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  • Parminder J.S. Vig, PhD

    vig.jpg

    Professor, Neurology
    Professor, Biochemistry
    Associate Professor, Neurobiology and Anatomical Sciences
    Chief, Neuroscience Research Division
    Office: ND244
    Phone: (601) 984-5513
    Lab: N323/327/329; (601) 984-5508
    Fax: (601) 984-6626
    E-mail: pvig@umc.edu

    Education

    • BSc (Hons)  - Panjab University, Chandigarh, India, 1981, Biophysics
    • MSc (Hons)  - Panjab University, Chandigarh, India, 1982, Biophysics
    • PhD - Postgraduate Institute of Medical Education and Research, Chandigarh, India, 1988, Biochemistry
    • Postdoctoral Fellow - Department of Neurology, UMMC, Jackson, MS, 1989-1992
    • MSc, University of Phoenix, Arizona, 2003, Computer Information Systems

    Teaching responsibilities

    • Section Leader (Cerebellum) for Foundations of Neuroscience
    • Lecture for Biochemistry Methods
    • Lecture for Cellular Biochemistry
    • Lecture for Statistical module, Neuroscience

    Research interests

    • Assessing the role of calcium signaling and trophic molecules in the pathogenesis of dominant cerebellar ataxias and other neurodegenerative diseases using cell culture systems and genetically modified animal models.
    • Drug or therapeutic peptide delivery to the brain using innovative delivery systems.
    • Understanding the mechanisms of West Nile virus induced neuropathy in cell culture models.

    Research program

    • vig 1x.jpgFor the past several years, the major focus of the lab was to understand the molecular mechansims of nerve cell degeneration in dominantly inherited cerebellar ataxias in order to develop treatment strategies for human patients with SCA1 or other ataxias. The current studies are looking at alterations in glia-neuron crosstalk and to determine if abnormal interactions between Bergmann glia and Purkinje cells affect Purkinje cell differentiation and function in the cerebellum. Students joining the lab learn different techniques from basic histology, immunohistochemistry and protein biochemistry to molecular biology methodologies like RT-PCR and gene-array analysis. Both in vitro cell lines and slice cultures and in vivo mouse models are being used. 
    • Based on the knowledge gained using in vitro and in vivo models of SCA1, in collaboration with Drs. Raucher and Bidwell, novel elastin-like polypeptide (ELP) based therapeutic peptides (TPs) have been designed and being tested. 
    • vig 2x.jpgThe lab is collaborating with Dr. Bai at University of Southern Mississippi and Drs. Leis and Stokic at Methodist Rehab Center, to study the neurodegenerative mechanisms of neuro-invasive form of West Nile infection. The long-term goal of this project is to determine the neuro-pathologic basis of WNV infection with a hope to develop specific treatments that will have a broader impact, and help design innovative strategies to treat WNV as well as other forms of neuro-invasive viral infections.

    Current funding

    • Wilson Foundation (Methodist Rehab Center). Contractual Research Agreement, Glial Response to West Nile Infection Mediated Neurodegeneration. Vig (PI)  2013-15
    • Wilson Foundation (Methodist Rehab Center). Contractual Research Agreement, Neuropathologic basis of WNV infection: Mechanisms and treatment. Vig (PI) 2014-17
    • Cure Ataxia.org (Philanthropy): Ataxia Research at UMMC. Vig (PI)  2010-open

    Selected publications

    Reviews, chapters and books 

    • Vig PJS, Paliwal VK and Nath R:  A comparative study of  direct current plasma atomic emission spectrometry and atomic absorption spectrophotometry for biological monitoring of trace metals.  In: Dillon HK, Ho MH, eds, Biological Monitoring of Exposure to Chemicals: Metals. New York: John Wiley, 1991: 163-171.
    • Desaiah D, Subramony SH, Vig PJS and Currier RD: Phosphoinositide second messenger system in human OPCA and the mouse model. In: Eds. Harding A, Deufel T, Advances in Neurology, vol. 61, New York: Raven Press 1993: 167-173.
    • Subramony SH, Vig PJS. Clinical aspects of SCA-1. In:  Wells RD, Warren ST, eds, Genetic instabilities and hereditary neurological diseases. San Diego: Academic Press, pp. 231-239 (1998).
    • Subramony SH, McDaniel DO, Smith SC, Vig PJS (1998) Spinocerebellar ataxia type 3  in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle. 1998-2007. Available at: http://www.genetests.org.
    • Fratkin JD, Vig PJS (2012). Neuropathology of degenerative ataxias. Handb Clin Neurol, 103:111-125.
    • Subramony SH, Vig PJS.  Spinocerebellar ataxia 3 In:  The Cerebellum and its Disorders.  Eds: Manto M-U, Pandolofo M, Cambridge Univ. Press, pp. 428-439 (2002)
    • McGowan, JWD., Bidwell, GL III, and Vig, PJS.  Challenges and New Strategies for Therapeutic Peptide Delivery to the Central Nervous System.  Therapeutic Delivery, 6(7):841-53, 2015.

    Peer-reviewed papers

    • Vig PJS, Bhatia M, Gill KD and Nath R: Cadmium inhibits brain calmodulin activity in monkey brain. J Appl Toxicol 1989; 9:313-316.
    • Vig PJS, Mehrotra BD and Desaiah D: Chlordecone interaction of calmodulin binding with phosphodiesterase. J Appl Toxicol 1990; 10:55-57
    • Vig PJS and Nath R: In Vivo effects of cadmium on calmodulin and calmodulin regulated enzymes in rat brain. Biochemistry International 1991; 23:927-934.
    • Vig PJS, Yallapragada PR, Kodavanti PRS and Desaiah D: Modulation of calmodulin properties by amiodarone and its major metabolite desethylamiodarone. Pharmacol Toxicol 1991; 68:26-33.
    • Vig PJS, Yallapragada PR, Trottman CH, Mehrotra BD and Desaiah D: Effect of organochlorine and organotin compounds on active conformation of calmodulin. J Environ Sci Hlth A1991; 26:521-534.
    • Vig PJS, Ravi K and Nath R: Interaction of metals with brain calmodulin purified from normal and cadmium exposed rats. Drug Chem Toxicol 1991; 14:207-218.
    • Vig PJS and Desaiah D: Modulation of protein kinase C activity by amiodarone and desethylamiodarone. NeuroToxicology 1991; 12:595-602.
    • Pentyala SN, Vig PJS, Sekhon BS and Desaiah D: Effect of carbon tetrachloride on inositol 1,4,5-trisphosphate dependent and independent regulation of rat brain microsomal Ca2+-fluxes. Cellular Signaling 1994; 6: 561-567.
    • Vig PJS, Pentyala SN, Chetty CS, Rajanna B and Desaiah D: Lead alters inositol polyphosphate receptor activities: Protection by ATP. Pharmacology and Toxicology 1994; 75:17-22.
    •  Rao JV, Desaiah D, Vig PJS, Venkateswarlu Y, Marine biomolecules inhibit rat brain nitric oxide synthase. Toxicol.  129: 103-112 (1998)
    • Pala I, Srinivasan A, Vig P J S and Desaiah D. Modulation of calmodulin and protein kinase C activities by penicillium mycotoxins. Intl. J. Toxicology 18 :91-96 (1999).
    • Pande M, Cameron JA, Vig PJS, Ali SF, D Desaiah. Inhibition of calcium ATPase by phencyclidine in rat brain. Mol Cell Biochem 194:(1-2) 173-177 (1999).
    • Desaiah D, Vig PJS, Subramony SH and Currier RD: Inositol 1,4,5-trisphosphate receptors and protein kinase C in olivopontocerebellar atrophy. Brain Res 1991; 552:36-40.
    • Vig PJS, Subramony SH, Currier RD and Desaiah D: Inositol 1,4,5-trisphosphate metabolism in the cerebella of Lurcher mutant mice and patients with olivopontocerebellar atrophy. J Neurological Sci 1992; 110:139-143.
    • Vig PJS, Fratkin JD, Desaiah D, Currier RD, Subramony SH. Decreased parvalbumin immunoreactivity in surviving Purkinje cells of patients with spinocerebellar ataxia - 1. Neurology 1996; 47: 249-253.
    • Paulson HL, Perez MK, Trottier Y, Trojanowski JQ, Subramony SH, Das SS, Vig P, Mandel J-L, Fischbeck KH, Pittman RN. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron 1997;19: 333-344
    • Vig, PJS, Subramony SH, Burright EN, Fratkin JD, McDaniel DO, Desaiah D, Qin Z: Reduced immunoreactivity to calcium-binding proteins in Purkinje cells precedes onset of ataxia in spinocerebellar ataxia-1. Neurology 50(1): 106-113 (1998)
    • Vig, PJS, Subramony SH, Burright EN, Fratkin JD, McDaniel DO, Desaiah D, Qin Z: Reduced immunoreactivity to calcium-binding proteins in Purkinje cells precedes onset of ataxia in spinocerebellar ataxia-1. Neurology 50(1): 106-113 (1998)
    • Vig PJS, McDaniel DO, Subramony S H, Qin Z. The effects of calbindin D-28K and parvalbumin antisense oligonucleotides on the survival of cultured Purkinje cells. Res Commun Mol Pathol Pharmacol. 103: (3) 249-259 (1999)
    • Subramony SH, Vig PJS, McDaniel DO. Dominantly inherited ataxias. Semin Neurol 19: (4) 419-425 (1999)
    • Vig P J S, Subramony SH, Qin Z, McDaniel DO, Fratkin J. Relationship between ataxin-1 nuclear inclusions and Purkinje cell specific proteins in SCA-1 transgenic mice. J Neurol Sci. 15; 174: (2) 100-110 (2000)
    • Vig PJS, Subramony SH, McDaniel DO. Calcium homeostasis and spinocerebellar ataxia-1 (SCA-1) Brain Res. Bull. 56, 221-225 (2001)
    • Akifumi Mizutani, Lei Wang, Harini Rajan, PJS Vig, William A Alaynick, Joshua P Thaler and Chih-Cheng Tsai. BOAT, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1. EMBO J. 24: 3339-3351 (2005).
    • P J S Vig, S.H. Subramony, D R D'Souza, J. Wei, M E Lopez. Intranasal administration of IGF-I improves behavior and Purkinje cell pathology in SCA1 mice. Brain Res. Bull. 69:574-579, (2006).
    • D.R. D'Souza, J. Wei, M. E. Lopez, J.D. Hebert, S.H. Subramony, P.J.S.Vig Tissue transglutaminase crosslinks ataxin-I: Possible role in SCA1 pathogenesis. Neuroscience Letters 409: 4-9 (2006)
    • Vig, PJS, Shao, Q, Lopez, ME, (2009). Glial response to polyglutamine-mediated stress. Biosci. Hypotheses 2, 148-150.
    • Vig PJS (2009) S100B - A common connection between depression and cerebellar disorders. . Biosci. Hypotheses 2, 343 -344.
    • PJS Vig, Q Shao, SH Subramony, M E Lopez and E Safaya, (2009) Bergmann Glial S100B activates myo-inositol monophosphatase 1 and co-localizes to Purkinje Cell Vacuoles in SCA1 Transgenic Mice. Cerebellum 8, 231- 244.
    • Hearst S, Lopez M, Shao Q, Liu Y, Vig PJ (2010). Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation . J. Neurochem 1143 Aug (3):706-716
    • Vig PJS, Wei J, Shao Q, Lopez ME, Halperin R, Gerber J (2012). Suppression of Calbindin-D28k Expression Exacerbates SCA1 Phenotype in a Disease Mouse Model. Cerebellum, Sep;11(3):718-732
    • PJS Vig (2013) Editorial: Astroglial and Protein Aggregation Diseases. Journal of Neurology & Translational Neuroscience 1:1013
    • Hearst SM, Walker LR, Shao Q, Lopez M, Raucher D, Vig PJS (2011). The Design and Delivery of a Thermally Responsive Peptide to Inhibit S100B Mediated Neurodegeneration. Neuroscience 2011 Dec 1;197:369-80
    • Hearst SM, Shao Q, Lopez M, Raucher D, Vig PJS (2014). Focused Cerebellar Laser Light Induced Hyperthermia Improves Symptoms and Pathology of Polyglutamine Disease SCA1 in a Mouse Model. Cerebellum: 13(5):596-606
    • Hearst SM, Shao Q, Lopez M, Raucher D, Vig PJS (2014). The design and delivery of a PKA inhibitory polypeptide to treat SCA1. J Neurochem; 131(1):101-14 

    Patents

    • Vig PJS and Hearst S. “Therapeutic use of dopamine D2 receptor agonists for treating SCA1” USPTO Full Utility Patent filled; March 2010; under review.
    • Vig PJS, Raucher D and Hearst S. “Composition and methods for targeted delivery of a therapeutic compound to the brain or spinal cord of a subject for treatment of neurodegenerative diseases. USPTO Full Utility Patent under review

    Previous academic appointments

    • 1992-94: Instructor, Neurology, UMMC
    • 1994-99: Assistant Professor, Neurology, UMMC
    • 1999-2004: Associate Professor, Neurology, UMMC
    • 2005-Present: Professor, Neurology, UMMC
      Adjunct Appointment: Professor, Biochemistry, UMMC
    • 2012-Present: Chief of Neuroscience Research Division, Neurology, UMMC

    Accomplishments and honors

    • 1979: University Medal for Ist Year in BSc (Honors) Biophysics.
    • 1980: University Medal for 2nd Year in BSc (Honors) Biophysics.
    • 1981: University Medal for 3rd Year in BSc (Honors) Biophysics.
    • 1982: University Gold Medal in MSc (Honors) Biophysics.
    • 1989: Superior Poster Presentation Award: South Central Chapter, SOT, Oxford, MS.
    • 1991: Superior Poster Presentation Award: South Central Chapter, SOT, Oxford, MS.
    • 1995: Certificate of Appreciation for excellence in research mentoring, Sigma Xi, UMMC Chapter.
    • 1996: Certificate of Appreciation for excellence in research mentoring, Sigma Xi, UMMC Chapter.
    • 1999: Honorable Mention: 1999 Ross Barnett Reservoir Photography Contest.
    • 2003: Excellence in Research Award, Silver Medal, UMMC
    • 2011: Excellence in Research Award, Gold Medal, UMMC