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  • Fei Xing, PhD

     xing, fei



    Primary research interest

    • The role of cancer microenvironment in brain relapse and dormancy.
    • Non-coding RNA in brain metastasis.
    • Development of therapeutic compounds to suppress brain metastasis.

    Other activities

    • Member of the American Association for Cancer Research
    • Member of the European Association for Cancer Research
    • Member of the American Society of Clinical Oncology
    • Member of the Metastasis Research Society

    Selected publications

    • Fei Xing, Hiroshi Okuda, Aya Kobayashi, Misako Watabe, Sudha K. Pai, Puspa R. Pandey, Shigeru Hirota, Brian E. Moore, Wen Liu, Koji Fukuda, Vishnu Modur, Megumi Iiizumi1, Andrew Wilber, Elizabeth Peralta and Kounosuke Watabe. (2013) Reactive astrocytes promote the growth of cancer stem-like cells of metastatic breast tumor by activating Notch signaling in brain. EMBO Mol. Med. 5, 384 (cover story)(F1000 recommended).
    • Fei Xing, Hiroshi Okuda, Misako Watabe, Aya Kobayashi, Sudha K. Pai, Wen Liu, Puspa R. Pandey, Koji Fukuda, Shigeru Hirota, Tamotsu Sugai, Go Wakabayshi, Keisuke Koeda, Masahiro Kashiwaba, Kazuyuki Suzuki, Toshimi Chiba, Masaki Endo and Kounosuke Watabe.(2011) Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene. 30, 4075-4086.
    • Hiroshi Okuda*, Fei Xing* Puspa R Pandey, Sambad Sharma, Misako Watabe, Sudha K. Pai, Yin-Yuan Mo, Megumi Iiizumi- Gairani, Shigeru Hirota, and Kounosuke Watabe. (2013) miR-7 suppresses brain metastasis of cancer stem-like cells by modulating Kruppel-like factor 4 in breast cancer. Cancer Res, 73, 1434 (cover story) * equal contribution.
    • Wen Liu*, Fei Xing*, Megumi Iiizumi-Gairani, Hiroshi Okuda, Misako Watabe, Sudha K. Pai, Puspa R. Pandey, Shigeru Hirota, , Aya Kobayashi, Yin-Yuan Mo, Koji Fukuda, Yi Li  and Kounosuke Watabe. (2012) Metastasis suppressor, NDRG1, pleiotropically inhibits tumor metastasis by modulating Wnt-β-catenin signaling: Targeting Wnt-NDRG1 pathway as a potential therapeutic opportunity. EMBO Mol. Med., 4, 93. * equal contribution
    • Puspa R. Pandey, Fei Xing, Sambad Sharma, Misako Watabe, Sudha K. Pai, Megumi Iiizumi- Gairani, Koji Fukuda, Shigeru Hirota, Yin-Yuan Mo and Kounosuke Watabe (2012) Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. Oncogene, 10.519
    • Aya Kobayashi, Hiroshi Okuda, Fei Xing, Puspa R. Pandey, Misako Watabe, Shigeru Hirota, Sudha K. Pai, Wen Liu, Koji Fukuda, Christopher Chambers and Kounosuke Watabe (2011). Roles of BMP7 in dormancy and recurrence of Human prostate cancer stem-like cell in bone. JEM 2011 Dec 19;208(13):2641-55
    • Fei Xing, Kounosuke Watabe (2013). MicroRNAs as biomarkers for brain metastasis of breast cancer. Biomarkers in Medicine June 2013, Vol. 7, No. 3, Pages 387-390
    • Fei Xing, Kerui Wu, and Kounosuke Watabe (2013) MicroRNAs in Cancer Stem Cells: New Regulators of Stemness. Current Pharmaceutical Design, 2014 Jan 28