General: Immunology, cardiovascular and renal physiology
Specific: Immune system dysfunction in the pathogenesis of hypertension, autoimmunity
Measurements of blood pressure in rodents. Flow cytometry techniques including immunophenotyping, apoptosis, proliferation, calcium flux, and cell cycle analyses. Cell culture and cell line cloning including hybridoma production. Basic biochemical and molecular techniques including ELISA, immunoblotting, immunoprecipitation, PCR, cloning, protein expression, and protein purification.
Identifying the role of autoantibody secreting plasma cells in the pathogenesis of hypertension in systemic lupus erythematosus (SLE)
Examining the role of regulatory T cell dysfunction in hypertension and renal injury in SLE