Clostridium Difficile

Main Content

Mild to Moderate Infection

Indications

  • C. diff positive diarrhea not meeting criteria for severe or severe, complicated infection.

First line treatment*

  • Vancomycin 125mg PO every 6 hours

Duration

  • 10 days

Notes

For all patients: Discontinue acid suppressants, pro-kinetics, and concomitant antibiotics if possible.

*Metronidazole is no longer first line and is now only recommended for patients without access to Vancomycin or Fidaxomicin and only in mild cases and as adjunct in fulminant colitis particularly in the setting of ileus.

Disclaimer: The contents of this application are for the exclusive and specific use of University of Mississippi Medical Center faculty and trainees. Any other use is neither authorized nor sanctioned by UMMC. The information is for educational purposes only. The contents of this application are for the exclusive and specific use of UMMC faculty and trainees. Any other use is neither authorized nor sanctioned by UMMC. The information is for educational purposes only.