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  • Grant Proposals and MBC Members


    2008 NSF-CRIF Proposal by Ed Lewis at MSU for a 600 MHz NMR. NSF funded this proposal for $510 K and with matching from MSU (mostly from Chemistry) we purchased a Bruker 600 MHz NMR with Biomolecular probes for $750 K. The NMR will be installed in the next few weeks (late March 2010). MBC was mentioned prominently in the proposal.

    NSF MRI RR2 Proposal, John J. Correia "MRI-R2: Acquisition of Aviv XL-FDS Fluorescence Detection System," Shared Instrumentation Program, $438,784. Upgrade of existing Beckman Analytical Ultracentrifuge to fluorescence to allow analysis of biomolecular interactions between labeled molecules at extremely low concentrations and against an impure background like cell extracts. "Includes two-year service contract support and three years for a technician." This grant was funded and the FDS will be installed in late March.

    Members at UMMC

    John J Correia, Biochemistry

    • Major biophysical equipment: Beckman XLA Analytical Ultracentrifuge; Anton Paar DMA 500 density meter; Anton Paar AMVn Automated Viscometer
    • Biophysical expertise: Macromolecular Interactions; Thermodynamics of Anti-Mitotic Drugs; Microtubule Assembly
    • Core facility:  UMMC AUC Facility; service for fee available

    Drazen Raucher, Biochemistry

    • Major biophysical equipment: Zeiss Axiovert 200 Microscope  and
      fluorescence capability for live cell studies; laser optical tweezers
    • Biophysical expertise: Confocal, fluorescence, flow cytometry, video
      enhanced DIC microscopy 

     Jonathan Hosier, Biochemistry

    • Major biophysical equipment: Spectro Genesis Inductively Coupled
      Plasma Optical Emission Spectrometer
    • Biophysical expertise: Quantitative metal analysis; Isolation of integral membrane proteins; oxygen electrode assays of mitochondrial function

    Stan Smith, Pharmacology

    • Major biophysical equipment: Laser Flash Photolysis Unit; Scanning Spectrophotometer
    • Biophysical expertise: Conformational Dynamics and Drug/Ligand Binding of Macromolecules

    Rodney Baker, Pharmacology

    • Major biophysical equipment: Liquid Chromatography/Tandem Mass Spectrometer, Gas Chromatography/Mass Spectrometer
    • Biophysical expertise: Mass Spectrometry; MS Core Facility at UMMC

    University of Mississippi

    Randy Wadkins, Chemistry, biochemistry: rwadkins@olemiss.edu

    • Major biophysical equipment: ISS K2 fluorescence lifetime instrument; SGI Altix 3700 supercomputer (through Miss. Center for Supercomputing Res.); Mammalian cell culture
    • Biophysical expertise: Ligand-DNA interactions; cellular pharmacology; image processing; topoisomerase-interactive agents

    Susan Pedigo, Chemistry, biochemistry: spedigo@olemiss.edu

    • Major biophysical equipment: Aviv 202SF Circular Dichroism Spectrometer equipped with an automated titrimeter; Cary 50 Spectrophotometer; Microcal Nano II Differential Scanning Calorimeter
    • Biophysical expertise: Ligand binding, linked equilibria, protein stability

    Mike Mossing, Chemistry, biochemistry: mmossing@olemiss.edu

    • Major biophysical equipment: JY Horiba/Spex Fluoromax 3
      Spectrofluorometer, Akta Protein Chromatogaphy System, PE Cyclone Phosphorimager
    • Biophysical expertise: Thermodynamics and Kinetics of Protein-DNA
      interactions; Protein Engineering, Protein Folding; CD, Fluorescence
      and Protein NMR spectroscopy

    Robert J. Doerksen: Department of Medicinal Chemistry, School of Pharmacy: rjd@olemiss.edu

    • Major biophysical equipment: Computer hardware: 64-core Beowulf
      cluster, 8-core workstation, and other workstations. Computer
      software: Q-Chem, Schrodinger, CPMD
    • Biophysical expertise: Quantum chemistry, quantum chemical and
      molecular dynamics, including ab initio molecular dynamics, docking,
      binding free energy calculations, comparative protein modeling,
      pharmacophore modeling, and quantitative structure-property
      relationships to model and understand protein structure and
      dynamics, enzyme catalysis and protein-ligand interactions

    Nathan Hammer: Department of Chemistry and Biochemistry: nhammer@olemiss.edu

    • Major biophysical equipment: High-resolution Raman spectrometer, single molecule spectroscopy microscope, Coherent Innova 200 Ar ion laser, Spectraphysics 2018 mixed Ar/Kr ion laser
    • Biophysical expertise: Raman and SERS spectroscopy to study noncovalent interactions, Single molecule spectroscopy of biomolecules

    Mississippi College

    David H. Magers: Department of Chemistry and Biochemistry: magers@mc.edu  

    • Major biophysical equipment:  Parallel Quantum Solutions 16-node/32-processor Beowulf cluster running; 6 dual processor 64 bit and one quad-processor Linux workstations; Gaussian 03', and Quickprop by Schrondinger
      Biophysical expertise:  ab initio calculations; molecular modeling of small molecules; advanced electronic structure theory

    University of Southern Mississippi

    Charles McCormick: Department of Polymer Science: Charles.McCormick@usm.edu

    Vijay Rangachari: Department of Chemistry and Biochemistry: Vijay.Rangachari@usm.edu

    • Biophysical expertise:Protein misfodling in neurodegenerative diseases. Biophysics of amyloid aggregation in Alzheimer's and Parkinson's disease. Rational structure based drug design. Use of traditional medicines in drug design.

    Millsaps College

    Wolfgang H. Kramer: Department of Chemistry and Biochemistry: kramewh@millsaps.edu

    • Major biophysical equipment: Luzchem Photoreactor with timer, stirrer and 300 and 350 nm lamps, Rayonet Photoreactor with 254nm lamps, ORIEL mercury arc-lamp with fiber-optics and filters, Jasco J-720 CD spectrometer
    • Biophysical expertise: Photochemistry of organic and bioorganic compounds

    Mississippi State University

    Ed Lewis: Chair, Department of Chemistry: Edwin.Lewis@nau.edu

    Tougaloo College

    Bettye Sue Hennington: Biology Department: bhennington@tougaloo.edu

    • Major biophysical equipment: Mass Spec

    University of Alabama, Huntsville

    John W Shriver: Department of Chemistry and Biology; Director, Biomolecular NMR Laboratory: shriverj@uah.edu

    • Major biophysical equipment: 500 MHz Varian INOVA spectrometer with variable temperature probe (-40 to 100 C), z-axis pulsed field gradients, three channel waveform generators, and a micro LC 3 mm probe coupled to a Varian chromatography workstation with stopped flow module. We also have a 5 mm Penta probe for H, C, N, P, and D NMR. 800 MHz Varian INOVA spectrometer with variable temperature probe (-40 to 100 C), tri-axial gradients, four channel waveform generators, and H, C, N, D xyz PFG triple resonance probe
    • Biophysical expertise: NMR