Programs

Cancer Molecular Biology

Cancer Molecular Biology program members study the basic science that is behind our ability to develop safer and more effective cancer treatments.

Program members conduct basic and translational research and commonly use molecular, biological, genetic and pharmacologic tools to perform analysis of pathways intrinsic to cancer therapeutics, with emphasis on angiogenesis, receptor-mediated signaling, apoptosis, epigenetics and transcriptional interference.

Work progresses through three divisions:

Cancer genetics, headed by Dr. Yin-Yuan Mo, seeks to understand how genetic alterations affect cancer initiation, progression and metastasis. Program focuses on:
  • Determining how epigenetic regulation influences cancer initiation, progression and metastasis
  • Understanding how inherited genetic variation influences predisposition to cancer
  • Determining the causes of genetic instability, encompassing the source and causes of mutations along with how cells try to repair DNA damage to avoid mutations.
  • Scientific members
    • Yin-Yuan Mo
    • Joseph Maher
    • Kristine Willett

Molecular cancer therapeutics, headed by Dr. Radhika Pochampally, seeks to develop safer and more effective cancer treatments. The program’s scientific goals include:

  • Identifying, studying and validating unique molecular targets that may not be high priorities for the pharmaceutical industry.
  • Studying innovative cancer therapy approaches that affect survival of tumor cells by novel mechanisms
  • Investigating molecular and pharmacologic mechanisms of drug action and drug delivery as well as tumor cells drug resistance.
  • Collaborating with the Drug Discovery Core to screen and identify novel natural small-molecule inhibitors and understanding the mechanisms of these drugs on processes required for the proliferation and survival of cancer cells.
  • Developing new ways to deliver cancer-fighting drugs directly to a tumor.
  • Providing proof of concept for early phase clinical trials for cancer therapies.
  • Scientific members
    • Radhika Pochampally
    • Gene Bidwell
    • Drazen Raucher
    • Yu-Dong Zhou
  • Members
    • Asok Dasmahapatra
    • Seongbong Jo
    • Sharon Lobert
    • Dale Nagle
    • Eddie Perkins

Tumor cell biology, led by Dr. Azeddine Atfi, seeks to understand the molecular and cellular processes that cause cancer and cancer progression. The program’s scientific goals include:

  • Understanding signal transduction pathways.
  • Understanding DNA repair mechanisms.
  • Understanding drug resistance
  • Understanding cancer immunology
  • Understanding cell to cell interactions
  • Discovering processes that may prevent cancer from developing in high risk patients.
  • Scientific members
    • Azeddine Atfi
  • Members
    • Ingrid Espinoza
    • Christian Gomez
    • Damian Romero
    • Keli Xu
    • Xinchun Zhou