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Clinical Trials

October 2020

  1. The Program of Randomized Trials to Evaluate Pre-operative Antiseptic Skin Solutions in Orthopaedic Trauma (PREP-IT) Investigators. Effectiveness of Iodophor vs Chlorhexidine Solutions for Surgical Site Infections and Unplanned Reoperations for Patients Who Underwent Fracture Repair: The PREP-IT Master Protocol. JAMA Netw Open. 2020;3(4):e202215. doi:10.1001/jamanetworkopen.2020.2215

    University of Mississippi Medical Center (Jackson, MS): Patrick F. Bergin, George V. Russell, Matthew L. Graves, John Morellato, LaRita C. Jones, Heather K. Champion, Leslie N. Johnson, and Susan Q. Allbritton.

    The PREP-IT master protocol increases efficiency through shared trial infrastructure and study design components. Because prophylactic skin antisepsis is used prior to all surgical procedures and the application, cost, and availability of all study solutions are similar, the results of the PREP-IT trials are poised to inform clinical guidelines and bring about an immediate change in clinical practice.