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  • Research Summary of Merry L. Lindsey, PhD

    Cardiac extracellular matrix biology is our major research focus, particularly changes to the matrix that are the cause or effect of pathophysiological processes. These changes include cell-matrix interactions, which both affect and react to processes involved in tissue repair. My laboratory primarily uses the murine model of myocardial infarction (MI). In addition to physiological parameters, we also measure biochemical, cell biological, and proteomic outputs. The main focuses of my laboratory are: a) the role of macrophage-derived MMPs in LV remodeling post-MI; b) the role of the cardiac fibroblast in the remodeling process, and c) the influence of aging on LV remodeling.