• Laser-Capture Microdissection of Human Orbitofrontal Cortex

    Laser-Capture Microdissection of Human Orbitofrontal Cortex

    Postmortem Brain Core

    Craig A. Stockmeier, PhD - Core Director
    CPN Principal Investigator  
    Director, Administrative Core, CPN 
    Director, Postmortem Brain Core, CPN  
    Director, Division of Neurobiology &Human Behavior  
    Professor of Psychiatry and Human Behavior, UMMC  
    Guyton Building, Room G137
    Phone: (601) 984-5898; fax: (601) 984-5899  
    E-mail: cstockmeier@umc.edu   

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    Gouri Mahajan, MBBS – Core Manager 
    Department of Psychiatry and Human Behavior 
    Guyton Building, Room G131 
    Phone: (601) 984-6676; fax: (601) 984-5899 
    Email:  gmahajan@umc.edu

    Core Collaborators, (CWRU)

    • James C. Overholser, PhD
      Professor of Psychology
      Case Western Reserve University (CWRU), Cleveland, OH 
    • George Jurjus, MD, Assistant Professor of Psychiatry
      Louis Stokes Cleveland VA Medical Center, Cleveland, OH


    Despite the benefits of modern brain imaging in living patients and the numerous animal models of psychiatric illness, there will always be a significant need for the analysis of actual brain tissue postmortem. Studies on postmortem tissues can zero in on individual neurons and their helper cells, neuroglia to assess cellular anatomic features, protein expression and interactions with processes from other individual nerve cells revealing information not attainable from living patients or animal models.

    The CPN Postmortem Brain Core is directed by Dr. Craig A. Stockmeier. Dr. Stockmeier has extensive experience in the development and management of a significant postmortem human brain collection in the country devoted specifically to psychiatric neuroscience. This human brain core was funded by the National Institutes of Mental Health from 1989 – 2007 and has been funded by the National Center for Research Resources (NCRR )/National Institute of General Medical Sciences (NIGMS) since 2007.

    The brain collection is run in collaboration with the Departments of Psychiatry and Psychology, Case Western Reserve University, Cleveland, OH and the Cuyahoga County Coroner Office, Cleveland. The psychiatric assessment team includes James C. Overholser, PhD and George J. Jurjus, MD. Dr. Overholser, a clinical psychologist, has a long-standing career interest in depressive disorders in adolescents and adults. Dr. Jurjus Director of Inpatient Psychiatry and Detoxification at Cleveland Wade Park VA Hospital has been part of the retrospective diagnostic team since 1997 and provides additional expertise in psychoactive substance use disorders.

    Dr. Stockmeier and his collaborators organize all aspects of the brain collection, including storage of tissue samples and accompanying clinical information. CPN principal investigators are provided with high-quality postmortem human brain samples meeting inclusion criteria for their research aims involving psychiatric illnesses, as well as the critical supporting information for the brain tissue. Dr. Stockmeier further advises CPN investigators in the selection and matching of appropriate control and psychiatric subjects for their biological studies. 


    • Leica Cryostat CM3050S
    • Laser Capture Microdissection (for use by Core Manager only)
    • -80º Freezers
    • Microm HM400E


    Rates for Postmortem Brain Core Services



    Postmortem Brain Core 

    UMMC (internal)/hour 

    Non-UMMC (external)/hour 

    NIH Funding

    Base Cost = $31.64

    Base Cost x 1.495 = $47.30

    Other Funding

    Base Cost x 1.20 = $37.97

    Base Cost x 1.20) x 1.495 = $56.76