Angela R. Subauste, MD
Professor
Department:
SOM-Medicine-ENDO
Email:
asubauste@umc.edu
Work Phone:
(601) 984-5525
Education
| University of Michigan, Ann Arbor, Michigan, MD, Metabolic Diseases | 2005 |
| University of Michigan, Ann Arbor, Michigan, MD, Division of Endocrinology and Metabolism | 2004 |
| Southern Illinois University School of Medicine, Springfield, Illinois, MD, Internal Medicine | 2002 |
| University of Michigan, Ann Arbor, Clerkship, Endocrinology | 1998 |
| University of Texas at Houston, Clerkship, Infectious Diseases | 1998 |
| Universidad Peruana Cayetano Heredia, Lima Peru, Medical School | 1997 |
| University of Alabama at Birmingham, Clerkship, Nephrology | 1996 |
| University of Alabama at Birmingham, Clerkship, Hematology | 1995 |
| VA - Phoenix, Arizona, Clerkship, Pulmonary Disease and Intensive Care | 1995 |
Specialty Certification Licensure
| Licensure, Mississippi Medical License, State of Mississippi | 06/2012 - Present |
| Licensure, Physician License, State of Michigan | 03/2005 - 06/2012 |
| Certification, American Board of Endocrinology, Diabetes and Metabolism, ABIM | 2005 - Present |
| Certification, American Board of Internal Medicine, ABIM | 08/2002 - 07/2012 |
| Certification, Educational Commission for Foreign Medical Graduates | 10/1998 - Present |
| Licensure, Clinical Academic Medical License | 07/2004 - 2005 |
| Licensure, State of Michigan Medical License, State of Michigan | 06/2002 - 07/2004 |
| Licensure, State of Illinois Medical License, State of Illinois | 06/1999 - 06/2002 |
Current Positions
| Associate Professor, School of Medicine | 07/2016 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, UMMC, School of Medicine, Department of Medicine | 06/2012 - 06/2016 |
| Assistant Professor, University of Michigan, School of Medicine | 07/2009 - 02/2012 |
Sponsored Program Funding
| Intramural, Type 2 diabetes and cardiorespiratory fitness., UMMC | 12/2015 - 01/2017 |
| Extramural, Jackson Heart Study Field Center, NIH Heart, Lung and Blood Institute | 08/2013 - 05/2018 |
| Extramural, Role of Lipid Intermedidates in the Limited Human Adipose tissue expandability with insulin resistance, National Institue of Diabetes Digestive and Kidney Disases | 09/2012 - 08/2015 |
| Intramural, Effect of chronic exercise on the spatial coupling of mTOR and Autophagy., DOM | 07/2012 - 06/2013 |
| Extramural, Pilot Study of the Safety, Feasibility and Potential Efficacy of Continuous Glucose Monitoring and Insulin Pump Therapy in Diabetic Gastroparesis (GLUMIT-DG), Tonascia | 09/2011 - 08/2013 |
| Intramural, Metabolomic Signature of Heart Failure., University of Michigan | 07/2011 - 06/2012 |
| Intramural, Role of fatty acids in the sarcopenia of aging., Claude D. Pepper Older Americans Independence Center | 07/2009 - 08/2010 |
| Extramural, An Open-Label Treatment Protocol to Provide Metreleptin for the Treatment of Diabetes Mellitus and/or Hypertriglyceridemia Associated with Lipodystrophy., Amylin | 01/2009 - 01/2014 |
| Extramural, Insulin Resistance and Hepatic Steatosis in Hepatitis C., NIDDK | 09/2005 - 07/2011 |
Publications
Journal Article | |
| Akinci, B; Subauste, A; Ajluni, N; Esfandiari, NH; Meral, R; Neidert, AH; Eraslan, A; Hench, R; Rus, D; Mckenna, B; Hussain, HK; Chenevert, TL; Tayeh, MK; Rupani, AR; Innis, JW; Mantzoros, CS; Conjeevaram, HS; Burant, CF; Oral, EA. Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two different clinical settings. Cell Press: Med. 2021, Jul; 2(7): 785-884 | 2021 |
| Subauste A Paracoccidiodomicosis in pediatric population Folia Dermatologica Peru. 1997; 8:30-8 | 1997 |
| Garla V, Subauste A, Butler J, Lien LF, The role of sodium glucose co-transporter inhibitors in heart failure prevention. Journal of diabetes and its complications, 2021 Mar;35(3):107811 | 2021 |
| Garla VV, Salim S, Kovvuru KR, Subauste A, Hungry bone syndrome secondary to prostate cancer successfully treated with radium therapy. BMJ case reports, 2018 Jul 6;2018 | 2018 |
| Lager CJ, Esfandiari NH, Luo Y, Subauste AR, Kraftson AT, Brown MB, Varban OA, Meral R, Cassidy RB, Nay CK, Lockwood AL, Bellers D, Buda CM, Oral EA, Metabolic Parameters, Weight Loss, and Comorbidities 4 Years After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy. Obesity surgery, 2018 Nov;28(11):3415-3423 | 2018 |
| Kumar A, Blackshear C, Subauste JS, Esfandiari NH, Oral EA, Subauste AR, Fatty Liver Disease, Women, and Aldosterone: Finding a Link in the Jackson Heart Study. Journal of the Endocrine Society, 2017 May 1;1(5):460-469 | 2017 |
| Lager CJ, Esfandiari NH, Subauste AR, Kraftson AT, Brown MB, Cassidy RB, Bellers D, Lockwood AL, Varban OA, Oral EA, Milestone Weight Loss Goals (Weight Normalization and Remission of Obesity) after Gastric Bypass Surgery: Long-Term Results from the University of Michigan. Obesity surgery, 2017 Jul;27(7):1659-1666 | 2017 |
| Lager CJ, Esfandiari NH, Subauste AR, Kraftson AT, Brown MB, Cassidy RB, Nay CK, Lockwood AL, Varban OA, Oral EA, Roux-En-Y Gastric Bypass Vs. Sleeve Gastrectomy: Balancing the Risks of Surgery with the Benefits of Weight Loss. Obesity surgery, 2017 Jan;27(1):154-161 | 2017 |
| Horton WB, Boler PL, Subauste AR, Diabetes Mellitus and the Skin: Recognition and Management of Cutaneous Manifestations. Southern medical journal, 2016 Oct;109(10):636-646 | 2016 |
| Mamoon A, Subauste A, Subauste MC, Subauste J, Retinoic acid regulates several genes in bile acid and lipid metabolism via upregulation of small heterodimer partner in hepatocytes. Gene, 2014 Oct 25;550(2):165-70 | 2014 |
| Subauste AR, Esfandiari NH, Qu Y, Oral EA, Aaronson KD, Pagani FD, Gianchandani RG, Impact of left ventricular assist device on diabetes management: an evaluation through case analysis and clinical impact. Hospital practice (1995), 2014 Aug;42(3):116-22 | 2014 |
| Subauste AR, Das AK, Li X, Elliott BG, Evans C, El Azzouny M, Treutelaar M, Oral E, Leff T, Burant CF, Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations. Diabetes, 2012 Nov;61(11):2922-31 | 2012 |
| Portillo JA, Okenka G, Reed E, Subauste A, Van Grol J, Gentil K, Komatsu M, Tanaka K, Landreth G, Levine B, Subauste CS, The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels. PloS one, 2010 Dec 31;5(12):e14472 | 2010 |
| Subauste CS, Subauste A, Wessendarp M, Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4(+) T cells from HIV-1-infected patients. Journal of immunology (Baltimore, Md. : 1950), 2007 Feb 1;178(3):1645-53 | 2007 |
| Subauste AR, Burant CF, Role of FoxO1 in FFA-induced oxidative stress in adipocytes. American journal of physiology. Endocrinology and metabolism, 2007 Jul;293(1):E159-64 | 2007 |
| Subauste A, Burant CF, DGAT: novel therapeutic target for obesity and type 2 diabetes mellitus. Current drug targets. Immune, endocrine and metabolic disorders, 2003 Dec;3(4):263-70 | 2003 |
| Subauste AR, Elliott B, Das AK, Burant CF, A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation. Differentiation; research in biological diversity, 2010 Sep-Oct;80(2-3):140-6 | |
| Baker RC, Nikitina Y, Subauste AR, Analysis of adipose tissue lipid using mass spectrometry. Methods in enzymology, 2014;538:89-105 | |
| Calles-Escandón J, Koch KL, Hasler WL, Van Natta ML, Pasricha PJ, Tonascia J, Parkman HP, Hamilton F, Herman WH, Basina M, Buckingham B, Earle K, Kirkeby K, Hairston K, Bright T, Rothberg AE, Kraftson AT, Siraj ES, Subauste A, Lee LA, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Fass R, Snape WJ, Vaughn IA, Miriel LA, Farrugia G, NIDDK Gastroparesis Clinical Research Consortium (GpCRC), Glucose sensor-augmented continuous subcutaneous insulin infusion in patients with diabetic gastroparesis: An open-label pilot prospective study. PloS one, 2018;13(4):e0194759 | |
| Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG, Prediction of Incident Diabetes in the Jackson Heart Study Using High-Dimensional Machine Learning. PloS one, 2016;11(10):e0163942 | |
| Horton WB, Taylor JS, Ragland TJ, Subauste AR, Diabetic muscle infarction: a systematic review. BMJ open diabetes research & care, 2015;3(1):e000082 | |
| Subauste A, Gianani R, Chang AM, Plunkett C, Pietropaolo SL, Zhang YJ, Barinas-Mitchell E, Kuller LH, Galecki A, Halter JB, Pietropaolo M, Islet autoimmunity identifies a unique pattern of impaired pancreatic beta-cell function, markedly reduced pancreatic beta cell mass and insulin resistance in clinically diagnosed type 2 diabetes. PloS one, 2014;9(9):e106537 | |
Abstracts | |
| Bowes, C; Subauste, A. A Case of Hypoplastic Left Heart Syndrome and Paraganglioma. Endocrine Society Annual Meeting. 2020. | |
| Kerut, S; Subauste, A. Primary Macronodular Adrenal Hyperplasia Associated With Autosomal Dominant ARMC5 Mutation. Endocrine Society Annual Meeting. 2020. | |
| Coleman, CJ; Henry, M; Bowes, C; Subauste, A. An Unfortunate Coincidence. ACP Meeting 2019. | |
| Wright, V; Subauste, A. Hypoglycemia and Lactic Acidosis: The Deadly Signs of Untreated Non-Hodgkin's Lymphoma. Endocrine Society Annual Meeting. 2019. | |
| Bello, MO; Subauste, A. Bilateral Macronodular Adrenal Hyperplasia: A rare case of Cushing’s disease. Endocrinology Society Annual Meeting 2018. | |
| Ramadhas, A; Azur, A; Subauste, A. A Case of Struma Ovarii with Hyperthyroidism. Endocrine Society Annual Meeting 2018. | |
| Adah, O; Subauste, A; Subauste, AR. Metabolic Dysfunction due to fish oil in the setting of a high fat diet. The Obesity Society Annual Meeting. 2016. | |
| Grayson, B; Vick, K; Subauste, A. Plasma Cytokine Alterations following human vertical sleeve gastrectomy. The Obesity Society Annual Meeting 2016. | |
| Lager, C; Esfandiari, N; Kraftson, A; Subauste, A; Lockwood, A; Verban, O; Oral, EA. Likelihood of achieving normal weight 5 years after gastric bypass surgery: Results from the University of Michigan Post Bariatric Surgery Clinic. Endocrinology Society Annual Meeting 2016. | |
| Majors, C; Parham, J; Subauste, A. Agranulocytosis after treatment with methimazole. Endocrinology Society Annual Meeting 2016. | |
| Idiopathic Thyroid Abscess: a rare cause of rapidly enlarging thyroid mass. Endocrinology Society Annual Meeting 2016 | |
| Subauste, AR, Chang, A; Plunkett, C; Pietropaolo, M GAD65 and IA-2 Autoantibodies Identify a Population of Type 2 Diabetes Patients with Impaired beta-Cell Function and Obesity Independent Insulin Resistance. American Diabetes Association Annual Meeting, 2013. | |
| Moran, T; Subauste, A; Subauste, J. The Occult Thyroid Malignancy. Endocrinology Society Annual Meeting 2013. | |
| Phillips, J, Atchley, L; Holguin, G; Mains, T; Asher, F; Subauste, A; Subauste, J. Disseminated blastomycosis: a rare cause of central diabetes. Endocrinology Society Annual Meeting 2013. | |
| Cornford, AS; Horowitz, JF; Schenk, S; Burant, CF, Subauste, AR. AGPAT1 decreases insulin signaling by activating the mTOR pathway. American Diabetes Association Annual Meeting, 2007. | |
| Subauste, A; Burant, CF. Lipodystrophy Due to AGPAT2 Mutations Results from Defective Adipogenesis. American Diabetes Association Annual Meeting, 2005. | |
| Subauste, A; Burant, CF. Reversal of Free Fatty Acid-Induced Alteration in Adipocyte Metabolism by Resveratrol. American Diabetes Association Annual Meeting, 2005 | |
| Subauste A; Treutelaar M, Li X, Burant CF. Understanding and treating Congenital Generalized Lipodystrophy. Department of Medicine. University of Michigan. | |
Book Chapter | |
| Subauste, Jose S., and Angela Subauste Diabetes mellitus and muscle infarction Diabetes Mellitus. Impact on Bone, Dental and Musculoskeletal Health, 275–83. Elsevier, 2020. | |
Presentations
| State/Local Invited Seminars/Lectures, Diabetes Lecture, Advanced Practice Provider Annual Conference | 09/2017 |
| State/Local Invited Seminars/Lectures, Leptin Therapy: Advances and Controversies, Physiology Seminar Series, UMMC | 09/2016 |
| State/Local Invited Seminars/Lectures, Grand Rounds: Obesity Management, DOM | 08/2016 |
| Seminar, Skeletal muscle as an endocrine organ, Pharmacology, UMMC | 05/2014 |
| Medicine Research Conference, When fat makes you stronger: role of omega-3 fatty acids in muscle strength, DOM, UMMC | 05/2014 |
| Physiology in Medicine Series, The Obesity Crisis: Challenges and Opportunities., DOM/Physiology, UMMC | 03/2014 |
| Grand Rounds, Diabetes Update | 02/2014 |
| State/Local Invited Seminars/Lectures, Diabetes: Update, Management and Medication Review, Grenada Lake | 10/2013 |
| Mississippi College PA's Course Lecture, Diabetes Mellitus - Type I, Type II, Hypoglycemia, Mississippi College, Clinton, MS | 10/2012 |
| Regional Invited Seminars/Lectures, Diabetes management in the outpatient setting, MS LA Annual ACP meeting, Point Clear, AL | 09/2012 |
| Research Seminar, When fat makes you stronger, Endocrinology Division, University of Michigan | 02/2012 |
| Invited Symposia, From lipodystrophies to obesity, Endocrinology division U of M, University of Michigan | 03/2011 |
| Invited Symposia, From lipodystrophies to obesity, LSU, Shreveport, LA | 01/2011 |
| Abstract, Agpat1 decreases insulin signaling by activating the mTOR pathway, American Diabetes Association Annual Meeting | 2007 |
| Invited Symposia, Lipodystrophy Due to AGPAT2 Mutations Results from Defective Adipogenesis, Washington University | 06/2005 |
| Abstract, Reversal of Free Fatty Acity-induced Alteration in Adipocyte Metabolism by Resveratrol, American Diabetes Association Annual Meeting | 2005 |
| Abstract, Understanding and treating congenital generalized lipodystrophy, Ann Arbor, Michigan | 2004 |
| State/Local Invited Seminars/Lectures, Endocrine Grand Rounds: Insulin Pumps 2021, Endocrine Division, UMMC | |
| Medical Students talk on insulin management inpatient 2020, UMMC | |
| State/Local Invited Seminars/Lectures, Endocrine Grand Rounds: Monogenic Diabetes 2020, Endocrine Division, UMMC | |
| Residents Noon Conference: Diabetes Talk 2020, UMMC | |
| State/Local Invited Seminars/Lectures, Endocrine Grand Rounds: Fatty Liver Disease 2019, Endocrine Division, UMMC | |
| State/Local Invited Seminars/Lectures, Journal Club 2018, Residents noon conference | |
| State/Local Invited Seminars/Lectures, Update on Diabetes Management.2017, Residents Noon Conference |
Honors, Awards, and Recognition
| Award for Outstanding Research-Role of AGPAT2 in Congenital Generalized Lipodystrophy, Department of Internal Medicine. University of Michigan, Ann Arbor | |
| Invited Lecture-Cellular and Molecular basis of Adipogenic defect in individuals with Congenital Generalized Lipodystorphy and AGPAT2 mutations, Washington University, St. Louis | |
| Pfizer Scholarship Award in Endocrinology | |
| ACP meeting: Invited Speaker. Diabetes Update., ACP Mississippi and Alabama Chapter | |
| Excellence in Research Bronze Award, UMMC | |
| Excellence in Research Silver Award, UMMC |
Professional Membership and Service
| Endocrine Society, Member | |
| American Diabetes Association, Member | |
| The Obesity Society, Member |
Committee Service
| Jackson Heart Study, Member | |
| SCHOOL OF MEDICINE-ADMISSIONS INTERVIEW, Member | |
| CME Conference committee, Member | |
| SCHOOL OF MEDICINE-GRADUATE MEDICAL EDUCATION, Member |
Community Service
| Mississippi Food Network, Supporter | |
| Area 8 Special Olympics Mississippi, Volunteer | |
| Mississippi Public Broadcasting, Supporter | |
| Mississippi Diabetes Association, Co-captain Walk for Diabetes 2019 |
Other Service
| Insulin Pump Clinic | |
| Clinical Diabetes and Endocrinology | |
| Obesity Society National Meeting 2016 | |
| Weight Management Program, Research Physician | |
| Journal of Lipid Research | |
| Post-Bariatric Surgery clinic, University of Michigan, Co-Director | |
| Michigan Nutrition and Obesity Research Center, Human Phenotyping Core, Member | |
| Journal of Molecular Endocrinology | |
| Hyperglycemia clinic, University of Michigan, Implementatio of clinic | |
| Poster Day. Department of Medicine UMMC., Poster Judge | |
| Advisor for School of Medicine Obesity curriculum in preparation for Liaison Committee on Medical Education (LCME) review., Advisor | |
| Milestones Committee. Endocrinology Fellowship. Department of Medicine. University of Mississippi Medical Center., Member | |
| American Journal of Physiology: Endocrinology and Metabolism, Ad hoc reviewer | |
| Grant reviewer- COBRE, Internal grant reviewer | |
| Journal of Clinical and Translational Endocrinology, Ad hoc reviewer | |
| PlosOne, Ad hoc reviewer | |
| Journal of Clinical Endocrinology and Metabolism, Ad hoc reviewer |
Teaching Experience
| Medicine, Lecture, Lecturer, Third year Medical Students Boot camp | Annual 2021 |
| Medicine, Lecture, Lecturer, Endocrinology Grand Rounds: Insulin pumps. | 2021 |
| Medicine, Lecture, Lecturer, Internal Medicine rotation: Medical Students talk on inpatient insulin management. | 2020 - 2020 |
| Medicine, Lecture, Lecturer, Endocrinology Grand Rounds: Monogenic Diabetes. | 2020 |
| Medicine, Lecture, Lecturer, Department of Medicine. Residents Noon Conference. Diabetes talk. | 2020 |
| Medicine, Lecture, Lecturer, Endocrinology Grand Rounds: Fatty liver disease. | 2019 |
| IMP1, Medicine, Small Group, Facilitator, Introduction to the Medical Profession | Fall 2019 |
| Medicine, Small Group, Facilitator, Department of Medicine. Residents Noon Conference. Journal Club. | 2018 - 2018 |
| Medicine, Lecture, Lecturer, Residents Noon Conference. Update on Diabetes Management. | 2017 |
| Medicine, Lecture, Lecturer, UMMC Advanced Practice Provider Annual Conference. | Annual 2017 - 2017 |
| Medicine, Lecture, Lecturer, Physiology Seminar Series: Leptin Therapy: Advances and Controversies. | 2016 - 2016 |
| Medicine, Lecture, Lecturer, Department of Medicine Grand Rounds: Obesity Mangement. | 2016 - 2016 |
| 611/701, Medicine, Course, Course Presenter, Medical Physiology | Annual 2014- present |
| Medicine, Lecture, Lecturer, Department of Medicine Grand Rounds: Update on Diabetes Management. | 2014 - 2014 |
| Medicine, Lecture, Lecturer, Department of Pharmacology and Toxicology Seminar series: Skeletal Muscle as an Endocrine Organ. | 2014 - 2014 |
| Medicine, Lecture, Lecturer, Physiology Seminar Series: The Obesity Crisis. | 2014 - 2014 |
| PH620, Medicine, Course, Course Presenter, Medical Pharmacology | Annual 2014 - 2017 |
| Mississippi College PA, Course, Lecturer, Mississippi College PA-Endocrinology | Annual 2012-present |
Directed Student Learning
| Dissertation Committee Member, NOVEL CANDIDATE GENE GPR50: FUNCTIONAL SIGNIFICANCE OF ENHANCED EXPRESSION IN WHITE ADIPOSE TISSUE Advised: Jessica Faulkner | 2013 - 2014 |
| Supervised Research, Advised: Omo Adah |
Fellows supervised
| Endocrinology, Post-Doc Advisor, 3 fellows supervised, Research lab | 08/2012 - 03/2018 |
| Endocrinology fellowship, Attending Physician, 21 fellows supervised, Inpatient consult service | 07/2012 - Present |
| Endocrinology Fellowship Program, Attending Physician, 21 fellows supervised, Pavilion clinic | 07/2012 - Present |
Residency Training
| Medicine-UMMC, Attending Physician | 2012 - Present |
| Medicine-University of Michigan, Attending Physician | 2008 - 06/2011 |