I have been trained in molecular biology and have been working in the field of cancer research for over 15 years. My research projects cover microRNAs and long non-coding RNAs (lncRNAs), and their roles in tumorigenesis and drug resistance.
Our studies in last 10 years demonstrate that microRNAs play a critical role in regulation of genes involved in tumor cell growth, invasion, metastasis and drug responsiveness. For example, we have shown that oncogenic miR-21 and tumor suppressive miR-145 are closely associated with the AKT pathway. On the other hand, lncRNA Linc-RoR serves as a strong negative regulator of p53 in response to DNA damage. At the same time, p53 transcriptionally activates several lncRNAs including Linc-RoR and Loc285194. In particular, lncRNA AK023948 directly regulates AKT activity by increasing the stability of PI3K regulatory subunit p85β. Thus, further characterization of AK023948/AKT axis will provide new insight into breast cancer biology and help identify novel cancer biomarkers or therapeutic targets.
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