The Pilot Program is to aid investigators in generating data, with the assistance of Center Research Cores, for the submission of competitive, extramural grant applications linked to the overall theme of psychiatric neuroscience. Funds are available via Pilot Projects or Pilot Vouchers for research into the basic science mechanisms of psychiatric and neuropsychiatric disorders including disorders of mood or alcohol and substance dependence, neurological disorders, autism, cancer of the CNS and the role of vasculature on CNS function.
Project Investigator(08/01/14-07/01/16)- Circadian regulation of drug reward: Diurnal rhythms in mesolimbic neural firing and drug-seeking
It is well recognized that the responsiveness to drugs of abuse varies across the day. The long-term objective of our research is to understand the mechanisms underlying diurnal variations in drug reward and their influences on the development and expression of drug addiction. This research program may ultimately provide novel insights into the pathophysiology of addiction and suggest new strategies for the treatment of addictive disorders.
Recent publications - PubMed articles
Project Investigator (Awarded 8/01/14-7/31/16) - HELLP Syndrome
Decreases in associative memory and increases in depression and anxiety have been reported in women with a history of HELLP syndrome. They also have increased inflammatory cytokines which in other systems have been linked to depression and cognitive changes. The studies outlined in this project will evaluate an animal model of HELLP syndrome to determine if suppression of CD4+ T cells or inflammatory cytokines during pregnancy, through administration of Orencia (Abatacept) or dexamethasone, improves blood brain barrier permeability, thereby decreasing neuroinflammation and improving behavioral changes in rats with a history of HELLP syndrome.
Recent publications - PubMed articles
Pilot Voucher Recipient (Awarded 11/01/14-10/30/15)- ShRNA-mediated suppression of gap junction protein Connexin 43
“Voucher funds will test the hypothesis that a novel experimental approach can be used to target astrocytes to suppress the expression of the protein connexin 43 in the prefrontal cortex of the rat.”
Project Investigator(Awarded 08/01/14-07/31/16) - Long-term consequences of in utero methamphetamine exposure
Methamphetamine (METH) abuse is a major public health threat that has reached epidemic levels in rural Southern and Midwestern Regions in the United States and world-wide. Almost half of all METH users are women of childbearing age and a proportion of those use the drug throughout pregnancy, putting the fetus at serious risk for developmental and behavioral impairments. The experiments proposed in this application will provide vital information regarding which factors of in utero METH exposure contribute to the impairment of the offspring. These results will serve public health interests by providing knowledge which may lead to the development of effective interventions to improve the well-being of drug abusing pregnant women and protect their highly vulnerable offspring.
Project investigator (Awarded 9/22/15-7/1/16)-“Genetics in the Relation between PTSD and Trauma Cue-Evoked Cocaine Attentional Bias.”
Evidence for genetic factors that may influence trauma cue-induced attentional bias to cocaine cues among cocaine dependent patients with PTSD would help identify specific patients that are at heightened risk for relapse and other negative clinical outcomes. Results of this study would also highlight the need to develop interventions focused on improving emotion regulation for this at-risk group of patients that can be integrated into standard substance use disorder treatment programs. Finally, by examining moderators and mechanisms that may underlie negative substance use-related outcomes among cocaine dependent PTSD patients in Mississippi, the results of this study may aid in the development and refinement of interventions for an underserved population in need of more health-care resources.
Recent Publications-PubMed articles
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