Cancer Institute

  • Radhika Pochampally

    pochampally_radhika.jpgAssociate Professor, Department of Biochemistry
    Cancer Genetics Program
    PhD, Microbiology/Cancer biology, 2000, Louisiana State University Health Sciences Center, New Orleans.
    Postdoc, 2001-04, Tulane University Health Science Center, New Orleans, LA

    Contact information
    2500 N State St., Room R761
    Jackson, MS 39216
    Phone: (601) 815-6832
    E-mail: rpochampally@umc.edu

    Research interests

    • Role of mesenchymal stromal cells in stroma of breast and bone cancers
    • Development of affinity tagged liposomal nanoparticles for cancer therapy

    Research synopsis

    Multipotential Mesenchymal Stromal cells (MSCs) hold great potential for treating human degenerative diseases and injuries. Recent, studies regarding the biology of breast cancer stroma indicate that mesenchymal stem cells (MSCs) provide the supportive stroma for solid tumors. The general focus of research in my laboratory is to understand the stromal supportive properties of Mesenchymal Stem Cells (MSCs) from bone marrow and their therapeutic potential. Projects to understand the therapeutic potential of MSCs include (a) epigenetic regulation of MSCs under stress that mimic microenvironment in solid tumors (b) role of microRNA regulation in survival and differentiation of MSCs (c) post translational regulation using autophagic pathway in the survival of MSCs in solid tumor stroma.

    A second ongoing project aims to understand the role of MSCs in the osteosarcoma genesis and develop targeted nanotechnology based therapeutics. The projects involve (a) Identification of Osteosarcoma tumor initiating cells and (b) develop affinity tagged therapeutic options using targeted curcumin nanoparticles to Osteosarcoma cancer cells. 

    Selected publications

    • Dhule S, Penfornis P, Frazier T, Walker R, Tan G, He J, John V and Pochampally R (2011) Formulation, characterization and evaluation of curcumin-loaded γ-Cyclodextrin liposomal nanoparticles on osteosarcoma cell lines. Nanomedicine. Aug 10. [Epub ahead of print] PMID: 21839055
    • Oskowitz, AZ, Penfornis P, Tucker A, Prockop DJ, and Pochampally R (2011) Drosha but not Dicer regulates hMSCs cell cycle progression through a miRNA independent mechanism. International Journal of Biochemistry and Cell Biology. Jul 20. [Epub ahead of print] PMID: 21794839
    • Oskowitz AZ, McFerrin H, Gutshow M, Carter ML and Pochampally R (2011) Serum Deprived Human Multipotent Mesenchymal Stromal Cells (MSCs) are Highly Angiogenic. Stem Cell Research Jan 31. [Epub ahead of print] PMID: 21421339
    • Sanchez C, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule S, Rowan BG, Kelekar A, Krause DS and Pochampally R (2011) Activation of Autophagy in Mesenchymal Stem Cells Provides Tumor Stromal Support Carcinogenesis Jul;32(7):964-72. PMID: 21317300
    • Penfornis, P and Pochampally R (2011) Isolation of Mesenchymal Stem Cells from Bone Marrow, Molecular Methods 698: 11-21. PMID: 21431507
    • Shoji M, Oskowitz A, Malone C, Prockop D J and Pochampally R (2011) Human Mesenchymal Stromal Cells (MSCs) Reduce Neointimal Hyperplasia in a Mouse Model for Flow-Restriction by Transient Suppression of Anti-Inflammatory Cytokines, Journal of Atherosclerosis and Thrombosis Jun 28;18(6):464-74. PMID: 21307612
    • Adhikari A, Agarwal N, Wood B, Porretta C, Ruiz B, Pochampally R, Iwakuma T (2010) CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance, Cancer Research Jun 1;70(11):4602-12. PMID: 20460510
    • DeComas A, Penfornis P, Frazier T, Meyer M and Pochampally R (2010) Derivation and Characterization of an Extra-Axial Chordoma Cell Line (EACH-1) from a Scapular Tumor, Journal of Bone and Joint Surgery May; 92(5): 1231-40. PMID: 20439670