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  • Romain Harmancey, PhD

    Harmancey 100x150...

    Assistant Professor
    Office: G563
    Lab: G564
    Office phone: (601) 815-0196
    Lab phone: (601) 815-0197
    E-mail: rharmancey@umc.edu

    Areas of expertise

    • General: Cardiovascular physiology, metabolism
    • Specific: Myocardial metabolic and structural remodeling in obesity and diabetes; Diabetic cardiomyopathy

    Research methods

    Our laboratory utilizes genetic engineering and dietary manipulations in rodents to investigate the molecular bases of cardiometabolic diseases. Metabolic fluxes and contractile function are assessed simultaneously in the isolated heart perfused in the working mode. Molecular signaling pathways are further interrogated in myocyte cell lines and in primary cultures of isolated cardiac myocytes using molecular cloning and transfection methods followed by transcriptome analysis and immunoblotting.

    Current projects

    • Mechanisms of glucose and insulin-mediated gene regulation in the heart.
    • Effects of myocardial insulin resistance on cardiac adaptation to hemodynamic and ischemic stress.
    • Role of the mitochondrial uncoupling protein 3 in the control of substrate selection for energy provision of the heart.