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  • Sean P. Didion, PhD

    Didion_Sean.jpgAssociate Professor
    Office: G313
    Phone: (601) 984-1716
    Fax: (601) 984-1637
    E-mail: sdidion@umc.edu

    Current research

    Our laboratory uses an integrative approach, including the use of molecular, genetic and pharmacological methods, to address important questions related to cardiovascular disease. With the advances in genetic technology that has allowed for manipulation of the mouse genome and with the mouse being ideally suited as a model of human disease, all of their studies make use of these extremely powerful tools to study vascular function. Examination of vascular function, particularly endothelial function, is important clinically considering that endothelial function has a major impact on the vessel wall and has emerged as an independent predictor of cardiovascular disease and events, including stroke and carotid artery disease. Techniques in our laboratory allow for the in vitro as well as in vivo examination of endothelial responses in cerebral blood vessels.

    Our research interests in vascular biology can be divided into two main research areas:

    • Role of superoxide and endogenous superoxide dismutases in cerebral blood vessels;
    • The contribution of pro-inflammatory cytokines and anti-inflammatory cytokines in promoting superoxide and endothelial dysfunction in response to in hypertension and obesity.

    Selected publications

    • Didion SP, Faraci FM. Effects of NADH and NADPH on superoxide levels and cerebral vascular tone. Am J Physiol Heart Circ Physiol. 282:H688-H695, 2002. PMID: 11788419
    • Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circulation Research. 91:938-944, 2002. PMID: 12234811
    • Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. Angiotensin II induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension. 43:1074-1079, 2004. PMID:15007032
    • Didion SP, Faraci FM. Impaired endothelium-dependent responses and enhanced influence of rho-kinase in cerebral arterioles in type II diabetes. Stroke. 36:342-347, 2005. PMID: 15637328
    • Baumbach GL, Didion SP, Faraci FM. Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase. Stroke. 37:1850-5, 2006. PMID: 16763183
    • Didion SP, Kinzenbaw DA, Schrader LI, Faraci FM. Heterozygous CuZn-superoxide dismutase deficiency produces a vascular phenotype with aging. Hypertension. 48:1072-1079, 2006. PMID: 17043164
    • Schrader LI, Kinzenbaw DA, Johnson AW, Faraci FM, Didion SP. Interleukin-6 deficiency protects against angiotensin II-induced endothelial dysfunction and hypertrophy. Arterioscler Thromb Vasc Biol. 27:2576-2581, 2007. PMID: 17962626
    • Didion SP. Chlamydophila pneumonia and endothelial activation: The smoke that precedes the fire of atherosclerosis? Circulation Research.102:861-863, 2008. PMID: 18436797
    • Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress in cerebral vascular dysfunction with aging. Am J Physiol Heart Circ Physiol. 296:H1914-1919, 2009. PMID:19395552
    • Didion SP, Kinzenbaw DA, Schrader LI, Chu Y, Faraci FM. Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction. Hypertension. 54:619-624, 2009. PMID: 19620507
    • Didion SP. Tacrolimus-induced hypertension: what’s endothelial and hematopoietic FKBP12 got to do with it. Hypertension. 57:1058-1060,2011. PMID: 21518964