Primary Practice Location:University Hospital 2500 N. State St. Jackson, MS 39216
Appointments: (888) 815-2005
Areas of Practice: Children's Endocrinology
After finishing my Medical School and Pediatric Residency in Turkey, in 1993, I had come to US to be trained in Pediatric Endocrinology, followed by Molecular Genetics. In 1999, I had returned to Turkey as a faculty member and continued until 2016 when I joined UMMC. Overall, in my career, besides functioning as a clinician and professor, I have been an active translational researcher. My research has focused on the question of how the hypothalamo-pituitary–gonadal axis is governed, more specifically, what starts puberty, which remains to date to be an enigma. In this research, we have previously discovered the essential roles of neurokinin B and its receptor (Topaloglu et al Nat Genet 2009) as well as of Kisspeptin (Topaloglu et al N Engl J Med 2012) in human puberty and reproduction. These findings greatly helped the seminal characterization of the “GnRH pulse generator” as the KNDy neurons of the arcuate nucleus in the hypothalamus. However, my eventual aim is to gain full insight into the central regulation of this axis. Here at UMMC, I enjoy being a Pediatric Endocrinologist and a hands-on teacher for medical students and residents. Besides, I have a developing molecular/cellular lab to achieve my research ambitions.