Brigitte E. Martin, PhD
Assistant Professor
Department:
SOM-Cell and Molecular Biology
Email:
bmartin1@umc.edu
Work Phone:
(601) 984-1864
Biography
Brigitte E Martin, PhD, is an Assistant Professor in the Department of Cell and Molecular Biology at the University of Mississippi Medical Center (UMMC) in Jackson, Mississippi. Her long-term research interests focus on studying viral infection dynamics, emphasizing both virus and host responses to enhance disease diagnostics and prognostics. She has extensive academic training and research experience in virology encompass multiple disciplines, including molecular biology, cellular biology, immunology, and epidemiology.
As a PhD candidate in Veterinary Medical Science, she received training from Dr. Xiu-Feng (Henry) Wan in molecular biology techniques used to study the influenza virus and embarked on influenza-focused research. Her dissertation centered on developing and applying a novel methodology for the antigenic characterization of influenza, utilizing polyclonal antibodies for proximity ligation assays.
Dr. Martin’s postdoctoral training at the University of Illinois under Dr. Christopher Brooke involved developing and publishing molecular and cellular biology techniques to determine the outcome of influenza infection with varying numbers of virions per infected cell, considering both the presence and absence of the host antiviral immune response. As a former T32 postdoctoral fellow at the University of Mississippi Medical Center, she further explored the implications of viral infection at the organismal level, with a particular focus on cardiovascular physiology.
Currently, Dr. Martin’s research bridges her previous work in cardiovascular physiology and viral pathogenesis, investigating changes in cardiac function, biomarkers, and viral genomic heterogeneity from the onset of influenza infection to recovery.
Education
| Mississippi State University College of Veterinary Medicine, PhD, Veterinary Medical Science | 2017 |
Current Positions
| Assistant Professor, School of Medicine, Department of Biochemistry | 08/2023 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Sponsored Program Funding
| Extramural, Host-pathogen molecular and cardiovascular interaction during influenza infection, NIH/NIGMS | 09/2023 - 02/2028 |
Publications
Journal Article | |
| Rexrode LE, Hartley J, Showmaker KC, Challagundla L, Vandewege MW, Martin BE, Blair E, Bollavarapu R, Antonyraj RB, Hilton K, Gardiner A, Valeri J, Gisabella B, Garrett MR, Theoharides TC, Pantazopoulos H, Molecular profiling of the hippocampus of children with autism spectrum disorder. Molecular psychiatry, 2024 Jul;29(7):1968-1979 | 2024 |
| Martin BE, Taylor EB, Attipoe EM, Wu W, Stec DE, Showmaker KC, Garrett MR, Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice. Physiological genomics, 2023 Feb 1;55(2):79-89 | 2023 |
| Martin BE, Garrett MR, Race and Sex Differences in Vital Signs Associated with COVID-19 and Flu Diagnoses in Mississippi. Journal of racial and ethnic health disparities, 2023 Feb;10(1):228-236 | 2023 |
| Martin BE, Harris JD, Sun J, Koelle K, Brooke CB, Cellular co-infection can modulate the efficiency of influenza A virus production and shape the interferon response. PLoS pathogens, 2020 Oct;16(10):e1008974 | 2020 |
| Alnaji FG, Holmes JR, Rendon G, Vera JC, Fields CJ, Martin BE, Brooke CB, Sequencing Framework for the Sensitive Detection and Precise Mapping of Defective Interfering Particle-Associated Deletions across Influenza A and B Viruses. Journal of virology, 2019 Jun 1;93(11) | 2019 |
| Martin BE, Brooke CB, Flu Shows the Power of Diversity. Cell, 2019 Jan 10;176(1-2):9-10 | 2019 |
| Martin BE, Sun H, Carrel M, Cunningham FL, Baroch JA, Hanson-Dorr KC, Young SG, Schmit B, Nolting JM, Yoon KJ, Lutman MW, Pedersen K, Lager K, Bowman AS, Slemons RD, Smith DR, DeLiberto T, Wan XF, Feral Swine in the United States Have Been Exposed to both Avian and Swine Influenza A Viruses. Applied and environmental microbiology, 2017 Oct 1;83(19) | 2017 |
| Martin BE, Bowman AS, Li L, Nolting JM, Smith DR, Hanson LA, Wan XF, Detection of Antigenic Variants of Subtype H3 Swine Influenza A Viruses from Clinical Samples. Journal of clinical microbiology, 2017 Apr;55(4):1037-1045 | 2017 |
| Zhao N, Martin BE, Yang CK, Luo F, Wan XF, Association analyses of large-scale glycan microarray data reveal novel host-specific substructures in influenza A virus binding glycans. Scientific reports, 2015 Oct 28;5:15778 | 2015 |
| Martin BE, Jia K, Sun H, Ye J, Hall C, Ware D, Wan XF, Detection of influenza antigenic variants directly from clinical samples using polyclonal antibody based proximity ligation assays. Virology, 2015 Feb;476:151-158 | 2015 |
| Xu Y, Cao H, Liu H, Sun H, Martin B, Zhao Y, Wang Q, Deng G, Xue J, Zong Y, Zhu J, Wen F, Long LP, Wong SS, Zhao N, Fu X, Liao M, Hu G, Webby R, Gao GF, Wan XF, Identification of the source of A (H10N8) virus causing human infection. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2015 Mar;30:159-163 | 2015 |
| Feng Z, Gomez J, Bowman AS, Ye J, Long LP, Nelson SW, Yang J, Martin B, Jia K, Nolting JM, Cunningham F, Cardona C, Zhang J, Yoon KJ, Slemons RD, Wan XF, Antigenic characterization of H3N2 influenza A viruses from Ohio agricultural fairs. Journal of virology, 2013 Jul;87(13):7655-67 | 2013 |
| Showmaker KC, Sanders WS, Eves-van den Akker S, Martin BE, Platt RN 2nd, Stokes JV, Hsu CY, Bartlett BD, Peterson DG, Wubben MJ, A genomic resource for the sedentary semi-endoparasitic reniform nematode, Rotylenchulus reniformis Linford & Oliveira. Journal of nematology, 2019;51:1-2 | |
| Showmaker KC, Sanders WS, den Akker SE, Martin BE, Callahan FE, Peterson DG, Wubben MJ, Five life stage-specific transcriptome assemblies for the reniform nematode, Rotylenchulus reniformis Linford & Oliveira. Journal of nematology, 2018;50(4):1-2 | |
| Showmaker KC, Arick MA 2nd, Hsu CY, Martin BE, Wang X, Jia J, Wubben MJ, Nichols RL, Allen TW, Peterson DG, Lu SE, The genome of the cotton bacterial blight pathogen Xanthomonas citri pv. malvacearum strain MSCT1. Standards in genomic sciences, 2017;12:42 | |
Presentations
| Poster Presentation, Cardiac transcriptomic profiling in obese and lean mice during influenza infection, American Society for Virology, Palais des congrès de Montréal in Montréal, Québec, Canada | 07/2025 |
| State/Local Invited Seminars/Lectures, Molecular Center of Health and Disease COBRE, University of Mississippi Medical Center | 05/2025 |
| State/Local Invited Seminars/Lectures, Cardiovascular and Renal Research Center COBRE, University of Mississippi Medical Center | 05/2025 |
| State/Local Invited Seminars/Lectures, Cardiovascular Consequences of Influenza Virus Infection in Mice, Cell and Molecular Biology Seminar, University of Mississippi Medical Center | 01/2025 |
| State/Local Invited Seminars/Lectures, Cardiovascular Consequences of Influenza Virus Infection in Mice, Biological Sciences Seminar, Misssissippi State University | 01/2025 |
| State/Local Invited Seminars/Lectures, Cardiovascular, biomarker, and viral genomic differences during influenza infection, Molecular Center of Health and Disease COBRE, University of Mississippi Medical Center | 01/2025 |
| National and International Invited Seminars/Lectures, Temporal cardiovascular impacts of influenza infection in mice, American Society for Virology. Columbus, Columbus, OH | 06/2024 |
| National and International Invited Seminars/Lectures, Temporal dynamics of cardiovascular response to influenza infection in mice, 9th National IDeA Symposium of Biomedical Research Excellence (NISBRE), Washington DC | 06/2024 |
| State/Local Invited Seminars/Lectures, Cardiovascular, biomarker, and viral genomic differences during influenza infection, Molecular Center of Health and Disease COBRE, University of Mississippi Medical Center | 05/2024 |
| Poster Presentation, Cardiovascular and renal physiological impacts seen in blood tests of flu diagnosed patients, American Physiology Summit, Long Beach, CA | 04/2024 |
| State/Local Invited Seminars/Lectures, Cardiovascular, biomarker, and viral genomic differences during influenza infection, Molecular Center of Health and Disease, University of Mississippi Medical Center | 01/2024 |
Honors, Awards, and Recognition
| Bronze level for the Office of the Associate Vice Chancellor for Research Excellence Awards, University of Mississippi Medical Center | 2024 |
Professional Membership and Service
| American Physiological Society, Member, Annual national meeting | 2022 - Present |
| Infection Genomics for One Health Carl R. Woese Institute for Genomic Biology, Fellow | 2018 - 2020 |
| American Society for Virology, Member, Annual international meeting | 2018 - Present |
| Phi Kappa Phi, Member | 2014 - Present |
| Golden Key, Member | 2013 - Present |
| American Society for Microbiologists, Member | 2012 - Present |
Committee Service
| MEDICAL CENTER-ANIMAL CARE AND USE, Member | 2024 - Present |
| Medical Student Research Program (MSRP) Review Committee, Member | 2023 - Present |
Other Service
| Seminar Director, Cell and Molecular Biology | 08/2023 - Present |
Teaching Experience
| Molecular Center of Health and Disease COBRE, Lecturer, MCHD Summer Omics Academy | Summer 2024-2025 - 2025 |
| ID714, Graduate, Course, Lecturer, Professional Skills | Spring 2024-2025 - 2025 |
| Micro702, Graduate, Course, Lecturer, Molecular and Cellular Virology | Spring 2024-2025 - 2025 |
| Micro741, Graduate, Course, Lecturer, FUNDAMENTAL MICROBIOLOGY AND IMMUNOLOGY | Spring 2024-2025 - 2025 |
| NSCI710, Graduate, Course, Lecturer, Biostatistics | Spring 2024-2025 - 2025 |
| Molecular Center of Health and Disease COBRE, Lecturer, MCHD Summer Omics Academy | Summer 2023-2024 - 2024 |
| Micro741, Graduate, Course, Lecturer, FUNDAMENTAL MICROBIOLOGY AND IMMUNOLOGY | Spring 2023-2024 - 2024 |
| ID714, Graduate, Course, Lecturer, Professional Skilss | Spring 2023-2024 - 2024 |
| NSCI710, Graduate, Course, Lecturer, Biostatistics | Spring 2023-2024 - 2024 |
Directed Student Learning
| Research Advisor, Advised: Reanna Hales | 2024 - Present |
| Base Pair, Advised: Mia Parnell | 2024 - Present |
| Dissertation Committee Member, Advised: Komal Beeton | 2023 - Present |
| Dissertation Defense Committee Member, Advised: Ashley Johnson | 2023 - 2025 |