Policies and Guidance

External IRB Review

IRB accreditation logo.jpgA Reliance Agreement, also referred to as an IRB Authorization Agreement, allows the IRB of one institution to rely on the IRB of another institution for review of human subjects research. The scope of the reliance agreement may be limited to a specific protocol or to any protocol agreed upon by both parties on a case-by-case basis.

Existing reliance agreements

WCG

The University of Mississippi Medical Center has a reliance agreement with the WIRB-Copernicus Group to allow for review by WIRB IRB, CGIRB and its partner IRBs for industry-sponsored, industry-initiated studies where the sponsor has selected WIRB or one of its partners as the reviewing IRB. Registering to use WIRB is easy.

Log on to https://connexus.wirb.com.

  • Click on "Register Me" and follow the instructions provided.
  • You will receive an e-mail containing your activation link.
  • Click on the link in the email and follow the instructions to log-in.
  • Welcome to WIRB ConnexusTM!

Schulman

The University of Mississippi Medical Center has a reliance agreement with Schulman for industry-sponsored, industry-initiated studies where the sponsor has selected Schulman as the reviewing IRB.

NCI-CIRB

The University of Mississippi Medical Center has a reliance agreement with the National Cancer Institute Central IRB (NCI CIRB) to rely on the NCI CIRB review for certain cooperative group oncology trials.

UMMC requirements

Before the study may begin

  • Obtain approval from the external IRB
  • Submit an abbreviated application to the Human Research Office through IDEATE. This will ensure that all institutional requirements are satisfied.*
  • A UMMC reliance approval letter will be sent to you, permitting the research to begin.

* Studies that require Radiation Safety (RSC), Biosafety and Embryonic Stem Cell (ESCRO) review will continue to submit to UMMC's RSC, Biosafety, and ESCRO. The committee determination letters will be submitted with the abbreviated application.

After the study begins

All amendments (including personnel changes), continuing reviews and final reports must be submitted to the Human Research Office through IDEATE.