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  • Zhi He, MD


    Assistant Professor
    Pathology Research
    Phone: (601) 984-1558
    E-mail: zhe@umc.edu

    Education and Training

    • Xiangya School of Medicine Central South University, formerly Xiangya Medical College, Changsha, China
    • Xiangya School of Medicine Central South University
    • Department of Ophthalmology & Visual Sciences, University of Louisville, KY

    Research interests

    The focus of Dr. He's research is:

    • Low birth rate (LBR) and decreased fetal nephron development possible relation to increased rate of hypertension and cardiovascular disease among African-American adults
    • Analysis of glomerular number and volume in populations at high risk of hypertension and end-stage renal disease
    • Studies on morphological changes in the peritoneum during dialysis
    • VHL gene mutation in renal cell carcinomas
    • HPV genotyping and hybridization in cervical intraepithial neoplasia
    • The mechanisms of the analgesic tolerance to intrathecal of opoids in rats
    • The mechanism of ocular inflammation in diabetic patients and in animal model

    Publications of note

    Dr. Zhi He has 79 publications and presentations.

    Peer review articles


    • Park SW, He Z, Shen X, Roman RJ, Ma T. Differential action of methamphetamine on tyrosine hydroxylase and dopamine transport in the nigrostriatal pathway of μ-opioid receptor knockout mice. Int J Neurosci. 2012 Feb 14.
    • Zhou X, Lawrence TJ, He Z, Pound CR, Mao J, Bigler SA. The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer. Exp Mol Pathol. 2012 Feb;92(1):105-10.
    • T Peters, R Potter, X Li, Z He, Glenn Hoskins and Michael Flessner, Mouse Model of Foreign Body Reaction that after the Submesothelium Trasperitoneal transport. The American Journal of Physiology 2011;300 (1):F283-9.
    • Zhou X, He Z, Henegar J, Allen B and Bigler S. Expression of allograft inflammatory factor-1 (AIF-1) in acute cellular rejection of cardiac allografts. Cardiovascular Pathology, 2010 Sep-Oct; 20 (5):e177-84. Epub 2010 Sep 20.
    • Barker AK, McDaniel DO, Zhou X, He Z, Aru G, Thomas T and Moore CK Combined analysis of allograft factor-1, IL-18 and TLR expression and the association with allograft rejection and corenary vasculopathy. The American Surgeon, 2010 August; 76:873-878
    • Michael Flesnner, Kimberly Credit, Karla Richardson, Rebacca Potter, Xiaorong Li, Zhi He, Glenn Hoskins and Jeffrey Henegar. Peritoneal Inflammation after Twenty-week Exposure to Dialysis Solution: Effect of Solution Versus Catheter-foreign body reaction. Peritoneal Dialysis International. 30:284-94, 2010.
    • Michael F. Flessner, Xiaorong Li, Rebecca Potter and Zhi He Foreign Body Response to Sterile Catheters is Variable Over 20 Weeks Adv Perit Dial, 2010;26:101-4
    • Elizabeth L. Brandon, Jian-Wei Gu, Lauren Cantwell, Zhi He, Gray Wallace, and John E. Hall. Obesity promotes melanoma tumor growth: Role of leptin USACancer Biol Ther. 2009 October ; 8(19): 1871–1879.
    • Flessner MF, Credit K, Henderson K, Vanpelt HM, Potter R, He Z, Henegar J, Robert B. (2007) Peritoneal changes after exposure to sterile solutions by catheter. J Am Soc Nephrol. 18(8):2294-302.
    • Choi J, Credit K, Henderson K, Deverkadra R, Vanpelt HM, He Z, Flessner MF.(2006) Antibiotic prophylaxis an animal model of chronic peritoneal exposure. Perit Dial Int. 2006 Mar-Apr;26(2):188-90.
    • Choi J, Credit K, Henderson K, Deverkadra R, He Z, Wiig H, Vanpelt H, Flessner MF. (2006) Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collegen to antibody penetration. Clin Cancer Res. 2006 Mar 15;12(6):1906-12
    • Flessner MF, Choi J, Vanpelt H, He Z, Credit K, Henegar J, Hughson M. (2006) Correlating structure with solute and water transport in a chronic model of peritoneal inflammation Am J Physiol Renal Physiol. 2006 Jan;290(1):F232-40. Epub 2005 Aug 23
    • Hu L, Guo M, He Z, Thornton J, McDaniel LS, Hughson MD (2005)
      Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents. Mod Pathol. 2005 Feb; 8(2): 267-73
    • He Z, Liu S, Guo M, Mao J, Hughson MD (2004)
      Expression of fibronectin and HIF-1alpha in renal cell carcinomas: relationship to von Hippel-Lindau gene inactivation. Cancer Genet Cytogenet. 2004 Jul 15; 152(2):89-94.
    • Guo M, Hu L, Baliga M, He Z, Hughson MD (2004)
      The predictive value of p16 (INK4a) and hybrid capture 2 human papillomavirus testing for high-grade cervical intraepithelial neoplasia. Am J Clin Pathol. 2004 Dec; 122(6): 894-901
    • Flessner MF, Choi J, He Z, Credit K (2004)
      Physiological characterization of human ovarian cancer cells in a rat model of intraperitoneal antineoplastic therapy. J Appl Physiol, 2004 Oct; 97(4): 1518-26.
    • Guo M., Hu LL., Zhang HZ., He Z., Baliga M. (2004)
      Predictive value of p16 INK4A in detection of CIN 2/3 from high-risk HPV positive ASC-US: a biopsy comparison study. Acta Cytol 48:794, 2004
    • Huang H, He Z, Roberts LJ 2nd, Salahudeen AK. (2003)
      Deferoxamine reduces cold-ischemic renal injury in a syngeneic kidney transplant model. American Journal of Transplantation, 2003 Dec.; 3(12): 1531-7,
    • Hughson MD, He Z, Liu S, Coleman J, Shingleton WB (2003)
      Expression of HIF-1 and ubiquitin in conventional renal cell carcinoma: relationship to mutations of the von Hippel-Lindau tumor suppressor gene. Cancer Genet Cytogenet. 143:145-53.
    • Hughson MD, He Z, Henegar J, McMurray R (2001)
      Alveolar hemorrhage and renal microangiopathy in systemic lupus erythematosus. Arch Pathol Lab Med. 125:475-83.
    • Wongchanapai W, Tsang BK, He Z, Ma T, Ho IK (1998)
      Supersensitivity of spinal opioid receptors to antagonists in intrathecal butorphanol and morphine dependence. Life Sci. 63:2175-80.
    • Tsang BK, He Z, Wongchanapai W, Ho IK, Eichhorn JH (1998)
      Visceral analgesic tolerance to intrathecal butorphanol in rats. Can J Anaesth. 45:1019-23.
    • Wongchanapai W, Tsang BK, He Z, Ho IK (1998)
      Relative involvement of spinal opioid receptors in physical dependence on intrathecal butorphanol and morphine. Pharmacol Biochem Behav. 60:899-907.
    • Wongchanapai W, Tsang BK, He Z, Ho IK (1998)
      Differential involvement of opioid receptors in intrathecal butorphanol-induced analgesia: compared to morphine. Pharmacol Biochem Behav. 59:723-7.
    • Tsang BK, He Z, Wongchanapai W, Coleman EC, Ho IK, Eichorn JH (1997) Induction of tolerance to intrathecal butorphanol in rats. Acta Anaesthesiol Sin. 35:237-40.
    • Wongchanapai W, Tsang BK, He Z, Ho IK (1997)
      Antinociceptive effect of intrathecal butorphanol through opioid receptors: compared to morphine. Research Communications in Alcohol and Substances Abuse 18:19-26.
    • Tsang BK, He Z, Ma T, Ho IK, Eichhorn JH (1997)
      Decreased paralysis and better motor coordination with microspinal versus PE10 intrathecal catheters in pain study rats. Anesth Analg. 84:591-4.
    • Haque ZU and He Z (1992)
      Influence of fat-like perception enhance (lipo) on the physicochemical properties of caseinate J Dairy Sci. 75(1). p126
    • Lu YQ, He Z, Wang FX, Qiu QB, Wang J, and Zhu XJ (1983)
      The effects of sodium salicylate and sulfadiazine on the morphology of erythrocytes of Hb Shuangfeng propositus. Bulletin of Hunan Medical College 8:248-255. (Chinese)
    • Zhu DE, Lu YQ, Hu HL, Cheng ZY, and He Z (1982) New variant Hb Shuangfeng, and HbE, A concise report of the studies on their structures, functions and biosynthesis. Bulletin of Hunan Medical College 4:7-17. (Chinese)



    • Z He, R Potter, K Credit, X Li, M Flessner. Do Large Peritoneal Volumes Cause Inflammation Via Mesothelial Cell Stretching? Abstract #293, oal presentation. 32nd American Annual Dialysis Meeting, Feb. 26-28, 2012
    • R Reddy, R Iverson, B Brimhall, S Bigler, X zhou, Z He, L Young-Gaylor. CDX2 Expression and Previously Undescribed CDX1 Expression in Primary Gastrointestinal and Metastatic Carcinoid Tumors: An Immunohistochemical Study of 43 Cases. USCAP 101st Annual Meeting, March 17-23, 2012 Vancouver, Canada
    • X Zhou, Z He, S Redfield, K Brown, S Bigler. C-terminal portion of group 3 POTEs antigen correlates with progression of prostate cancer. USCAP march 2012 Vancouver, Canada
    • S Redfield, Z He, J Mao, S Bigler, X Zhou. The c-terminal common to group 3 POTEs is a nucleolar marker associated with cellular proliferation and cancer metastasis. USCAP 2012 march 2012 Vancouver, Canada
    • TJ Lawrence, X Zhou, Z He, C Pound, SA Bigler. Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Is Associated with the Progression of Prostatic Adenocarcinoma Independent of Race and Age. Modern Pathology, Vol 24, suppl (February 2011), 206A.
    • Z He, R Potter, K Credit, X Li, M Flessner. Cell stretch during peritoneal dialysis increases mesothelial TGFβ and VEGF production. TH-FC058, Oral presentation ASN November 18, 2010
    • X Li, Z He, M Flessner, E Gomez-Sanchez Exposure of peritoneum to polymer catheters for 1-7 days results in acute inflammation in rats. SA-PO2653, ASN November 20, 2010
    • Xinchun Zhou, Jinghe Mao, Zhi He and Jeffrey Henegar Lipidomics in identifying lipid biomarkers of prostate cancer ----EB meeting April 24, 2010
    • Michael F. Flessner, Elise Gomez-Sanchez, Rebecca Potter, Xiarong Li, Zhi He, Jeffrey Henegar, Glenn Hoskins Sterile Biofilm on Intraperitoneal Polymers Results in Submesothelial Inflammation in Mice. SA-PO2965----ASN Oct 27-Nov 1, 2009
    • Toni Peters, Rebecca Potter, Xiarong Li, Zhe He, Jeffrey Henegar, Michael F. Flessner. Variable Inflammatory Response in Mice to Chronic Intraperitoneal Implantation of Three Sterile Catheter Materials SA-PO2969----ASN Oct 27-Nov 1, 2009
    • Wang JM, He Z, Frtakin J. Expression of Tau Isoforms in Triple Transgenic Mice. Specificity of Subcellular Localization During Development. The American Association of Neuropathologists 2009
    • Wang JM, Gomez-Sanchez E, Austin M, Stockmeier C, Bigler S, He Z, Henry S, Hill R, Brinton RD. Estradiol-17 Promotes Neurogenesis in Rodents in an OVX Time Dependent Manner. Society of Biological Psychiatry 64th Annual Meeting, Vancouver, May 14-16, 2009
    • Wang JM, Irwin RW, Z. He, Bigler S, Brinton RD. Estradiol-17β increases the apoE expression in Rβ k/o mouse hippocampus but not in ERα k/o mouse. Society for Neuroscience annual Meeting, Nov 15, 2008
    • Zhi He, Rebecca Potter, Kimberly Credit, Xiarong Li, Michael F. Flessner.
      Stretching of Mesothelial Cells during Peritoneal Dialysis Does Not
      Increase IL-6 or VEGF Production. JASN 2008, 19:80A (Oral Presentation)
    • Michael F. Flessner, Kimberly Credit, Rebecca Potter, Karla Henderson, Xiarong Li, Zhi He, Jeffrey Henegar. Sterile Biofilm on Silicone Intraperitoneal Catheters Causes PeritonealInflammation in Rodents. JASN 2008, 19:80A (Oral Presentation)
    • Rebecca Potter, Kimberly Credit, Karla Henderson, Xiarong Li, Zhi He, Michael Flessner. Daily Peritoneal Exposure to a Biocompatible Solution over 20 Weeks Demonstrates Marked Inflammatory Differences between Rodents with and without Indwelling Catheters. JASN 2008, 19:702A
    • Karla Henderson, Xiarong Li, Kimberly Credit, Rebecca Potter, Zhi
      He, Michael Flessner. Ethyl Pyruvate and Pyridoxamine Fail To Ameliorate Peritoneal Inflammation from 20 Weeks of Daily Exposure to a Conventional Dialysis Solution. JASN 2007, 18:693A
    • Kimberly Credit, Karla Henderson, Xiarong Li, Zhi He, Jeff Henegar, Michael Flessner. Daily Peritoneal Exposure to a Biocompatible Dialysis Solution over 20 Weeks in a Rodent Model without a Catheter Demonstrates Less Inflammation Than 8 Weeks of Exposure with a Catheter. JASN 2007, 18:693A
    • Vanpelt H, Credit K, Henderson K, Deverkadra R, He Z, Flessner MF. Early time course of inflammatory changes in a chronic rodent model of peritoneal exposure to dialysis solutions JASN 2006, 17:755A
    • Credit K, Vanpelt H, Henderson K, Deverkadra R, He Z, Flessner MF.Use of indwelling catheter in a chronic peritoneal exposure model markedly increases inflammatory changes JASN 2006, 17:750A
    • X Zhou, Z He, J Henegar, S Bigler, B Allen Allograft inflammatory Factor-1 (AIF-1) Immunohistochemistry Stain in Biiopsies of Human Heart Transplants. Modern Pathology 2006, 19(S1): 51A.
    • Choi J, Vanpelt H, He Z, Henegar J, Hughson M, Flessner MF. “Effect of N-Acetylglucosamine on Morphological Changes in the Peritoneum During Dialysis” Poster presented at the 1st North American Chapter Meeting of the International Society for Peritoneal Dialysis, Chicago, IL, May 2005.
    • Choi J, Credit K, Henderson K, Deverkadra R, Vanpelt H, Holifield T, He Z, Flessner MF. “Relationship between changes in morphology and filtration efficiency of the peritoneum during chronic exposure to peritoneal dialysis solution: cause or consequence?” Poster presented at Experimental Biology, San Diego, CA, April 2005.
    • M Guo, L Hu, J Zhou, Z He, L Martin, M Baliga. Predicative value of p16 in detection of CIN2/3 from women with LSIL Pap results, a biopsy comparison study. Modern Pathology 18 (Supply 1), 66A, 2005.
    • He Z, Choi J, Henegar J, Hughson MD, Flessner E, Flessner MF. Increase in extracellular matrix proteins in the parietal peritoneum of rats treated with hypertonic dialysis solution. Experimental Biology, 2004.
    • Choi J, Credit K, He Z, Deverkadra R, Henderson K, Flessner MF. “Acute modifications of tissue hyaluronic acid do not affect transport of water, small solutes, and protein across the visceral peritoneum” Experimental Biology, 2004.
    • Shawn Liu, Zhi He, Jinghe Mao, Michael D, Hughson
      Expression of fibronectin and HIF-1alpha in Conventional Renal Cell Carcinomas: The Relationship to von Hippel-Lindau Gene Inactivation
      Modern Pathology 2004, 17(S1): 687
    • Luli Hu, Ming Guo, Shawn Liu, Zhi He, Warren May, Michael Hughson
      P16INK4a expression and human papillomavirus type 16/18 infection in cervical intraepithelial neoplasm of adolescents. Modern Pathology 2004, 17(S1): 831
    • Choi J, Flessner E, He Z, Henegar J, Hughson M, Flessner M. Chronic treatment with filtered, buffered hypertonic dialysis solutions increases VEGF content, vascularity, and thickness of the sub-mesothelium of rats. Journal of the American Society of Nephrology, 14:34A, November 2003.
    • Huang H, He Z, Jenkins JK, Salahudeen AK. Fenoldopam induces heme oxygenase-1 and markedly suppresses cold-ischemia-associated acute renal injury in a syngeneic kidney transplant model. Journal of the American Society of Nephrology, 14:183A, November 2003.
    • He Z, Liu S, and Hughson M. (2001) VHL Expression in Clear Renal Cell Carcinoma. The 9th SCBA International Symposium August 5-10, 2001,
    • He Z, Tsang BK, Wongchanapai W, Jang CG, Ma T, Ho IK, Eichhorn JH Effect of tolerance to intrathecal opioid on mRNA of NMDARl subunit in rats' spinal cord: an in situ hybridization study. The Toxicologist 1998, 42(l-S): 245.
    • Tsang BK, Ma T, Wongchanapai W, He Z, Ho ,IK; Eichhorn JH Alteration of [3H]-MK801 binding in the spinal cord of opioid tolerant rats: a quantitative autoradiographic study. The Toxicologist 1998; 42(I-S): 245.
    • Tsang BK, He Z, Ho IK, Eichhorn JH Assessment of degree of tolerance induced by intrathecal butorphanol by tail-flick test in rats. Anesthsia and Analgesia 1997; 84:S555.
    • Tsang BK, He Z, Ho IK, Eichhorn JH Intrathcal butorphanol infusion induces tolerance to visceral analgesia. Orientation Workshop on OpioidResearch Across the Strait, Taiwan. 1996.
    • Tsang BK, He Z, Ma T, Ho IK, Eichhorn JH Decreased paralysis from Microspinal vs. PElO intrathecal catheters in pain study rats. Anesthesiology 1996; 85:A774.
    • Tsang BK, He Z, Ho IK, Eichhorn JH Analgesic tolerance to spinal butorphanol in rats. 11th World Congress of Anesthesiologists 1996; P404.
    • Tsang BK, He Z, Ho IK, Eichhorn JH Influence of implantation of two different intrathecal catheters on motor dysfunction in rats. Annual Meeting, American Pain Society, 1995.
    • Haque ZU and He Z Effect of acylation on the functional properties of beta- and k-casein. 71th ADSA Annual Meeting, 1994.
    • Rantamaki P, He Z and Haque ZU Effect of some cations on emulsifying properties of bovine serum albumin and ovalbumin, 71th ADSA Annual Meeting, 1994.
    • Haque ZU, Rantamaki P and He Z Effect of trace amounts of ions on some functional properties of BSA, IFT Annual Meeting, 1994.
    • Haque ZU, and He Z Effect of lipro on gelation properties of egg white and whey proteins, IFT Annual Meeting, 1993.
    • Haque ZU and He Z Lipo, a protein-based fat-like perception enhancers, IFT Annual Meeting, 1993.
    • He Z and Haque ZU Effect of Lipo on the physicochemical properties of beta-lactoglobulin, ADSA Annual Meeting, 1993.
    • BhattacheIjee P, Rhodes L, He Z and Paterson CA Prostanoid receptors in rabbit iris-ciliary body. Invest Ophthal. & Vis. Science 1991; 32:833.
    • Bhattacherjee P, Rhodes L, He Z and Paterson CA Adenylate cyclase-coupled prostanoid receptors in iris¬ciliary body. Prostaglandins, Leukotrienes and Lipoxins, 91, XIth Washington International Spring Symposium, 1991.
    • He Z, BhattacheIjee P, Radtke ND and Paterson CA Ocular inflammatory responses in diabetic rats. Invest aphthal. & Vis. Science 1991; 32:675.
    • He Z, Ma TG, Zhou M, Radtke ND and Tseng MT Effects of excitatory amino acids and N-methyl-D-aspartate (NMDA) receptor antagonists on calcium uptake in bovine retinal membrane. Invest. Ophthal. & Vis. Science 1990; 31:385.
    • Zhou M, Ma TG, He Z, Rigor BM and Tseng MT Ketamine inhibits lipid peroxidation in ischemic bovine retina. Scientist for Neuroscience 1990; 16(ptl):19.