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With more than a dozen specialized areas, UMMC's core facilities offer researchers tools, technology and expertise to compete for grants and make their investigations stand apart.Core facilities, often directed by faculty researchers and staffed by expert technicians, offer investigators services from ultracentrifuge analysis to complete veterinary care. Core facilities collaborate across departments, universities, states and nations.
The University of Mississippi Medical Center has an ever-growing list of core facilities available for researchers. You may get information, including contact information, for these core facilities by following the links.
The main goal of the Analytical and Assay Core is to provide support for various radioimmunoassays, enzyme-linked immunoassays (ELISA), molecular and chemical analyses. These facilities and services are available to all members of the department and to collaborators at UMMC as well as other educational and research institutions.
Analytical ultracentrifugation (AUC) methods provide simultaneous velocity and equilibrium experiments so that protein associative behavior in solution can be explored in detail. The facility includes a Beckman XLA Analytical Ultracentrifuge equipped with absorption optics, an AVIV FDS system for fluorescence detection, an Anton Paar DMA 5000 for density measurements, and an Anton Paar AMVm micro viscometer.
The mission of the Animal Behavior Core facility is to improve the scope and competitiveness of functional CNS research at UMMC, COBRE and INBRE facilities in Mississippi.
The Biomedical Materials Science Program is a comprehensive program which includes faculty in the Schools of Medicine and Dentistry. These facilities allow research and characterization of a diverse range of materials (metals, polymers, ceramics, composites), of a wide range of properties (physical, mechanical, electrochemical, biological, etc.), and at all levels of interest - from atomistic to macroscopic.
The Department of Pathology's Biospecimen Repository serves as a bridge between basic scientists and real cancers affecting real patients. While clonal cell lines used in laboratory research are vital for many types of experiments, they cannot substitute for the diversity of cancers seen in our patient population. The repository provides researchers with biological cancer specimens in a very efficient manner. All samples are collected, processed and distributed in strict accordance with protocols that have been reviewed and approved by the UMMC Institutional Review Board. Assuring absolute privacy and uncompromised medical care for our tissue donors is our highest priority.
Phoenix Technical Services Inc. (PTS), a locally owned company, provides integrated repair and preventative maintenance services on-site to the UMMC research departments.
The UMMC Cancer Institute Flow Cytometry Core Facility provides state-of-the-art flow cytometry analysis and related services to the UMMC research community and affiliated institutions. Flow cytometry analysis and sorting as well as consultation for experimental design and data interpretation are provided.
The Histology Core Facility offers a variety of services including general histology, specialized histological staining, immunohistochemistry, light microscopy and image analysis. Training in various techniques is also available.
The Mass Spectrometry Core Facility (MSCF) provides Lipidomics, Quantitative Peptidomics/Proteomics and Metabolomics capabilities to researchers at UMMC as well as to other researchers from intrastate as well as interstate locales. The MSCF provides extensive expertise in LC/MS/MS, HPLC, sample preparation, method/assay development and data analysis and interpretation. Specific assays available include: Eicosanoids, Prostaglandins /Isoprostanes, Creatinine, LysoPhosphatidic acid, Cortisol, Erythromycin, Serotonin, Vitamin D3, Vincristine-Noscapine, and Angiotensin Peptides. In addition, methodologies for Protein Quantitation, Lipid Quantitation/Lipidomics, and Proteomics on IP pulldowns, gel bands, and samples enriched in the protein target of interest are available.
The Imaging Core of the Center for Psychiatric Neuroscience can assist in sample preparation, microscope-based image analyses such as confocal laser scanning microscopy, three-dimensional object counting (stereology), two-dimensional gray level analysis, single or double-label immunohistochemistry, immunofluorescence labeling and Western blotting. Core personnel can either provide the service or train users.
The Laboratory Animal Facilities operates as a research-support entity for UMMC. This organization provides the management and resources to maintain full accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care International. Efforts by the Laboratory Animal Facilities are 100% service-based to UMMC animal-based research programs. Support functions include daily animal husbandry requirements, animal quarantine and conditioning programs, animal surgical and anesthetic support, laboratory animal veterinary medical care programs, and regulatory support.
The Molecular and Genomics Core provides expertise in molecular, cell biology and genetic technologies to researchers at UMMC and across the region. The core facility is equipped to perform genetic and genomic analysis on human and several model organisms, including rat and mouse. The Core provides a variety of genomics services, including sample processing, genotyping, sequencing, gene expression and early-stage bioinformatics analysis.
The Non-Embryonic Stem Cell Core is available to support investigators interested in stem cell research in the fields of cancer and regenerative medicine. NESCC is part of the infrastructure to support and conduct basic and clinical research related to stem cells. Services include: isolate, expand and distribute cancer stem cells for investigator-initiated studies; expand and distribute human iPS cells; isolate and expand adult stem cells such as Mesenchymal stem cells from bone marrow and adipose tissue; develop cutting edge stem cell technologies and establish new iPS and stem differentiation protocols for human diseases; provide seminars, workshops, and hands-on training on stem cell research; provide consultation on stem cell research protocol design and grant preparation planning; and develop collaborative studies to utilize cancer stem cells for preclinical studies.
The Transgenic Core provides microinjection service of fertilized mouse embryos for the production of transgenic mice for the UMMC research community. The Transgenic Core can also provide interested investigators help in the design of transgenic constructs as well as in genotyping of transgenic mice.
The Postmortem Brain Core of the Center for Psychiatric Neuroscience provides tissue specimens from human and non-human primate brain. The human samples are from normal control subjects and psychiatrically-characterized subjects, permitting studies on major depressive disorder, schizophrenia, psychoactive substance use disorders and smoking. Immunohistochemistry, cell counting, Western blotting, and gene expression studies can be performed on samples. Brain tissues are also available from male and female non-human primates exposed long-term to an antidepressant medication. A laser capture microdissection system, with fluorescence capabilities, is available to capture a single cell or pure multiple cell types from specific regions of tissue sections, permitting increased sensitivity and accuracy of downstream biological assays on discrete populations of cells.
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