Faculty, Staff and Associates

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  • Babette LaMarca, PhD

    LaMarca photo.jpg

    Phone: (601) 815-1430
    E-mail: bblamarca@umc.edu

    Current research

    My laboratory is interested in identifying immune mechanisms that cause hypertension during pregnancy. Specifically, my research focuses on the interactions between lymphocytes and autoantibodies in the pathophysiology of hypertension in response to placental ischemia. Over the years, we have developed models designed to identify how immune cells or their products cause changes in blood pressure during pregnancy.

    We have a strong translational research component with our tight collaborations with the Maternal-Fetal Medicine department in Obstetrics and Gynecology. Through this collaboration, we obtain human tissues to study alterations in genes and or proteins in response to low oxygen environment or placental ischemia. Furthermore, we examine how novel therapeutics may provide an avenue for treatment in pre-eclamptic women by blocking these altered genes and proteins.

    Selected publications

    • Parrish, M. R., Martin, J. N., Jr., LaMarca, B. B, Ellis, B., Parrish, S. A., Owens, M. Y., and May, W. L. (2013) Randomized, placebo controlled, double blind trial evaluating early pregnancy phytonutrient supplementation in the prevention of preeclampsia, Journal of perinatology : official journal of the California Perinatal Association. http://www.ncbi.nlm.nih.gov/pubmed/23448939
    • Martin, J. N., Jr., Brewer, J. M., Wallace, K., Sunesara, I., Canizaro, A., Blake, P. G., LaMarca, B., and Owens, M. Y. (2013) Hellp syndrome and composite major maternal morbidity: importance of Mississippi classification system, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. http://www.ncbi.nlm.nih.gov/pubmed/23387811
    • Kiprono, L. V., Wallace, K., Moseley, J., Martin, J., Jr., and LaMarca, B. (2013) Progesterone blunts vascular endothelial cell secretion of endothelin-1 in response to placental ischemia, American journal of obstetrics and gynecology. http://www.ncbi.nlm.nih.gov/pubmed/23545163
    • Herse, F., and LaMarca, B. (2013) Angiotensin II Type 1 Receptor Autoantibody (AT1-AA)-Mediated Pregnancy Hypertension, Am J Reprod Immunol 69, 413-418. http://www.ncbi.nlm.nih.gov/pubmed/23279165
    • Wallace, K., Novotny, S., Heath, J., Moseley, J., Martin, J. N., Jr., Owens, M. Y., and LaMarca, B. (2012) Hypertension in response to CD4(+) T cells from reduced uterine perfusion pregnant rats is associated with activation of the endothelin-1 system, American journal of physiology. Regulatory, integrative and comparative physiology 303, R144-149. http://www.ncbi.nlm.nih.gov/pubmed/22647295
    • Novotny, S. R., Wallace, K., Heath, J., Moseley, J., Dhillon, P., Weimer, A., Wallukat, G., Herse, F., Wenzel, K., Martin, J. N., Jr., Dechend, R., and LaMarca, B. (2012) Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats, American journal of physiology. Regulatory, integrative and comparative physiology 302, R1197-1201. http://www.ncbi.nlm.nih.gov/pubmed/22461177
    • Li, J., LaMarca, B., and Reckelhoff, J. F. (2012) A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model, American journal of physiology. Heart and circulatory physiology 303, H1-8. http://www.ncbi.nlm.nih.gov/pubmed/22523250
    • LaMarca, B. (2012) Endothelial dysfunction. An important mediator in the pathophysiology of hypertension during pre-eclampsia, Minerva ginecologica 64, 309-320. http://www.ncbi.nlm.nih.gov/pubmed/22728575
    • Herse, F., LaMarca, B., Hubel, C. A., Kaartokallio, T., Lokki, A. I., Ekholm, E., Laivuori, H., Gauster, M., Huppertz, B., Sugulle, M., Ryan, M. J., Novotny, S., Brewer, J., Park, J. K., Kacik, M., Hoyer, J., Verlohren, S., Wallukat, G., Rothe, M., Luft, F. C., Muller, D. N., Schunck, W. H., Staff, A. C., and Dechend, R. (2012) Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia, Circulation 126, 2990-2999. http://www.ncbi.nlm.nih.gov/pubmed/23155181
    • Dhillion, P., Wallace, K., Herse, F., Scott, J., Wallukat, G., Heath, J., Mosely, J., Martin, J. N., Jr., Dechend, R., and LaMarca, B. (2012) IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy, American journal of physiology. Regulatory, integrative and comparative physiology 303, R353-358. http://www.ncbi.nlm.nih.gov/pubmed/22718806