Kristin S. Edwards
Assistant Professor
Department:
SOM-Pharmacology/Toxicology
Email:
kedwards1@umc.edu
Work Phone:
(601) 815-3423
Biography
Dr. Edwards is currently an assistant professor in the Department of Cell and Molecular Biology at UMMC. She received her BS degree in biology and chemistry from Jacksonville State University and her PhD in biochemistry from UMMC.
Her PhD research focused on the mechanisms by which the echinocandin group of antifungal drugs affect mitochondrial bioenergetics. Her postdoctoral research focused on the deficiency of the mitochondrial inner membrane protein, uncoupling protein 3, and its impairment of cardiac energetics and contractile recovery following ischemia and reperfusion. She has established protocols for isolating mitochondria from various tissues and measuring mitochondrial function, reactive oxygen species production, ATP production, and membrane potential. Her work has led to various awards, including the APS- Cardiovascular Section Research Recognition Award.
Dr. Edward’s current research focuses on the role of mitochondrial dysfunction associated with inflammatory bowel disease (IBD); the role of mitochondrial dysfunction in the comorbidities associated with IBD; and how mitochondrial targeted therapeutics are a beneficial treatment option for IBD and other human diseases.
Education
| University of Mississippi Medical Center, PhD, Biochemistry | 2017 |
| Jacksonville State University, BS, Biology and Chemistry | 2011 |
| University of Mississippi Medical Center, Postdoctoral Research Fellowship, Physiology |
Current Positions
| Assistant Professor, School of Medicine, Department of Pharmacology / Toxicology | 07/2023 - Present |
| Director, School of Medicine, Department of Pharmacology / Toxicology | 07/2023 - Present |
| The University of Mississippi Medical Center Jackson, Mississippi 39216 | |
Academic Appointments or Other Previous Appointments
| Assistant Professor, University of Mississippi Medical Center, School of Graduate School in the Health Sciences, Department of Cell and Molecular Biology | 05/2020 - 06/2023 |
| Assistant Professor, Jacksonville State University, Department of Chemistry and Geosciences | 2019 - 05/2020 |
| Postdoctoral Research Fellow, University of Mississippi Medical Center, School of Graduate School in the Health Sciences, Department of Physiology And Biophysics | 03/2017 - 11/2018 |
| Graduate Assistant, University of Mississippi Medical Center, School of Graduate School in the Health Sciences, Department of Biochemistry | 08/2011 - 03/2017 |
Publications
Journal Article | |
| Shirey, K. and Rayburn, J. Old World vs. New World: a preliminary comparison of the developmental toxicity of venom from two tarantula species, Grammostola rosea and Haplopelma lividium, using frog embryos from Xenopus laevis BIOS 84(3):127-135. DOI:10.1893/0005-3155-84.3.127 | 2013 |
| Vasumathi, N., Zettili, M., and Shirey, K. Bromination of dimethyl maleate using bromoform as catalyst under different energy sources: A case study for its role in biotransformations. Journal of the Alabama Academy of Science. 80 (3-4): 220-232. | 2009 |
| Vasumathi, N., Zettili, M., and Shirey, K. Effects of concentration, temperature, and varied energy conditions on the specific rotations of isoborneol and (s)-(-)-endo borneol. Journal of Undergraduate Chemistry Research. 8 (4):115-121. | 2008 |
Book Chapter | |
| K. Shirey Jacksonville State University CY 232 Lab Manual Edition 2010: The effect of concentration and solvent on the rotatory power of a chiral compound | 2010 |
Presentations
| Invited Symposia, Central Renin Angiotensin System Dysregulation in the Parietal Cortex of Hyperandrogenic Female Mice: Implications for Cognitive Dysfunction in PCOS Women., ASPET 2024 | 05/2024 |
| Invited Symposia, Sex-specific colonic mitochondrial dysfunction and improvement with mitochondrial targeted therapies in the indomethacin-induced inflammatory bowel disease model in rats., UMDF Mitochondrial Medicine Conference 2023 | 06/2023 |
| Poster Presentation, Colonic Mitochondrial Dysfunction in Rodent Models of PCOS., UMDF Mitochondrial Medicine Conference 2023 | 06/2023 |
| Poster Presentation, Leptin Inhibition Ameliorates Renal Mitochondrial Dysfunction And Associated Renal Injury In Polycystic Ovary Syndrome, APS Summit | 04/2023 |
| Invited Symposia, Colonic Mitochondrial Dysfunction and Sub-Acute Gastrointestinal Inflammation in Two Hyperandrogenemic Rodent Models of PCOS, AE-PCOS 2023 | 04/2023 |
| Invited Symposia, Colonic Mitochondrial Dysfunction and Sub-Acute Gastrointestinal Inflammation in Two Hyperandrogenemic Rodent Models of PCOS., ENDO 2023 | 04/2023 |
| Poster Presentation, Altered mitochondrial function associated with hypercoagulability in a rodent fracture model., AAST 2023 | 2023 |
| Regional Invited Seminars/Lectures, Sex-specific effects of indomethacin-induced inflammatory bowel disease on mitochondrial function, Department of Physiology & Anatomy at the University of North Texas Health Science Center | 11/2022 |
| Poster Presentation, Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced inflammatory bowel disease model in rats., UMMC Research Day | 11/2022 |
| Poster Presentation, Streptococcus pneumoniae Oxidizes Hemeproteins to Exacerbate Toxicity of Lung Cells and to Disrupt Mitochondrial Complex I Leading to Inhibition of Cellular Respiration., ASM Southcentral | 10/2022 |
| State/Local Invited Seminars/Lectures, Sex-specific effects of indomethacin-induced inflammatory bowel disease on mitochondrial function, Department of Chemistry at Mississippi State University | 04/2022 |
| Poster Presentation, Aging Female Offspring Exposed to Maternal Hyperandrogenemia have Increased Renal Mitochondrial Content and Decreased Mitochondrial Reactive Oxygen Species, Experimental Biology | 04/2022 |
| Invited Symposia, Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced inflammatory bowel disease model in rats. *GIL Section Research Recognition Award, Experimental Biology | 04/2022 |
| Poster Presentation, Oxidative stress and white adipose tissue in a rat model of polycystic ovary syndrome., 2021 Androgen Excess- Polycystic Ovary Syndrome Meeting., Virtual | 11/2021 |
| Poster Presentation, Colonic mitochondrial function is altered in hyperandrogenemic female rats., APS New Trends in Sex and Gender Medicine conference, Vitrual | 10/2021 |
| Poster Presentation, Sodium-Glucose Cotransporter-2 Inhibition Improves Mitochondrial Dysfunction in White Adipose Tissue in Hyperandrogenemic Female Rats., APS New Trends in Sex and Gender Medicine conference, Virtual | 10/2021 |
| Poster Presentation, Sex-specific effects of indomethacin-induced inflammatory bowel disease on mitochondrial function, APS New Trends in Sex and Gender Medicine conference, Virtual | 10/2021 |
| Poster Presentation, Sex differences in mitochondrial dysfunction following the induction of Crohn’s Disease in rats, ACS National Meeting | 08/2021 |
Honors, Awards, and Recognition
| APS- Cardiovascular Section Research Recognition Award, APS | 2018 |
| Research Day Postdoctoral Poster Award, SGSHS | 2017 |
| Regions Outstanding Graduate Research Award, UMMC SGSHS | 2017 |
| Research Day Graduate Student Poster Winner, SGSHS | 2015 |
| Biology Outstanding Undergraduate Research Award, Jacksonville State University | 2011 |
| Biology Outstanding Academic Award, Jacksonville State University | 2011 |
| Biology Presentation, Jacksonville State University College of Arts and Sciences | 2011 |
| Richard J. Beschi Leadership Award, Jacksonville State University Department of Physical and Earth Sciences | 2010 |
Professional Membership and Service
| Endocrinology, Member | 2022 - Present |
| American Heart Association, Member | 2017 - Present |
| American Physiological Society, Member | 2017 - Present |
| American Society of Biochemistry and Molecular Biology, Member | 2015 - Present |
| National Society of Environmental Toxicology and Chemistry, Member | 2010 - 2011 |
| Regional Society of Environmental Toxicology and Chemistry, Member | 2010 - 2011 |
| Alabama Academy of Science, Member | 2009 - 2011 |
| Association of Southeastern Biologist, Member | 2009 - 2011 |
| American Chemical Society, Member | 2007 - Present |
Committee Service
| SCHOOL OF MEDICINE-ADMISSIONS FILE REVIEW SUBCOMMITTEE, Member | 2022 - Present |
| Women's Health Research Center, Member | 2022 - Present |
| Group on Women in Medicine and Science Executive Board, Member | 2022 - Present |
| Graduate Women in Medical Science Programming Committee, Member | 2020 - Present |
| JSU Chemistry Curriculum Committee, Member | 2019 - 2020 |
| JSU Faculty Commons Advisory Board Member, Member | 2019 - 2020 |
| JSU Chemistry Faculty Search Committee, Member | 2019 - 2019 |
| Postdoctoral Studies Advisory Committee, Member | 2017 - 2018 |
| Financial Aid Committee, Member | 2013 - 2014 |
| UMMC Graduate Student Body Philanthropy Committee, Member | 2013 - 2014 |
Community Service
| Rural Interdisciplinary Case Experience, Participant | 10/2015 - 10/2015 |
| UMMC Project REACH at Davis Magnet School, Volunteer Teacher | 08/2014 - 07/2016 |
| UMMC Discovery U, Volunteer | 03/2014 - 04/2018 |
Other Service
| Journal of Basic and Applied Pharmaceutical Science | 08/2025 - Present |
| NIH DHMI study section | 02/2025 - Present |
| Endocrinology Society’s Research Experiences for Graduate and Medical Students (REGMS) Award Application Reviewer | 2024 - Present |
| Endocrine Society’s Early Career Forum Application Reviewer | 2024 - Present |
| AHA pre-doctoral fellowship recommendations for two students (both awarded) | 08/2023 - Present |
| AHA Predoctoral and Postdoctoral Fellowship Reviewer | 08/2023 - Present |
| Journal Article Reviewer for Biomedicine & Pharmacotherapy | 07/2023 - Present |
| Jornal Article Reviewer for Journal of Physiology-Cell Physiology | 07/2022 - Present |
| Biology of Sex Differences | 05/2022 - Present |
| GWIMS Leadership Development Conference, Participant | 04/2022 - 12/2022 |
| Frontiers in Pharmacology | 03/2022 - Present |
| AHA Hypertension Journal | 02/2022 - Present |
| ACS Project SEED | 2020 - 05/2020 |
| JSU ACS Student Chapter, Faculty Advisor | 2019 - 05/2020 |
| UMMC Graduate Student Body, Secretary/Treasurer | 08/2015 - 05/2016 |
| UMMC Graduate Student Body, Secretary | 08/2014 - 05/2015 |
| Beta Beta Beta JSU Chapter, President | 08/2008 - 07/2010 |
Teaching Experience
| PH723, Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2024-2025 |
| SOM 620, Medicine, Course, Lecturer, The Gastrointestinal System | Fall 2024-2025 |
| CMB 740, Graduate, Lecture, Lecturer, Biochemical Methods | Fall 2023-2024 |
| PH 723, Graduate, Course, Lecturer, Mechanisms of Drug Action | Spring 2023-2024 |
| D 626, Dentistry, Course, Lecturer, Dental Pharmacology | Spring 2023-2024 |
| PH 726, Graduate, Course, Lecturer, Fundamental Pharmacology | Spring 2023-2024 |
| CMB 740, Graduate, Lecture, Lecturer, Biochemical Methods | Fall 2022-2023 |
| CMB 740, Graduate, Lecture, Lecturer, Biochemical Methods | Fall 2021-2022 |
| CMB740, Graduate, Lecture, Lecturer, Biochemical Methods | Fall 2020-2021 - 2020 |
Directed Student Learning
| Dissertation Committee Member, Early Metastatic Dissemination in High-Risk Neuroblastoma Facilitates Divergent Genetic Evolution & Metabolic Reprogramming Advised: Kyle Woodward | 2024 - Present |
| Dissertation Committee Member, Insulin Resistance and Tubular Energy Metabolism During Obesity-Induced Renal Disease Prior to Puberty Advised: Sautan Mandal | 2024 - Present |
| Dissertation Committee Member, The Role M1 Macrophages in Preeclampsia Advised: Marcus Robbins | 2024 - Present |
| Dissertation Committee Member, Endothelial PHD2 Deficiency on Metabolic Reprogramming in Heart Failure Advised: Quinesha Williams | 2024 - Present |
| Directed Individual/Independent Study, Advised: Viraj Patel | 2024 - 2024 |
| Dissertation Committee Member, Adiponectin as a Potential Therapeutic Target for Cardiometabolic Complications in Polycystic Ovary Syndrome Advised: Ahmed Abdelhameed | 2023 - Present |
| Dissertation Committee Member, The Pathological Consequences of Streptococcus pneumoniae Produced Hydrogen Peroxide Advised: Anna Scasny | 2023 - 2024 |
| Dissertation Committee Member, Bisphenols exposure induces bone loss and osteoporosis by binding to and activating the endocannabinoid receptors Advised: Matthew Dubuisson | 2022 - Present |
| Directed Individual/Independent Study, Advised: Ashley Motton | 2022 - 2023 |
| Research Advisor, Advised: Hanna Bynum | 2021 - 2024 |
| Directed Individual/Independent Study, Advised: Sha'kiah Jones | 2021 - 2021 |
Fellows supervised
| UMMC SGSHS, Research Advisor, 1 fellows supervised, Edwards | 05/2020 - Present |