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  • Thomas Adair, PhD

    Adair, Tom-web.jpgProfessor
    Office: G159
    Lab: G173
    Office phone: (601) 984-1806
    E-mail: tadair@umc.edu

    Areas of expertise

    • General: Cardiovascular and microcirculatory physiology. Vascular biology.

    • Specific: Growth regulation of the vascular system; metabolic control of angiogenesis, especially the role of oxygen and adenosine; role of epithelial sodium channels (ENaC) in angiogenesis; modeling and computer simulation of the cardiovascular system.

    Biography

    Dr. Adair pioneered work in the field of angiogenesis showing that oxygen is a major control element in growth regulation of the vascular system and was the first to prove that exercise stimulates production of vascular endothelial growth factor, a key proangiogenic substance. He has published more than 150 papers and reviews in the field over the past 30 years and has been a consultant for various governmental agencies. He is also an award-winning teacher, served on the National Board of Medical Examiners, and has authored or contributed to numerous physiology textbooks and review books.

    Research methods and techniques

    Methods for studying angiogenesis both in vivo and in vitro include long-term electrical stimulation of skeletal muscle in rabbits, rats, and mice; chick embryo CAM and whole body assays; rat and mouse aortic ring angiogenesis assays; mouse left ventricular angiogenesis assay; in vivo angioreactor. Analytical methods: histology, morphometric and stereological analyses of the vasculature, immunohistochemistry, and molecular biology methods for studying proangiogenic and antiangiogenic growth factors.