• Guyton-Coleman-Model_sm_2147493681_2147483650

    Integrating Systems to Understand Whole-Body Physiology

    Controlled experiments confirm hypotheses: miniscule models of how some aspect of the body works. But changes in one system propagate to other systems, making it difficult to assess the importance of a mechanism to whole-body physiology. Mathematical models of confirmed hypotheses can be tied together to create integrative models of greater complexity in which effects propagate from system to system. This allows us to better understand how dysfunction in one system can lead to problems in...