General: Cardiovascular physiology, proteomics
Specific: Inflammatory and fibrotic mechanisms in the pathogenesis of left ventricular remodeling following myocardial infarction, cardiac aging
Matrix metalloproteinase assays, in vivo myocardial injury models (myocardial infarction by coronary artery litigation), murine cardiovascular function analyses, two-dimensional gel electrophoresis, proteomics, histology, immunoblotting, fibroblast tissue culture, macrophage cell physiology assays.
Identifying novel MMP substrates in post-MI tissues
Using omics strategies to identify novel extracellular matrix signaling pathways altered post-MI
Examining the roles of macrophages and fibroblasts in post-MI remodeling of the left ventricle
Determining the role of aging on the remodeling process
Discovering novel biomarkers of adverse left ventricular remodeling