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  • Kimberly L. Simpson, PhD

    Simpson, KimberlyAssociate Professor
    Department of Neurobiology and Anatomical Sciences
    Office: R710
    Phone: (601) 984-5491
    Lab: R711; Phone: (601) 984-5056
    Fax: (601) 984-1655
    E-mail: ksimpson@umc.edu


    • BS - Biology, Ursinus College, Collegeville, PA, 1991
    • PhD - Neuroscience, Medical College of PA-Hahnemann University, Philadelphia, PA, 1998

    Major Research Interests

    • Functional Organization of the Locus Coeruleus - Norepinephrine System and Dorsal Raphe - Serotonergic System.
    • The Influence of Antidepressant Drugs on the Developing Nervous System.

    Selected Publications

    • Schneider, J. S., Pope, A., Simpson, K., Taggart, J., Smith, M. G., and DiStefano, L. (1992) Recovery from experimental Parkinsonism in primates with GM1 ganglioside treatment. Science 256:843-846.
    • Simpson, K.L., Altman, D.W., Wang, L., Kirifides, M., Lin, R.C.S., and Waterhouse, B.D. (1997) Lateralization and functional organization of the locus coeruleus projection to the trigeminal somatosensory pathway in rat. J. Comp. Neurol. 385:135-147.
    • Waterhouse, B.D., Devilbiss, D., Fleischer, D., Sessler, F.M., and Simpson, K.L. (1998) New perspectives on the functional organization and postsynaptic influences of the locus deruleus efferent projection system. Adv. Pharmacol. 42:749-754.
    • Simpson, K.L., Fisher, T.M., Lin, R.C.S., and Waterhouse, B.D. (1998) Projection patterns from the raphe nuclear complex to the ependymal wall of the ventricular system in the rat. J. Comp. Neurol. 399:61-72.
    • Simpson, K.L., Waterhouse, B.D., and Lin, R.C.S. (1999) Origin, distribution, and morphology of galaninergic fibers in the rodent trigeminal system. J. Comp. Neurol. 411:524-534.
    • Kirfides, M.L., Simpson, K.L., Lin, R.C., and Waterhouse, B.D. (2001) Topographic organization and neurochemical identity of dorsal raphe neurons that project to the trigeminal somatosensory pathway in the rat. J. Comp. Neurol. 435:325-340.
    • Von Lubitz, D.K., Simpson, K.L., and Lin R.C. (2001) Right thing at a wrong time? Adensosine A3 receptors and cerebroprotection in stroke. Ann. N.Y. Acad. Sci. 939:85-96.
    • Simpson, K. L. and Lin, R. C. S. (2001) Cellular and Molecular Mechanisms of Ischemic Tolerance. In R. Lin (ed.) New Concepts in Cerebral Ischemia (CRC Press, New York) pp. 263-306.
    • Simpson, K. L., Waterhouse, B. D., and Lin, R. C. S. (2003) Differential Expression of Nitric Oxide in Serotonergic Projection Neurons: Neurochemical Identification of Dorsal Raphe Inputs to Rodent Trigeminal Somatosensory Targets. J. Comp. Neurol. 466:495-512.
    • Simpson, K. L. and Sweazey, R. D. (2006) Olfaction and Taste. In Haines, D. E. (ed.) Fundamental Neuroscience, third ed. Churchill Livingstone pp.367-378.
    • Simpson KL, Waterhouse BD, Lin RCS. (2006) Characterization of Neurochemically Specific Projections from the Locus Coeruleus with respect to Somatosensory-related Barrels. Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 288:166-73.
    • Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RCS, Paul IA. (2006) Neonatal Antidepressant Exposure has Lasting Effects on Behavior and Serotonin Circuitry. Neuropsychopharmacology 31:47-57.
    • Simpson, K. L. and Lin, R. C. S. (2007) Neuroanatomical and Chemical Organization of the Locus Coeruleus. In G. Ordway, M. Schwartz, and A. Frazer, (Eds.) Brain Norepinephrine: Neurobiology and Therapeutics. Cambridge University Press, pp 9-52.
    • Simpson KL, Wang Y, Lin RCS. (2008) Patterns of Convergence in Rat Zona Incerta from the Trigeminal Nuclear Complex: A Light and Electron Microscopic Study. J. Comp. Neurol. 507:1521-1541.
    • DeVillers-Sidani E, Simpson KL, Lu Y-F, Lin RC, Merzenich MM. (2008) Manipulating Critical Period Closure across Different Sectors of the Primary Auditory Cortex. Nature Neuroscience 11:957-965.
    • Fan L-W, Chen R-F, Mitchell HJ, Lin RCS, Simpson KL, Rhodes PG, Cai Z. (2008) α-Phenyl-n-tert-butyl-nitrone Attenuates Lipopolysaccharide-Induced Brain Injury and Improves Neurological Reflexes and Early Sensorimotor Behavioral Performance in Juvenile Rats. Journal of Neuroscience Research 86:3536-3547.
    • Devillars-Sidani E, Alzghoul L, Zhou X, Simpson KL, Lin RC, Merzenich MM (2010) Recovery of functional and structural age-related changes in the rat primary auditory cortex with operant conditioning. Proc. Natl. Acad. Sci. USA 107:13900-5.
    • Lu Y, Simpson KL, Weaver KJ, and Lin RC (2010) Coexpression of serotonin and nitric oxide in the raphe complex: cortical versus subcortical circuit. Anat. Rec. 293:1954-65.
    • Weaver KJ, Paul IA, Lin RC, and Simpson KL (2010) Neonatal exposure to citalopram selectively alters the expression of the serotonin transporter in the hippocampus: Dose-dependent effects. Anat. Rec. 293:1920-32.
    • Fan LW, Tien LT, Zheng B, Pang Y, Lin RC, Simpson KL, Ma T, Rhodes PG, and Cai Z. (2011) Dopaminergic neuronal injury in the adult rat brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicity Brain Behav. Immun. 25:286-297.