• Current Obesity Research

      Recently published scientific articles and book chapters on obesity-related studies by UMMC faculty include:

    1. Alexander BT, Dasinger JH, Intapad S. Fetal programming and CV pathology. Comprehensive Physiology. 2015;5: 997‐1025
    2. Bassi M, Werner IF, Zoccal DB, Menani JV, Columbari E, Hall JE, da Silva AA, do Carmo JM, Columbari DSA. Control of respiratory and cardiovascular functions by leptin. Life Sciences. 2015;125:25-31.PMCID: PMC4355938
    3. Bassi M, Werner IF, Zoccal DB, Menani JV, Columbari E, Hall JE, da Silva AA, do Carmo JM, Columbari DSA. Control of respiratory and cardiovascular functions by leptin. Life Sciences 2015 Jan 30. pii: S0024-3205(15)00060-0. doi: 10.1016/j.lfs.2015.01.019
    4. Correa WG, Durand MT, Becari C, Tezini GC, do Carmo JM, de Oliveira M, Prado CM, Fazn R Jr, Salgado HC. Pyridostigmine prevents haemodynamic alterations but does not affect their nycthemeral oscillations in infarcted mice. Auton Neurosci. 2015; 187:50-5
    5. da Silva AA, Spradley FT, Granger JP, Hall JE, do Carmo JM. Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling. J Neurophysiol. 2015 Feb 25;
    6. da Silva AA, do Carmo JM, Wang Z, Hall JE. Leptin, autonomic nervous system, and hypertension. In: Leptin: Regulation and clinical applications. Ed. Sam Dagogo-Jack. Springer, 2015. Pp 175-188
    7. deShazo RD, Hall JE, Skipworth LB.  Obesity Bias, Medical Technology, and the Hormonal Hypothesis: Should We Stop Demonizing Fat People? Am J Med. 2015;128:456-460.
    8. do Carmo JM, da Silva AA, Hall JE. Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and netabolic functions in spontaneously hypertensive rats. J Hypertens. 2015; Feb 7. [Epub ahead of print] PMID: 25668357
    9. George EM, Liu H, Robinson GG, Mahdi F, Perkins E, Bidwell GL 3rd. Growth factor purification and delivery systems (PADS) for therapeutic angiogenesis. Vasc Cell. 2015; 7(1):1.
    10. George EM, Granger JP.  Potential therapeutic value of the heme oxygenase system in preeclampsia.  Pregnancy Hypertens. 2015 Jan;5(1):139
    11. Gillis EE, Williams JM, Garrett MR, Mooney JN, and Sasser JM.  The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia.  Am J Physiol Regul Integr Comp Physiol. 2015 Apr 22
    12. Hall JE, do Carmo JM, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohormonal and renal mechanisms. Circulation Res. 2015;116:991-1006.
    13. Hall ME, Yanes LL, Long RC, Koch CA. Hormones of the Cardiovascular System, in www.thyroidmanager.org, February 2, 2015, Published by ENDOCRINE EDUCATION Inc, South Dartmouth, MA 02748, February,2015
    14. Henegar JR, Zhang Z, Hata C, Narciso I, Hall ME,Hall JE. Catheter-based radiofrequency renal denervation: location effects on renal norepinephrine. Am J Hypertens. 2015; 2015 Jan 8. pii: hpu258. [Epub ahead of print]
    15. Horton WB, Taylor JS, Ragland TJ, Subauste AR. Diabetic muscle infarction: A systematic review. BMJ Open Diabetes Res Care. 2015;3:3000082. PMCID: PMC4410119
    16. Iwano H, Kamimura D, Fox E, Hall M, Vlachos P, Little WC. Altered Spatial Distribution of the Diastolic Left Ventricular Pressure Difference in Heart Failure. J Am Soc Echocardiogr.  2015, [Epub ahead of print]
    17. Maranon R, Lima R, Spradley FT, do Carmo JM, Zhang H, Smith A, Bui BE, Thomas RL, Moulana M, Hall JE, Granger JP, Reckelhoff JF. Roles of the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats. Am J Physiol Regu Integr Comp Physiol. 2015
    18. McPherson K, Cornelius D, Thomas D, Taylor L, Spires D, Johnson A, Lamarca B, Garrett MR, Williams JM. Early development of glomerular injury in Dahl salt-sensitive rats with metabolic syndrome independent of diabetes and hypertension. FASEB J. 2015;29:964.8.
    19. Mittwede PN, Bergin PF, Clemmer JS, Xiang L. Obesity, malnutrition, and the response to critical illness. Crit Care Med. 2015. In press
    20. Mittwede PN, Xiang L, Lu S, Clemmer JS, Hester RL. Oxidative stress contributes to orthopedic trauma-induced acute kidney injury in obese rats. Am J Physiol Renal Physiol. 2015;308:F157-63. PMCID: PMC4338927
    21. Palei AC, Spradley FT, Granger JP. Chronic hyperleptinemia results in the development of hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2015;308: R855-R861. PMCID: PMC4436978
    22. Palei AC, Spradley FT, Granger JP. Role of nitric oxide on blood pressure regulation in pregnant rats on a high-fat diet (HFD). Pregnancy Hypertens. 2015;5(1):7. PMID: 25787364
    23. Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira AS, Burke SD, George E, Granger J, Ananth Karumanchi S.   Ouabain inhibits placental sFlt1 production by repressing HSP27 dependent HIF-1α pathway.  Pregnancy Hypertens. 2015 Jan;5(1):13
    24. Ressler IB, Grayson BE, Ulrich-Lai YM, Seeley RJ. Diet-Induced Obesity Exacerbates Metabolic and Behavioral Effects of Polycystic Ovary Syndrome in a Rodent Model.  Am J Physiol Endocrinol Metab. June 2015 (in press)
    25. Sasser JM, Brinson KN, Tipton A, Sullivan JC.  Blood pressure, sex and female sex hormones influence renal inner medullary nitric oxide synthase activity and expression in Spontaneously Hypertensive Rats. Journal of the American Heart Association, 4(4). pii: e001738, 2015
    26. Spires D, Taylor L, McPherson K, Williams JM. Effects of endothelin-A receptor and angiotensin converting enzyme inhibition on the development of progressive proteinuria in diabetic Dahl SS rats with pre-existing renal disease. FASEB J. 2015;29:959.8
    27. Spradley FT, EM George, AC. Palei, JP Warrington and JP. Granger 2015 Preeclampsia: Angiogenic factors, blood pressure, and the kidney. In: Chronic Kidney Disease and Hypertension. Springer New York Copyright 2015. DOI 10.1007/978-1-4939-1982-6. Print ISBN 978-1-4939-1981-9.
    28. Spradley FT, Palei AC, Granger JP. Enhanced angiogenic balance and vasorelaxation during pregnancy in obese MC4R-deficient rats. Pregnancy Hypertens. 2015;5(1):9.
    29. Taylor L, Fizer B, McPherson K, Williams JM. The effects of atorvastatin on the progression of metabolic syndrome associated kidney disease. FASEB J. 2015;29:964.4.
    30. Xiang L, Mittwede PN, Clemmer JS. Glucose homeostasis and cardiovascular alterations in diabetes. Compr Physiol. 2015. In press
    31. Yabluchanskiy A, Ma Y, Deleon-Pennell KY, Altara R, Halade GV, Voorhees AP, Nguyen NT, Jin YF, Winniford MD, Hall ME, Han HC, Lindsey ML.  Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization.  J Gerontol A Biol Sci Med.   2015, [Epub ahead of print]
    32. Ashpole NM, Warrington JP, Mitschelen MC, Yan H, Sosnowska D, Gautam T, Farley JA, Csiszar A, Ungvari Z, Sonntag WE. Systemic influences contribute to prolonged microvascular rarefaction following brain irradiation: A role for endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2014;307:H858-68. PMCID: PMC4166745
    33. Baker RC, Nikitina Y, Subauste AR. Analysis of adipose lipid using mass spectrometry. Methods Enzymol.  2014;538:89-105. PMID: 24529435
    34. Bassi M, Furuya WI, Menani JV, Colombari DS, do Carmo JM, daSilva AA, Hall JE, Moreira TS, Wenker IC, Mulkey DK, Colombari E.  Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob/ob) mice. Acta Physiol(Oxf). 2014; 211:240-248.
    35. Bassi M, Nakamura NB, Furuya WI, Colombari DS, Menani JV, do Carmo JM, da Silva AA, Hall JE, Colombari E. Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function. Acta Physiol (Oxf). 2014 Sep10
    36. Bassi M, Furuya WI, Menani JV, Colombari DS, do Carmo JM, da Silva AA, Hall JE, Moreira TS, Wenker IC, Mulkey DK, Colombari E. Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob/ob) mice. Acta Physiol (Oxf). 2014 May;211(1):240-8.
    37. Bergin PF, Knelp C, Pierce C, Hendrix ST, Porter SE, Graves ML,Russell GV. Modifier 22 for acetabular fractures in morbidly obese patients: does it affect reimbursement? Clin Orthop Relat Res. 2014 Apr 29.
    38. Bidwell GL 3rd, George EM. Maternally sequestered therapeutic polypeptides - a new approach for the management of preeclampsia. Front Pharmacol. 2014;5:201.
    39. Chade AR, Stewart NJ, Peavy PR. Disparate effects of single endothelin A and B receptor blocker therapy on the progression of renal injury in advanced renovascular disease. Kidney Int.  2014; 85:833-844. PMCID: PMC3972340
    40. Chinthalapudi K, Rangarajan ES, Patil DN, George EM, Brown DT, Izard T. Lipid binding promotes oligomerization and focal adhesion activity of vinculin. J Cell Biol. 2014; 207:643-56.
    41. Clemmer JS, Xiang L, Lu S, Mittwede PN, Hester RL. β2-adrenergic regulation of stress hyperglycemia following hemorrhage in the obese Zucker rat. Physiol Rep. 2014;2(12). PMCID: PMC4332203
    42. de Castro Brás LE, Cates C, DeLeon-Pennell KY, Ma Y, Halade GV,Yabluchanskiy A, Fields GB, Weintraub ST, Lindsey ML. Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the post-myocardial infarction left ventricle. Antioxid Redox Signal. 2014 Feb 19.
    43. da Silva AA, do Carmo JM, Wang Z, Hall JE.  The brain melanocortin system, sympathetic control, and obesity hypertension.  Physiology.  2014;29:196-202.  PMID:24789984
    44. da Silva AA, do Carmo JM, Wang Z, Hall JE. The brain melanocortin system, sympathetic control, and obesity hypertension. Physiology (Bethesda). 2014 May;29(3):196-202.
    45. Dasinger JH, Intapad S, Alexander BT. Chapter 61, "Placental insufficiency: The impact on cardiovascular health in the mother and her offspring across the lifespan," Book: Pathophysiology and Pharmacotherapy of Cardiovascular Disease, Editors: Jagadeesh, Balakumar, and Maung, Springer Healthcare, Adis Books, Auckland, New Zealand.
    46. do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE. Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1438-47.
    47. Dreisbach AW, Smith SV, Kyle PB, Ramaiah M, Amenuke M, Garrett MR, Lirette ST, Griswold ME, Roman RJ. Urinary CYP eicosanoid excretion correlates with glomerular filtration in African-Americans with chronic kidney disease. Prostaglandins Other Lipid Mediat. 2014;113-115:45-51. PMCID: PMC4396182
    48. Durand MT, Becari C, de Oliveira M, do Carmo JM, Silva CA, Prado CM, Fazan R Jr, Salgado HC. Pyridostigmine restores cardiac autonomic balance after small myocardial infarction in mice. PLoS One. 2014;9(8):e104476.
    49. Fülöp T, Alemu B, Dossabhoy NR, Bain JH, Pruett DE, Szombathelyi A, Dreisbach AW, Tapolyai M. Safety and Efficacy of Percutaneous Renal Biopsy by Physicians-in-Training in an Academic Teaching Setting. South Med J. 2014 Aug;107(8):520-525.
    50. Ge Y, Murphy SR, Fan F, Williams JM, Falck JR, Liu R, and Roman RJ. Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats. Am J Physiol. 2014;307:F509-15. PMCID: PMC4154113
    51. George EM. New approaches for managing preeclampsia: clues from clinical and basic research. Clin Ther. 2014 Dec 1;36(12):1873-81.
    52. George EM, Warrington JP, Spradley FT, Palei AC, Granger JP. The heme oxygenases: important regulators of pregnancy and preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 1;307(7):R769-77.
    53. George EM, Garrett MR, Granger JP. Placental ischemia induces changes in gene expression in chronic tissue. Mamm Genome. 2014 Jun;25(5-6):253-61.
    54. George EM, Liu H, Robinson GG, Bidwell GL. A polypeptide drug carrier for maternal delivery and prevention of fetal exposure. J Drug Target. 2014; 22(10):935-47.
    55. George EM and Granger JP. Animal Models of Preeclampsia. In: Chesley's Hypertensive Disorders of Pregnancy. Taylor Robert, Roberts James, Cunningham FG, and Lindheimer Marshall(Eds.), Chesley's Hypertensive Disorders of Pregnancy, 4th Edition. 2014.
    56. Gillis EE, Williams JM, Garrett MR, Mooney JN, and Sasser JM.  The Dahl salt-sensitive rat is a sponstaneous model of superimposed preeclampsia.  Am J Physiol Regul Integr Comp Physiol. 2015 Apr 22.
    57. Gillis EE, Mooney JN, Garrett MR, Sasser JM. Sildenafil Treatment Improves the Maternal Syndrome in the Preeclamptic Dahl Salt Sensitive (S) Rat. FASEB J.  29:810.7, 2015.
    58. Gillis EE, Mooney JN, Williams JM, Garrett MR, Sasser JM. The Dahl S rat on a normal salt diet is a spontaneous model of preeclampsia.  FASEB J.  28:857.5, 2014.
    59. Gillis EE, Garrett MR, Sasser JM. Increased uterine artery resistance index results in placental hypoxia and TNF-α in the Dahl salt sensitive rat during pregnancy.  Hypertension. 64:A090, 2014.
    60. Gillis EE, Mooney JN, Garrett MR, Sasser JM. The Dahl salt sensitive rat is a novel model of chronic hypertension with superimposed preeclampsia. Pregnancy Hypertension. 5:47-48, 2014.
    61. Hall JE, do Carmo JM, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohormonal and renal mechanisms. Circulation Res. 13;116(6):991-1006, 2014
    62. Hall ME, do Carmo JM, da Silva AA, Juncos LA, Wang Z, Hall JE.  Obesity, hypertension, and chronic kidney disease. Int J Nephrol Renovasc Dis. 2014; 7:75-88. PMCID:PMC3933708
    63. Henegar JR, Zhang Y, Rama RD, Hata C, Hall ME, Hall JE.  Catheter-based radiorefrequency renal denervation lowers blood pressure in obese hypertensive dogs. Am J Hypertens. 2014 Apr 6. doi: 10.1093/ajh/hpu048. [Epub ahead of print]. PMID:24709437
    64. Hosick PA, AlAmodi AA, Storm MV, Gousset MU, Pruett BE, Gray W 3rd, Stout J, Stec DE. Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet. Int J Obes  (Lond). 2014;38:132-139.
    65. Intapad S, Warrington JP, Spradley FT, Palei AC, Drummond HA, Ryan MJ, Granger JP, Alexander BT. Reduced uterine perfusion pressure induces hypertension in the pregnant mouse. Am J Physiol Regul Integr Comp Physiol. 2014 Dec 1;307(11):R1353-7
    66. Intapad S, Ojeda NB, Dasinger JH, Alexander BT. Sex differences in the developmental origins of cardiovascular disease. Physiology (Bethesda). 2014; 122-132. PMCID:PMC3949204
    67. Jordan JH, D'Agostino RB Jr, Hamilton CA, Vasu S, Hall ME, Kitzman DW, Thohan V, Lawrence JA, Ellis LR, Lash TL, Hundley WG. Longitudinal assessment of concurrent changes in left ventricular ejection fraction and left ventricular myocardial tissue characteristics after administration of cardiotoxic chemotherapies using T1-weighted and T2-weighted cardiovascular magnetic resonance. Circ Cardiovasc Imaging.  2014; 7:872-879
    68. Lu S, Xiang L, Clemmer JS, Mittwede PN, Hester RL. Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels. Microcirculation. 2014;21(8):754-60. PMCID: PMC4229396
    69. Ma Y, Yabluchanskiy A, Hall ME, Lindsey ML. Using plasma matrix metalloproteinase-9 and monocyte chemoattractant protein-1 to predict future cardiovascular events in subjects with carotid atherosclerosis. Atherosclerosis. 2014; 232:231-233.
    70. Ma Y, de Castro Brás LE, Toba H, Iyer RP, Hall ME, Winniford MD, Lange RA, Tyagi SC, Lindsey ML. Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling. Pflugers Arch. 2014 Jun;466(6):1113-27
    71. Ma Y, Iyer RP, de Castro Bras LE, Toba H, Yabluchanskiy A, Deleon-Pennell, Hall ME, Lange RA, Lindsey ML. Cross talk between Inflammation and extracellular matrix following myocardial infarction. In: Inflammation and Heart Failure, Elsevier, 2014. pp. 67-79.
    72. Mamoon A, Subauste A, Subauste MC, Subauste J. Retinoic acid regulates several genes in bile acid and lipid metabolism via upregulation of small heterodimer partner in hepatocytes. Gene. 2014;550:165-70.
    73. Maranon RO, Lima R, Mathbout M, do Carmo JM, Hall JE, Reckelhoff JF. Postmenopausal hypertension: role of the sympathetic nervous system in an animal model. Am J Physiol Regu Integr Comp Physiol. 2014; 306:R248:R256. PMCID: PMC3921310
    74. Milks MW, Upadhya B, Hall ME, Vas S, Hundley WG, Stacey RB. Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease. J Comput Assist Tomogr. 2014. Epub ahead of print.15;113(6):1018-23
    75. Murphy S, Wu W, White TN, Williams JM, Mayoux E, Roman RJ. Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy with hypertension. (850-P) Diabetes. 2014 63: Supplement 1 A217:850-P.
    76. Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A,Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 2014;7:79-85. PMCID: PMC4277258
    77. Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira AS, Burke SD, George EM, Granger JP, Karumanchi SA. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. FASEB J. 2014; 28(10):4324-34
    78. Santiago-Font J, Amaral L, Gillis E, Moseley J, LaMarca B, Sasser J. Serelaxin reduces mean arterial pressure and improves fetal growth in the RUPP rat model of preeclampsia. American Journal of Obstetrics and Gynecology. 212:S324, 2015
    79. Sasser JM. New Targets for Renal Interstitial Fibrosis: Relaxin Family Peptide Receptor 1 - Angiotensin Type 2 Receptor Heterodimers (Editorial Commentary).  Kidney International. 86:9-10, 2014.
    80. Sasser JM, Cunningham MC, Baylis C.  Serelaxin reduces Oxidative Stress and Asymmetric Dimethylarginine in Angiotensin II Induced Hypertension.  Am J Physiol Renal Physiol, 307:F1355-62, 2014.
    81. Stacey RB, Andersen M, Haag J, Hall ME, McLeod G, Upadhya B, Hundley WG, Thohan V. Right ventricular morphology and systolic function in left ventricular noncompaction cardiomyopathy. Am J Cardiol. 2014 Mar
    82. Subauste AR, Chang A, Plunkett C, Pietropaolo M. Islet autoimmunity identifies a unique pattern of impaired pancreatic beta-cell function, markedly reduced pancreatic beta cell mass and insulin resistance in clinically diagnosed type 2 diabetes. Plos One. 2014. Sep 16;9(9). PMCID: PMC4165581
    83. Subauste AR, Esfandiari N, Oral E, Gianchandani R. Impact of left ventricular assist device on diabetes management: an evaluation through case analysis and clinical impact. Hospital Practice. 2014; 42:116-22.
    84. Toba H, Cortez D, Lindsey ML, Chilton RJ. Applications of miRNATechnology for Atherosclerosis. Curr Atheroscler Rep. 2014; 16:386.
    85. Vamenta-Morris H, Dreisbach AW, Shoemaker-Moyle M, Abdel-Rahman EM. Internet claims on dietary and herbal supplements in advanced nephropathy: Truth or myth. Am J Nephrol 2014;40(5):393-398
    86. Wang X, Johnson AC, Williams JM, White T, Chade AR, Zhang J, Liu R, Roman RJ, Lee JW, Kyle PB, Solberg-Woods L, Garrett MR. Nephron deficiency and predisposition to renal injury in a novel one-kidney genetic model. J Am Soc Nephrol. [ePublished]October 27, 2014, doi: 10.1681/ASN.2014040328
    87. Warrington JP, Fan F, Murphy SR, Roman RJ, Drummond HA, Granger JP, Ryan MJ. Placental ischemia in pregnant rats impairs cerebral blood flow autoregulation and increases blood-brain barrier permeability. Physiol Rep. 2014 Aug 1;2(8)
    88. Warrington JP, Coleman K, Skaggs C, Hosick PA, George EM, Stec DE, Ryan MJ, Granger JP, Drummond HA. Heme oxygenase-1 promotes migration and -epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas. Am J Physiol Regul Integr Comp Physiol. 2014 May;306(9):R641-6
    89. Westbrook L, Johnson AC, Regner KR, Williams JM, Mattson DL, Kyle PB, Henegar JR, Garrett MR. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. J Am Soc Nephrol. 2014;25:2499-510. PMCID: PMC4214519
    90. Xiang L, Lu S, Mittwede PN, Clemmer JS, Hester RL. Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma.  Am J Physiol Heart Circ Physiol.  2014; 306:H684-H689. PMCID: PMC3949061
    91. Xiang L, Lu S, Mittwede PN, Clemmer JS, Husband GW, Hester RL. β(2)-Adrenoreceptor blockade improves early posttrauma hyperglycemia and pulmonary injury in obese rats. Am J Physiol Heart Circ Physiol. 2014;307(4):H621-7. PMCID: PMC4137123
    92. Xiang L, Mittwede PN, Hester RL. Comment on Sato et al Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle Diabetes. 2014;63:4115-4129. Diabetes. 2014 Dec;63(12):e20-1.
    93. Yabluchanskiy A, Ma Y, Chiao YA, Lopez EF, Voorhees AP, Toba H, Hall ME, Han HC, Lindsey ML, Jin YF. Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1398-407
    94. Yan H, Mitschelen M, Toth P, Ashpole N, Farley JA, Hodges EL, Warrington JP, Han S, Fung K, Csiszar A, Ungvari Z, Sonntag WE. Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis dwarf rat. J Gerontol A Biol Sci Med Sci. 2014; 69:1353-62. PMCID: PMC4271094
    95. Alexander BT, Intapad S. Activation of the sympathetic nervous system, is it the key to the developmental origins of enhanced cardiovascular risk? Am J Physiol Renal Physiol. 2013;305:F641-F642. PMCID: PMC3761202
    96. Chade AR. Renal Vascular Structure and Rarefaction. Compr Physiol. 2013; 3:817-831. PMCID: PMC3936257
    97. Chade AR, Stewart N. Angiogenic Cytokines in renovascular disease: Do they have potential for therapeutic use? J Am Soc Hypertens. 2013; 7:180-190. PMCID: PMC3605220
    98. da Silva AA, do Carmo JM, Hall JE. Role of leptin and central nervous system melanocortins in obesity hypertension. Curr Opin Nephrol Hypertens. 2013: 22:135-140. PMCID: PMC3905446
    99. do Carmo JM, da Silva AA, Sessums PO, Ebaady SH, Pace BR,Rushing JS, Davis MT, Hall JE. Role of Shp2 in forebrain neurons in regulating metabolic and cardiovascular functions and responses to leptin. Int J Obes (Lond). 2013; doi:10.1038/ijo.2013.177. PMCID: PMC3954949
    100. do Carmo JM, da Silva AA, Dubinion J, Sessums PO, Ebaady SH,Wang Z, Hall JE. Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway. IUBMB Life. 2013; 65:692-698.
    101. do Carmo JM, da Silva AA, Rushing JS, Pace B, Hall JE.  Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons. Am JPhysiol Regul Integr Comp Physiol. 2013: 305:R359-R368. PMCID:PMC3833394
    102. Dubinion JH, do Carmo JM, Adi A, Hamza S, da Silva AA, Hall JE. Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin. Hypertension. 2013; 61:1066-1074. PMCID: PMC3678380
    103. Eirin A, Zhu XY, Li Z, Ebrahimi B, Zhang X, Tang H, Korsmo M, Chade AR, Grande JP, Lerman A, Textor S, Lerman, LO. Endothelial outgrowth cells shift macrophage phenotype and improve kidney viability in swine renal artery stenosis. Arterioscler Thromb Vasc Biol. 2013; 33:1006-1013. PMCIDPMC3644980
    104. Flynn E, Lee J, Hutchens ZM, Chade AR, Maric-Bilkan C. C-peptide preserves the renal microvasculature architecture in the streptozotocin-induced diabetic rat. J Diabetes Complications. 2013; 27:538-547. PMCID: PMC3818424
    105. Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ,Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, RiceK, Duan Q, Chen F, Li Y, Tang H, Fornage M, Keene KL, Andrews JS,Smith JA, Faul JD, Guangfa Z, Guo W, Liu Y, Murray SS, Musani SK,Srinivasan S, Velez Edwards DR, Wang H, Becker LC, Bovet P, BochudM, Broeckel U, Burnier M, Carty C, Chasman DI, Ehret G, Chen WM,Chen G, Chen W, Ding J, Dreisbach AW, Evans MK, Guo X, Garcia ME,Jensen R, Keller MF, Lettre G, Lotay V, Martin LW, Moore JH,Morrison AC, Mosley TH, Ogunniyi A, Palmas W, Papanicolaou G,Penman A, Polak JF, Ridker PM, Salako B, Singleton AB, Shriner D,Taylor KD, Vasan R, Wiggins K, Williams SM, Yanek LR, Zhao W,Zonderman AB, Becker DM, Berenson G, Boerwinkle E, Bottinger E,Cushman M, Eaton C, Nyberg F, Heiss G, Hirschhron JN, Howard VJ,Karczewsk KJ, Lanktree MB, Liu K, Liu Y, Loos R, Margolis K, SnyderM; Asian Genetic Epidemiology Network Consortium, Psaty BM, Schork NJ, Weir DR, Rotimi CN, Sale MM, Harris T, Kardia SL, Hunt SC,Arnett D, Redline S, Cooper RS, Risch NJ, Rao DC, Rotter JI,Chakravarti A, Reiner AP, Levy D, Keating BJ, Zhu X. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.  Am J Hum Genet. 2013;93:545-554. PMCID: PMC3769920
    106. George, EM, Palei AC, Dent EA, Granger JP.  Sildenafil attenuates placental ischemia induced hypertension. Am JPhysiol Regul Comp Physiol. 2013; 305:R397R403. PMCID:PMC3833396
    107. George EM, Stec DE, and Granger JP. Heme oxygenase inhibition increases blood pressure in pregnant rats.  Am J Hypertens.  2013: 26:924-930. PMCID: PMC3731822
    108. Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, Lopez EF, Ghasemi O, Jin YF, Lindsey ML. Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2013;305:H1830-H1842.  PMCID: PMC3882541
    109. Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Role of the kidney in hypertension.  In: Hypertension.  Eds. EL Schiffrin and RM Touyz.  Futura Science Group, 2013.pp 2-19.  Doi:10.2217/EBO.12.475
    110. Heaberlin JR, Ma Y, Zhang J, Ahuja SS, Lindsey ML, Halade GV. Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction.  Cardiovasc Pathol. 2013; 22:481-487. PMCID: PMC3965668
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