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  • Vestibular Physiology Laboratory

    Dr. Wu Zhou is professor and director of research in the Department of Otolaryngology and Communicative Sciences. He has been on the otolaryngology faculty since 1999.

    Dr. Zhou’s research examines the neural mechanisms of sensorimotor transformation in the vestibular system. In particular, he studies how the cortical and subcortical brain structures generate compensatory eye movements to stabilize gaze during active and passive head movements. In collaboration with Dr. Hong Zhu and Dr. William Mustain, Dr. Zhou is investigating the neural mechanisms underlying vestibular-evoked myogenic potentials (VEMP).


    • 1996-99 - Research associate, Neurology, University of Mississippi Medical Center
    • 1999-2003 - Assistant professor, Surgery, UMMC
    • 2003-06 - Associate professor, Otolaryngology, UMMC
    • 2006-present - Professor and director of research, Otolaryngology, UMMC

    Selected peer-reviewed publications


    • Tang X, Xu Y, Simpson I, Jeffcoat B, Mustain W and Zhou W. The conjugacy of the vestibulo-ocular reflex (VOR) responses to single labyrinth stimulation in awake monkeys. Experimental Brain Research, 2010, 206(3):249-55. PMID 20820761
    • Donnellan K, Wei W, Jeffcoat B, Mustain W, Xu Y, Eby T and Zhou W. Frequency tuning of bone conducted tone burst-evoked myogenic potential in extraocular muscles (BOVEMP) in normal human subjects. Laryngoscope 2010 120: 2555-2560.
    • Lewis A, Mustain W, Xu Y, Thomas Eby and Zhou W. Frequency tuning in the tone burst-evoked myogenic potentials in extraocular muscles (OVEMP) in normal human subjects. Journal of Otolaryngology-Head & Neck Surgery, 2010, 39(5):491-7.
    • Xu Y, Simpson I, Tang X and Zhou W. Acoustic clicks activate both the canal and otolith vestibulo-ocular reflex pathways in behaving monkeys. JARO, 10(4):569-77, 2009. PMID 19626369
    • Jeffcoat B, Shelukin A, Fong A, Mustain W, and Zhou W. Alexander’s Law Revisited. Journal of Neurophysiology 100:154-159, 2008. PMID 18450584
    • Zhou W, Xu Y, Simpson I and Cai YD. Multiplicative computation in the vestibulo-ocular reflex (VOR). Journal of Neurophysiology 2007; 97: 2780-2789. PMID 17251367
    • Zhou W, Tang BF, Newlands SD, and King WM. Responses of monkey vestibular-only neurons to translation and angular rotation. Journal of Neurophysiology 2006; 96: 2915-2930.
    • Zhou W, Simpson I, Xu Y, and Fong A. Activity-dependent modulation: a non-linearity in the unilateral vestibulo-ocular reflex (VOR) pathways. Experimental Brain Research 2005; 163: 267–272. PMID 15818497
    • Zhou W, Mustain W and Simpson I. Sound-evoked vestibulo-ocular reflexes (VOR) in trained monkeys. Experimental Brain Research 2004; 156: 129-134. PMID 15344848
    • Zhou W, Weldon P, Tang BF and King WM. Rapid motor learning in the translational vestibulo-ocular reflex.Journal of Neuroscience 2003; 23(10):4288-98. PMID 12764117
    • Zhou W and King WM. Attentional sensitivity and asymmetries of vertical saccade generation in monkey. Vision Research 2002; 42:771-9. PMID 11888542
    • Zhou W, Tang BF and King WM. Responses of rostral fastigial neurons to linear acceleration in an alert monkey. Experimental Brain Research 2001;139(1):111-5. PMID 11482837
    • Zhou W and King WM. Monocular and binocular mechanisms of saccade generation. Brain and Behavioral Sciences 1999; 22(4):704-5.
    • Zhou W and King WM. Premotor commands encode monocular eye movements. Nature 1998; 393: 692-6. PMID 9641680
    • Zhou W and King WM. Binocular eye movement not coordinated during REM sleep. Experimental Brain Research 1997; 117: 153-60. PMID 9386014

    Ongoing research support

    • IH R01DC08585, Zhou (PI), 5/01/07-04/30/12
    • Multiplicative Computation in Vestibulo-Ocular Reflex (VOR)