Cancer Institute

  • Thomas J. Payne

    Professor, Department of Otolaryngology and Communicative Sciences
    Cancer Epidemiology Program
    PhD, Clinical Psychology, 1987, State University of New York at Binghamton, NY
    Resident, 1986-87, University of Mississippi / VA Medical Centers Consortium

    Contact information
    ACT Center for Tobacco Treatment, Education and Research
    UMHC Cancer Institute, 350 W. Woodrow Wilson Drive, Suite 611
    Jackson, MS 39213
    Phone: (601) 815-1180
    E-mail: tjpayne1@umc.edu

     payne_thomas.jpg

    Research interests

    • Biopsychosocial factors associated with nicotine dependence and treatment factors
    • Tobacco Regulatory Science
    • Vulnerable populations
    • Sociocultural factors associated with cardiovascular disease

     

    Research synopsis

    Tobacco use remains one of the most significant causes of many forms of cancer on a global basis. The overall goal of our research program is to better understand factors associated with the persistence of tobacco use, as well as predict successful treatment outcome, i.e., achieving abstinence. Our genetics research efforts comprise a substantial, long-term component of this work. In conjunction with our colleagues, this research group has published numerous papers over the last 10 years identifying a wide variety of specific genes and genetic profiles that are associated with nicotine dependence. This work has contributed substantial evidence regarding the importance of ethnicity in determining the role of specific genetic variants. Most recently, we have directed our efforts toward the role of genetics as it relates to phenotypic characteristics associated with nicotine dependence, the impact on treatment outcome and medication response, and psychometric aspects of key instruments. Other psychological / behavioral research related to tobacco use and dependence has been conducted in the areas of cue reactivity; treatment adherence; psychosocial factors associated with treatment outcome; healthcare provider attitudes, confidence and practices regarding tobacco treatment, and the impact of training experiences on those characteristics. Dr. Payne is also involved in research examining the role of sociocultural factors on cardiovascular disease risk in African-Americans. This work is conducted via his association with the Jackson Heart Study; Dr. Payne is one of the founding members of the sociocultural research group, having established the model and primary methodology for conducting this work.

    Recent accomplishments and honors

    • Past President, Association for the Treatment of Tobacco Use and Dependence
    • Delegate, ATTUD-NAADAC negotiations for Uniform Individual TTS Certification
    • Fellow, Society of Behavioral Medicine
    • Member: Mississippi Coalition for Tobacco Cessation, Mississippi Multicultural Leadership Committee
    • Tobacco Advisory Commission, appointment by Gov. Phil Bryant
    • SRNT Treatment Network Researcher Highlight
    • UMMC Gold Medallion Research Award
    • President's Cancer Panel

    Selected publications

    • Cigarette Smoking and Chronic Kidney Disease in African Americans in the Jackson Heart Study. Hall ME, Wang W, Okhomina V, Agarwal M, Hall JE, Dreisbach AW, Juncos LA, Winniford MD, Payne TJ, Robertson RM, Bhatnagar A, Young BA.J Am Heart Assoc. 2016 May 25;5(6). pii: e003280. doi: 10.1161/JAHA.116.003280.PMID:27225196
    • Psychosocial Factors Are Associated With Blood Pressure Progression Among African Americans in the Jackson Heart Study.” Ford CD, Sims M, Higginbotham JC, Crowther MR, Wyatt SB, Musani SK, Payne TJ, Fox ER, Parton JM. Am J Hypertens. 2016 Mar 10. pii: hpw013. PMID: 26964661
    • Perceived discrimination is associated with health behaviors among African Americans in the Jackson Heart Study.  Sims, M., Diez-Roux, A. V., Gebreab, S. Y., Brenner, A., Dubbert, P., Wyatt, S., Bruce, M., Hickson, D., Payne, T. J., Taylor, H. Feb. 2016, ).. J Epidemiology Community Health. doi:10.1136/jech-2015-206390 Feb. 2016 PMID: 26417003
    • Ethnic-specific genetic association of variants in the corticotropin-releasing hormone receptor 1 gene with nicotine dependence. Tang X, Zhan S, Yang L, Cui W, Ma JZ, Payne TJ, Li MD. Biomed Res Int. 2015;2015:263864. doi: 10.1155/2015/263864. Epub 2015 Feb 22
    • The contribution of rare and common variants in 30 genes to risk nicotine dependence. Yang, J., Wang, S., Yang, Z., Hodgkinson, C.A., Iarikova, P., Ma, J.Z., Payne, T.J., Goldman, D., & Li, M.D. (2014). Molecular Psychiatry 2014 doi: 10.1038/mp.2014.156. [Epub ahead of print].
    • The impact of brief tobacco treatment training on practice behaviors, self-efficacy, and attitudes among healthcare providers. Payne, T. J., Gaughf, N. W., Sutton, M. J., Sheffer, C. E., Elci, O., U., Cropsey, K. L., Taylor, S., Netters, T., Whitworth, C., Deutsch, P., & Crews, K. M. (2014). International Journal of Clinical Practice. doi:10.1111/ijcp.12386
    • Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. Wang S, D van der Vaart A, Xu Q, Seneviratne C, Pomerleau OF, Pomerleau CS, Payne TJ, Ma JZ, Li MD. Hum Genet. 2014 May;133(5):575-86. doi: 10.1007/s00439-013-1398-9. Epub 2013 Nov 20 PMID: 24253422
    • Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants. Wang S, Yang Z, Ma JZ, Payne TJ, Li MD. Mol Neurobiol. 2014 Feb;49(1):601-14. doi: 10.1007/s12035-013-8541-4. Epub 2013 Aug 30.
    •  Depressive symptoms among heavy cigarette smokers: the influence of daily rate, gender, and race. Payne TJ, Ma JZ, Crews KM, Li MD. Nicotine Tob Res. 2013 Oct;15(10):1714-21. doi: 10.1093/ntr/ntt047. Epub 2013 Apr 8. PMID: 23569006
    • Tobacco dependence treatment: influence of training experiences on clinical activities among otolaryngologists. Sutton MJ, Payne TJ, Gaughf NW, Crews KM, Elci OU, Peck SB, Schweinfurth J. “Laryngoscope. 2013 Dec;123(12):3005-9. doi: 10.1002/lary.23513. Epub 2013 Oct 1 PMID: 24122575
    • Tobacco cessation via public dental clinics: Results of a randomized trial. Gordon JS, Andrews JA, Albert DA, Crews KC, Payne TJ, Severson HH (2010). American Journal of Public Health, 100, 1307-1312.