Cancer Institute

  • Larry A. Walker

    Emeritus Professor, School of Pharmacology
    Molecular Cancer Therapeutics
    PhD, Pharmacology, 1979, Vanderbilt University, Nashville, TN
    Postdoc, 1979-81, Dartmouth Medical School, Hanover, NH
    Postdoc, 1979, Bosch Institute for Klin. Pharmakologie, Stuttgart, Germany

    Contact information 
    P.O. Box 1848
    Thad Cochran Research Center


    Research interests

    • Drug discovery and development from natural products
    • Efficacy and hematological toxicity of 8-aminoquinoline anti-infectives
    • Medicinal plants and their pharmacology and toxicology

    Research synopsis

    In 1987, Dr. Walker was tapped to lead a natural products discovery biological screening program at the University of Mississippi, and this unit was transferred to form the core of the discovery operation when the NCNPR opened in 1995. At that time he assumed responsibilities as Associate Director of NCNPR, and in 2001, he was named Director. He retired in 2016. He maintains a strong interest in the discovery of natural products and mechanisms of action, and in the development of the 8-aminoquinoline anti-infectives, probing their pharmacology, bioactivation, pharmacokinetics, and toxicity issues. During his tenure, the NCNPR's discovery efforts  expanded to include pathways/targets relevant to cancer. In 2008/9, Dr. Walker served on the steering committee for the University of Mississippi Medical Center Cancer Institute.

    Recent accomplishments and honors

    •  2009 - FDA Commissioner's Special Citation Award
    • 2009 - University of Mississippi Distinguished Research and Creative Achievement Award
    • 2005/07 - National Cancer Institute's PDQ Cancer Complementary and Alternative Medicine Editorial Board

    Selected publications