Professor, Department of PharmacologyCancer Genetics ProgramPhD, Toxicology, 1997, Texas A&M UniversityPostdoc, 1998-2000, Duke UniversityPostdoc, 1997-98, Indiana University
Contact informationBox 1848, 305 Faser HallSchool of PharmacyUniversity, MS 38677Phone: (662) 915-6691E-mail: email@example.com
There is a new appreciation that environmental factors that act during key developmental stages can increase the risk of developing adult disease, and that this disease susceptibility can be passed on multi- or transgenerationally. Fish are a well suited, but underutilized, model organism for testing the multigenerational and epigenetic consequences of environmental contaminant exposure. PAHs are ubiquitous environmental contaminants that have been long recognized as carcinogens but more recently are being recognized for the reproductive and developmental toxicities. Specifically, we use zebrafish to probe mechanisms of multigenerational toxicity of an environmentally relevant endocrine disruptor benzo[a]pyrene. Funded by National Institute of Environmental Health Sciences. The nanoparticle industry is booming, and silver nanoparticles specifically have the highest number of new uses compared to any other. Unfortunately, the toxicological implications of the environmental release of these particles is largely unknown and no regulatory framework exists for them. Our studies not only highlight mechanisms of toxicity but provide useful information for setting risk guidelines. Funded by US Army Corps of Engineers. Many natural products have been suggested as having cancer chemopreventative properties. We use prostate or endometrial cells to further explore the molecular mechanisms of particular constituents present in natural products.
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