Mississippi Center for Heart Research

Employment Opportunities

Postdoctoral fellowship positions (full time)

The Mississippi Center for Heart Research is recruiting for multiple immediate postdoctoral fellow positions in either the pre-faculty or pre-industry categories. Our center is dedicated to performing cardiovascular research that involves: 1) developing multidimensional approaches to examine the mechanisms whereby the cardiovascular system responds to stress or injury; 2) applying the knowledge gained to develop therapeutic strategies to prevent, slow, or reverse the progression of cardiovascular disease; 3) disseminating our results to scientific, medical, and general communities and educating new generations of cardiovascular scientists; and 4) educating the next generation of scientists.

Candidates (MD and/or PhD) must have solid experience with contemporary techniques, preferably with emphasis in cardiovascular physiology. Expertise with rodent cardiac surgery, vascular surgery, proteomics, cell and molecular biology, cell metabolism, or computational biology approaches is preferred. Suitable candidates must also have excellent organizational and communication skills, be enthusiastic about their work, and be highly motivated to succeed. Positions are available in the laboratories of the following principal investigators:

  • Michael E. Hall, PhD: conducting clinical and translational studies to better understand heart failure. We use state-of-the-art imaging methods in obese humans to determine the mechanisms that link increased renal sinus fat to kidney dysfunction and hypertension. We also evaluate proteomics in plasma samples from humans following myocardial infarction. Our research is providing the necessary tools to translate basic pathophysiologic mechanisms into potential prevention and treatment strategies for treating obesity associated hypertension, renal injury and myocardial infarction.
  • Romain Harmancey, PhD: investigating the molecular mechanisms by which nutrient oversupply leads to contractile dysfunction in the heart. We identify metabolic networks and specific proteins affected by dietary manipulations to regulate insulin and nutrients in rodents. The identified proteins are targeted in vivo and in vitro to determine their role in the global regulation of myocardial metabolism and contractile function under physiological and pathological conditions. Current research in our laboratory focuses on: a) the role of glucose and of its metabolites as regulators of gene expression in the heart; b) the consequences of altered insulin signaling on myocardial adaptation to stress conditions such as an increase in workload or ischemia; and c) the role of mitochondrial UCP3 in the control of energy providing substrate selection by the heart.
  • Ji Li, PhD: understanding the molecular mechanisms of coronary artery disease, the most common cause of age-related cardiovascular disease. We study the signaling mechanisms that underlie the reduced tolerance in elderly patient hearts to stress from restricted blood flow (ischemia) and the restoration of normal blood flow (reperfusion). Our work devises novel strategies to boost cardiac tolerance of these events in aged populations or prevent patients' decline in resilience. Closely tied to this work, we explore the intrinsic relationship between diabetes and cardiovascular disease.
  • Merry L. Lindsey, PhD: delineating mechanisms of cardiac extracellular matrix remodeling, particularly changes to the matrix that are the cause or effect of pathophysiological processes. These changes include cell-matrix interactions, which both affect and react to processes involved in tissue repair. We primarily use the murine model of myocardial infarction (MI). Current research in our laboratory focuses on: a) the role of macrophage-derived matrix metalloproteinases in LV remodeling post-MI; b) the role of the cardiac macrophages and fibroblasts in the remodeling process, and c) the influence of aging on LV remodeling.

Our laboratories are located in the Arthur C. Guyton Research Building. The selected candidates will receive training in a highly collaborative environment and state-of-the-art facilities. Salaries are competitive, and there is an opportunity to advance to a faculty position. Applicants should send a cover letter including a brief statement of research interests and career goals, curriculum vitae, and the names of three references to Elizabeth Flynn.

All postdoctoral appointments are designated as security-sensitive positions.
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