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  • Béla Kanyicska, PhD

     kanyicska.jpgAssociate Professor
    Office: N608
    Phone: (601) 984-6917
    Lab: N608; Phone: (601) 815-1285
    E-mail: bkanyicska@umc.edu


    • BA - Biology and chemistry, Eötvös Loránd University (ELTE), Budapest, Hungary, 1974
    • MS - Biochemistry, Eötvös Loránd University (ELTE), Budapest, Hungary, 1975
    • PhD - Neuroscience, Semmelweis University, Budapest, Hungary, 1999

    Research interests

    Hypothalamic neuronal circuitry is responsible for the integration of endocrine, autonomic and behavioral responses in order to ensure homeostasis of the organism. My research area lies in the "endocrine arm" of this vast and multifaceted regulatory system and it concerns with the regulation of hormone secretion of the anterior lobe of the pituitary gland. Specifically, my present research objective is to elucidate the intracellular signaling mechanisms by which endothelin-like peptides and dopamine affect pituitary hormone secretion and establish how steroid background influences the endothelin system in the pituitary gland and in the hypothalamus, respectively.

    Teaching responsibilities

    • Histology for medical, dental and graduate students

    Current research topics

    • Cellular/molecular mechanisms by which long-term steroid (estradiol and/or progesterone) treatment affect the endothelin system in the pituitary gland and the central nervous system (various in vivo experimental models, real-time PCR, proteomics)
    • Modulation of GABA and glutamate neurotransmission in hypothalamus by endothelins (long-term neuron culture, patch-clamp recording, immunocytochemistry)
    • Systems level integration (modeling) of mechanistic information obtained at sub-cellular and single-cell levels to elucidate the regulation of neuroendocrine hypothalamic functions by endothelins and ovarian steroids

    Selected publications

    • da Silva,A.A., do Carmo,J.M., Kanyicska,B., Dubinion,J., Brandon,E., Hall,J.E. Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rates. Hypertension 51:884-890 (2008)
    • Kanyicska,B., Sellix,M.T. and Freeman,M.E.: Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycle. Endocrine 20:53-58 (2003)
    • Kanyicska,B., Sellix,M.T. and Freeman,M.E.: Autocrine regulation of prolactin secretion by endothelins: a permissive role for estradiol. Endocrine 16:133-137 (2001)
    • Kanyicska,B., Lerant,A. and Freeman,M.E.: Endothelin-like immunoreactivity in lactotrophs, gonadotrophs and somatotrophs of the rat anterior pituitary gland are affected differentially by ovarian hormones Endocrine 14:263-268 (2001)
    • Kanyicska,B., Lerant,A. and Freeman,M.E.: Endothelin-1 is an autocrine regulator of prolactin secretion. Endocrinology 139:5164-5173 (1998)
    • Kanyicska,B., Freeman,M.E. and Dryer,S.E.: Endothelin-1 evokes persistent activation of large-conductance K+ channels in rat lactotrophs: reversal of this effect by long-term exposure to dopamine agonist. Endocrinology 138:3141-3153 (1997)
    • Kanyicska,B., Livingstone,J.D. and Freeman,M.E.: Long-term exposure to dopamine reverses the inhibitory effect of endothelin-1 on prolactin secretion. Endocrinology 136:990-994 (1995)
    • Seri,I., Rudas,R., Bors,Zs., Kanyicska,B., Tulassay,T.: Effects of low-dose dopamine infusion on cardiovascular and renal functions, cerebral blood flow and plasma catecholamine levels in sick preterm neonates. Pediatric Research 34:742-749 (1993)
    • Kanyicska,B. and Freeman,M.E.: Characterization of endothelin receptors in the anterior pituitary. Am. J. Physiol. 265:E601-E608 (1993)
    • Kanyicska,B., Burris,T.P. and Freeman,M.E.: The effects of endothelins on anterior pituitary hormone secretion are mediated by different guanine nucleotide-binding proteins. Endocrinology 129:2607-2613 (1991)
    • Burris,T.P., Kanyicska,B. and Freeman,M.E.: Inhibition of prolactin secretion by endothelin-3 is pertussis toxin sensitive. Eur. J. Pharmacol. 198:223-225 (1991)
    • Kanyicska,B., Burris,T.P. and Freeman,M.E.: Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture. Biochem.Biophys.Res.Comm. 174:338-343 (1991)
    • Bagdy,G., Szemerédi,K., Kanyicska,B. and Murphy,D.L.: Different serotonin receptors mediate blood pressure, heart rate, plasma catecholamine and prolactin responses to m- chlorophenylpiperazine in conscious rats. J.Pharm.Exp.Ther. 250:72-78 (1989)
    • Kiss,J.Z., Kanyicska,B. and Nagy,G.: The hypothalamic paraventricular nucleus has a pivotal role in regulation of prolactin release in lactating rats. Endocrinology 119:870-873 (1986)
    • Gy're,K., Szentendrei,T., Kanyicska,B., Fekete,M.I.K. and Rónai,A.: Dopamine receptor binding of a novel dibenzodioxazocine derivative EGYT-2509. Polish J. Pharmacology 37:253-262 (1985)
    • Kanyicska,B., Simonyi,A., Harsing,L., Vizi,E.S., Fekete,M.I.K. and Stark,E.: Catalepsy, hypermotility, increase of striatal acetylcholine release induced by opioids morphine and Met- enkephalin as affected by prolonged hydrocortisone and ACTH treatment. Polish J. Pharmacology 37:437-443 (1985)
    • Kanyicska,B., Stark,E., Horvà th,G., Simonyi,A., Fekete,M.I.K.: Long term ACTH induced diminished responsiveness of prolactin secretion to morphine. Life Sciences 33:427-432 (1983)
    • Antoni,F., Kanyicska,B. and Makara,G.B.: Effects of naloxone and neonatal treatment with Monosodium-L-Glutamate on growth hormone and prolactin release induced by electrical stimulation of the medial basal hypothalamus in rats. J. Endocrinology 109:427-432 (1983)
    • Fekete,M.I.K., Szentendrei,T., Kanyicska,B. and Palkovits,M.: Effects of anxiolytic drugs on catecholamine and DOPAC (dihydroxyphenylacetic acid) levels in brain regions in rats subjected to stress. Psychoneuroendocrinology 6:113-120 (1981)
    • Fekete,M.I.K., Szentendrei,T., Herman, J.P. and Kanyicska,B.: Effects of reserpine and antidepressants on dopamine and DOPAC (dihydroxyphenylacetic acid) concentration in the striatum, olfactory tubercle and median eminence. Eur. J. Pharmacology 64:231-238 (1980)
    • Palkovits,M., Mezey,E., Zaborszky,L., Feminger,A., Fekete,M.I.K., Herman, J.-P. and Kanyicska,B: Noradrenergic innervation of the rat hypothalamus: experimental biochemical and electron microscopic studies. Brain Research 191:161-171 (1980)
    • Palkovits,M., Mezey,E., Zaborszky,L., Feminger, A., Versteeg,D.H.G., Wijnen, H.J.L.M., Dejong,W., Fekete,M.I.K., Herman,J.-P. and Kanyicska,B.: Adrenergic innervation of the rat hypothalamus. Neuroscience Letters 18:237-243 (1980)
    • Palkovits,M., Zaborszky,L., Brownstein, M.J., Fekete,M.I.K., Herman,J.-P. and Kanyicska,B.: Distribution of norepinephrine and dopamine in the cerebral cortical areas of the rat brain. Brain Research Bulletin 4:593-604 (1979)
    • Fekete,M.I.K., Herman,J.-P., Kanyicska,B. and Palkovits, M.: Dopamine, noradrenaline and dihydroxyphenylacetic acid (DOPAC) levels of individual brain nuclei, effects of haloperidol and pargyline. J.Neural Transmission 45:207-218 (1979)
    • Fekete, M.I.K., Kanyicska,B. and Herman, J.-P.: Simultaneous radioenzymatic assay of catecholamines and dihydroxyphenylacetic acid (DOPAC), comparison of the effects of drugs on the tuberoinfundibular and striatal dopamine metabolism and on plasma prolactin level. Life Sciences 23:1549-1556 (1978)

    Reviews and book chapters

    • Freeman,M.E.,Kanyicska,B., Lerant,A. and Nagy,G.M.: Prolactin: structure, function and regulation of its secretion. Physiological Reviews 80:1523-1631 (2000)
    • Kanyicska,B., Burris,T.P. and Freeman,M.E.: Endothelins: a new class of hypophysiotrophic regulators. In: Progress in Endocrinology, eds. Mornex,R., Jaffiol,C. and Leclere,J., Parthenon Publ., Carnforth, England, 1992, pp.136-142
    • Kanyicska,B., Fekete,M.I.K., Simonyi,A., Szentendrei,T. and Stark,E.: Altered effectiveness of morphine and clonidine on prolactin and growth hormone secretion by long term adrenocorticotropin or hydrocortisone treatment. In: Stress: The Role of Catecholamines and Other Transmitters, edited by E. A. Usdin, Gordon and Breach Science Publishers, New York, 1984, pp.345-351.