Wellcome Trust Conference Center. Cambridge, UK | 07/2010 |
| State/Local Invited Seminars/Lectures, Coilin, Cajal bodies and Cancer, Cancer Institute, Works in Progress seminar series, The University of Mississippi Medical Center | 05/2010 |
| State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Depatment of Pharmacology, Ole Miss | 10/2008 |
| State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Chemstry and Biochemsitry, University of Southern Mississippi | 10/2008 |
| State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Physiology, University of Mississippi Medical Center | 03/2008 |
| Invited Symposia, Making a Subnuclear Domain, Department of Biochemistry, University of Mississippi Medical Center | 05/2007 |
| National and International Invited Seminars/Lectures, Rational selection of Friedreich’s ataxia therapeutics, Third International Friedreich’s Ataxia Scientific Conference, National Institutes of Health, Bethesda, Maryland | 11/2006 |
| State/Local Invited Seminars/Lectures, Ataxias and Disrupted Nuclear Efficiency, Center for Investigating Neurodegenerative Disease, University of Mississippi Medical Center | 09/2006 |
| State/Local Invited Seminars/Lectures, Establishing a Neurodegenerative Disease Center of Excellence, Multidisciplinary Research Meeting, Department of Anesthesiology, University of Mississippi Medical Center | 04/2006 |
| State/Local Invited Seminars/Lectures, Friedreich’s ataxia small molecule screening, Neurodegenerative Disease Research Interest Group, University of Mississippi Medical Center | 02/2006 |
| State/Local Invited Seminars/Lectures, Inclusive inclusions? Neurodegenerative disease and nuclear cell biology, Department of Biochemistry, University of Mississippi Medical Center | 04/2005 |
| State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Biological Sciences, Mississippi State University | 09/2004 |
| Regional Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center-Shreveport | 09/2004 |
| State/Local Invited Seminars/Lectures, Everything you always wanted to know about snRNPs (but were afraid to ask), Department of Biochemistry, University of Mississippi Medical Center | 04/2004 |
| State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Pharmacology and Toxicology, University of Mississippi Medical Center | 04/2004 |
| State/Local Invited Seminars/Lectures, Genomics to Biology, 68th Annual Meeting of the Mississippi Academy of Sciences, Biloxi, Mississippi | 02/2004 |
| State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Biochemistry, Mississippi State University | 10/2003 |
| State/Local Invited Seminars/Lectures, Nuclear Organization and Disease, Department of Chemistry, Jackson State University | 07/2003 |
| State/Local Invited Seminars/Lectures, Coilin, Cajal bodies and Spinal Muscular Atrophy, Department of Physiology, University of Mississippi Medical Center | 02/2003 |
| State/Local Invited Seminars/Lectures, Cajal bodies, Spinal Muscular Atrophy and Cancer, Department of Biochemistry, University of Mississippi Medical Center | 10/2002 |
Honors, Awards, and Recognition
| Nelson Order, UMMC | 2015 |
| Hall of Fame, Evers Society | 2015 |
| “All-Star” Professor for excellence in teaching, Evers' Society | 2013 |
| “All-Star” Professor for excellence in teaching, Chosen by medical students at UMMC (2011-2012). Medical Biochemistry won M1 basic science course of the year (for the fourth year in a row) | 2011 |
| Postdoctoral Training Fellowship, National Institutes of Health | 1999 |
| March of Dimes Scholarship Award, March of Dimes | 1990 |
| All-Star Professor for Excellence in Teaching Award, University of Mississippi Medical Center (Medical Students) | |
| HEADWAE Award, Mississippi State Legislature (UMMC Graduate School) | |
| Basic Science Professor of the Year, University of Mississippi Medical Center (Medical Students) | |
| Excellence in Research Award (Gold Level), University of Mississippi Medical Center | |
| Excellence in Research Award (Silver Level), University of Mississippi Medical Center | |
| Travel Grant Recipient and Invited Speaker, 3rd International Friedreich Ataxia Conference, National Institutes of Health | |
| Young Investigator Travel Grant, National Ataxia Foundation | |
| All Star Excellence in Teaching Award, University of Mississippi Medical Center (Medical Students) | |
| Excellence in Research Award (Bronze Level), University of Mississippi Medical Center | |
| Excellence in Teaching Awards, Georgia State University |
Professional Membership and Service
| American Society for Biochemistry and Molecular Biology, Member | 2021 - Present |
| Cancer Institute, University of Mississippi Medical Center, Associate Member | 2012 - Present |
| American Society for Cell Biology, Member | 2009 - Present |
| American Society for Microbiology, Member | 1992 - 1998 |
| American Diabetes Association, Reviewer, Grant Proposal | |
| Annals of Neurology, Reviewer, Journal Article | |
| Ataxia UK, Reviewer, Grant Proposal | |
| Austrian Research Fund, Reviewer, Grant Proposal | |
| BMC Systems Biology, Reviewer, Journal Article | |
| Cellular and Molecular Life Sciences, Reviewer, Journal Article | |
| Chromosoma, Reviewer, Journal Article | |
| European Journal of Neuroscience, Reviewer, Journal Article | |
| Future Medicine, Reviewer, Journal Article | |
| Gene Therapy, Reviewer, Journal Article | |
| John Sealy Memorial Endowment Fund, Reviewer, Grant Proposal | |
| Journal of Cell Biology, Reviewer, Journal Article | |
| Journal of Cell Science, Reviewer, Journal Article | |
| Muscular Dystrophy Association, Reviewer, Grant Proposal | |
| Neuroscience Letters, Reviewer, Journal Article | |
| PloSOne, Reviewer, Journal Article | |
| Searle Scholars Program, Reviewer, Applications | |
| Telethon, Reviewer, Grant Proposal | |
| The US Civilian Research and Development Foundation, Reviewer, Grant Proposal | |
| Wellcome Trust, Reviewer, Grant Proposal |
Committee Service
| GRE evaluation workgroup for the SGSHS, Member | 2021 - Present |
| Quality Enhancement Plan Committee of the Medical Center, Member | 2021 - Present |
| Chair of the Foundational Sciences Subcommittee of the SOM CC, Chair | 2021 - Present |
| Department of Cell and Molecular Biology Retreat Primary Presenter | 2021 - Present |
| Basic Sciences Workgroup of the Medical Center, Task Force Member | 2020 - 2021 |
| Preclincal Coordinators Subcommittee of the SOM CC, Chair | 2019 - 2021 |
| SOM Curriculum Committee Steering Committee, Member | 2019 - 2021 |
| Annual Development of the Cell and Molecular Biology PhD program Institutional Effectiveness Plan | 2018 - Present |
| Cell and Molecular Biology Ph.D. Program Director | 2018 - Present |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-GRADUATE COUNCIL | 2018 - Present |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-CURRICULUM, Member | 2018 - Present |
| SCHOOL OF MEDICINE-CURRICULUM, Member | 2018 - Present |
| SCHOOL OF GRADUATE STUDIES IN THE HEALTH SCIENCES-GRADUATE PROGRAM REVIEW, Member | 2015 - Present |
| Grievance Committee for Graduate School, Member | 2010 - 2010 |
| Point man for the Dept. of Biochemistry for submission of a T32 training grant | 2010 - Present |
| Medical Center - Research Advisory Committee, Member | 2010 - 2011 |
| Ad Hoc Committee to develop a curriculum for a new Master of Science track in Biotechnology, Member | 2009 - Present |
| Graduate Student Academic Awards Committee, Member | 2009 - Present |
| Vice Chair of Medical Student Research Program, Vice Chair | 2009 - 2011 |
| Reviewer for UMMC Intramural Research Support Program, Member | 2009 - 2009 |
| School Of Graduate Studies - Curriculum Committee, Member | 2008 - Present |
| School Of Medicine - Admissions, Member | 2008 - Present |
| School Of Medicine Academic Awards Committee, Member | 2008 - Present |
| Completion of the UMMC Leadership Development Program | 2007 - 2008 |
| Team to select speakers and judge posters for the UMMC graduate student research day, Member | 2007 - 2007 |
| Department of Biochemistry, Annual Retreat Organizer | 2006 - 2008 |
| Ad Hoc Committee for Graduate Student employee status, Member | 2006 - 2006 |
| School Of Medicine - Curriculum, Member | 2005 - 2008 |
| Research Space subcommittee, Member | 2005 - Present |
| Department of Biochemistry, Departmental Happy Hour Organizer | 2005 - 2008 |
| Department of Biochemistry, Seminar Director | 2003 - 2008 |
| Team to establish the Center for Investigation of Neurodegenerative Disease, Member |
Community Service
| Muscular Dystrophy Association Labor Day Telethon, TV appearance | 2007 - 2007 |
| American Cancer Society Relay for Life, Participant | 2005 - 2006 |
| Mississippi Academy of Science meeting, Judge | 2004 - 2004 |
| Science Fair, Chastain Middle School, Judge | 2002 - 2002 |
| Jackson Cancer Research Group (J-CRIG), Member |
Teaching Experience
| 740, Biochemical Methods | |
| 744, Graduate, Course, Course Presenter, Cellular Biochemistry | |
| 727, Current Issues in Biomedical Research and Translational Medicine | |
| 710, Medicine, Course, Lecturer, Graduate Biochemistry | |
| Professional Skills for Graduate Students and Postdoctoral Fellows | |
| 709, Course, Responsible Conduct of Research | |
| Department of Biochemistry Journal Club | Spring 2012 |
| 701, Course, Course Coordinator, Basic Biochemistry in Health Care | 2010 |
| Small Group, Friedreich ataxia: From gene discovery to potential treatments | Fall 2007 |
| Small Group, Nuclear Organization and Disease | Fall 2003 |
Directed Student Learning
| Supervised Research, Advised: Zunamys Carrero | 2012 - 2013 |
| Supervised Research, Advised: Hanna Broome | 2010 - Present |
| Supervised Research, Advised: Heather Douglas | 2010 - Present |
| Postdoctoral Advisor, Advised: Venkatramreddy Velma | 2009 - Present |
| Directed Individual/Independent Study, Advised: Andrew Gilder | 2008 - Present |
| Postdoctoral Advisor, Advised: Angela Whitton | 2008 - 2009 |
| Postdoctorl Advisor, Advised: Cory Toyota | 2008 - 2009 |
| Supervised Research, Advised: Scoty Hearst | 2008 - 2009 |
| Supervised Research, Advised: Dustin Markle | 2008 - 2008 |
| Supervised Research, Advised: Kenya Murray | 2008 - 2008 |
| Supervised Research, Advised: Scoty Hearst | 2008 - 2008 |
| Supervised Research, Advised: Andrew Gilder | 2007 - 2007 |
| Supervised Research, Advised: Aruna Rawat | 2007 - 2007 |
| Supervised Research, Advised: Nafez Abu Tarcoush | 2007 - 2007 |
| Postdoctoral Research Advisor, Advised: Sandy Negi | 2006 - 2007 |
| Supervised Research, Advised: Shama Moktan | 2006 - 2006 |
| Supervised Research, Advised: Payal Vayas | 2004 - 2004 |
| Supervised Research, Advised: Eric George | 2003 - 2003 |
| Supervised Research, Advised: Iqbal Massodi | 2003 - 2003 |
| Supervised Research, Advised: Xianghui Li | 2003 - 2003 |
| Dissertation Committee Chair, Advised: Hongzhi Xu, Angela Reiken, Andrew Gilder | |
| Dissertation Committee Member, Advised: Sheetal Bhan, Bob Sample, Iqbal Massodi, Payal Vyas, Moonsung Choi, Sandeep Negi, Naved Alam, Eric George, Lee Bidwell, Holland Alday, Ashish Aggarwal, Scoty Hearst | |
| Postdoctoral Research Advisor, Advised: June Sun | |
| Supervised Research, Advised: James Freeman, Dustin Markle | |
| Supervised Research, Advised: James Freeman | |
| Supervised Research, Advised: Kenya Murray | |
| Supervised Research, Advised: Lee Bidwell, Eric George, Xianghui Li, Iqbal Massodi, Payal Vayas, Shama Moktan, Nafez Abu Tarboush, Aruna Rawat | |
| Supervised Research, Advised: Tommy Nalls Jr. |