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Grants

April 2021

  1. Evaluation of mesenchymal stem cells and their cell reprogramming potential within microsurgical flaps. Abelardo Medina, MD. NIH/NIGMS/UMMC COBRE grant 2020 (P20GM104357)

    Even though it is widely accepted that CD34+ adipose-derived stem cells (ADSCs) are in a “niche” in the adipose stromal vascular fraction (SVF) to provide cells for multiple somatic determinations, there is no conclusive evidence of any local inductive factor or uneven intracellular distribution of fate determinants that trigger an asymmetric division of ADSCs into daughter cells. Numerous authors have demonstrated that the type of surgery, changes in the harvesting techniques, and variation in the culture media composition can alter not only the distribution of cell subsets, but also their basic features, viability, and peripheral functions. In this multifactorial equation, the impact of the non-physiological conditions experienced during the current fat tissue harvesting procedures on the profile of isolated cells and their differentiation capacities remains unknown. In this regard, the current practice for tissue harvesting (abdominoplasty and liposuction procedures) provide specimens that were under considerable time of ischemia and hypoxia along with under the effect of local medications (i.e., epinephrine, lidocaine, sodium bicarbonate, etc.). This modified environment may affect the recruitment, proliferative potential, gene expression and final determination of stem/precursor cells.

March 2021

  1. Chronic Venous Thrombosis: Relief with Adjunctive Catheter-Directed Therapy (C-TARCT) Ajinkya Desai, MD, NIH funded multicenter RCT

    The primary goal of the trial is to evaluate the efficacy of iliac venous stenting in patient who have moderate to severe post-thrombotic syndrome due to chronic iliofemoral DVT. 

February 2021

  1. P20GM104357; (Medina, Abelardo, $ 40,000)

    NIH/NIGMS/UMMC COBRE Grant 2020

    Principal investigator of the project entitled “Evaluation of mesenchymal stem cells and their cell reprogramming potential within microsurgical flaps.”

    Even though it is widely accepted that CD34+ adipose-derived stem cells (ADSCs) are in a “niche” in the adipose stromal vascular fraction (SVF) to provide cells for multiple somatic determinations, there is no conclusive evidence of any local inductive factor or uneven intracellular distribution of fate determinants that trigger an asymmetric division of ADSCs into daughter cells. Numerous authors have demonstrated that the type of surgery, changes in the harvesting techniques, and variation in the culture media composition can alter not only the distribution of cell subsets, but also their basic features, viability, and peripheral functions. In this multifactorial equation, the impact of the non-physiological conditions experienced during the current fat tissue harvesting procedures on the profile of isolated cells and their differentiation capacities remains unknown. In this regard, the current practice for tissue harvesting (abdominoplasty and liposuction procedures) provide specimens that were under considerable time of ischemia and hypoxia along with under the effect of local medications (i.e., epinephrine, lidocaine, sodium bicarbonate, etc.). This modified environment may affect the recruitment, proliferative potential, gene expression and final determination of stem/precursor cells.

  2. P20GM104357; (Medina, Abelardo, $ 40,000)

    NIH/NIGMS/UMMC COBRE grant 2021

    Principal investigator of the project entitled “Evaluation of mesenchymal stem cells and their cell reprogramming potential within microsurgical flaps.”