Contact information Phone: (601) 984-6242E-mail: email@example.com
The long-range goal of our research is to understand antimitotic structure-function relationships. Antimitotic agents have been important in cancer chemotherapy for more than 40 years. These drugs interact with tubulin the major protein of mitotic spindles. Mitotic microtubules are dynamic, undergoing assembly and disassembly while aligning chromosomes at the metaphase plate. Antimitotics halt cell division at metaphase by altering microtubule dynamics. Their efficacy in destroying tumors is limited by their toxic profile. Understanding their mechanism of action and the relationship between chemical structure and activity is important for designing new drug analogs, as well as for identifying drugs that can be used in combination at lower, less toxic doses. Often tumors are resistant to antimitotic agents either initially or after repeated drug cycles. We are investigating the tubulin isotype composition of normal and tumor tissues by quantitative real-time PCR, Western blotting and ELISAs. It is possible that tubulin variants in tissues may contribute to antimitotic efficacy and toxicity. Alternatively other proteins that interact with tubulin may be upregulated or downregulated in drug resistant cells and tumors. We are carrying out these studies in both cell culture and clinical studies..
2500 North State Street
Jackson, MS 39216
General Information: 601-984-1000
Patient Appointments: 888-815-2005