 | Assistant Professor
Office: TRC, Room 407
(601) 815-7983
Email
|
Research interests
The research of the Pantazopoulos lab is focused on identifying the neuropathological correlates of circadian rhythm and sleep dysfunction in major psychoses, which we pursue using a combination of human postmortem and animal model approaches. Our long-term research goal is to develop a foundation of changes in neurocircuitry regulating circadian rhythm abnormalities associated with mood disturbances in several diseases including bipolar disorder and schizophrenia that we can leverage to develop more effective treatments. In addition, we aim to identify basic biological mechanisms that will provide insight into how clock genes regulate neural functions in a brain region specific manner, linked to specific behaviors.
Additional lab projects consist of extracellular matrix abnormalities in schizophrenia, as well as studies focused on sleep designed to elucidate the role of extracellular matrix molecules, including perineuronal nets, in sleep and memory consolidation.
Current funding
NIH R01 Grant: MH125833
Diurnal Molecular Rhythms of the Human Hypothalamus and Involvement in Bipolar Disorder
2021-2025
Role: PI
Department of Defense Grant: W81XWH-20-1-0772
Matrix metalloproteinases in the degeneration of cochlear synapses
Role: Co-Investigator
Baszucki Brain Research Fund: CACNA1C Genotype: Correlation with Brain and Blood Levels of CACNA1C and Treatment Responsiveness
PI: Harry Pantazopoulos
2021-2022
Role: PI
Recent publications
* In the last four years
- Gisabella B, Babu J, Valeri J, Rexrode L, Pantazopoulos H. Sleep and Memory Consolidation Dysfunction in Psychiatric Disorders: Evidence for the Involvement of Extracellular Matrix Molecules. Front Neurosci. 2021 May 14;15:646678. doi: 10.3389/fnins.2021.646678. eCollection 2021.PMID: 34054408
- Pantazopoulos, H., Gisabella, B., Rexrode, L., Benefield, D., Yildiz, E., Seltzer, P., Chelini, G., Reich, A., Ardelt, A., and Berretta, S. 2020. Circadian Rhythms of Perineuronal Net Composition. eNeuro ENEURO 0034-19. PMID: PMC7405073
- Tsilioni, I, Pantazopoulos H., Conti, P., Leeman, S.E., and Theoharides, T.C. IL-38 inhibits microglia inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder-novel treatment. PNAS. 2020 In Press
- Pantazopoulos H., Katsel, P., Haroutunian, V., Chelini, G., Klengel, T. and Berretta, SMolecular Signature of Extracellular Matrix Pathology in Schizophrenia. Eur J Neurosci. 2020 In Press
- Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT. Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease. Neurobiol Dis. 2019 Jun 15;130:104511. doi: 10.1016/j.nbd.2019.104511. [Epub ahead of print] PubMed PMID: 31212068.
- Steullet P, Cabungcal JH, Bukhari SA, Ardelt MI, Pantazopoulos H, Hamati F, Salt TE, Cuenod M, Do KQ, Berretta S. The thalamic reticular nucleus in schizophrenia and bipolar disorder: role of parvalbumin-expressing neuron networks and oxidative stress. Mol Psychiatry. 2018 Oct;23(10):2057-2065. doi: 10.1038/mp.2017.230. Epub 2017 Nov 28. PubMed PMID: 29180672; PubMed Central PMCID: PMC5972042.
- Pantazopoulos H, Gamble K, Stork O, Amir S. Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders. Neural Plast. 2018;2018:5892657. doi: 10.1155/2018/5892657. eCollection 2018. PubMed PMID: 29887881; PubMed Central PMCID: PMC5985072.
- Chelini G, Pantazopoulos H, Durning P, Berretta S. The tetrapartite synapse: a key concept in the pathophysiology of schizophrenia. Eur Psychiatry. 2018 Apr;50:60-69. doi: 10.1016/j.eurpsy.2018.02.003. Epub 2018 Mar 2. Review. PubMed PMID: 29503098; PubMed Central PMCID: PMC5963512.
- Sullivan K, Pantazopoulos H, Liebson E, Woo TW, Baldessarini RJ, Hedreen J, Berretta S. What can we learn about brain donors? Use of clinical information in human postmortem brain research. Handb Clin Neurol. 2018;150:181-196. doi: 10.1016/B978-0-444-63639-3.00014-1. Review. PubMed PMID: 29496141.
- Wells AM, Ridener E, Bourbonais CA, Kim W, Pantazopoulos H, Carroll FI, Kim KS, Cohen BM, Carlezon WA Jr. Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism. J Neurosci. 2017 Aug 9;37(32):7656-7668. doi: 10.1523/JNEUROSCI.0885-17.2017. Epub 2017 Jul 3. PubMed PMID: 28674176; PubMed Central PMCID: PMC5551063.
- Pantazopoulos H, Wiseman JT, Markota M, Ehrenfeld L, Berretta S. Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms. Biol Psychiatry. 2017 Mar 15;81(6):536-547. doi: 10.1016/j.biopsych.2016.04.006. Epub 2016 Apr 16. PubMed PMID: 27259817; PubMed Central PMCID: PMC5065936.
- Dauth S, Grevesse T, Pantazopoulos H, Campbell PH, Maoz BM, Berretta S, Parker KK. Extracellular matrix protein expression is brain region dependent. J Comp Neurol. 2016 May 1;524(7):1309-36. doi: 10.1002/cne.23965. Epub 2016 Feb 1. PubMed PMID: 26780384.
- Pantazopoulos H, Berretta S. In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders. Neural Plast. 2016;2016:9847696. doi: 10.1155/2016/9847696. Epub 2015 Dec 29. Review. PubMed PMID: 26839720; PubMed Central PMCID: PMC4709762.
- Complete list can be accessed at MyNCBI.