General: Cardiovascular physiology and pharmacology, Cancer pharmacology
Specific: Signal transduction in ischemic heart and heart failure, cardiovascular complications of diabetes, and signaling targets in cancer prevention
In vivo myocardial infarction of animal model by ligation of left anterior descending coronary artery; in vivo heart failure of animal model induced by transverse aortic constriction; ex vivo working heart perfusion system for measuring substrate metabolism with radiolabeling glucose and fatty acid; IonOptix system for measuring contractile functions and transit calcium signaling of isolated cardiomyocytes; in vitro cell culture to determine anti-cancer activity of natural products from herb medicine; and signal transduction is determined by molecular biology approaches.
Sestrin2 signaling in age-related cardiovascular disease
Metabolic regulation in ischemic heart and heart failure
Glucose transport trafficking in the diabetic heart
AMPK signaling pathway in heart disease and cancer biology