There is an extreme paucity of evidence to support prophylactic antibiotic treatment. The most commonly suggested regimen is listed below.
There is little data on which to base firm recommendation for penetrating brain or spinal injuries. However, infection in this population is not uncommon and carries significant morbidity. Many institutions treat empirically, although studies to support an exact regimen and duration of treatment do not exist. The most commonly suggested regimen is listed above, however any combination adequately covering gram positive, gram negative and anaerobic pathogens is reasonable.
*Every Vancomycin order requires pharmacokinetic consult.